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The map label for this gene is typA [H]

Identifier: 83313282

GI number: 83313282

Start: 4598566

End: 4599399

Strand: Reverse

Name: typA [H]

Synonym: amb4183

Alternate gene names: 83313282

Gene position: 4599399-4598566 (Counterclockwise)

Preceding gene: 83313283

Following gene: 83313281

Centisome position: 92.6

GC content: 66.07

Gene sequence:

>834_bases
ATGGAACTTCGCAACATCGCCATTATCGCCCACGTCGACCACGGCAAGACCACTCTGGTGGATGCCATGCTGCGGCAATC
GGGAACCTTCCGCGAAAACCAGCAGGTTGCTGAACGCGTGATGGATTCCAACGACCTGGAAAAGGAACGCGGCATCACCA
TCCTGGCCAAGTGCACCTCGGTCGAGTGGAAGGGAACGCGCATCAACATCGTCGACACCCCCGGCCACGCCGACTTCGGT
GGCGAGGTCGAGCGTATCCTGTCCATGGTGGACGGCGTCGTGGTGCTGGTGGACGCGGCCGAGGGCCCCATGCCCCAGAC
CAAGTTCGTCACCGGCAAGGCCCTGGGCCTGGGCTTGCGCCCCATCGTCGTGATCAACAAGGTGGATCGCGGCGACGCGC
GCCCCCACGAAGTGCACGACGAGTGCTTCGACCTGTTCGCGGCGCTGGACGCCGACGACAACCAGCTGGACTTCCCCACC
ATGTTCGCGGTGGGCCGCGACGGCTGGGCCGACGACAGCCTGGATGGCCCGCGCAAGGACCTCTCGGCCCTGTTCGACCT
GATCGTCGCTCATGTGCCGCCGCCCCGGCGCGACCTGGAGGCGCCGTTCTCCATGCTGGCCACCACGCTGGAAGCCGACC
CCTATCTCGGCCGCGTGCTGACCGGGCGCATCTATTCCGGCACGGCCAAGCTGAACATGCAGGTCAAGGGCCTGTCCCAC
GACGGCCAGCTGCTCGACAGTTCCGTCTCTCCAAGCTGCTGGCCTTCCGCGGCATCGAGCGCATTCCGGTGGAAAGCGCC
GAGGCGGGCGACATCATCGCCATCGCCGGCATGA

Upstream 100 bases:

>100_bases
ATCTCCCATTACGGCGCCCGGCCCGAGCGTTCGCTCAAGGATCTGGCCCGCGCCAAGCTGGGTCCCCATATCTTCGAAAA
TCTCCGGTAAGACGAGTCCC

Downstream 100 bases:

>100_bases
CCAAGCCCACCGTGGCCGACACCATCTGCGCCCCCGAGGTCACCGAGCCCCTCAAGGCCAATCCCATCGACCCGCCGACC
CTGTCCATGACCTTCTCGGT

Product: stress response membrane GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MELRNIAIIAHVDHGKTTLVDAMLRQSGTFRENQQVAERVMDSNDLEKERGITILAKCTSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVVVLVDAAEGPMPQTKFVTGKALGLGLRPIVVINKVDRGDARPHEVHDECFDLFAALDADDNQLDFPT
MFAVGRDGWADDSLDGPRKDLSALFDLIVAHVPPPRRDLEAPFSMLATTLEADPYLGRVLTGRIYSGTAKLNMQVKGLSH
DGQLLDSSVSPSCWPSAASSAFRWKAPRRATSSPSPA

Sequences:

>Translated_277_residues
MELRNIAIIAHVDHGKTTLVDAMLRQSGTFRENQQVAERVMDSNDLEKERGITILAKCTSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVVVLVDAAEGPMPQTKFVTGKALGLGLRPIVVINKVDRGDARPHEVHDECFDLFAALDADDNQLDFPT
MFAVGRDGWADDSLDGPRKDLSALFDLIVAHVPPPRRDLEAPFSMLATTLEADPYLGRVLTGRIYSGTAKLNMQVKGLSH
DGQLLDSSVSPSCWPSAASSAFRWKAPRRATSSPSPA
>Mature_277_residues
MELRNIAIIAHVDHGKTTLVDAMLRQSGTFRENQQVAERVMDSNDLEKERGITILAKCTSVEWKGTRINIVDTPGHADFG
GEVERILSMVDGVVVLVDAAEGPMPQTKFVTGKALGLGLRPIVVINKVDRGDARPHEVHDECFDLFAALDADDNQLDFPT
MFAVGRDGWADDSLDGPRKDLSALFDLIVAHVPPPRRDLEAPFSMLATTLEADPYLGRVLTGRIYSGTAKLNMQVKGLSH
DGQLLDSSVSPSCWPSAASSAFRWKAPRRATSSPSPA

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=232, Percent_Identity=32.7586206896552, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI94966754, Length=132, Percent_Identity=41.6666666666667, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI18390331, Length=139, Percent_Identity=41.726618705036, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI25306283, Length=134, Percent_Identity=41.044776119403, Blast_Score=98, Evalue=9e-21,
Organism=Homo sapiens, GI19923640, Length=134, Percent_Identity=41.044776119403, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI25306287, Length=134, Percent_Identity=41.044776119403, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4503483, Length=144, Percent_Identity=34.7222222222222, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI310132016, Length=111, Percent_Identity=37.8378378378378, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310110807, Length=111, Percent_Identity=37.8378378378378, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI310123363, Length=111, Percent_Identity=37.8378378378378, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI34147630, Length=253, Percent_Identity=30.0395256916996, Blast_Score=85, Evalue=9e-17,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=36.7647058823529, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI94966752, Length=128, Percent_Identity=30.46875, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI48994988, Length=248, Percent_Identity=58.0645161290323, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1788922, Length=156, Percent_Identity=39.7435897435897, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1789738, Length=139, Percent_Identity=40.2877697841727, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790412, Length=242, Percent_Identity=29.7520661157025, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1789737, Length=242, Percent_Identity=29.7520661157025, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790835, Length=145, Percent_Identity=33.1034482758621, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556745, Length=131, Percent_Identity=43.5114503816794, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17533571, Length=160, Percent_Identity=39.375, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17557151, Length=240, Percent_Identity=30, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=128, Percent_Identity=37.5, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988811, Length=128, Percent_Identity=37.5, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17506493, Length=180, Percent_Identity=30, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=36.5671641791045, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17556456, Length=257, Percent_Identity=28.4046692607004, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI25141371, Length=256, Percent_Identity=28.90625, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71994658, Length=131, Percent_Identity=36.6412213740458, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323320, Length=238, Percent_Identity=33.6134453781513, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324707, Length=161, Percent_Identity=36.6459627329193, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=161, Percent_Identity=36.6459627329193, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=167, Percent_Identity=36.5269461077844, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322359, Length=144, Percent_Identity=40.9722222222222, Blast_Score=92, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324761, Length=254, Percent_Identity=29.9212598425197, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324166, Length=142, Percent_Identity=38.0281690140845, Blast_Score=82, Evalue=7e-17,
Organism=Drosophila melanogaster, GI78706572, Length=244, Percent_Identity=33.6065573770492, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24582462, Length=141, Percent_Identity=42.5531914893617, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24585711, Length=149, Percent_Identity=35.5704697986577, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585713, Length=149, Percent_Identity=35.5704697986577, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585709, Length=149, Percent_Identity=35.5704697986577, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363316, Length=252, Percent_Identity=29.7619047619048, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17864358, Length=252, Percent_Identity=29.7619047619048, Blast_Score=95, Evalue=4e-20,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=37.6811594202899, Blast_Score=95, Evalue=5e-20,
Organism=Drosophila melanogaster, GI21357743, Length=134, Percent_Identity=38.8059701492537, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921738, Length=249, Percent_Identity=29.718875502008, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221458488, Length=161, Percent_Identity=40.3726708074534, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 30144; Mature: 30144

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRNIAIIAHVDHGKTTLVDAMLRQSGTFRENQQVAERVMDSNDLEKERGITILAKCTS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEECC
VEWKGTRINIVDTPGHADFGGEVERILSMVDGVVVLVDAAEGPMPQTKFVTGKALGLGLR
CEECCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCEEECCHHHCCCCC
PIVVINKVDRGDARPHEVHDECFDLFAALDADDNQLDFPTMFAVGRDGWADDSLDGPRKD
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
LSALFDLIVAHVPPPRRDLEAPFSMLATTLEADPYLGRVLTGRIYSGTAKLNMQVKGLSH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHEECEEEECEEEEEEEEECCCC
DGQLLDSSVSPSCWPSAASSAFRWKAPRRATSSPSPA
CCHHHCCCCCCCCCCHHHCCCEEECCCCCCCCCCCCC
>Mature Secondary Structure
MELRNIAIIAHVDHGKTTLVDAMLRQSGTFRENQQVAERVMDSNDLEKERGITILAKCTS
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCHHHCCCEEEEEECC
VEWKGTRINIVDTPGHADFGGEVERILSMVDGVVVLVDAAEGPMPQTKFVTGKALGLGLR
CEECCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCEEECCHHHCCCCC
PIVVINKVDRGDARPHEVHDECFDLFAALDADDNQLDFPTMFAVGRDGWADDSLDGPRKD
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
LSALFDLIVAHVPPPRRDLEAPFSMLATTLEADPYLGRVLTGRIYSGTAKLNMQVKGLSH
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHEECEEEECEEEEEEEEECCCC
DGQLLDSSVSPSCWPSAASSAFRWKAPRRATSSPSPA
CCHHHCCCCCCCCCCHHHCCCEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]