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The map label for this gene is nuoF1 [H]

Identifier: 83311881

GI number: 83311881

Start: 2968957

End: 2970240

Strand: Reverse

Name: nuoF1 [H]

Synonym: amb2782

Alternate gene names: 83311881

Gene position: 2970240-2968957 (Counterclockwise)

Preceding gene: 83311882

Following gene: 83311880

Centisome position: 59.8

GC content: 65.58

Gene sequence:

>1284_bases
ATGCTGCGCGACTCCGATAGGATCTTCACCAATCTCTACGGCATCCATGACTGGCGCCTGAAGGGCGCCATGGCCCGTGG
CGACTGGAACGGCACCAAGGATATTCTGGCCAAGGGCCGCGACTGGATCATCGAAGAGATGAAGAATTCCGGTTTGCGCG
GCCGTGGCGGCGCCGGTTTCCCGACGGGCGTCAAGTGGTCGTTCATGCCCAAGACCGAGGGGCCGCGTCCCCATTATCTG
GTCATCAACGCCGATGAAGGCGAGCCCGGCACCTGCAAGGACCGGGAAATGATGCGCTTCGATCCGCACAAGCTGATCGA
GGGCGCGCTGATCGCCAGCTTCGCCATCGGGGCGCATGCCGCCTACATCTACATTCGCGGCGAGTTCGTCCGTGAGGCCG
AGCACCTCAACATCGCCATCGACGAGGCGCGCGCCGCCGGCCTGCTGGGCCCCAACGCCTGCGGTTCGGGCTGGGATTGC
GAGGTCTACGTCCATCGCGGCGCCGGCGCCTATATCTGCGGCGAGGAATCGGCGCTGATCGAAAGCCTGGAAGGCAAGAA
GGGCCAGCCCCGCCTGAAGCCGCCGTTCCCGGCCGGCGTTGGCCTCTACGGCTGCCCGACCACGGTGAACAACGTGGAAT
CCATCGCGGTGGCGCCGACCATCCTGCGTCGCGGCGCCGCCTGGTTCTCCGGTCTGGGCAAGCCCAACAACACCGGCACC
AAGGTGTTCTGCATCTCCGGCCACGTGAACACGCCGTGCAACGTGGAAGAAGAGATGGGCATCCCGCTGAAGGAGCTTAT
CGAGAAGCATGCCGGCGGTGTGCGGGGCGGCTGGGACAACCTGCTGGCCATCATTCCCGGCGGCTCTTCCGTTCCCATGC
TGACCAAGCAGCAGTGCGAGGAAGTCACCATGGACTTCGACGCCCTGCGCGCCATGCGCTCGGGCCTGGGCACGGCCGCC
GTGATGGTGATGGACAAGTCCACCGATCTGGTGCGCGCCATCCATCGCCTGTCGCGCTTCTACTGGCATGAAAGCTGCGG
CCAGTGCACGCCGTGCCGCGAAGGCACCGGCTGGATGAGCCGCATGATGGGCCGCATGGTCACCGGCGACGCCGAGTTGT
CGGAAATCGATCTGCTGGAAGAGATTTCCCGCCAGATCGAAGGCCACACCATCTGCGCCCTGGGTGACGCCGCCGCCTGG
CCGATCCAGGGCCTGATCCGCGCCTTCCGTCCCGAGATGGAACGCCGGATCCTGGATCGCCAAGCCAAGACCAACGCGGC
CTGA

Upstream 100 bases:

>100_bases
AGACGCCGAAGCCCGGTCCCCAGAACGGTCGTCAGTTCTCGTGCCCGGCCGGTGGCCCCACCAGCCTGACCGAGTTGAAG
TTCGAGGGGGGGAAGGCCTG

Downstream 100 bases:

>100_bases
GAAGAGAGAAGCCCCAATGCCCAAGCTGACCATTGACGGCAGGGAAATCGAAGTCGAGGCCGGGACGACCATCATCCAGG
CCGCCGACCTGCTCGGTATC

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MLRDSDRIFTNLYGIHDWRLKGAMARGDWNGTKDILAKGRDWIIEEMKNSGLRGRGGAGFPTGVKWSFMPKTEGPRPHYL
VINADEGEPGTCKDREMMRFDPHKLIEGALIASFAIGAHAAYIYIRGEFVREAEHLNIAIDEARAAGLLGPNACGSGWDC
EVYVHRGAGAYICGEESALIESLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGAAWFSGLGKPNNTGT
KVFCISGHVNTPCNVEEEMGIPLKELIEKHAGGVRGGWDNLLAIIPGGSSVPMLTKQQCEEVTMDFDALRAMRSGLGTAA
VMVMDKSTDLVRAIHRLSRFYWHESCGQCTPCREGTGWMSRMMGRMVTGDAELSEIDLLEEISRQIEGHTICALGDAAAW
PIQGLIRAFRPEMERRILDRQAKTNAA

Sequences:

>Translated_427_residues
MLRDSDRIFTNLYGIHDWRLKGAMARGDWNGTKDILAKGRDWIIEEMKNSGLRGRGGAGFPTGVKWSFMPKTEGPRPHYL
VINADEGEPGTCKDREMMRFDPHKLIEGALIASFAIGAHAAYIYIRGEFVREAEHLNIAIDEARAAGLLGPNACGSGWDC
EVYVHRGAGAYICGEESALIESLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGAAWFSGLGKPNNTGT
KVFCISGHVNTPCNVEEEMGIPLKELIEKHAGGVRGGWDNLLAIIPGGSSVPMLTKQQCEEVTMDFDALRAMRSGLGTAA
VMVMDKSTDLVRAIHRLSRFYWHESCGQCTPCREGTGWMSRMMGRMVTGDAELSEIDLLEEISRQIEGHTICALGDAAAW
PIQGLIRAFRPEMERRILDRQAKTNAA
>Mature_427_residues
MLRDSDRIFTNLYGIHDWRLKGAMARGDWNGTKDILAKGRDWIIEEMKNSGLRGRGGAGFPTGVKWSFMPKTEGPRPHYL
VINADEGEPGTCKDREMMRFDPHKLIEGALIASFAIGAHAAYIYIRGEFVREAEHLNIAIDEARAAGLLGPNACGSGWDC
EVYVHRGAGAYICGEESALIESLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGAAWFSGLGKPNNTGT
KVFCISGHVNTPCNVEEEMGIPLKELIEKHAGGVRGGWDNLLAIIPGGSSVPMLTKQQCEEVTMDFDALRAMRSGLGTAA
VMVMDKSTDLVRAIHRLSRFYWHESCGQCTPCREGTGWMSRMMGRMVTGDAELSEIDLLEEISRQIEGHTICALGDAAAW
PIQGLIRAFRPEMERRILDRQAKTNAA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=416, Percent_Identity=71.3942307692308, Blast_Score=630, Evalue=0.0,
Organism=Homo sapiens, GI260656005, Length=416, Percent_Identity=71.3942307692308, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1788620, Length=375, Percent_Identity=45.0666666666667, Blast_Score=326, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17531727, Length=425, Percent_Identity=69.8823529411765, Blast_Score=626, Evalue=1e-180,
Organism=Drosophila melanogaster, GI19920794, Length=416, Percent_Identity=70.6730769230769, Blast_Score=633, Evalue=0.0,
Organism=Drosophila melanogaster, GI45550452, Length=425, Percent_Identity=65.8823529411765, Blast_Score=598, Evalue=1e-171,
Organism=Drosophila melanogaster, GI24653819, Length=419, Percent_Identity=48.9260143198091, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24653817, Length=419, Percent_Identity=45.8233890214797, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 46730; Mature: 46730

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRDSDRIFTNLYGIHDWRLKGAMARGDWNGTKDILAKGRDWIIEEMKNSGLRGRGGAGF
CCCCCHHHHHHHHCCEEEEECCCEECCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGVKWSFMPKTEGPRPHYLVINADEGEPGTCKDREMMRFDPHKLIEGALIASFAIGAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFVREAEHLNIAIDEARAAGLLGPNACGSGWDCEVYVHRGAGAYICGEESALI
EEEEEECHHHHHHHHCEEEEECHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGAAWFSGLGKPNNTGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCC
KVFCISGHVNTPCNVEEEMGIPLKELIEKHAGGVRGGWDNLLAIIPGGSSVPMLTKQQCE
EEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
EVTMDFDALRAMRSGLGTAAVMVMDKSTDLVRAIHRLSRFYWHESCGQCTPCREGTGWMS
HHHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RMMGRMVTGDAELSEIDLLEEISRQIEGHTICALGDAAAWPIQGLIRAFRPEMERRILDR
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QAKTNAA
HHHCCCC
>Mature Secondary Structure
MLRDSDRIFTNLYGIHDWRLKGAMARGDWNGTKDILAKGRDWIIEEMKNSGLRGRGGAGF
CCCCCHHHHHHHHCCEEEEECCCEECCCCCCCHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGVKWSFMPKTEGPRPHYLVINADEGEPGTCKDREMMRFDPHKLIEGALIASFAIGAHA
CCCCEEEECCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCEE
AYIYIRGEFVREAEHLNIAIDEARAAGLLGPNACGSGWDCEVYVHRGAGAYICGEESALI
EEEEEECHHHHHHHHCEEEEECHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPAGVGLYGCPTTVNNVESIAVAPTILRRGAAWFSGLGKPNNTGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHCCCCCCCCCC
KVFCISGHVNTPCNVEEEMGIPLKELIEKHAGGVRGGWDNLLAIIPGGSSVPMLTKQQCE
EEEEEECCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCHHHHH
EVTMDFDALRAMRSGLGTAAVMVMDKSTDLVRAIHRLSRFYWHESCGQCTPCREGTGWMS
HHHCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
RMMGRMVTGDAELSEIDLLEEISRQIEGHTICALGDAAAWPIQGLIRAFRPEMERRILDR
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
QAKTNAA
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]