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The map label for this gene is pepA [H]

Identifier: 83312775

GI number: 83312775

Start: 4038054

End: 4039556

Strand: Reverse

Name: pepA [H]

Synonym: amb3676

Alternate gene names: 83312775

Gene position: 4039556-4038054 (Counterclockwise)

Preceding gene: 83312776

Following gene: 83312774

Centisome position: 81.33

GC content: 68.93

Gene sequence:

>1503_bases
ATGAAGATCGCCTTTTCCAAGCCCTCCCTGCCTGCTTCCGGCGCCGTCGCCGTCGGCATTCTCGAAGGCAAGGTGCTGAC
CGGCACCGCCCAGGCCCTGGACGCCCAGGCCAAGGGCGGCCTCGCCCGCGCCATCGCTGCCTCGGGCCGCTTCGAGGGCA
AGAAGGGCCAGACGCTGCTGATCCTCGCCCCCGCCGGGCTGGAGCTGTCCCGCGTGCTGCTGGTCGGCCTGGGCAAGGCC
AAGGACCTGGACGCCCTGGCGGCGCAGGCCTTCGGCGGCACCGTGGTGGGCCAGCTGCAGACGTCGGGCGACGCCGATGT
GGCGGTGGCCCTGGACGTCATCCCCGGCTCGCCCCTGTCGCCGGCCGAGTTCGCCGCCCAGGCGGCGCTGGGCGCCCGGC
TGCGCTCGTACCGCTTCGACAAGTACATGACCAAGCAGAAGAAGGAGGACAAGCCCTCCTTGAAGAAGCTGTCCCTGCTG
ACCGATGCCGCCGCCGACGCCAAGGCCGCCTTCGGGGCGCTGGACAAGGTGGCCGATGCGGTGTTCCTCACCCGCGACGT
GGTCTCCGAGCCCGCCAACATCATTCACCCCGAGTCGCTGGCCGAGAAGGCGGAGTCCCTCAAGGACCTGGGCGTCGAGG
TCGAGGTGCTGGGCGAAAAGCAGATGAAGAAGCTGGGCATGGGCTCGCTGCTGGGCGTCGGCCAGGGCTCGGAGCGCGAA
TCCAAGCTGGTGATCATGCGCTGGTCCAACGCCGCCAAGAAGGACGAGGCGCCGGTGGCCTTCGTCGGCAAGGGCGTCAC
CTTCGATTCCGGCGGCATCTCCATCAAGCCGGGCGCCGGCATGGAGGACATGAAGTGGGACATGGCCGGGGCCGGCGCGG
TGATCGGCGCCCTGGCCGCCCTGGCCGGGCGCAAGGCCAAGGTCAACGCCATCGGCGTGGTCGGGCTGGTGGAGAACATG
CCGTCGGGCACCGCCCAGCGCCCCGGCGACGTGGTGACCTCCATGTCGGGCCAGACCATCGAGGTGATCAACACCGACGC
CGAGGGGCGCCTGGTGCTGGCCGATGCGCTCTGGTACACCCAGGACCGCTTCAAGCCGAAATTCATGGTGGACCTCGCCA
CCCTGACCGGCGCCATCATCATCGCGCTGGGCAATGAATACGCCGGCCTGATGTCGTCCGACGACAAGCTGGCCGATCGC
CTGACGGCGGCCGGCAAGGCGGTGGACGAGAAGCTGTGGCGTCTGCCGCTGGGCGAGTCCTACGACAAGCAGATCAAGTC
GGACATCGCCGACATGAAGAATGTGGGCGGGCGCGAAGGCGGCTCCATCACCGCCGCCCAGTTCCTCAAGCGCTTCACCA
ACGACGTGGCCTGGGCTCACCTGGACATCGCCGGCGTGGCCTGGAGCAAGAAGGACGTCGCCACCTGCCCCAAGGGCGCC
ACCGCCTTCGGCGTGCGCCTGCTGGACCGGCTGGTGGCCGATTTCTACGAGGACAAGAAGTAG

Upstream 100 bases:

>100_bases
AAGAACGAGATGAGGGGGTAACCCTCTTTCCTTCCCGGCCCAGCGCGCTACATTGGGATCAGTGAATTCCATCCCAATGT
TCCGAGCCGTGAGGATGTCC

Downstream 100 bases:

>100_bases
CGTAGTCAGGAAATTGTCATCCCGAGCGTAAGCGAGGGATCTCTGCCTGATCCGATGGTGCCGGTTCTGATCCGCCGGAT
CAGGATGAGATCCCTCCGCC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLLILAPAGLELSRVLLVGLGKA
KDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLSPAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLL
TDAAADAKAAFGALDKVADAVFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAALAGRKAKVNAIGVVGLVENM
PSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADR
LTAAGKAVDEKLWRLPLGESYDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
TAFGVRLLDRLVADFYEDKK

Sequences:

>Translated_500_residues
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLLILAPAGLELSRVLLVGLGKA
KDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLSPAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLL
TDAAADAKAAFGALDKVADAVFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAALAGRKAKVNAIGVVGLVENM
PSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADR
LTAAGKAVDEKLWRLPLGESYDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
TAFGVRLLDRLVADFYEDKK
>Mature_500_residues
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLLILAPAGLELSRVLLVGLGKA
KDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLSPAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLL
TDAAADAKAAFGALDKVADAVFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAALAGRKAKVNAIGVVGLVENM
PSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYTQDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADR
LTAAGKAVDEKLWRLPLGESYDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
TAFGVRLLDRLVADFYEDKK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=386, Percent_Identity=39.8963730569948, Blast_Score=241, Evalue=8e-64,
Organism=Homo sapiens, GI47155554, Length=385, Percent_Identity=30.3896103896104, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1790710, Length=493, Percent_Identity=40.973630831643, Blast_Score=355, Evalue=5e-99,
Organism=Escherichia coli, GI87082123, Length=318, Percent_Identity=40.251572327044, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=320, Percent_Identity=32.1875, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17565172, Length=397, Percent_Identity=25.9445843828715, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129969, Length=451, Percent_Identity=28.8248337028825, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24662227, Length=347, Percent_Identity=32.2766570605187, Blast_Score=184, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24661038, Length=481, Percent_Identity=30.7692307692308, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI21355645, Length=345, Percent_Identity=30.7246376811594, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24662223, Length=345, Percent_Identity=30.7246376811594, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI161077148, Length=451, Percent_Identity=30.5986696230599, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI20130057, Length=451, Percent_Identity=30.5986696230599, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21355725, Length=287, Percent_Identity=34.8432055749129, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI20129963, Length=454, Percent_Identity=29.295154185022, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI19922386, Length=348, Percent_Identity=31.0344827586207, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357381, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI221379063, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI221379062, Length=326, Percent_Identity=33.1288343558282, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24646701, Length=325, Percent_Identity=26.4615384615385, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24646703, Length=325, Percent_Identity=26.4615384615385, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21358201, Length=325, Percent_Identity=26.4615384615385, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52199; Mature: 52199

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLL
CEEECCCCCCCCCCCEEEEEECCEEEECHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEE
ILAPAGLELSRVLLVGLGKAKDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLS
EEECCCCCHHHHHHEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCC
PAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLLTDAAADAKAAFGALDKVADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCEEECCCCCCCC
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAA
CCEEEEEECCCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHH
LAGRKAKVNAIGVVGLVENMPSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYT
HCCCCCEEEEEEEEEHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEEHHHHH
QDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADRLTAAGKAVDEKLWRLPLGES
HHCCCCHHEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
YDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECEECCCCCCCCCCCC
TAFGVRLLDRLVADFYEDKK
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIAFSKPSLPASGAVAVGILEGKVLTGTAQALDAQAKGGLARAIAASGRFEGKKGQTLL
CEEECCCCCCCCCCCEEEEEECCEEEECHHHHHHHHHCCCHHHHHHHCCCCCCCCCCEEE
ILAPAGLELSRVLLVGLGKAKDLDALAAQAFGGTVVGQLQTSGDADVAVALDVIPGSPLS
EEECCCCCHHHHHHEECCCCCCHHHHHHHHCCCEEEEEEECCCCCCEEEEEEECCCCCCC
PAEFAAQAALGARLRSYRFDKYMTKQKKEDKPSLKKLSLLTDAAADAKAAFGALDKVADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLTRDVVSEPANIIHPESLAEKAESLKDLGVEVEVLGEKQMKKLGMGSLLGVGQGSERE
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCHHHHHHCCCCCEEECCCCCCCC
SKLVIMRWSNAAKKDEAPVAFVGKGVTFDSGGISIKPGAGMEDMKWDMAGAGAVIGALAA
CCEEEEEECCCCCCCCCCEEEEECCEEECCCCEEECCCCCCCCCCCCCCCCHHHHHHHHH
LAGRKAKVNAIGVVGLVENMPSGTAQRPGDVVTSMSGQTIEVINTDAEGRLVLADALWYT
HCCCCCEEEEEEEEEHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCEEEEEHHHHH
QDRFKPKFMVDLATLTGAIIIALGNEYAGLMSSDDKLADRLTAAGKAVDEKLWRLPLGES
HHCCCCHHEEEHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
YDKQIKSDIADMKNVGGREGGSITAAQFLKRFTNDVAWAHLDIAGVAWSKKDVATCPKGA
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECEECCCCCCCCCCCC
TAFGVRLLDRLVADFYEDKK
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]