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The map label for this gene is fabG2 [H]

Identifier: 83312681

GI number: 83312681

Start: 3933105

End: 3933866

Strand: Reverse

Name: fabG2 [H]

Synonym: amb3582

Alternate gene names: 83312681

Gene position: 3933866-3933105 (Counterclockwise)

Preceding gene: 83312682

Following gene: 83312680

Centisome position: 79.2

GC content: 71.52

Gene sequence:

>762_bases
ATGAACGTCAACGGATTGGCCGCCATCGTCACCGGCGGCGGCTCGGGACTGGGGCAGGCCACGGCGCGCGCCCTGGCCAA
GGCGGGGGCCAAGGTCGCGGTGTTCGACATCAATGCCGCCGCCGCCGAGGCGACGGCCAAGGAAATCGGCGGAGTCTTCG
CCGCCTGCGACGTCACCGACGAGGCTTCGACCCTGGCCGCCCTGGCCCAGGCCCGCGACGCCCACGGCCCGGCCCGCATC
GCGGTGAGCTGCGCCGGCGTGGTGACGCCGGGCAAGGTGGTGGGGCGCAAGGGCCCCATGCCGCTGGAGACCTTCGCCCG
AGTCATTCAGGTCAATCTGGTCGGCACCTTCAACGTCATGCGCCTGGCCGCCGCCGACATGGCGGGGCTGGAGCCCCTGG
CGGATGGCGAGCGCGGCGTGATCGTCAACACCGCCTCCATCGCCGCCTGGGACGGGCAGGTGGGGCAGTGCGCCTACGCC
TCGTCCAAGGGCGGGGTCGCCGCCCTGTCGCTGCCCGCCGCCCGCGAATTCGCCCCGCTGGGCATCCGAGTCATGGCGGT
GGCGCCGGGCTATATGGAGACTCCCATGCTGGCCGGCATGCCCGACGAGGTCATGGACAATCTGGTGGCCTCGACCCTGT
TCCCCCATCGCCTGGGGCGGCCCGAGGAATTCGCCAAGATGGTCCTGGCCATCTGCGACAATCCCATGCTCAACGGCAGC
GCCATCCGCCTGGACGGCGCGGTGCGGATGCCGCCGCAATAA

Upstream 100 bases:

>100_bases
CAAACCCCCTTTTTGAATCAAAGGGTGGTTTGGAGGTCTCCTCCAATCGGGGGCGGGGCGGAAGCCCCGAAACAACGATA
ATCGCGAGGGGAGTTCGACA

Downstream 100 bases:

>100_bases
TGGCCCGGCGACTGAGGGGCTGGGCAAAATGATGTCATACGGTTGCCACAATCGGCTGGTGTAGTCCCGGATGTCACGGA
ACCTTCGCTTGTTGGCGAGG

Product: dehydrogenase

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MNVNGLAAIVTGGGSGLGQATARALAKAGAKVAVFDINAAAAEATAKEIGGVFAACDVTDEASTLAALAQARDAHGPARI
AVSCAGVVTPGKVVGRKGPMPLETFARVIQVNLVGTFNVMRLAAADMAGLEPLADGERGVIVNTASIAAWDGQVGQCAYA
SSKGGVAALSLPAAREFAPLGIRVMAVAPGYMETPMLAGMPDEVMDNLVASTLFPHRLGRPEEFAKMVLAICDNPMLNGS
AIRLDGAVRMPPQ

Sequences:

>Translated_253_residues
MNVNGLAAIVTGGGSGLGQATARALAKAGAKVAVFDINAAAAEATAKEIGGVFAACDVTDEASTLAALAQARDAHGPARI
AVSCAGVVTPGKVVGRKGPMPLETFARVIQVNLVGTFNVMRLAAADMAGLEPLADGERGVIVNTASIAAWDGQVGQCAYA
SSKGGVAALSLPAAREFAPLGIRVMAVAPGYMETPMLAGMPDEVMDNLVASTLFPHRLGRPEEFAKMVLAICDNPMLNGS
AIRLDGAVRMPPQ
>Mature_253_residues
MNVNGLAAIVTGGGSGLGQATARALAKAGAKVAVFDINAAAAEATAKEIGGVFAACDVTDEASTLAALAQARDAHGPARI
AVSCAGVVTPGKVVGRKGPMPLETFARVIQVNLVGTFNVMRLAAADMAGLEPLADGERGVIVNTASIAAWDGQVGQCAYA
SSKGGVAALSLPAAREFAPLGIRVMAVAPGYMETPMLAGMPDEVMDNLVASTLFPHRLGRPEEFAKMVLAICDNPMLNGS
AIRLDGAVRMPPQ

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.5882352941176, Blast_Score=244, Evalue=6e-65,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=47.843137254902, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI15277342, Length=259, Percent_Identity=35.9073359073359, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.2181069958848, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI59889578, Length=209, Percent_Identity=28.2296650717703, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31542939, Length=215, Percent_Identity=29.7674418604651, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI10190704, Length=234, Percent_Identity=28.2051282051282, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI224922801, Length=184, Percent_Identity=30.4347826086957, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI7705925, Length=195, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787335, Length=258, Percent_Identity=32.1705426356589, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=28.3018867924528, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=34.5238095238095, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1787905, Length=239, Percent_Identity=33.4728033472803, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=30.3501945525292, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=27.6679841897233, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786812, Length=245, Percent_Identity=28.9795918367347, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789057, Length=201, Percent_Identity=29.8507462686567, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1789208, Length=256, Percent_Identity=27.734375, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=45.6349206349206, Blast_Score=221, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17555706, Length=250, Percent_Identity=35.6, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=33.203125, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17567345, Length=205, Percent_Identity=30.2439024390244, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=271, Percent_Identity=29.1512915129151, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17564282, Length=216, Percent_Identity=28.7037037037037, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193203117, Length=209, Percent_Identity=29.1866028708134, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193203115, Length=208, Percent_Identity=29.3269230769231, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=269, Percent_Identity=26.0223048327138, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=25.3731343283582, Blast_Score=64, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=219, Percent_Identity=29.6803652968037, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6320089, Length=221, Percent_Identity=29.4117647058824, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6322861, Length=196, Percent_Identity=30.6122448979592, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737361, Length=249, Percent_Identity=50.2008032128514, Blast_Score=236, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=38.6454183266932, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24644339, Length=239, Percent_Identity=29.2887029288703, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI23397609, Length=225, Percent_Identity=31.1111111111111, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28571526, Length=231, Percent_Identity=29.4372294372294, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21357041, Length=231, Percent_Identity=28.5714285714286, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25609; Mature: 25609

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVNGLAAIVTGGGSGLGQATARALAKAGAKVAVFDINAAAAEATAKEIGGVFAACDVTD
CCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEECCCC
EASTLAALAQARDAHGPARIAVSCAGVVTPGKVVGRKGPMPLETFARVIQVNLVGTFNVM
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCCCCCCHHHHHHHHEEEEECHHHHH
RLAAADMAGLEPLADGERGVIVNTASIAAWDGQVGQCAYASSKGGVAALSLPAAREFAPL
HHHHHHHCCCCCCCCCCCEEEEEECEEEEECCCCCCEEEECCCCCEEEEECCCCCCCCCC
GIRVMAVAPGYMETPMLAGMPDEVMDNLVASTLFPHRLGRPEEFAKMVLAICDNPMLNGS
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
AIRLDGAVRMPPQ
EEEECCEEECCCC
>Mature Secondary Structure
MNVNGLAAIVTGGGSGLGQATARALAKAGAKVAVFDINAAAAEATAKEIGGVFAACDVTD
CCCCEEEEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEECCCC
EASTLAALAQARDAHGPARIAVSCAGVVTPGKVVGRKGPMPLETFARVIQVNLVGTFNVM
HHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHCCCCCCCHHHHHHHHEEEEECHHHHH
RLAAADMAGLEPLADGERGVIVNTASIAAWDGQVGQCAYASSKGGVAALSLPAAREFAPL
HHHHHHHCCCCCCCCCCCEEEEEECEEEEECCCCCCEEEECCCCCEEEEECCCCCCCCCC
GIRVMAVAPGYMETPMLAGMPDEVMDNLVASTLFPHRLGRPEEFAKMVLAICDNPMLNGS
CEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCC
AIRLDGAVRMPPQ
EEEECCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]