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The map label for this gene is pbpC [H]

Identifier: 83591445

GI number: 83591445

Start: 123031

End: 125151

Strand: Direct

Name: pbpC [H]

Synonym: Rru_A0105

Alternate gene names: 83591445

Gene position: 123031-125151 (Clockwise)

Preceding gene: 83591444

Following gene: 83591446

Centisome position: 2.83

GC content: 72.94

Gene sequence:

>2121_bases
ATGACACCGCCGGGACGGCGCGGGATCGGGCGATGGCTTCGCCGCCTCGCCCTGGGGGGCCTGGGGCTGGCGCTGCTTGT
CGGCGCCGGCGACCACCTGTTGCCGCCCGATCTTGGCCGCCTGACCCCGTCAACCCGGGTGATGGCGGCCAATGGCGCCG
TGCTGCGCGCCTTTCTGACCGCCGAGGGGGCTTGGCGGCTGCCCGGCGACCCGGCGGCGGTCGATCCCTTCTATCTGGCC
TTGCTCCAGGCCTTTGAGGACCGGCGCTTCGCCTCTCATCCCGGCGTCGATCCCTTGGCCGTCGCGCGGGCGCTTGGGCA
ATGGCTGGCCAATGGCAAGGTGATCTCCGGCGCGTCGACCCTGACCATGCAGACCGTGCGGCTGCTTGATCCGCGTCCCG
AGCGGACCATCGCCGCCAAACTGGTTGAAATGGTCCGGGCGGTGCAGCTTGAAGCCCATCTCGGCAAGACCGGCGTGCTG
GGCGCCTATCTGACCCTGGCCCCCTTTGGCGGCAATCTGGAAGGGGTGCGCGCCGGATCGCTGGCGTGGCTGGGCAAGGA
TCCCCGCCGTCTGACCCCGGGCGAGGCGGCCTTGCTGGTCGCCCTGCCCCAGGCGCCCGAGGCCCTGCGCCCCGACCGCC
ATCCCGCCGCCGCGCGGGCGGCGCGCGACAAGGTGCTGGAGCGGGCGGTGCGCGATGGGCTGCTCGACCCGGCCCAGGCG
CGCGAGGCCAAGGCCGAGCCGGTGCCGACGACGCGCCGGCCAATGCCGTTTTCCGCCCCCCATCTGACCGAACGTCTGGC
CGCCGGGGCGCCGGCGGGCGCGCCGATCGCCACGACGATCGACGAGGGGCTGCAAAACCGGCTGGAGCGGTTGGCGCGGC
GGGTGGCCGTGCCTTTGGGCCCCGGGCAATCGCTGGCCCTGCTGGCCGCCGAATCGGCCAGCGGCCGGATCCTGGCCAGC
GTCGGCTCGCCCGATTACCTTGATCCGGAGCGGGTGGGGGCGATCGACATGACGCGGGCGGTGCGCTCGCCGGGATCGGC
GCTCAAGCCGTTGCTTTACGGCATGGCCTTCGAGCGCCATATCGTCCATCCCGAGACGCTGATGATCGACCGGCCGACGC
GCTTTGGCGCTTATACCCCGGCCAATTTCGGCGATGCCCATTGGGGGGAGGTCAGCGTGCGCGAGGCCCTGGCCCAATCG
CTCAATGTGCCGGCGGTCATGCTGCTTGATCGCCTGGGACCGCTGGCCTTCGCCACCCGCTTGCAAAGCGCCGGCATCGC
CCTGCGCCTGCCCAAAGGCGTCGAGCGGCCGGGATTGCCCTTGGCCCTGGGCGGCCTGGGGGTGAGGCTTGAAGATCTGG
TGGGCCTGTTCGCCGCGATCGATGCCGGGGGCGCGGCGCCCCCCTTGCGCGCCCTTGCCGGTGCGCCCTTGCCGGCGCGC
CGGGTGCTTGAGCCGGCGGCGGCTTGGCAGGTCGCCGATATCCTGGCGGGCAGTCCGCCGCCCCCGGGGATGATCCTGGC
CGATCTGCGCCAGGGCGGTCGGACCGTGGCCTTCAAGACCGGCACCTCCTATGGCTTCCGCGACGCCTGGGCGGTGGGGT
TTGATGGCAAGGTGACGATCGGCGTTTGGGTTGGCCGCCCCGATGGCACGCCAAGCCCCGGCGCCTTTGGCCGGGCCACC
GCCGCACCCTTGCTGTTCCAGGCCTTTGAAGCGCTTGAAGGTCGGCCGCCGCCGCCGCGGTCCCGGCCCGACGGCGTGTT
TATCGGCGCCAATGGCGATCTGCCGCCGCCGCTGCGCCGCTTGGACGGCGAGCCGCCGCGCGCCGGTCGGCGGCTGGCCG
TCGACCGCGACGCCCTGACCATCGCCTTTCCCCCCGATGGCTCGGTCCTTGATCCGGCGTCCCTGGTCGATGGTCTGGCC
CTGTCGGCGCGCGGCGGGCAAAGGCCGCTGACTTGGCTGGTCGATGGCCGGCCCCTGGTCAGCCCGGCCTTCGCCCGAAC
CGCCCGCTGGATGCCGCCAAGCCTTCCCCGGGGCGGCGCCCTGGCGGTCAGGGTGAGCGTGGTTGACGCCGGCGGCCAGG
GGGACACGGCCCAGGTGTGGATCGGCCAATCCCCGCCGTAA

Upstream 100 bases:

>100_bases
TCGTTGTTCCCGGCGCCGCCGTCGAGGATATGGATCGCCCGGCCTTGCGGGCTAATCAGGGGGCGGGGCGGCTGTCGATC
GCCGCCCGCTGACCGCGCCG

Downstream 100 bases:

>100_bases
CGGACCGTTAAACCCTTTTCGGTATAGGAATGAGCGTGGGGAGACGTTCCCCAGGCTCTTCCTGGCCTTCCGTTTTCCCT
GGATCCGGGCTTTGATGCGC

Product: penicillin-binding protein 1C

Products: NA

Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MTPPGRRGIGRWLRRLALGGLGLALLVGAGDHLLPPDLGRLTPSTRVMAANGAVLRAFLTAEGAWRLPGDPAAVDPFYLA
LLQAFEDRRFASHPGVDPLAVARALGQWLANGKVISGASTLTMQTVRLLDPRPERTIAAKLVEMVRAVQLEAHLGKTGVL
GAYLTLAPFGGNLEGVRAGSLAWLGKDPRRLTPGEAALLVALPQAPEALRPDRHPAAARAARDKVLERAVRDGLLDPAQA
REAKAEPVPTTRRPMPFSAPHLTERLAAGAPAGAPIATTIDEGLQNRLERLARRVAVPLGPGQSLALLAAESASGRILAS
VGSPDYLDPERVGAIDMTRAVRSPGSALKPLLYGMAFERHIVHPETLMIDRPTRFGAYTPANFGDAHWGEVSVREALAQS
LNVPAVMLLDRLGPLAFATRLQSAGIALRLPKGVERPGLPLALGGLGVRLEDLVGLFAAIDAGGAAPPLRALAGAPLPAR
RVLEPAAAWQVADILAGSPPPPGMILADLRQGGRTVAFKTGTSYGFRDAWAVGFDGKVTIGVWVGRPDGTPSPGAFGRAT
AAPLLFQAFEALEGRPPPPRSRPDGVFIGANGDLPPPLRRLDGEPPRAGRRLAVDRDALTIAFPPDGSVLDPASLVDGLA
LSARGGQRPLTWLVDGRPLVSPAFARTARWMPPSLPRGGALAVRVSVVDAGGQGDTAQVWIGQSPP

Sequences:

>Translated_706_residues
MTPPGRRGIGRWLRRLALGGLGLALLVGAGDHLLPPDLGRLTPSTRVMAANGAVLRAFLTAEGAWRLPGDPAAVDPFYLA
LLQAFEDRRFASHPGVDPLAVARALGQWLANGKVISGASTLTMQTVRLLDPRPERTIAAKLVEMVRAVQLEAHLGKTGVL
GAYLTLAPFGGNLEGVRAGSLAWLGKDPRRLTPGEAALLVALPQAPEALRPDRHPAAARAARDKVLERAVRDGLLDPAQA
REAKAEPVPTTRRPMPFSAPHLTERLAAGAPAGAPIATTIDEGLQNRLERLARRVAVPLGPGQSLALLAAESASGRILAS
VGSPDYLDPERVGAIDMTRAVRSPGSALKPLLYGMAFERHIVHPETLMIDRPTRFGAYTPANFGDAHWGEVSVREALAQS
LNVPAVMLLDRLGPLAFATRLQSAGIALRLPKGVERPGLPLALGGLGVRLEDLVGLFAAIDAGGAAPPLRALAGAPLPAR
RVLEPAAAWQVADILAGSPPPPGMILADLRQGGRTVAFKTGTSYGFRDAWAVGFDGKVTIGVWVGRPDGTPSPGAFGRAT
AAPLLFQAFEALEGRPPPPRSRPDGVFIGANGDLPPPLRRLDGEPPRAGRRLAVDRDALTIAFPPDGSVLDPASLVDGLA
LSARGGQRPLTWLVDGRPLVSPAFARTARWMPPSLPRGGALAVRVSVVDAGGQGDTAQVWIGQSPP
>Mature_705_residues
TPPGRRGIGRWLRRLALGGLGLALLVGAGDHLLPPDLGRLTPSTRVMAANGAVLRAFLTAEGAWRLPGDPAAVDPFYLAL
LQAFEDRRFASHPGVDPLAVARALGQWLANGKVISGASTLTMQTVRLLDPRPERTIAAKLVEMVRAVQLEAHLGKTGVLG
AYLTLAPFGGNLEGVRAGSLAWLGKDPRRLTPGEAALLVALPQAPEALRPDRHPAAARAARDKVLERAVRDGLLDPAQAR
EAKAEPVPTTRRPMPFSAPHLTERLAAGAPAGAPIATTIDEGLQNRLERLARRVAVPLGPGQSLALLAAESASGRILASV
GSPDYLDPERVGAIDMTRAVRSPGSALKPLLYGMAFERHIVHPETLMIDRPTRFGAYTPANFGDAHWGEVSVREALAQSL
NVPAVMLLDRLGPLAFATRLQSAGIALRLPKGVERPGLPLALGGLGVRLEDLVGLFAAIDAGGAAPPLRALAGAPLPARR
VLEPAAAWQVADILAGSPPPPGMILADLRQGGRTVAFKTGTSYGFRDAWAVGFDGKVTIGVWVGRPDGTPSPGAFGRATA
APLLFQAFEALEGRPPPPRSRPDGVFIGANGDLPPPLRRLDGEPPRAGRRLAVDRDALTIAFPPDGSVLDPASLVDGLAL
SARGGQRPLTWLVDGRPLVSPAFARTARWMPPSLPRGGALAVRVSVVDAGGQGDTAQVWIGQSPP

Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]

COG id: COG4953

COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1788867, Length=583, Percent_Identity=44.5969125214408, Blast_Score=427, Evalue=1e-121,
Organism=Escherichia coli, GI1786343, Length=543, Percent_Identity=27.6243093922652, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI87082258, Length=266, Percent_Identity=29.3233082706767, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011815
- InterPro:   IPR009647
- InterPro:   IPR001460 [H]

Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-

Molecular weight: Translated: 73921; Mature: 73790

Theoretical pI: Translated: 11.20; Mature: 11.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPGRRGIGRWLRRLALGGLGLALLVGAGDHLLPPDLGRLTPSTRVMAANGAVLRAFLT
CCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
AEGAWRLPGDPAAVDPFYLALLQAFEDRRFASHPGVDPLAVARALGQWLANGKVISGAST
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCH
LTMQTVRLLDPRPERTIAAKLVEMVRAVQLEAHLGKTGVLGAYLTLAPFGGNLEGVRAGS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCEECCC
LAWLGKDPRRLTPGEAALLVALPQAPEALRPDRHPAAARAARDKVLERAVRDGLLDPAQA
EEECCCCCCCCCCCCEEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
REAKAEPVPTTRRPMPFSAPHLTERLAAGAPAGAPIATTIDEGLQNRLERLARRVAVPLG
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PGQSLALLAAESASGRILASVGSPDYLDPERVGAIDMTRAVRSPGSALKPLLYGMAFERH
CCCCEEEEEECCCCCEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVHPETLMIDRPTRFGAYTPANFGDAHWGEVSVREALAQSLNVPAVMLLDRLGPLAFATR
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
LQSAGIALRLPKGVERPGLPLALGGLGVRLEDLVGLFAAIDAGGAAPPLRALAGAPLPAR
HHHCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHH
RVLEPAAAWQVADILAGSPPPPGMILADLRQGGRTVAFKTGTSYGFRDAWAVGFDGKVTI
HHHCHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCEEEEECCCCCCCCCEEEECCCCEEEE
GVWVGRPDGTPSPGAFGRATAAPLLFQAFEALEGRPPPPRSRPDGVFIGANGDLPPPLRR
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHH
LDGEPPRAGRRLAVDRDALTIAFPPDGSVLDPASLVDGLALSARGGQRPLTWLVDGRPLV
CCCCCCCCCCEEEEECCEEEEEECCCCCCCCHHHHHHCCEEECCCCCCCEEEEECCCCCC
SPAFARTARWMPPSLPRGGALAVRVSVVDAGGQGDTAQVWIGQSPP
CHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCC
>Mature Secondary Structure 
TPPGRRGIGRWLRRLALGGLGLALLVGAGDHLLPPDLGRLTPSTRVMAANGAVLRAFLT
CCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCEEEEEEC
AEGAWRLPGDPAAVDPFYLALLQAFEDRRFASHPGVDPLAVARALGQWLANGKVISGAST
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCEEECCCCH
LTMQTVRLLDPRPERTIAAKLVEMVRAVQLEAHLGKTGVLGAYLTLAPFGGNLEGVRAGS
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEEECCCCCCCCEECCC
LAWLGKDPRRLTPGEAALLVALPQAPEALRPDRHPAAARAARDKVLERAVRDGLLDPAQA
EEECCCCCCCCCCCCEEEEEECCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
REAKAEPVPTTRRPMPFSAPHLTERLAAGAPAGAPIATTIDEGLQNRLERLARRVAVPLG
HHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
PGQSLALLAAESASGRILASVGSPDYLDPERVGAIDMTRAVRSPGSALKPLLYGMAFERH
CCCCEEEEEECCCCCEEEEECCCCCCCCHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
IVHPETLMIDRPTRFGAYTPANFGDAHWGEVSVREALAQSLNVPAVMLLDRLGPLAFATR
CCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCHHHHHHH
LQSAGIALRLPKGVERPGLPLALGGLGVRLEDLVGLFAAIDAGGAAPPLRALAGAPLPAR
HHHCCEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCHH
RVLEPAAAWQVADILAGSPPPPGMILADLRQGGRTVAFKTGTSYGFRDAWAVGFDGKVTI
HHHCHHHHHHHHHHHCCCCCCCCCEEHHHHCCCCEEEEECCCCCCCCCEEEECCCCEEEE
GVWVGRPDGTPSPGAFGRATAAPLLFQAFEALEGRPPPPRSRPDGVFIGANGDLPPPLRR
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCHHHH
LDGEPPRAGRRLAVDRDALTIAFPPDGSVLDPASLVDGLALSARGGQRPLTWLVDGRPLV
CCCCCCCCCCEEEEECCEEEEEECCCCCCCCHHHHHHCCEEECCCCCCCEEEEECCCCCC
SPAFARTARWMPPSLPRGGALAVRVSVVDAGGQGDTAQVWIGQSPP
CHHHHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10542235; 9205837; 9278503; 9841666 [H]