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The map label for this gene is folP-A [H]

Identifier: 83312304

GI number: 83312304

Start: 3471806

End: 3472804

Strand: Reverse

Name: folP-A [H]

Synonym: amb3205

Alternate gene names: 83312304

Gene position: 3472804-3471806 (Counterclockwise)

Preceding gene: 83312305

Following gene: 83312303

Centisome position: 69.92

GC content: 71.67

Gene sequence:

>999_bases
GTGCCTGAGGCAGGGATCACATCGGCCTTTACCCGAAGCCCCGCTTTGCCGCGGGGCTTCGACGTATCGGCGGGCGGGCT
CTACCTGCTGCCCACCGGTCTGGTGTGGGGCGAGCAGGCGGCGGCGGCGGTGATTTCCGGCAATGGCTGGCCTCTGGCCG
ACGGCTGGGCCGCCTTCACCGCCCTGGGCGTGGCGACCCGCCGTCCTGGGGGCGGGGCCGATCTGGCCGTGGCCTCCTTC
GCCGAGGTGGTGGACTGGGCCGAGGGCGAGGACCCGGCCCTCGCTCGTCAGGTGGCCGAGACCGTCCACGCCATGGGAAG
CCGGCGCAAGCCCTGGGGCGGGCTGGAGCTGGACCGGCCGCGCATCATGGGCATCGTCAACGTCACTCCCGACAGCTTCT
CCGATGGTGGCGAGGTCTTCGACAGCACGGCCGCCATCGCACGCGGCTTGGCCCTGGCCGAGGCGGGGGCGACCATCATC
GACCTGGGCGGCGAATCCACCCGGCCCGGCGCCGATCCGGTCAGCCCGGCGGAGGAGGCGCGGCGCGTGCTTCCCGTGGT
GCGCGCCCTGGCCGAAAAGGGCCTGTGCGTCTCCATCGACACCCGCCATGCCGCCGTGATGGACGCGGCGGTCGAGGCGG
GGGCGCGGATCATCAACGACGTCACCGCCCTGCTCGGCGATCCCGAGTCTCCCAAGGTGGCGGCCCGAAGCGGCGCCGAT
CTTTGCCTGATGCACATGCAGGGCGACGACCCGCGCACCATGCAGGCGGAGCCCCGCTATGCCTGCGCGCCACTCGACGT
GTTCGACCATCTGGCCCGACGGGTCCAGGACTGCGAAGCCTGGGCATTGCCCGTCAGCGGATCTGCCTCGATCCTGGTAT
CGGCTTTGGCAAGACGCCCGGGCATTGTGCCCAGGTGCTGGGGAGTCTGGCTCTGCTGCACGGTCTGGGGCTGCCGCTGC
TGCTGGGAGTGTCGCGCAAGAGCTTCGTGGCCCGGCTGA

Upstream 100 bases:

>100_bases
GACAACGGCGACTACCGCCCCAAGGACCCGCCGCGCCGCTCCTCGGTGCCCAGCTCCGGTCCCGGCAACCGCCCCGGCTA
TGATCCGGAGCCGCAGCCCG

Downstream 100 bases:

>100_bases
GCCGGGACGAGGTTGCGACGGCCCGGCTGCCCGGCACCTTGGCGGCCAATCTGGCCGGTCTGGATGCCGGGTTTCAGGTG
CTGCGCGTCCACGACGTGCC

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MPEAGITSAFTRSPALPRGFDVSAGGLYLLPTGLVWGEQAAAAVISGNGWPLADGWAAFTALGVATRRPGGGADLAVASF
AEVVDWAEGEDPALARQVAETVHAMGSRRKPWGGLELDRPRIMGIVNVTPDSFSDGGEVFDSTAAIARGLALAEAGATII
DLGGESTRPGADPVSPAEEARRVLPVVRALAEKGLCVSIDTRHAAVMDAAVEAGARIINDVTALLGDPESPKVAARSGAD
LCLMHMQGDDPRTMQAEPRYACAPLDVFDHLARRVQDCEAWALPVSGSASILVSALARRPGIVPRCWGVWLCCTVWGCRC
CWECRARASWPG

Sequences:

>Translated_332_residues
MPEAGITSAFTRSPALPRGFDVSAGGLYLLPTGLVWGEQAAAAVISGNGWPLADGWAAFTALGVATRRPGGGADLAVASF
AEVVDWAEGEDPALARQVAETVHAMGSRRKPWGGLELDRPRIMGIVNVTPDSFSDGGEVFDSTAAIARGLALAEAGATII
DLGGESTRPGADPVSPAEEARRVLPVVRALAEKGLCVSIDTRHAAVMDAAVEAGARIINDVTALLGDPESPKVAARSGAD
LCLMHMQGDDPRTMQAEPRYACAPLDVFDHLARRVQDCEAWALPVSGSASILVSALARRPGIVPRCWGVWLCCTVWGCRC
CWECRARASWPG
>Mature_331_residues
PEAGITSAFTRSPALPRGFDVSAGGLYLLPTGLVWGEQAAAAVISGNGWPLADGWAAFTALGVATRRPGGGADLAVASFA
EVVDWAEGEDPALARQVAETVHAMGSRRKPWGGLELDRPRIMGIVNVTPDSFSDGGEVFDSTAAIARGLALAEAGATIID
LGGESTRPGADPVSPAEEARRVLPVVRALAEKGLCVSIDTRHAAVMDAAVEAGARIINDVTALLGDPESPKVAARSGADL
CLMHMQGDDPRTMQAEPRYACAPLDVFDHLARRVQDCEAWALPVSGSASILVSALARRPGIVPRCWGVWLCCTVWGCRCC
WECRARASWPG

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=166, Percent_Identity=45.7831325301205, Blast_Score=140, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6324073, Length=142, Percent_Identity=38.0281690140845, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 34749; Mature: 34618

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEAGITSAFTRSPALPRGFDVSAGGLYLLPTGLVWGEQAAAAVISGNGWPLADGWAAFT
CCCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCEECCCCCEEEEECCCCCCCCHHHHHH
ALGVATRRPGGGADLAVASFAEVVDWAEGEDPALARQVAETVHAMGSRRKPWGGLELDRP
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RIMGIVNVTPDSFSDGGEVFDSTAAIARGLALAEAGATIIDLGGESTRPGADPVSPAEEA
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHH
RRVLPVVRALAEKGLCVSIDTRHAAVMDAAVEAGARIINDVTALLGDPESPKVAARSGAD
HHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
LCLMHMQGDDPRTMQAEPRYACAPLDVFDHLARRVQDCEAWALPVSGSASILVSALARRP
EEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCC
GIVPRCWGVWLCCTVWGCRCCWECRARASWPG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PEAGITSAFTRSPALPRGFDVSAGGLYLLPTGLVWGEQAAAAVISGNGWPLADGWAAFT
CCCCCCHHHHCCCCCCCCCCCCCCCEEEEECCCEECCCCCEEEEECCCCCCCCHHHHHH
ALGVATRRPGGGADLAVASFAEVVDWAEGEDPALARQVAETVHAMGSRRKPWGGLELDRP
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
RIMGIVNVTPDSFSDGGEVFDSTAAIARGLALAEAGATIIDLGGESTRPGADPVSPAEEA
EEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCHHHHH
RRVLPVVRALAEKGLCVSIDTRHAAVMDAAVEAGARIINDVTALLGDPESPKVAARSGAD
HHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCC
LCLMHMQGDDPRTMQAEPRYACAPLDVFDHLARRVQDCEAWALPVSGSASILVSALARRP
EEEEEECCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHCC
GIVPRCWGVWLCCTVWGCRCCWECRARASWPG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]