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The map label for this gene is lhgO [H]

Identifier: 83312916

GI number: 83312916

Start: 4216829

End: 4217953

Strand: Reverse

Name: lhgO [H]

Synonym: amb3817

Alternate gene names: 83312916

Gene position: 4217953-4216829 (Counterclockwise)

Preceding gene: 83312919

Following gene: 83312915

Centisome position: 84.92

GC content: 70.76

Gene sequence:

>1125_bases
ATGGGGAAGAACAAGGTGTTGACCCAAAGCGCCGCCGAGCGGGTGGATTGCGTGGTGATCGGAGCCGGAGTGGTGGGGCT
GGCCGTGGCCCGGTCCCTGGCCCATGCCGGCGCCGAGGTGATTATCCTCGAGGCGGAGGGCGCCATCGGCTCGGGGATCT
CGTCGCGCAACTCCGAAGTGATCCATGCCGGGATGTATTATCCGGCGGGCAGCCTGCGGGCGCGGCTGTGCGTCGAGGGC
AACCGCCTGCTCCGCGACTATGCCGCCAGCCGGGGCGTCGCCCACGCCATGACCGGCAAGCTGATCGTCGCCACCGACGA
GGCCGAGGCCGCCCAACTGGACGCCATCCTGGCCAAGGGCCGCGCCAACGGCGTCGAGGGGCTGACCCGCATTTCCGCCG
CCCATGCCCGCGAGATGGAGCCCGATTTGGCTTGCGTCGCGGCGCTGTGGTCGCCGGCCACCGGCATCATCGACACCCAT
GGGCTGATGCTGTCCCTGCTGGGCGAGGCCGAGGAGCGGGGCGCCGCCCTGGCGCTGAAGTCGCCGGTGACAGGGGGCCG
CGCCACCGATGACGGCATGCTGCTGTCGGTGGGCGGGGCCGAGCCCACTACCTTGCTGGCCCGCAATGTGGTGCTGGCCG
CCGGGCTGTCCTCGCCGCGCCTGGGCGCCGCCCTGGGCTTGAAGAACGTGCCGCCGGCCCATCTGTGCAAGGGCAATTAC
TTCACCCTGTCGGGTCGCACGCCCTTTACCCGGCTGGTCTATCCCGTGCCGGTGGCCGCCGGGCTGGGGGTGCATTTCAC
CCTGGACCTGGGCGGGCGCGGGCGCTTTGGTCCCGACGTGGAATGGGTGGAGGCCGAGGATTATCAGGTGGATCCTCGGC
GCGGCGATTCCTTCTACGCCGCCATCCGCCGCTACTGGCCGGATCTGGCCGACGGCGCGCTGGAGCCGGCCTATGCCGGC
ATCCGCCCGAAGATCACCGCCGAGGGCGAGCCGGCCGCCGATTTCCTGATCCATGGTCCGCGAGAGACCGGAGTGCCCGG
CGTGGCGGCGCTGTACGGCATCGAGAGTCCGGGCCTGACGTCCAGCCTTGCCATCGCCGGGCATGTGGGGGAGTTGCTGG
CATGA

Upstream 100 bases:

>100_bases
CAGCGGAGTCTAGCGACGGCGGGGGGCGGGTGCAACGGCGATGCGTCTTTAACCCTTGATCCGCCGATGCTATCCTCCGC
GACATCTAGATGTGCCTTCG

Downstream 100 bases:

>100_bases
CGCGACCGAGCGATGCTAACCGCTCCGATTGTCATCCCGAGCCAAGCCGAGGGATCCCCGCTTGGCGCGGCGGTGCCAGC
CTTGAAAAGCCGTGCCAGGA

Product: dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MGKNKVLTQSAAERVDCVVIGAGVVGLAVARSLAHAGAEVIILEAEGAIGSGISSRNSEVIHAGMYYPAGSLRARLCVEG
NRLLRDYAASRGVAHAMTGKLIVATDEAEAAQLDAILAKGRANGVEGLTRISAAHAREMEPDLACVAALWSPATGIIDTH
GLMLSLLGEAEERGAALALKSPVTGGRATDDGMLLSVGGAEPTTLLARNVVLAAGLSSPRLGAALGLKNVPPAHLCKGNY
FTLSGRTPFTRLVYPVPVAAGLGVHFTLDLGGRGRFGPDVEWVEAEDYQVDPRRGDSFYAAIRRYWPDLADGALEPAYAG
IRPKITAEGEPAADFLIHGPRETGVPGVAALYGIESPGLTSSLAIAGHVGELLA

Sequences:

>Translated_374_residues
MGKNKVLTQSAAERVDCVVIGAGVVGLAVARSLAHAGAEVIILEAEGAIGSGISSRNSEVIHAGMYYPAGSLRARLCVEG
NRLLRDYAASRGVAHAMTGKLIVATDEAEAAQLDAILAKGRANGVEGLTRISAAHAREMEPDLACVAALWSPATGIIDTH
GLMLSLLGEAEERGAALALKSPVTGGRATDDGMLLSVGGAEPTTLLARNVVLAAGLSSPRLGAALGLKNVPPAHLCKGNY
FTLSGRTPFTRLVYPVPVAAGLGVHFTLDLGGRGRFGPDVEWVEAEDYQVDPRRGDSFYAAIRRYWPDLADGALEPAYAG
IRPKITAEGEPAADFLIHGPRETGVPGVAALYGIESPGLTSSLAIAGHVGELLA
>Mature_373_residues
GKNKVLTQSAAERVDCVVIGAGVVGLAVARSLAHAGAEVIILEAEGAIGSGISSRNSEVIHAGMYYPAGSLRARLCVEGN
RLLRDYAASRGVAHAMTGKLIVATDEAEAAQLDAILAKGRANGVEGLTRISAAHAREMEPDLACVAALWSPATGIIDTHG
LMLSLLGEAEERGAALALKSPVTGGRATDDGMLLSVGGAEPTTLLARNVVLAAGLSSPRLGAALGLKNVPPAHLCKGNYF
TLSGRTPFTRLVYPVPVAAGLGVHFTLDLGGRGRFGPDVEWVEAEDYQVDPRRGDSFYAAIRRYWPDLADGALEPAYAGI
RPKITAEGEPAADFLIHGPRETGVPGVAALYGIESPGLTSSLAIAGHVGELLA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=268, Percent_Identity=32.089552238806, Blast_Score=123, Evalue=3e-28,
Organism=Escherichia coli, GI87082148, Length=379, Percent_Identity=26.6490765171504, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17565764, Length=275, Percent_Identity=35.2727272727273, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI24585081, Length=384, Percent_Identity=31.25, Blast_Score=137, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 38593; Mature: 38461

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNKVLTQSAAERVDCVVIGAGVVGLAVARSLAHAGAEVIILEAEGAIGSGISSRNSEV
CCCCCEEHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCE
IHAGMYYPAGSLRARLCVEGNRLLRDYAASRGVAHAMTGKLIVATDEAEAAQLDAILAKG
EEEEEECCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHHHHHHCC
RANGVEGLTRISAAHAREMEPDLACVAALWSPATGIIDTHGLMLSLLGEAEERGAALALK
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCEEEEE
SPVTGGRATDDGMLLSVGGAEPTTLLARNVVLAAGLSSPRLGAALGLKNVPPAHLCKGNY
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCCHHHHCCCCCCHHHEECCCE
FTLSGRTPFTRLVYPVPVAAGLGVHFTLDLGGRGRFGPDVEWVEAEDYQVDPRRGDSFYA
EEECCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCEECCCCCCHHHH
AIRRYWPDLADGALEPAYAGIRPKITAEGEPAADFLIHGPRETGVPGVAALYGIESPGLT
HHHHHCCCHHCCCCCCHHCCCCCEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCC
SSLAIAGHVGELLA
CHHHHHHHHHHHCC
>Mature Secondary Structure 
GKNKVLTQSAAERVDCVVIGAGVVGLAVARSLAHAGAEVIILEAEGAIGSGISSRNSEV
CCCCEEHHHHHCCCCEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCE
IHAGMYYPAGSLRARLCVEGNRLLRDYAASRGVAHAMTGKLIVATDEAEAAQLDAILAKG
EEEEEECCCCCCEEEEEECCCHHHHHHHHHCCCHHHHCCEEEEEECCCHHHHHHHHHHCC
RANGVEGLTRISAAHAREMEPDLACVAALWSPATGIIDTHGLMLSLLGEAEERGAALALK
CCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCEEEEE
SPVTGGRATDDGMLLSVGGAEPTTLLARNVVLAAGLSSPRLGAALGLKNVPPAHLCKGNY
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCCHHHHCCCCCCHHHEECCCE
FTLSGRTPFTRLVYPVPVAAGLGVHFTLDLGGRGRFGPDVEWVEAEDYQVDPRRGDSFYA
EEECCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCEEEECCCCEECCCCCCHHHH
AIRRYWPDLADGALEPAYAGIRPKITAEGEPAADFLIHGPRETGVPGVAALYGIESPGLT
HHHHHCCCHHCCCCCCHHCCCCCEEECCCCCCCCEEEECCCCCCCCCEEEEEECCCCCCC
SSLAIAGHVGELLA
CHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]