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The map label for this gene is crt [H]

Identifier: 83312682

GI number: 83312682

Start: 3934003

End: 3935040

Strand: Reverse

Name: crt [H]

Synonym: amb3583

Alternate gene names: 83312682

Gene position: 3935040-3934003 (Counterclockwise)

Preceding gene: 83312683

Following gene: 83312681

Centisome position: 79.22

GC content: 67.34

Gene sequence:

>1038_bases
TTGATGTCTGCTGAAATCCATTTCGACCGCACCGGCCATCTGGGCCGCATCACCCTGGACCGGCCCAAGGCGCTGAATGC
CCTGACGCTGGATCAGGTGCACGCCATGCATCCCCGCCTCGACCAGTGGGCGGCTGATGCCGACGTGGCCTGCATCACCA
TCGAGGGCGCGGGCGAGAAGGCGTTCTGCGCCGGCGGCGACATCAAGCAGCTTTACGAGGCCTGCAAGGCCGGAGACCTG
GAATTCGCCGCCGCCTTCTACCGCGACGAATACCGCCTCAACCGCCGCATTCACACCAGCCCCAAGCCCTATGTGGCGCT
TATCGACGGCATCGTCATGGGCGGCGGCGTGGGGGTGTCGGTGCACGGCCTGTACCGGGTCGCCACCGAGCGCACCCTGT
TCGCCATGCCCGAGACCGGCATCGGCTTCTTCCCCGATGTGGGCGGATCGTACTTCCTGCCCCGGCTGCCGGGCTCCATC
GGCATGTATCTCGGCCTGACGGGAGCGCGGCTGAAGGCGGCCGATACCCTGCATGTTGGCGTCGCCACCCATTTCGTGGA
AAGCGCCCAGCTTCCCGCCCTGATCGAGGCGCTGTCCGAGGCCCGCGACGCCGCCGAGGTCAAGGCCAGCCTGGACGGCT
TTGCTTCCGACCCCGGCCCGGCGGCCATCGACGCCCGGCGAGAGTTGATCGACCGCTGTTTCGGCAAGGCCAGTCTGGCC
GAGGTCTTTGCGGCGCTCGAAGGCGAAAGCGATCCCTTCGCCGCCGAGACCCTGGCCACCATCCGCGCCAAGTCGCCCCA
TCTGGTGGCGGTCAGCTTCGAGATGATCCGCCGCGGCGCCACCCTGTCCTTCGACGATTGCATGAAGATGGAGTTCCGCC
TGGCCATGGCGCTGGCGCCCGCCCATGACTTCGTCGAAGGCGTGCGCGCCCTGCTCATCGACCGTGACAACAAGCCCGCC
TGGAACCCGGCGGGGACGGAAGGCCAGGTGCTGGCCCATTTCGACGCGGTGCCGGGCTGTGGGGATTTGACCTTTTAA

Upstream 100 bases:

>100_bases
GTCCGGCGCGTCGGTGCCAATTCGGACAAGCCGTCACAGACTGAGATCCCTCGGTCGCGTTGCTTCCTCGGGATGACAAT
GGGTATTTGCCGGAGAGTAT

Downstream 100 bases:

>100_bases
TCCGGCTGCCGCCCGAACCGGCTTGGGGCGATGCCCCAAACCCCCTTTTTGAATCAAAGGGTGGTTTGGAGGTCTCCTCC
AATCGGGGGCGGGGCGGAAG

Product: enoyl-CoA hydratase/carnithine racemase

Products: NA

Alternate protein names: Crotonase [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MMSAEIHFDRTGHLGRITLDRPKALNALTLDQVHAMHPRLDQWAADADVACITIEGAGEKAFCAGGDIKQLYEACKAGDL
EFAAAFYRDEYRLNRRIHTSPKPYVALIDGIVMGGGVGVSVHGLYRVATERTLFAMPETGIGFFPDVGGSYFLPRLPGSI
GMYLGLTGARLKAADTLHVGVATHFVESAQLPALIEALSEARDAAEVKASLDGFASDPGPAAIDARRELIDRCFGKASLA
EVFAALEGESDPFAAETLATIRAKSPHLVAVSFEMIRRGATLSFDDCMKMEFRLAMALAPAHDFVEGVRALLIDRDNKPA
WNPAGTEGQVLAHFDAVPGCGDLTF

Sequences:

>Translated_345_residues
MMSAEIHFDRTGHLGRITLDRPKALNALTLDQVHAMHPRLDQWAADADVACITIEGAGEKAFCAGGDIKQLYEACKAGDL
EFAAAFYRDEYRLNRRIHTSPKPYVALIDGIVMGGGVGVSVHGLYRVATERTLFAMPETGIGFFPDVGGSYFLPRLPGSI
GMYLGLTGARLKAADTLHVGVATHFVESAQLPALIEALSEARDAAEVKASLDGFASDPGPAAIDARRELIDRCFGKASLA
EVFAALEGESDPFAAETLATIRAKSPHLVAVSFEMIRRGATLSFDDCMKMEFRLAMALAPAHDFVEGVRALLIDRDNKPA
WNPAGTEGQVLAHFDAVPGCGDLTF
>Mature_345_residues
MMSAEIHFDRTGHLGRITLDRPKALNALTLDQVHAMHPRLDQWAADADVACITIEGAGEKAFCAGGDIKQLYEACKAGDL
EFAAAFYRDEYRLNRRIHTSPKPYVALIDGIVMGGGVGVSVHGLYRVATERTLFAMPETGIGFFPDVGGSYFLPRLPGSI
GMYLGLTGARLKAADTLHVGVATHFVESAQLPALIEALSEARDAAEVKASLDGFASDPGPAAIDARRELIDRCFGKASLA
EVFAALEGESDPFAAETLATIRAKSPHLVAVSFEMIRRGATLSFDDCMKMEFRLAMALAPAHDFVEGVRALLIDRDNKPA
WNPAGTEGQVLAHFDAVPGCGDLTF

Specific function: Catalyzes The Reversible Dehydration Of L-Carnitinyl-CoA To Crotobetainyl-CoA. [C]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI37594471, Length=352, Percent_Identity=43.4659090909091, Blast_Score=297, Evalue=9e-81,
Organism=Homo sapiens, GI37594469, Length=300, Percent_Identity=43, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI194097323, Length=177, Percent_Identity=32.2033898305085, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI20127408, Length=190, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI221142681, Length=191, Percent_Identity=33.5078534031414, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788682, Length=210, Percent_Identity=29.0476190476191, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788597, Length=156, Percent_Identity=28.2051282051282, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1787659, Length=181, Percent_Identity=26.5193370165746, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1787660, Length=179, Percent_Identity=30.7262569832402, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144160, Length=353, Percent_Identity=42.2096317280453, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI25144157, Length=353, Percent_Identity=42.2096317280453, Blast_Score=280, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI25145438, Length=190, Percent_Identity=32.6315789473684, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558304, Length=183, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17554946, Length=190, Percent_Identity=30, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540714, Length=181, Percent_Identity=26.5193370165746, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144276, Length=190, Percent_Identity=27.3684210526316, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=190, Percent_Identity=27.3684210526316, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=340, Percent_Identity=32.9411764705882, Blast_Score=167, Evalue=3e-42,
Organism=Drosophila melanogaster, GI28571730, Length=348, Percent_Identity=43.9655172413793, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI28571729, Length=348, Percent_Identity=43.9655172413793, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI20129971, Length=184, Percent_Identity=33.1521739130435, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24653477, Length=184, Percent_Identity=33.1521739130435, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24653139, Length=175, Percent_Identity=26.8571428571429, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.55 [H]

Molecular weight: Translated: 37022; Mature: 37022

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSAEIHFDRTGHLGRITLDRPKALNALTLDQVHAMHPRLDQWAADADVACITIEGAGEK
CCCCEEEECCCCCEEEEEECCCCCCCEEHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCE
AFCAGGDIKQLYEACKAGDLEFAAAFYRDEYRLNRRIHTSPKPYVALIDGIVMGGGVGVS
EEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCEECCCCCCCEEEEHHHHCCCCCCEE
VHGLYRVATERTLFAMPETGIGFFPDVGGSYFLPRLPGSIGMYLGLTGARLKAADTLHVG
EHHEEEEHHCCEEEECCCCCCCCCCCCCCCEECCCCCCCHHHEEECCCCEEECCCEEEHH
VATHFVESAQLPALIEALSEARDAAEVKASLDGFASDPGPAAIDARRELIDRCFGKASLA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHH
EVFAALEGESDPFAAETLATIRAKSPHLVAVSFEMIRRGATLSFDDCMKMEFRLAMALAP
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCC
AHDFVEGVRALLIDRDNKPAWNPAGTEGQVLAHFDAVPGCGDLTF
HHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MMSAEIHFDRTGHLGRITLDRPKALNALTLDQVHAMHPRLDQWAADADVACITIEGAGEK
CCCCEEEECCCCCEEEEEECCCCCCCEEHHHHHHHHCCCHHHHCCCCCEEEEEEECCCCE
AFCAGGDIKQLYEACKAGDLEFAAAFYRDEYRLNRRIHTSPKPYVALIDGIVMGGGVGVS
EEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCEECCCCCCCEEEEHHHHCCCCCCEE
VHGLYRVATERTLFAMPETGIGFFPDVGGSYFLPRLPGSIGMYLGLTGARLKAADTLHVG
EHHEEEEHHCCEEEECCCCCCCCCCCCCCCEECCCCCCCHHHEEECCCCEEECCCEEEHH
VATHFVESAQLPALIEALSEARDAAEVKASLDGFASDPGPAAIDARRELIDRCFGKASLA
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCHHHH
EVFAALEGESDPFAAETLATIRAKSPHLVAVSFEMIRRGATLSFDDCMKMEFRLAMALAP
HHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHCC
AHDFVEGVRALLIDRDNKPAWNPAGTEGQVLAHFDAVPGCGDLTF
HHHHHHHHHHHEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]