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The map label for this gene is rpfC [H]

Identifier: 83313114

GI number: 83313114

Start: 4423236

End: 4425212

Strand: Reverse

Name: rpfC [H]

Synonym: amb4015

Alternate gene names: 83313114

Gene position: 4425212-4423236 (Counterclockwise)

Preceding gene: 83313116

Following gene: 83313108

Centisome position: 89.09

GC content: 69.6

Gene sequence:

>1977_bases
GTGTTCTTCCTGACGGTGCGCCTGGCCATTGCCATCGTGCTGGCCGTCGGGCTGGCCGCCCTGGCGCGGGCCAGGACGTC
GCGCATGATCATTGCCGTCACCCATCTGCACCTCTACACCTTCTTTTTCCTCAACGCCCTGGTCTTCGCCCATCCCCTGC
TGGATCGCCACGGCGGCATGTTCTTTCCGCTGATCGCCATGTCCATGTTCATGTTCGCGCCGGGACCGCTGCGGCGGGTG
GCGCTGCTATGCGCCGTCGGGCCGCTGGTCAGCCTGCTGGCCTGGGCCGAACTGCGCGAGGTGCCGGAAAGCCCGGCCGA
CATGGCCATCATCACCCTGATGACCGGGGTGGCCTATCTGGTCGGCGCCACCGCCCGCATCCAGTTCGAGCGCATGGGCC
GCCGCCAGTTTCTGCTGGTGGAGGGCGAGCGTCAGGCGCGCATCACCCTGCTGGACGCCAAGGAGGCGGCCGAGGCCGGC
ACGCGGGCCAAGAGCGAGTTCCTGGCGGTGATGAGCCACGAGATCCGTACCCCCATGAACGGCATTCTGGGCATGGTGCG
GCTGCTGCTCGACCGGCCGCTGGAGGCAGAGGACCGCGAGCGTCTGGAAATGGTCCACCATTCCGCCGAACTGCTGCTGG
GCATCCTGGACAACATTCTGGACCTGTCCAAGGTGGAGGCCGGGCGCATGGAATTCGAACGCTCGCCCTTCAGTCCAGCC
CGCACCCTGGCCGGCATCCAGACCCTGCTCTCGGCCCGCGCCCGCGAAAAGGGCCTGGAGCTGTCCCATGCCATTGGCCC
GGAGGTCCCCGAATGGGTGGAGGGCGATGGCGGACGCCTGCGGCAGATCCTGCTGAATCTGGCGGGCAATGCGTTGAAAT
TCACGGATTCAGGCCATGTGCTGATCCGGGTGGGACTGGCCGGCGATGGGTCTGGCCGGCTGGAATTCTCGGTGACCGAC
ACCGGGATCGGTCTTGGCGAGGCCGAGATCGGGCGGCTGTTCCATGCCTTCGCCCAGGCGGATTCCTCCATCACCCGGCG
CTTCGGCGGCACGGGGCTGGGCCTGGCCATCTGCCGCCGGCTGGTGGAGGCCCAGGGCGGCGAGATCGGGGTGGAAAGCC
GCCCCGGCGTGGGCAGCCGCTTCTGGTTCCGCCTCGCCCTGCCGGCTGGCCGGGCGCCGGCCCTGGGCGCGGTGGATGCT
CGGGGCGAGGTGGTTCTTCCCCCTCTCTCGGTGCTGGTGGCCGAGGATAATCCCATCAATCAGAAGGTGGCCCTGGGCTT
TCTCACCCAGGCCGGCCATCGCGTCACCGTCGCCGCCAACGGCGCCGAGGCCCTGGCCCTGGCGCGGGACGGCGGCTTCG
ACGTGGTGCTGATGGACATGCAGATGCCGGTGATGGACGGCCTGGAGGCGGTCTCGCGCATCCGGGCGCTGCCCGCTCCG
GCGGGGGACGTGCCGGTGATCGCCCTGACCGCCAACGCCATGCGCGGCGACGCCGAACGGTGCCGGGAGGCGGGCATGAA
CGCCCATGTGGCCAAGCCGGTGGATCCGGCCATCCTGTTCCGGGTCATCGGCGATGTGCTGGCGGGTGGTCCGGTCGGGG
CGACGCCCGCGGCCGGACAGACAGCGCCCTTCGCCGAACTGAGCGCCTATCTGGGGCCGGAGGGCATGACCAGCCTGGTC
AGCGCCTTTCTCACCCATGCCGAGGCGGCCTGTCGCATCCTGGCCGAGGAAACCGGCGATCTGCTGCGCCTGCACATGGC
GGCCCACGATCTCAAGAGCATGGCCGGGACGGCGGGTTGCGCGTCTCTCGCCGATCTCGCCGCCGCCATCGAGGTCGCCG
CCCGCGATGGCCGTGCCGACGAGGTACGCCGGCATATCCAGCCGCTGGGCGAGGTCTGGTCGGCGACCCGCGCAACGCTG
GAACAGCGTTTCGGGCGGGCTCAGGAATTGGCCGACAGCACCGTTCCGGCCAGATAG

Upstream 100 bases:

>100_bases
ACGTCTGCGGGACGGGGCCTATCTCTGCGTCCTGGCCACCAGCCTGACCAGCCTTGCCTTTGCGCCCCTCGACCTGCTGG
CGCTTGAAGGACGCCGGTTG

Downstream 100 bases:

>100_bases
AGCGAGCCGCAGATCAGGATGCGGGCGGGGGCCGAACCGGCCGCCACCAGCTCGGCGATGGCCGCCTCCACCGACGGCGC
GGGCTTGGCGTCCAGGCAGA

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MFFLTVRLAIAIVLAVGLAALARARTSRMIIAVTHLHLYTFFFLNALVFAHPLLDRHGGMFFPLIAMSMFMFAPGPLRRV
ALLCAVGPLVSLLAWAELREVPESPADMAIITLMTGVAYLVGATARIQFERMGRRQFLLVEGERQARITLLDAKEAAEAG
TRAKSEFLAVMSHEIRTPMNGILGMVRLLLDRPLEAEDRERLEMVHHSAELLLGILDNILDLSKVEAGRMEFERSPFSPA
RTLAGIQTLLSARAREKGLELSHAIGPEVPEWVEGDGGRLRQILLNLAGNALKFTDSGHVLIRVGLAGDGSGRLEFSVTD
TGIGLGEAEIGRLFHAFAQADSSITRRFGGTGLGLAICRRLVEAQGGEIGVESRPGVGSRFWFRLALPAGRAPALGAVDA
RGEVVLPPLSVLVAEDNPINQKVALGFLTQAGHRVTVAANGAEALALARDGGFDVVLMDMQMPVMDGLEAVSRIRALPAP
AGDVPVIALTANAMRGDAERCREAGMNAHVAKPVDPAILFRVIGDVLAGGPVGATPAAGQTAPFAELSAYLGPEGMTSLV
SAFLTHAEAACRILAEETGDLLRLHMAAHDLKSMAGTAGCASLADLAAAIEVAARDGRADEVRRHIQPLGEVWSATRATL
EQRFGRAQELADSTVPAR

Sequences:

>Translated_658_residues
MFFLTVRLAIAIVLAVGLAALARARTSRMIIAVTHLHLYTFFFLNALVFAHPLLDRHGGMFFPLIAMSMFMFAPGPLRRV
ALLCAVGPLVSLLAWAELREVPESPADMAIITLMTGVAYLVGATARIQFERMGRRQFLLVEGERQARITLLDAKEAAEAG
TRAKSEFLAVMSHEIRTPMNGILGMVRLLLDRPLEAEDRERLEMVHHSAELLLGILDNILDLSKVEAGRMEFERSPFSPA
RTLAGIQTLLSARAREKGLELSHAIGPEVPEWVEGDGGRLRQILLNLAGNALKFTDSGHVLIRVGLAGDGSGRLEFSVTD
TGIGLGEAEIGRLFHAFAQADSSITRRFGGTGLGLAICRRLVEAQGGEIGVESRPGVGSRFWFRLALPAGRAPALGAVDA
RGEVVLPPLSVLVAEDNPINQKVALGFLTQAGHRVTVAANGAEALALARDGGFDVVLMDMQMPVMDGLEAVSRIRALPAP
AGDVPVIALTANAMRGDAERCREAGMNAHVAKPVDPAILFRVIGDVLAGGPVGATPAAGQTAPFAELSAYLGPEGMTSLV
SAFLTHAEAACRILAEETGDLLRLHMAAHDLKSMAGTAGCASLADLAAAIEVAARDGRADEVRRHIQPLGEVWSATRATL
EQRFGRAQELADSTVPAR
>Mature_658_residues
MFFLTVRLAIAIVLAVGLAALARARTSRMIIAVTHLHLYTFFFLNALVFAHPLLDRHGGMFFPLIAMSMFMFAPGPLRRV
ALLCAVGPLVSLLAWAELREVPESPADMAIITLMTGVAYLVGATARIQFERMGRRQFLLVEGERQARITLLDAKEAAEAG
TRAKSEFLAVMSHEIRTPMNGILGMVRLLLDRPLEAEDRERLEMVHHSAELLLGILDNILDLSKVEAGRMEFERSPFSPA
RTLAGIQTLLSARAREKGLELSHAIGPEVPEWVEGDGGRLRQILLNLAGNALKFTDSGHVLIRVGLAGDGSGRLEFSVTD
TGIGLGEAEIGRLFHAFAQADSSITRRFGGTGLGLAICRRLVEAQGGEIGVESRPGVGSRFWFRLALPAGRAPALGAVDA
RGEVVLPPLSVLVAEDNPINQKVALGFLTQAGHRVTVAANGAEALALARDGGFDVVLMDMQMPVMDGLEAVSRIRALPAP
AGDVPVIALTANAMRGDAERCREAGMNAHVAKPVDPAILFRVIGDVLAGGPVGATPAAGQTAPFAELSAYLGPEGMTSLV
SAFLTHAEAACRILAEETGDLLRLHMAAHDLKSMAGTAGCASLADLAAAIEVAARDGRADEVRRHIQPLGEVWSATRATL
EQRFGRAQELADSTVPAR

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=523, Percent_Identity=32.887189292543, Blast_Score=239, Evalue=5e-64,
Organism=Escherichia coli, GI1789149, Length=370, Percent_Identity=37.027027027027, Blast_Score=219, Evalue=6e-58,
Organism=Escherichia coli, GI87081816, Length=486, Percent_Identity=32.7160493827161, Blast_Score=210, Evalue=3e-55,
Organism=Escherichia coli, GI1788713, Length=507, Percent_Identity=28.9940828402367, Blast_Score=195, Evalue=8e-51,
Organism=Escherichia coli, GI145693157, Length=251, Percent_Identity=39.0438247011952, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1788393, Length=218, Percent_Identity=31.651376146789, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=28.2527881040892, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790436, Length=234, Percent_Identity=29.0598290598291, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1786783, Length=230, Percent_Identity=28.695652173913, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=27.0742358078603, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87082128, Length=233, Percent_Identity=25.3218884120172, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=27.7533039647577, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=235, Percent_Identity=30.2127659574468, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=44.5945945945946, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6323034, Length=158, Percent_Identity=30.379746835443, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 70093; Mature: 70093

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFLTVRLAIAIVLAVGLAALARARTSRMIIAVTHLHLYTFFFLNALVFAHPLLDRHGGM
CEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FFPLIAMSMFMFAPGPLRRVALLCAVGPLVSLLAWAELREVPESPADMAIITLMTGVAYL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VGATARIQFERMGRRQFLLVEGERQARITLLDAKEAAEAGTRAKSEFLAVMSHEIRTPMN
HCCHHEEEHHHCCCEEEEEEECCCCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHCCCHH
GILGMVRLLLDRPLEAEDRERLEMVHHSAELLLGILDNILDLSKVEAGRMEFERSPFSPA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RTLAGIQTLLSARAREKGLELSHAIGPEVPEWVEGDGGRLRQILLNLAGNALKFTDSGHV
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEECCCCE
LIRVGLAGDGSGRLEFSVTDTGIGLGEAEIGRLFHAFAQADSSITRRFGGTGLGLAICRR
EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVEAQGGEIGVESRPGVGSRFWFRLALPAGRAPALGAVDARGEVVLPPLSVLVAEDNPIN
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCC
QKVALGFLTQAGHRVTVAANGAEALALARDGGFDVVLMDMQMPVMDGLEAVSRIRALPAP
HHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCC
AGDVPVIALTANAMRGDAERCREAGMNAHVAKPVDPAILFRVIGDVLAGGPVGATPAAGQ
CCCCCEEEEECCHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TAPFAELSAYLGPEGMTSLVSAFLTHAEAACRILAEETGDLLRLHMAAHDLKSMAGTAGC
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ASLADLAAAIEVAARDGRADEVRRHIQPLGEVWSATRATLEQRFGRAQELADSTVPAR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCC
>Mature Secondary Structure
MFFLTVRLAIAIVLAVGLAALARARTSRMIIAVTHLHLYTFFFLNALVFAHPLLDRHGGM
CEEHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FFPLIAMSMFMFAPGPLRRVALLCAVGPLVSLLAWAELREVPESPADMAIITLMTGVAYL
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
VGATARIQFERMGRRQFLLVEGERQARITLLDAKEAAEAGTRAKSEFLAVMSHEIRTPMN
HCCHHEEEHHHCCCEEEEEEECCCCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHCCCHH
GILGMVRLLLDRPLEAEDRERLEMVHHSAELLLGILDNILDLSKVEAGRMEFERSPFSPA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
RTLAGIQTLLSARAREKGLELSHAIGPEVPEWVEGDGGRLRQILLNLAGNALKFTDSGHV
HHHHHHHHHHHHHHHHCCCCHHHHCCCCCCHHHCCCCHHHHHHHHHHCCCEEEEECCCCE
LIRVGLAGDGSGRLEFSVTDTGIGLGEAEIGRLFHAFAQADSSITRRFGGTGLGLAICRR
EEEEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LVEAQGGEIGVESRPGVGSRFWFRLALPAGRAPALGAVDARGEVVLPPLSVLVAEDNPIN
HHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCEEECCCEEEEECCCCCC
QKVALGFLTQAGHRVTVAANGAEALALARDGGFDVVLMDMQMPVMDGLEAVSRIRALPAP
HHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHCCCCC
AGDVPVIALTANAMRGDAERCREAGMNAHVAKPVDPAILFRVIGDVLAGGPVGATPAAGQ
CCCCCEEEEECCHHCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
TAPFAELSAYLGPEGMTSLVSAFLTHAEAACRILAEETGDLLRLHMAAHDLKSMAGTAGC
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ASLADLAAAIEVAARDGRADEVRRHIQPLGEVWSATRATLEQRFGRAQELADSTVPAR
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]