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The map label for this gene is tpx [H]

Identifier: 83312975

GI number: 83312975

Start: 4282566

End: 4283120

Strand: Reverse

Name: tpx [H]

Synonym: amb3876

Alternate gene names: 83312975

Gene position: 4283120-4282566 (Counterclockwise)

Preceding gene: 83312976

Following gene: 83312969

Centisome position: 86.23

GC content: 66.67

Gene sequence:

>555_bases
ATGGGTGCACCTGGGGCAAAGTCGAGCCCTTCCAATAACAAGATCAGAGGTTCCGCCATGGCCGCCATCACCCTCAAGGG
CAATCCCATCAACACCAACGGCACCTTGCCGGCGGTCGGGGCCGCTGCCCCCGCCTTCTCGCTGACCACCGTCGATCTGG
CCGATATCGGCCTGGATTCCGTGGCGGGCAAGACCGTGGTTCTGAACATTTTCCCCAGCATCGACACGCCGGTCTGCGCC
GCCTCGGTGCGCCGCTTCAATGCCGAGCTGGACAAGCTGGGCAGCGTCGCCGTGCTGTGCGTTTCCGCCGACCTGCCCTT
CGCCCACAAGCGCTTCTGCGGCGCCGAGGGCCTGGAGCGGGTCCAGTCCCTGTCCGACATGCGCGACAAGGGCTTCGGCG
AGCGCTATGGCGTCAAGATCGTCGACGGCCCCCTGGCCGGTCTGCTGGCCCGCGCCGTGGTGGTGATCAAGGGCGGCAAG
GTGGCCTATGCCGAGTTGGTCCCCGAGATCGCCCAGGAGCCCAATTACGACGCCGCCATCGCCGCCGCGAAGTAA

Upstream 100 bases:

>100_bases
TTTGCTGATCTGCGCGCCGCCCATCACCCTGCTGCTGGTGTGGGGCGCCATCAAGCGCCGCTGAAATTTCTCAGGTCGCC
GCTCGACGACCGGTTGCCTG

Downstream 100 bases:

>100_bases
TTCGTCCCAAGCGTATCGAGGGAACGGGCCGCATCCGCCGGGATGCGGCCCGTTTTCCTTTTCAGGCATCGGGCCTGTTG
ATCCGGGCCAAGCGGGGCTG

Product: peroxiredoxin

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 184; Mature: 183

Protein sequence:

>184_residues
MGAPGAKSSPSNNKIRGSAMAAITLKGNPINTNGTLPAVGAAAPAFSLTTVDLADIGLDSVAGKTVVLNIFPSIDTPVCA
ASVRRFNAELDKLGSVAVLCVSADLPFAHKRFCGAEGLERVQSLSDMRDKGFGERYGVKIVDGPLAGLLARAVVVIKGGK
VAYAELVPEIAQEPNYDAAIAAAK

Sequences:

>Translated_184_residues
MGAPGAKSSPSNNKIRGSAMAAITLKGNPINTNGTLPAVGAAAPAFSLTTVDLADIGLDSVAGKTVVLNIFPSIDTPVCA
ASVRRFNAELDKLGSVAVLCVSADLPFAHKRFCGAEGLERVQSLSDMRDKGFGERYGVKIVDGPLAGLLARAVVVIKGGK
VAYAELVPEIAQEPNYDAAIAAAK
>Mature_183_residues
GAPGAKSSPSNNKIRGSAMAAITLKGNPINTNGTLPAVGAAAPAFSLTTVDLADIGLDSVAGKTVVLNIFPSIDTPVCAA
SVRRFNAELDKLGSVAVLCVSADLPFAHKRFCGAEGLERVQSLSDMRDKGFGERYGVKIVDGPLAGLLARAVVVIKGGKV
AYAELVPEIAQEPNYDAAIAAAK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=163, Percent_Identity=52.760736196319, Blast_Score=172, Evalue=1e-44,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 18821; Mature: 18690

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAPGAKSSPSNNKIRGSAMAAITLKGNPINTNGTLPAVGAAAPAFSLTTVDLADIGLDS
CCCCCCCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCCCEEEEEEHHHHCCCCC
VAGKTVVLNIFPSIDTPVCAASVRRFNAELDKLGSVAVLCVSADLPFAHKRFCGAEGLER
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCHHHHHH
VQSLSDMRDKGFGERYGVKIVDGPLAGLLARAVVVIKGGKVAYAELVPEIAQEPNYDAAI
HHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHEEEEECCCEEHHHHHHHHHHCCCCCEEE
AAAK
EECC
>Mature Secondary Structure 
GAPGAKSSPSNNKIRGSAMAAITLKGNPINTNGTLPAVGAAAPAFSLTTVDLADIGLDS
CCCCCCCCCCCCCCCCCEEEEEEEECCEECCCCCCCCCCCCCCCEEEEEEHHHHCCCCC
VAGKTVVLNIFPSIDTPVCAASVRRFNAELDKLGSVAVLCVSADLPFAHKRFCGAEGLER
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCHHHHHH
VQSLSDMRDKGFGERYGVKIVDGPLAGLLARAVVVIKGGKVAYAELVPEIAQEPNYDAAI
HHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHEEEEECCCEEHHHHHHHHHHCCCCCEEE
AAAK
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]