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The map label for this gene is pyrC [H]

Identifier: 83312713

GI number: 83312713

Start: 3967158

End: 3968468

Strand: Reverse

Name: pyrC [H]

Synonym: amb3614

Alternate gene names: 83312713

Gene position: 3968468-3967158 (Counterclockwise)

Preceding gene: 83312714

Following gene: 83312712

Centisome position: 79.89

GC content: 68.34

Gene sequence:

>1311_bases
ATGGCCGCCCGCAATTCCTCGGGCCTGGTGGCCTATGTCAACGCCCGCCTGCTGGACCCGGCCACCGGGCTGGATACCCG
GGGCGCCCTGCTGACCAATGGCGAGACCATCGCCGATGTGGGCCCCGGCCTGTTCCAGGGCGGCGTGCCCTCGGGCATGG
AGGTGGTGGACTGCAAGGGCCTGTGCCTTGCCCCCGGTCTGGTGGACATGCGCGTCCAGCTGCGCGAGCCGGGCGAGGAG
CACAAGGAGACCCTGAAATCGGCGGGTGAGGCGGCAGTGGCCGGCGGCGTCACCTCCATGGTCTGCCTGCCCAACACCAA
TCCGGTGATCGACGAGGTCGCCACCGTGGAATTCGTGGCGCGCCGCGCCCGCAAGATCGGTCTGGCCAAGGTCTATCCCT
ATGCCGCCGCCACCAAGCGGGTGGAGGGCAAGGAACTGGCCGAGATGGGCATGCTGGCCGAGGCCGGCGCCCTGGGCTTC
ACCGATGGCCTCAAGGCCATCCGCAACGCCCAGGTCATGCGCCGGGCGCTGACCTATGCCGCCACCTTCGGCCTGCTGAT
CGTCCAGCACCCGGAGGAGCCCTCCCTGGCCGAGGGCGGCATGATGAACGAGGGCGAACTGGCCACCCGCATGGGCCTGT
CCGGCATTCCGGTGGCCGCCGAGGCCATCATGCTGGAACGCGACATGCGGCTGGTGGAGATCACCAATGGGCGCTACCAC
GCCGCCCATGTGGCCACTGCCGCCGGCGTCGAGATCATCCGCAAGGCCAAGGCCAAGGGCCTGCCGGTCACCTGCGATAC
CGCGCCGCCCTATTTCGCCCTGAACGAACTGGCGGTGAAGGACTATCGCACCTTCGCCAAGCTGTCGCCGCCGCTCCGCT
CCGAAACCGATCGCCAGGCGGTGGTCGAGGGGCTGAAGGACGGCACCATCGACGCCGTGGCCTCGGACCATTCCCCCCAG
GACCAGGATTCCAAGCGGGTGCCCTTCGCCGTGGCCGAGTTCGGCGGCGTGGGTCTCGAGACCCTGCTGCCGGTCACCCT
GGACCTCGCCCATAACGGCCATATGAGCCTGATCGAGGCGCTGAGGCTGATCACCTGTGCTCCCTCCGCCATCCTCAATC
TGGCGGCCGGCCGCCTGAAGGTGGGGGCGGCGGCCGACCTGGTGCTGTTTGATCCCGATCGCGGCTGGAAGGTCAACGCC
AAGAGCTTCCATTCCAAGTCCAAGAACTCCCCCTTCGACGACCGCCCGGTGCAGGGCATGGTGATGCGCACCATCGTCGA
CGGGCGGACGGTGTATACGCACGATGCTTGA

Upstream 100 bases:

>100_bases
GCTCGCTGATCCGTTCGCAGGTGGAGATGGGCGTGGCGGTGCGCATGGCCTGCCTGGACATGCTGACCCGCGACCTGACC
CGCTCGGAAGGAGCCGTCTG

Downstream 100 bases:

>100_bases
GCTGGTCGCAGCTACCTTGGGCGGCTATCTGCTGGGCTCGGTGCCCTTCGGGCTGGTGCTGACCCGCCTCGCCGGGCTGG
GGGACATCCGCCAGATCGGC

Product: dihydroorotase-like protein

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MAARNSSGLVAYVNARLLDPATGLDTRGALLTNGETIADVGPGLFQGGVPSGMEVVDCKGLCLAPGLVDMRVQLREPGEE
HKETLKSAGEAAVAGGVTSMVCLPNTNPVIDEVATVEFVARRARKIGLAKVYPYAAATKRVEGKELAEMGMLAEAGALGF
TDGLKAIRNAQVMRRALTYAATFGLLIVQHPEEPSLAEGGMMNEGELATRMGLSGIPVAAEAIMLERDMRLVEITNGRYH
AAHVATAAGVEIIRKAKAKGLPVTCDTAPPYFALNELAVKDYRTFAKLSPPLRSETDRQAVVEGLKDGTIDAVASDHSPQ
DQDSKRVPFAVAEFGGVGLETLLPVTLDLAHNGHMSLIEALRLITCAPSAILNLAAGRLKVGAAADLVLFDPDRGWKVNA
KSFHSKSKNSPFDDRPVQGMVMRTIVDGRTVYTHDA

Sequences:

>Translated_436_residues
MAARNSSGLVAYVNARLLDPATGLDTRGALLTNGETIADVGPGLFQGGVPSGMEVVDCKGLCLAPGLVDMRVQLREPGEE
HKETLKSAGEAAVAGGVTSMVCLPNTNPVIDEVATVEFVARRARKIGLAKVYPYAAATKRVEGKELAEMGMLAEAGALGF
TDGLKAIRNAQVMRRALTYAATFGLLIVQHPEEPSLAEGGMMNEGELATRMGLSGIPVAAEAIMLERDMRLVEITNGRYH
AAHVATAAGVEIIRKAKAKGLPVTCDTAPPYFALNELAVKDYRTFAKLSPPLRSETDRQAVVEGLKDGTIDAVASDHSPQ
DQDSKRVPFAVAEFGGVGLETLLPVTLDLAHNGHMSLIEALRLITCAPSAILNLAAGRLKVGAAADLVLFDPDRGWKVNA
KSFHSKSKNSPFDDRPVQGMVMRTIVDGRTVYTHDA
>Mature_435_residues
AARNSSGLVAYVNARLLDPATGLDTRGALLTNGETIADVGPGLFQGGVPSGMEVVDCKGLCLAPGLVDMRVQLREPGEEH
KETLKSAGEAAVAGGVTSMVCLPNTNPVIDEVATVEFVARRARKIGLAKVYPYAAATKRVEGKELAEMGMLAEAGALGFT
DGLKAIRNAQVMRRALTYAATFGLLIVQHPEEPSLAEGGMMNEGELATRMGLSGIPVAAEAIMLERDMRLVEITNGRYHA
AHVATAAGVEIIRKAKAKGLPVTCDTAPPYFALNELAVKDYRTFAKLSPPLRSETDRQAVVEGLKDGTIDAVASDHSPQD
QDSKRVPFAVAEFGGVGLETLLPVTLDLAHNGHMSLIEALRLITCAPSAILNLAAGRLKVGAAADLVLFDPDRGWKVNAK
SFHSKSKNSPFDDRPVQGMVMRTIVDGRTVYTHDA

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=393, Percent_Identity=27.9898218829517, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI1786722, Length=397, Percent_Identity=27.9596977329975, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI87082175, Length=401, Percent_Identity=24.1895261845387, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193204318, Length=391, Percent_Identity=28.6445012787724, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6322218, Length=388, Percent_Identity=28.3505154639175, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24642586, Length=394, Percent_Identity=28.9340101522843, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI18859883, Length=421, Percent_Identity=25.1781472684086, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46203; Mature: 46072

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARNSSGLVAYVNARLLDPATGLDTRGALLTNGETIADVGPGLFQGGVPSGMEVVDCKG
CCCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCHHHCCCHHHCCCCCCCCEEEECCC
LCLAPGLVDMRVQLREPGEEHKETLKSAGEAAVAGGVTSMVCLPNTNPVIDEVATVEFVA
EEECCCCEEEHEEECCCCHHHHHHHHHCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
RRARKIGLAKVYPYAAATKRVEGKELAEMGMLAEAGALGFTDGLKAIRNAQVMRRALTYA
HHHHHCCHHHCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ATFGLLIVQHPEEPSLAEGGMMNEGELATRMGLSGIPVAAEAIMLERDMRLVEITNGRYH
HHHCEEEEECCCCCCHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCEEE
AAHVATAAGVEIIRKAKAKGLPVTCDTAPPYFALNELAVKDYRTFAKLSPPLRSETDRQA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VVEGLKDGTIDAVASDHSPQDQDSKRVPFAVAEFGGVGLETLLPVTLDLAHNGHMSLIEA
HHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEHHCCCCHHHHHCEEEEECCCCCHHHHHH
LRLITCAPSAILNLAAGRLKVGAAADLVLFDPDRGWKVNAKSFHSKSKNSPFDDRPVQGM
HHHHHCCHHHHHHHHCCCEEECCEEEEEEECCCCCCEECHHHHHCCCCCCCCCCCCCCHH
VMRTIVDGRTVYTHDA
HHHHHHCCCEEEECCC
>Mature Secondary Structure 
AARNSSGLVAYVNARLLDPATGLDTRGALLTNGETIADVGPGLFQGGVPSGMEVVDCKG
CCCCCCCEEEEEEEEEECCCCCCCCCCEEEECCCCHHHCCCHHHCCCCCCCCEEEECCC
LCLAPGLVDMRVQLREPGEEHKETLKSAGEAAVAGGVTSMVCLPNTNPVIDEVATVEFVA
EEECCCCEEEHEEECCCCHHHHHHHHHCCCHHHHCCCEEEEECCCCCHHHHHHHHHHHHH
RRARKIGLAKVYPYAAATKRVEGKELAEMGMLAEAGALGFTDGLKAIRNAQVMRRALTYA
HHHHHCCHHHCCCHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ATFGLLIVQHPEEPSLAEGGMMNEGELATRMGLSGIPVAAEAIMLERDMRLVEITNGRYH
HHHCEEEEECCCCCCHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHHCCCEEEEEECCEEE
AAHVATAAGVEIIRKAKAKGLPVTCDTAPPYFALNELAVKDYRTFAKLSPPLRSETDRQA
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
VVEGLKDGTIDAVASDHSPQDQDSKRVPFAVAEFGGVGLETLLPVTLDLAHNGHMSLIEA
HHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEHHCCCCHHHHHCEEEEECCCCCHHHHHH
LRLITCAPSAILNLAAGRLKVGAAADLVLFDPDRGWKVNAKSFHSKSKNSPFDDRPVQGM
HHHHHCCHHHHHHHHCCCEEECCEEEEEEECCCCCCEECHHHHHCCCCCCCCCCCCCCHH
VMRTIVDGRTVYTHDA
HHHHHHCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA