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The map label for this gene is groEL

Identifier: 83591502

GI number: 83591502

Start: 187808

End: 189439

Strand: Direct

Name: groEL

Synonym: Rru_A0162

Alternate gene names: 83591502

Gene position: 187808-189439 (Clockwise)

Preceding gene: 83591501

Following gene: 83591503

Centisome position: 4.31

GC content: 65.81

Gene sequence:

>1632_bases
ATGGCTGCCAAAGACGTCAAGTTTTCCAGCGACGCCCGTGATCGCCTGCTGCGCGGCGTCGACACCCTGGCCAATGCGGT
CAAGGTGACGCTCGGCCCCAAGGGCCGCAACGTGGTGATCGACAAAAGCTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TGTCCGTCGCCAAGGAAATCGAACTGAAGGACAAGTTCGAGAACATGGGCGCGCAGATGCTGCGCGAGGTCGCCTCCAAA
TCCGCCGATGTCGCCGGCGATGGCACGACCACCGCCACCGTGCTGGCCCAGGCCATCGTCCGCGAGGGCAGCAAGGCGGT
CGCCGCCGGCATGAACCCGATGGACCTCAAGCGCGGCATCGATCTGGCGGTCGCCGCCGTCGTCAAGGACGTGAAGACGC
GCTCGCGCAAGATCGCCACCAATGATGAAATTGCCCAGGTCGGCACCATCTCGGCCAATGGCGATGAAGAGGTCGGCAAG
ATCATCGCCCGGGCGATGGACAAGGTCGGTCACGAGGGCGTGATCACCGTCGAGGAGGCCAAGGGCCTCGATACCGAGCT
CGACGTGGTCGAAGGCATGCAGTTCGATCGCGGCTATCTGTCGCCCTATTTCGTGACCAACGCCGAGAAGATGGTCGCCG
ATCTGGAAAACCCCTACATCCTGATCCACGAAAAGAAGCTCTCGGGCCTGCAGCCGCTGCTGCCGGTGCTCGAAGCCGTC
GTCCAGTCGGGGCGGCCGCTGCTGATCATCGCCGAAGATGTCGAGGGCGAGGCCCTGGCCACCCTGGTGGTCAACCGTCT
GCGCGGCGGCCTCAAGGTCGCCTCGGTCAAGGCCCCGGGCTTTGGCGATCGCCGCAAGGCGATGCTCGAAGACATCGCCA
TCCTGACCGGTGGGCAGGTGATCAGCGAAGACCTGGGCATCAAGCTTGAGACCGTCACCCTCGACATGCTGGGCACGGCC
AAGACGGTGACGATCACCAAGGACAACACCACCATCGTCGACGGCGCCGGCGTCAAGGCCGATATCGACGCCCGCTGCGC
CCAGATCCGCGCCACCATCGAAGACACCACTAGCGATTACGACCGGGAAAAGCTGCAAGAACGTCTGGCCAAGTTGTCGG
GCGGCGTCGCGGTGATCCGGGTTGGCGGTGCCAGCGAAGTCGAGGTCAAGGAGAAGAAGGACCGCGTCGACGACGCGATG
CACGCCACCCGCGCCGCCGTTGAGGAAGGCATCATCGCCGGCGGCGGTGTCGCCCTGCTGCATGCGGCCAAGGCCCTGGA
CGCCCTGAGCCCGGCCAACGCCGATCAGAAGGTCGGGATCGAGATCGTGCGGCGCGCCCTGCAGGCGCCGGTGCGCCAGA
TCGCCGAGAACGCCGGCGTCGATGGCGCCGTGGTCGCCGGCAAGCTGCTTGAAAGCTCCGATGCCGATTTCGGCTACAAC
GCCCAGACCGGGGTCTATGAGAATCTGGTCAAGGTCGGGGTGATCGATCCGACCAAGGTCGTGCGCACCGCCCTCCAGGG
GGCGGCCTCGGTGGCCTCGCTGCTGATCACCACCGAGGCGATGGTCGCCGAAATCCCCGAGAAGAAGCCGGCCCTGCCCG
CCGGCGGCGGCATGGGCGACATGGACTTCTAA

Upstream 100 bases:

>100_bases
ACGGCGTCGAGTATCTCATCATGAAGGAATCCGACATTCTCGGCGTGATCGAGGATGCCGATGCGGCCCGCCGGGCGGCG
TGAGTCGAGGGGAGGAACCA

Downstream 100 bases:

>100_bases
GCCATCCTGGCTTGGACCAAGGGGGCCGCTTCCGATCGGGGGTGGCCCCTTTGTCTATTTTGCCGCCGATAGCGCTTTCA
TCTTGTAAGGATCATGTTTC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 543; Mature: 542

Protein sequence:

>543_residues
MAAKDVKFSSDARDRLLRGVDTLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASK
SADVAGDGTTTATVLAQAIVREGSKAVAAGMNPMDLKRGIDLAVAAVVKDVKTRSRKIATNDEIAQVGTISANGDEEVGK
IIARAMDKVGHEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILIHEKKLSGLQPLLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVASVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLDMLGTA
KTVTITKDNTTIVDGAGVKADIDARCAQIRATIEDTTSDYDREKLQERLAKLSGGVAVIRVGGASEVEVKEKKDRVDDAM
HATRAAVEEGIIAGGGVALLHAAKALDALSPANADQKVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLESSDADFGYN
AQTGVYENLVKVGVIDPTKVVRTALQGAASVASLLITTEAMVAEIPEKKPALPAGGGMGDMDF

Sequences:

>Translated_543_residues
MAAKDVKFSSDARDRLLRGVDTLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASK
SADVAGDGTTTATVLAQAIVREGSKAVAAGMNPMDLKRGIDLAVAAVVKDVKTRSRKIATNDEIAQVGTISANGDEEVGK
IIARAMDKVGHEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILIHEKKLSGLQPLLPVLEAV
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVASVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLDMLGTA
KTVTITKDNTTIVDGAGVKADIDARCAQIRATIEDTTSDYDREKLQERLAKLSGGVAVIRVGGASEVEVKEKKDRVDDAM
HATRAAVEEGIIAGGGVALLHAAKALDALSPANADQKVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLESSDADFGYN
AQTGVYENLVKVGVIDPTKVVRTALQGAASVASLLITTEAMVAEIPEKKPALPAGGGMGDMDF
>Mature_542_residues
AAKDVKFSSDARDRLLRGVDTLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEIELKDKFENMGAQMLREVASKS
ADVAGDGTTTATVLAQAIVREGSKAVAAGMNPMDLKRGIDLAVAAVVKDVKTRSRKIATNDEIAQVGTISANGDEEVGKI
IARAMDKVGHEGVITVEEAKGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILIHEKKLSGLQPLLPVLEAVV
QSGRPLLIIAEDVEGEALATLVVNRLRGGLKVASVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLETVTLDMLGTAK
TVTITKDNTTIVDGAGVKADIDARCAQIRATIEDTTSDYDREKLQERLAKLSGGVAVIRVGGASEVEVKEKKDRVDDAMH
ATRAAVEEGIIAGGGVALLHAAKALDALSPANADQKVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLESSDADFGYNA
QTGVYENLVKVGVIDPTKVVRTALQGAASVASLLITTEAMVAEIPEKKPALPAGGGMGDMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=55.3672316384181, Blast_Score=580, Evalue=1e-165,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=55.3672316384181, Blast_Score=580, Evalue=1e-165,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.4199623352166, Blast_Score=699, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=53.219696969697, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=239, Percent_Identity=49.3723849372385, Blast_Score=220, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.6539923954373, Blast_Score=590, Evalue=1e-169,
Organism=Saccharomyces cerevisiae, GI6322524, Length=521, Percent_Identity=21.4971209213052, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=56.3567362428843, Blast_Score=587, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=56.3567362428843, Blast_Score=587, Evalue=1e-167,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=52.9523809523809, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=52.9523809523809, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=52.9523809523809, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI17864606, Length=545, Percent_Identity=45.6880733944954, Blast_Score=468, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24584129, Length=534, Percent_Identity=37.2659176029963, Blast_Score=339, Evalue=3e-93,
Organism=Drosophila melanogaster, GI19921262, Length=534, Percent_Identity=37.2659176029963, Blast_Score=339, Evalue=3e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_RHORT (Q2RY28)

Other databases:

- EMBL:   CP000230
- RefSeq:   YP_425254.1
- HSSP:   P0A6F5
- ProteinModelPortal:   Q2RY28
- SMR:   Q2RY28
- STRING:   Q2RY28
- GeneID:   3833692
- GenomeReviews:   CP000230_GR
- KEGG:   rru:Rru_A0162
- NMPDR:   fig|1085.1.peg.953
- eggNOG:   COG0459
- HOGENOM:   HBG625289
- OMA:   DVKFHDS
- PhylomeDB:   Q2RY28
- ProtClustDB:   PRK12849
- BioCyc:   RRUB269796:RRU_A0162-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57045; Mature: 56914

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSSDARDRLLRGVDTLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMLREVASKSADVAGDGTTTATVLAQAIVREGSKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHCH
DLAVAAVVKDVKTRSRKIATNDEIAQVGTISANGDEEVGKIIARAMDKVGHEGVITVEEA
HHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILIHEKKLSGLQPLLPVLEAV
CCCCCHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVASVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLDMLGTAKTVTITKDNTTIVDGAGVKADIDARCAQIRATIEDTTSDY
HHHCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHH
DREKLQERLAKLSGGVAVIRVGGASEVEVKEKKDRVDDAMHATRAAVEEGIIAGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAAKALDALSPANADQKVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLESSDADFGYN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
AQTGVYENLVKVGVIDPTKVVRTALQGAASVASLLITTEAMVAEIPEKKPALPAGGGMGD
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MDF
CCC
>Mature Secondary Structure 
AAKDVKFSSDARDRLLRGVDTLANAVKVTLGPKGRNVVIDKSFGAPRITKDGVSVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELKDKFENMGAQMLREVASKSADVAGDGTTTATVLAQAIVREGSKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHHHCH
DLAVAAVVKDVKTRSRKIATNDEIAQVGTISANGDEEVGKIIARAMDKVGHEGVITVEEA
HHHHHHHHHHHHHHCCCCCCCCCHHHEEEECCCCHHHHHHHHHHHHHHCCCCCEEEECCC
KGLDTELDVVEGMQFDRGYLSPYFVTNAEKMVADLENPYILIHEKKLSGLQPLLPVLEAV
CCCCCHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHH
VQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVASVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLETVTLDMLGTAKTVTITKDNTTIVDGAGVKADIDARCAQIRATIEDTTSDY
HHHCCCCEEEEEEEEECCCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCHH
DREKLQERLAKLSGGVAVIRVGGASEVEVKEKKDRVDDAMHATRAAVEEGIIAGGGVALL
HHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
HAAKALDALSPANADQKVGIEIVRRALQAPVRQIAENAGVDGAVVAGKLLESSDADFGYN
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
AQTGVYENLVKVGVIDPTKVVRTALQGAASVASLLITTEAMVAEIPEKKPALPAGGGMGD
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
MDF
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA