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The map label for this gene is lldP [H]

Identifier: 83313227

GI number: 83313227

Start: 4532125

End: 4534380

Strand: Reverse

Name: lldP [H]

Synonym: amb4128

Alternate gene names: 83313227

Gene position: 4534380-4532125 (Counterclockwise)

Preceding gene: 83313233

Following gene: 83313226

Centisome position: 91.29

GC content: 63.87

Gene sequence:

>2256_bases
ATGCTGGCGCAGGAAGGCGTCGCGCACGCCGCGGCGGCGGTAAAGGTCGATGCGGTCATAGAAGACGCCGATCTTCAGCA
TGTCGAAGACACGGTGCATCACCTGACTCATCACCAGATTGTGGGCGGCCTCGTAGATGGCCAGATGGAATTCGGCATCG
GTGGCGGCCTCCTGGGCGGGGTCGTCCAGGGCGTGGGCCTTTTCCATGGCCTCCATGCAGGTGCGCAGCCGGGCCAGATC
CTCGGGCGTGGCGCGCTCGGCGGCCAGGGCGGCGGCATTGCCGGCCATCACGCGGCGGAACTCGAAATAATCGAAGACCG
TTTCCGGATGCGCCTGCAGCAGGCGGGCAAGCGGATCGGCCGCCGGTTCGGCGGCGGTCCCGGGGGGCGACGGGGGGGCG
GCGTGCATCATGATATGAGGATAGGCCGGTGCTGGGTCATAGCCAATCATGGATTTTTGGCATGGCAACTTTTCCATTTA
CATCGGAAGACGAATCGAGTTATCCACGCTAATCGCTTGGTCAAATTATGTTACCACGTTCAAGAAACCTTCAACACCAA
CACCTCACCGGCATCTTCAGCGGATGCACGGTCGAACCTTCGGGGAGGCACCATGCAAGCTTGGATGCAAGTCTACGACC
CGGCCGGGAATCTGTGGCTGTCGTCACTGATCGCCGCCATTCCGATCATTTTCTTCTTTGTCGCCCTGGCGATCCTGAAG
CTGAAGGGCCATGTGGCCGGCACCATCACCGTGCTGCTGTCCATCGCCGTGGCCATCGTGTTCTACAAGATGCCGGTGGC
CGCCGCCGTCATGGCGGGCGTCCAGGGCTTCCTGTTCGGCCTGTGGCCCATCGCCTGGATCATCATCGGCGCGGTGTTCC
TGTATAAGGTCACGGTCAAGACCGGCCAGTTCGAGATCATCCGCTCCTCGGTGGTGTCCATCACCGCCGACCAGCGCCTG
CAGATGCTGATGATCGGCTTCTCGTTCGGCGCCTTCCTGGAGGGTGCGGCGGGCTTCGGCGCGCCGGTGGCCATCACTGC
CGCTCTGCTGGTGGGCCTGGGCTTCAACCCGCTTTACGCCGCCGGCCTGTGCCTGATCGCCAACACCGCCCCGGTGGCCT
TTGGCGCCATGGGCATTCCGATCATCGTCGCCGGTCAGGTCTCGGGCCTGGACGCTTTCAAGATCGGCGCCATGGCCGGT
CGCCAGTTGCCGCTGCTGGCGGTGTTCGTGCCGTTCTGGATCATCTTCATCATGGACGGCTTCAAGGGCGTCCGCGAGAC
CTGGCCCGCCATCCTGGTGGCCGGTGGCTCGTTCGCCTTCGGCGTGTGGTTCACCTCCAACTATATCGGGCCGGAGCTGC
CCGACATCACCTCGGCGCTGATCAGCCTGGTGTGCATCACGGTGTTCCTCAAGTTCTGGCAGCCCAAGAACATCTTCCGC
TTCAAGGAAGAGGGCGAGGACGAGAAGCACTCCCACGACTACACCACCGGTCAGGTGGCCCGCGCCTGGGCGCCGTTCCT
GATCCTCACCGCCGTGGTGACGGTGTGGAGCCTGAAGCCCTTCAAGGCCATGTTCGCCAAGGGCGGCGAGCTGGTGTTCA
CCAACATCAACTGGGAAGTGCCCGCCCTGCACAACCTGGTCGCCAAGGTGCCGCCGATCGTCGCCGCCGCCAAGGCCGTG
CCCGCCGTCTATACCCTGAACCTGGTCTCGGCCACCGGCACCGCCATCCTGATCTCGGCCATCATCACCATCATCATGCT
GGGGATGAAGGGCTCGGAGGGGCTCAAGACCTTCGGCGAGACCCTGAACGAGCTGAAGCGCCCCATCTACACCATCGGCA
CGGTGCTGGCCTTCGCCTATGTGGCCAATGCCTCGGGCCTGTCCACCACCCTGGCCCTGCTGCTGACCGGCGCCGGCGAT
TTCTATCCCTTCTTCTCGCCGGTCCTGGGCTGGCTGGGCGTGTTCCTCACCGGCTCGGACACCTCGTCCAACGCCCTGTT
CGGAGCGCTCCAGGCCACCACCGCCCATCAGCTGGGAATCAGCGACATCCTGATGGTTGCCGCCAACACCACCGGCGGCG
TCACCGGCAAGATGATCTCGCCCCAGTCCATCGCGGTGGCCTGCGCCGCCGTGGGTCTGGTGGGCCACGAGGCCAACCTG
TTCCGCTTCACCTTGAAGCACAGCGTCTTCTTCGTGTGCATCATCGGCGTGATCACCACGCTTCAGGCCTATGTCCTGAC
CTGGATGATTCCGTAA

Upstream 100 bases:

>100_bases
GCGCCTCGCGCAGGGCTTCCTCGGTGGAGTTAATGTGGCTCTCGGCCATGGTTCGGGCCTGTTCGGGATTGCCGGCGGCG
ATGGCCTGCCAGACGGCCTG

Downstream 100 bases:

>100_bases
CCCTCCCGCATCCCCCTGATGCCGGACAAACTGGCCCGGGCGGTTTCGCCCGGGCCTTTCTTCTTTGGCCCCGGGGGGGT
ATAGAAGGCCTCATGAGCTT

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 751; Mature: 751

Protein sequence:

>751_residues
MLAQEGVAHAAAAVKVDAVIEDADLQHVEDTVHHLTHHQIVGGLVDGQMEFGIGGGLLGGVVQGVGLFHGLHAGAQPGQI
LGRGALGGQGGGIAGHHAAELEIIEDRFRMRLQQAGKRIGRRFGGGPGGRRGGGVHHDMRIGRCWVIANHGFLAWQLFHL
HRKTNRVIHANRLVKLCYHVQETFNTNTSPASSADARSNLRGGTMQAWMQVYDPAGNLWLSSLIAAIPIIFFFVALAILK
LKGHVAGTITVLLSIAVAIVFYKMPVAAAVMAGVQGFLFGLWPIAWIIIGAVFLYKVTVKTGQFEIIRSSVVSITADQRL
QMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIANTAPVAFGAMGIPIIVAGQVSGLDAFKIGAMAG
RQLPLLAVFVPFWIIFIMDGFKGVRETWPAILVAGGSFAFGVWFTSNYIGPELPDITSALISLVCITVFLKFWQPKNIFR
FKEEGEDEKHSHDYTTGQVARAWAPFLILTAVVTVWSLKPFKAMFAKGGELVFTNINWEVPALHNLVAKVPPIVAAAKAV
PAVYTLNLVSATGTAILISAIITIIMLGMKGSEGLKTFGETLNELKRPIYTIGTVLAFAYVANASGLSTTLALLLTGAGD
FYPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQLGISDILMVAANTTGGVTGKMISPQSIAVACAAVGLVGHEANL
FRFTLKHSVFFVCIIGVITTLQAYVLTWMIP

Sequences:

>Translated_751_residues
MLAQEGVAHAAAAVKVDAVIEDADLQHVEDTVHHLTHHQIVGGLVDGQMEFGIGGGLLGGVVQGVGLFHGLHAGAQPGQI
LGRGALGGQGGGIAGHHAAELEIIEDRFRMRLQQAGKRIGRRFGGGPGGRRGGGVHHDMRIGRCWVIANHGFLAWQLFHL
HRKTNRVIHANRLVKLCYHVQETFNTNTSPASSADARSNLRGGTMQAWMQVYDPAGNLWLSSLIAAIPIIFFFVALAILK
LKGHVAGTITVLLSIAVAIVFYKMPVAAAVMAGVQGFLFGLWPIAWIIIGAVFLYKVTVKTGQFEIIRSSVVSITADQRL
QMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIANTAPVAFGAMGIPIIVAGQVSGLDAFKIGAMAG
RQLPLLAVFVPFWIIFIMDGFKGVRETWPAILVAGGSFAFGVWFTSNYIGPELPDITSALISLVCITVFLKFWQPKNIFR
FKEEGEDEKHSHDYTTGQVARAWAPFLILTAVVTVWSLKPFKAMFAKGGELVFTNINWEVPALHNLVAKVPPIVAAAKAV
PAVYTLNLVSATGTAILISAIITIIMLGMKGSEGLKTFGETLNELKRPIYTIGTVLAFAYVANASGLSTTLALLLTGAGD
FYPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQLGISDILMVAANTTGGVTGKMISPQSIAVACAAVGLVGHEANL
FRFTLKHSVFFVCIIGVITTLQAYVLTWMIP
>Mature_751_residues
MLAQEGVAHAAAAVKVDAVIEDADLQHVEDTVHHLTHHQIVGGLVDGQMEFGIGGGLLGGVVQGVGLFHGLHAGAQPGQI
LGRGALGGQGGGIAGHHAAELEIIEDRFRMRLQQAGKRIGRRFGGGPGGRRGGGVHHDMRIGRCWVIANHGFLAWQLFHL
HRKTNRVIHANRLVKLCYHVQETFNTNTSPASSADARSNLRGGTMQAWMQVYDPAGNLWLSSLIAAIPIIFFFVALAILK
LKGHVAGTITVLLSIAVAIVFYKMPVAAAVMAGVQGFLFGLWPIAWIIIGAVFLYKVTVKTGQFEIIRSSVVSITADQRL
QMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIANTAPVAFGAMGIPIIVAGQVSGLDAFKIGAMAG
RQLPLLAVFVPFWIIFIMDGFKGVRETWPAILVAGGSFAFGVWFTSNYIGPELPDITSALISLVCITVFLKFWQPKNIFR
FKEEGEDEKHSHDYTTGQVARAWAPFLILTAVVTVWSLKPFKAMFAKGGELVFTNINWEVPALHNLVAKVPPIVAAAKAV
PAVYTLNLVSATGTAILISAIITIIMLGMKGSEGLKTFGETLNELKRPIYTIGTVLAFAYVANASGLSTTLALLLTGAGD
FYPFFSPVLGWLGVFLTGSDTSSNALFGALQATTAHQLGISDILMVAANTTGGVTGKMISPQSIAVACAAVGLVGHEANL
FRFTLKHSVFFVCIIGVITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=68.0580762250454, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=65.0537634408602, Blast_Score=695, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 79744; Mature: 79744

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAQEGVAHAAAAVKVDAVIEDADLQHVEDTVHHLTHHQIVGGLVDGQMEFGIGGGLLGG
CCCCHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
VVQGVGLFHGLHAGAQPGQILGRGALGGQGGGIAGHHAAELEIIEDRFRMRLQQAGKRIG
HHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRFGGGPGGRRGGGVHHDMRIGRCWVIANHGFLAWQLFHLHRKTNRVIHANRLVKLCYHV
HHCCCCCCCCCCCCCCCCCEECEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QETFNTNTSPASSADARSNLRGGTMQAWMQVYDPAGNLWLSSLIAAIPIIFFFVALAILK
HHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKGHVAGTITVLLSIAVAIVFYKMPVAAAVMAGVQGFLFGLWPIAWIIIGAVFLYKVTVK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGQFEIIRSSVVSITADQRLQMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHH
AGLCLIANTAPVAFGAMGIPIIVAGQVSGLDAFKIGAMAGRQLPLLAVFVPFWIIFIMDG
HHHHHEECCCCHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FKGVRETWPAILVAGGSFAFGVWFTSNYIGPELPDITSALISLVCITVFLKFWQPKNIFR
HHHHHHCCCEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
FKEEGEDEKHSHDYTTGQVARAWAPFLILTAVVTVWSLKPFKAMFAKGGELVFTNINWEV
EHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCC
PALHNLVAKVPPIVAAAKAVPAVYTLNLVSATGTAILISAIITIIMLGMKGSEGLKTFGE
HHHHHHHHHCCHHHHHHHHCCHHEEEEEHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TLNELKRPIYTIGTVLAFAYVANASGLSTTLALLLTGAGDFYPFFSPVLGWLGVFLTGSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCC
TSSNALFGALQATTAHQLGISDILMVAANTTGGVTGKMISPQSIAVACAAVGLVGHEANL
CCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
FRFTLKHSVFFVCIIGVITTLQAYVLTWMIP
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLAQEGVAHAAAAVKVDAVIEDADLQHVEDTVHHLTHHQIVGGLVDGQMEFGIGGGLLGG
CCCCHHHHHHHHHEEHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHH
VVQGVGLFHGLHAGAQPGQILGRGALGGQGGGIAGHHAAELEIIEDRFRMRLQQAGKRIG
HHHHHHHHHHHCCCCCCCHHEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
RRFGGGPGGRRGGGVHHDMRIGRCWVIANHGFLAWQLFHLHRKTNRVIHANRLVKLCYHV
HHCCCCCCCCCCCCCCCCCEECEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QETFNTNTSPASSADARSNLRGGTMQAWMQVYDPAGNLWLSSLIAAIPIIFFFVALAILK
HHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LKGHVAGTITVLLSIAVAIVFYKMPVAAAVMAGVQGFLFGLWPIAWIIIGAVFLYKVTVK
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TGQFEIIRSSVVSITADQRLQMLMIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHH
AGLCLIANTAPVAFGAMGIPIIVAGQVSGLDAFKIGAMAGRQLPLLAVFVPFWIIFIMDG
HHHHHEECCCCHHHCCCCCCEEEECCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FKGVRETWPAILVAGGSFAFGVWFTSNYIGPELPDITSALISLVCITVFLKFWQPKNIFR
HHHHHHCCCEEEEECCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEE
FKEEGEDEKHSHDYTTGQVARAWAPFLILTAVVTVWSLKPFKAMFAKGGELVFTNINWEV
EHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCEEEEECCCCC
PALHNLVAKVPPIVAAAKAVPAVYTLNLVSATGTAILISAIITIIMLGMKGSEGLKTFGE
HHHHHHHHHCCHHHHHHHHCCHHEEEEEHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
TLNELKRPIYTIGTVLAFAYVANASGLSTTLALLLTGAGDFYPFFSPVLGWLGVFLTGSD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEECCC
TSSNALFGALQATTAHQLGISDILMVAANTTGGVTGKMISPQSIAVACAAVGLVGHEANL
CCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHH
FRFTLKHSVFFVCIIGVITTLQAYVLTWMIP
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]