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The map label for this gene is ahcY [H]

Identifier: 83313490

GI number: 83313490

Start: 4793749

End: 4795140

Strand: Reverse

Name: ahcY [H]

Synonym: amb4391

Alternate gene names: 83313490

Gene position: 4795140-4793749 (Counterclockwise)

Preceding gene: 83313491

Following gene: 83313489

Centisome position: 96.54

GC content: 64.15

Gene sequence:

>1392_bases
ATGACCGATTACGTCGTTGCCGATATCGCCCTGGCCGCTTGGGGCCGCAAGGAGCTGGACATCGCCGAGAGCGAGATGCC
CGGCCTGATGGCCACCCGCGAGGAATTCGGCCCGTCGCAGCCGCTGAAGGGCGCCCGCATCGCCGGCTCGCTGCACATGA
CCATTCAGACCGGCGTGCTGATCGAGACCCTGAAGGCTCTGGGCGCCGACATCCGCTGGGCGTCGTGCAACATCTTCTCG
ACCCAGGACCACGCCGCCGCCGCCATCGCCGCCGCCGGCATCCCGGTGTTCGCCGTCAAGGGCGAGAACCTGGAAGAGTA
CTGGGACTACACCCACCGCATCTTCGAATGGGCCGATGGCGGCTGCCCCAACATGATCCTGGACGACGGCGGTGACGCCA
CTCTGCTGATCCATCTGGGCATGCGCGCCGAGAAGGACCTGTCGGTCCTCAACAACCCGACCTGCGAGGAAGAGGAAGTC
CTGTTCGCCTCCATCAAGAAGAAGCTGGCGACCGACAAGACCTTCTACACCCGCAACGGCACCGCCATCCGCGGCGTGAC
CGAGGAGACCACCACCGGCGTGCACCGTCTCTACGAGATGGAGAAGAAGGGCACCCTGCTGTGGCCGGCCATCAACGTCA
ACGACTCGGTGACCAAGTCCAAGTTCGATAACAAGTACGGCTGCCGCGAGTCGCTGGTCGATGGCATCCGCCGCGCCACC
GACGTCATGCTGGCCGGCAAGGTCGCCGTGGTCGCCGGCTTCGGCGATGTGGGCAAGGGCTCGGCCGAGTCGCTGGCGTC
CCAGGGCTGCCGCGTCATCGTCACCGAAATCGACCCCATCTGCGCCCTGCAGGCCTGCATGGAAGGCTATGAGGTCGCCA
CCATGGAAGAGGCCGCGCCCCGCGGCGACATCTTCGTCACCACCACCGGCAATGTGGACGTGATCACCGTCGATCACATG
CGCGCCATGAAGGACCGCGCCATCGTCTGCAACATCGGTCACTTCGACTCGGAGATCCAGGTCGCCGGCCTGAAGAACTT
CGAGTGGAACAACATCAAGCCGCAGGTGGACGAGATCAAGTTCCCCAGCGGCAACCGCATCCTGCTGCTGGCCGAGGGCC
GTCTCGTCAACCTGGGCTGCGCCACCGGCCACCCCTCCTTCGTGATGAGCGCCTCGTTCACCAACCAGGTGATGGCCCAG
ATCGAGATCTTCACCAATCCCGGCAAGTACGAGAAGAAGGTCTACGTCCTGCCCAAGACCCTGGACGAGAAGGTGGCCAT
GCTGCACCTCGCCAAGCTGGGCGCCACCCTGACCAAGCTGAACAAGAAGCAGTCCGATTATATCGGCGTCGCGGTCGAAG
GCCCCTTCAAGCCTGAAACCTATCGGTACTAG

Upstream 100 bases:

>100_bases
GGGCCATACTCACATAAAGATATCTTTATATCGTGTTGCGTTTTGCCGAAAGGGCTGGTACACAGGCGGCAACTGGAACA
TTCCTGTCCGAGGGACCATC

Downstream 100 bases:

>100_bases
ACTGCGAATACGTTAGACCGACGAAGCCCCCTTCCGGTGACGGAAGGGGGCTTTTTCTTGGGGAGAACCGAGCATGTGCA
CCTGTGGCAAGACCGGTCCC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MTDYVVADIALAAWGRKELDIAESEMPGLMATREEFGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADIRWASCNIFS
TQDHAAAAIAAAGIPVFAVKGENLEEYWDYTHRIFEWADGGCPNMILDDGGDATLLIHLGMRAEKDLSVLNNPTCEEEEV
LFASIKKKLATDKTFYTRNGTAIRGVTEETTTGVHRLYEMEKKGTLLWPAINVNDSVTKSKFDNKYGCRESLVDGIRRAT
DVMLAGKVAVVAGFGDVGKGSAESLASQGCRVIVTEIDPICALQACMEGYEVATMEEAAPRGDIFVTTTGNVDVITVDHM
RAMKDRAIVCNIGHFDSEIQVAGLKNFEWNNIKPQVDEIKFPSGNRILLLAEGRLVNLGCATGHPSFVMSASFTNQVMAQ
IEIFTNPGKYEKKVYVLPKTLDEKVAMLHLAKLGATLTKLNKKQSDYIGVAVEGPFKPETYRY

Sequences:

>Translated_463_residues
MTDYVVADIALAAWGRKELDIAESEMPGLMATREEFGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADIRWASCNIFS
TQDHAAAAIAAAGIPVFAVKGENLEEYWDYTHRIFEWADGGCPNMILDDGGDATLLIHLGMRAEKDLSVLNNPTCEEEEV
LFASIKKKLATDKTFYTRNGTAIRGVTEETTTGVHRLYEMEKKGTLLWPAINVNDSVTKSKFDNKYGCRESLVDGIRRAT
DVMLAGKVAVVAGFGDVGKGSAESLASQGCRVIVTEIDPICALQACMEGYEVATMEEAAPRGDIFVTTTGNVDVITVDHM
RAMKDRAIVCNIGHFDSEIQVAGLKNFEWNNIKPQVDEIKFPSGNRILLLAEGRLVNLGCATGHPSFVMSASFTNQVMAQ
IEIFTNPGKYEKKVYVLPKTLDEKVAMLHLAKLGATLTKLNKKQSDYIGVAVEGPFKPETYRY
>Mature_462_residues
TDYVVADIALAAWGRKELDIAESEMPGLMATREEFGPSQPLKGARIAGSLHMTIQTGVLIETLKALGADIRWASCNIFST
QDHAAAAIAAAGIPVFAVKGENLEEYWDYTHRIFEWADGGCPNMILDDGGDATLLIHLGMRAEKDLSVLNNPTCEEEEVL
FASIKKKLATDKTFYTRNGTAIRGVTEETTTGVHRLYEMEKKGTLLWPAINVNDSVTKSKFDNKYGCRESLVDGIRRATD
VMLAGKVAVVAGFGDVGKGSAESLASQGCRVIVTEIDPICALQACMEGYEVATMEEAAPRGDIFVTTTGNVDVITVDHMR
AMKDRAIVCNIGHFDSEIQVAGLKNFEWNNIKPQVDEIKFPSGNRILLLAEGRLVNLGCATGHPSFVMSASFTNQVMAQI
EIFTNPGKYEKKVYVLPKTLDEKVAMLHLAKLGATLTKLNKKQSDYIGVAVEGPFKPETYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=62.3376623376623, Blast_Score=537, Evalue=1e-153,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=61.3636363636364, Blast_Score=503, Evalue=1e-142,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=47.9569892473118, Blast_Score=434, Evalue=1e-122,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=47.9569892473118, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=47.9569892473118, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=47.9569892473118, Blast_Score=433, Evalue=1e-121,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=46.4516129032258, Blast_Score=408, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=60.8602150537634, Blast_Score=540, Evalue=1e-154,
Organism=Saccharomyces cerevisiae, GI6320882, Length=478, Percent_Identity=58.9958158995816, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=61.6883116883117, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=50.4310344827586, Blast_Score=433, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=48.068669527897, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=50.3239740820734, Blast_Score=430, Evalue=1e-120,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 50586; Mature: 50454

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDYVVADIALAAWGRKELDIAESEMPGLMATREEFGPSQPLKGARIAGSLHMTIQTGVL
CCCEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECEEEEEEECCHH
IETLKALGADIRWASCNIFSTQDHAAAAIAAAGIPVFAVKGENLEEYWDYTHRIFEWADG
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCC
GCPNMILDDGGDATLLIHLGMRAEKDLSVLNNPTCEEEEVLFASIKKKLATDKTFYTRNG
CCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
TAIRGVTEETTTGVHRLYEMEKKGTLLWPAINVNDSVTKSKFDNKYGCRESLVDGIRRAT
CEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHH
DVMLAGKVAVVAGFGDVGKGSAESLASQGCRVIVTEIDPICALQACMEGYEVATMEEAAP
HHHEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEHHHCCC
RGDIFVTTTGNVDVITVDHMRAMKDRAIVCNIGHFDSEIQVAGLKNFEWNNIKPQVDEIK
CCCEEEEECCCEEEEEEHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHEE
FPSGNRILLLAEGRLVNLGCATGHPSFVMSASFTNQVMAQIEIFTNPGKYEKKVYVLPKT
CCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHEEEEEEEEEECCCCCCCEEEEECCC
LDEKVAMLHLAKLGATLTKLNKKQSDYIGVAVEGPFKPETYRY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
TDYVVADIALAAWGRKELDIAESEMPGLMATREEFGPSQPLKGARIAGSLHMTIQTGVL
CCEEEEHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCEEECEEEEEEECCHH
IETLKALGADIRWASCNIFSTQDHAAAAIAAAGIPVFAVKGENLEEYWDYTHRIFEWADG
HHHHHHHCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHCCC
GCPNMILDDGGDATLLIHLGMRAEKDLSVLNNPTCEEEEVLFASIKKKLATDKTFYTRNG
CCCCEEEECCCCEEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEECCC
TAIRGVTEETTTGVHRLYEMEKKGTLLWPAINVNDSVTKSKFDNKYGCRESLVDGIRRAT
CEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHH
DVMLAGKVAVVAGFGDVGKGSAESLASQGCRVIVTEIDPICALQACMEGYEVATMEEAAP
HHHEECCEEEEEECCCCCCCCHHHHHHCCCEEEEECCCHHHHHHHHHCCCEEEEHHHCCC
RGDIFVTTTGNVDVITVDHMRAMKDRAIVCNIGHFDSEIQVAGLKNFEWNNIKPQVDEIK
CCCEEEEECCCEEEEEEHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCHHHEE
FPSGNRILLLAEGRLVNLGCATGHPSFVMSASFTNQVMAQIEIFTNPGKYEKKVYVLPKT
CCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHEEEEEEEEEECCCCCCCEEEEECCC
LDEKVAMLHLAKLGATLTKLNKKQSDYIGVAVEGPFKPETYRY
HHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]