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The map label for this gene is nuoH

Identifier: 83311879

GI number: 83311879

Start: 2965850

End: 2966875

Strand: Reverse

Name: nuoH

Synonym: amb2780

Alternate gene names: 83311879

Gene position: 2966875-2965850 (Counterclockwise)

Preceding gene: 83311880

Following gene: 83311878

Centisome position: 59.73

GC content: 62.48

Gene sequence:

>1026_bases
ATGGTTGACCTTCTGACCGGGCTGCTGCCCCCCTTCGTGTGGCGTCTGCTGATCATCGTTCTGCAGATCGTCGCCATCGT
CCTGCCGCTGCTGATCGCGGTGGCCTACCTCACTTATGCCGAGCGCAAGGTGATCGGCGCCATGCAGTTGCGCAAGGGAC
CCAACGTGGTTGGTCCCTTCGGCCTGCTGCAGCCCATGGCCGATGGCCTGAAGCTGTTCGTCAAGGAGACGGTGCTGCCC
ACCAGCGCCAACCGCGTGGTGTTCGTGGGCGCGCCCATGCTCACCTTCTTCCTGGCCCTGGTGGCCTGGGCGGTGATCCC
CTTCGACAAGGGCTGGGTGCTGGCCGACATCAATGTCGGCGTGCTGTACCTGTTCGCCATCTCGTCGCTCGGCGTCTACG
GCATCATTATGGCGGGCTGGGCGTCCAACTCGAAATACGCCTTCCTGGGCGGCCTGCGTTCGGCGGCCCAGATGGTGTCC
TACGAGGTCTCCATAGGCTTCATCCTGATTTCGGTGCTGCTGACCGTGGGTTCGCTGAACCTGTCGGACGTGGTGACGGC
GCAGTCGAAGATGTGGTTCATCGTTCCGCACTTCCCGCTGTTCATCCTGTTCATCATTTCCGGCCTGGCCGAGACCAACC
GTGCTCCCTTCGACCTTCCGGAAGCGGAAGCCGAGCTGGTGGCCGGCTACAACGTCGAATACTCGGCCATGACCTTCGCC
CTGTTCTTCCTGGGCGAGTACGCCAACATGCTGATGATGGGGGCCATGACCTCCATCCTGTTCCTGGGCGGCTGGATGGC
GCCGTTCGGCCTGGGCTGGCTGCCCATCCCCGGGCTGATCTGGTTCGTGCTGAAGATCTGCCTGGTGATGTTCGTCTTCC
TGTGGGTGCGTGCCACCTTCCCGCGCTATCGCTATGACCAGTTGATGCGTCTGGGTTGGAAGGTGTTCCTGCCGTTCTCG
CTGTTCTGGCTGGTGCTGACCGCAAGCGTTCTGACCGCTTTCGGCTGGCTGCCGAACCAGGGTTAA

Upstream 100 bases:

>100_bases
TATCAGACCGACCCGATCAGCCGCGCCTCCAAGACCATGGCGGAATGCACGGCAGCCTTCGGCGGTGGTTGCAACCACAA
GCACAAGAAGACGGGGACCC

Downstream 100 bases:

>100_bases
GGAGAGAAAGCGATGTCGTTCCTCGACCGCACCGCGCGCGCCTTTCTGCTGACCGAGCTCGTCCAGGGCTTGGCGCTGAC
GCTGCGCTATATGTTCAAGC

Product: NADH:ubiquinone oxidoreductase subunit 1

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MVDLLTGLLPPFVWRLLIIVLQIVAIVLPLLIAVAYLTYAERKVIGAMQLRKGPNVVGPFGLLQPMADGLKLFVKETVLP
TSANRVVFVGAPMLTFFLALVAWAVIPFDKGWVLADINVGVLYLFAISSLGVYGIIMAGWASNSKYAFLGGLRSAAQMVS
YEVSIGFILISVLLTVGSLNLSDVVTAQSKMWFIVPHFPLFILFIISGLAETNRAPFDLPEAEAELVAGYNVEYSAMTFA
LFFLGEYANMLMMGAMTSILFLGGWMAPFGLGWLPIPGLIWFVLKICLVMFVFLWVRATFPRYRYDQLMRLGWKVFLPFS
LFWLVLTASVLTAFGWLPNQG

Sequences:

>Translated_341_residues
MVDLLTGLLPPFVWRLLIIVLQIVAIVLPLLIAVAYLTYAERKVIGAMQLRKGPNVVGPFGLLQPMADGLKLFVKETVLP
TSANRVVFVGAPMLTFFLALVAWAVIPFDKGWVLADINVGVLYLFAISSLGVYGIIMAGWASNSKYAFLGGLRSAAQMVS
YEVSIGFILISVLLTVGSLNLSDVVTAQSKMWFIVPHFPLFILFIISGLAETNRAPFDLPEAEAELVAGYNVEYSAMTFA
LFFLGEYANMLMMGAMTSILFLGGWMAPFGLGWLPIPGLIWFVLKICLVMFVFLWVRATFPRYRYDQLMRLGWKVFLPFS
LFWLVLTASVLTAFGWLPNQG
>Mature_341_residues
MVDLLTGLLPPFVWRLLIIVLQIVAIVLPLLIAVAYLTYAERKVIGAMQLRKGPNVVGPFGLLQPMADGLKLFVKETVLP
TSANRVVFVGAPMLTFFLALVAWAVIPFDKGWVLADINVGVLYLFAISSLGVYGIIMAGWASNSKYAFLGGLRSAAQMVS
YEVSIGFILISVLLTVGSLNLSDVVTAQSKMWFIVPHFPLFILFIISGLAETNRAPFDLPEAEAELVAGYNVEYSAMTFA
LFFLGEYANMLMMGAMTSILFLGGWMAPFGLGWLPIPGLIWFVLKICLVMFVFLWVRATFPRYRYDQLMRLGWKVFLPFS
LFWLVLTASVLTAFGWLPNQG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=308, Percent_Identity=47.7272727272727, Blast_Score=273, Evalue=2e-73,
Organism=Escherichia coli, GI1788618, Length=323, Percent_Identity=43.343653250774, Blast_Score=289, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_MAGSA (Q2W3J1)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_422143.1
- STRING:   Q2W3J1
- GeneID:   3803870
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb2780
- NMPDR:   fig|342108.5.peg.2467
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q2W3J1
- BioCyc:   MMAG342108:AMB2780-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37778; Mature: 37778

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x130e6648)-; HASH(0x12bc4a48)-; HASH(0x13a2bed8)-; HASH(0x13a00578)-; HASH(0x137975e4)-; HASH(0xd639444)-; HASH(0x1398f008)-; HASH(0x137746a4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDLLTGLLPPFVWRLLIIVLQIVAIVLPLLIAVAYLTYAERKVIGAMQLRKGPNVVGPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
GLLQPMADGLKLFVKETVLPTSANRVVFVGAPMLTFFLALVAWAVIPFDKGWVLADINVG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCHH
VLYLFAISSLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVSIGFILISVLLTVGSLN
HHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSDVVTAQSKMWFIVPHFPLFILFIISGLAETNRAPFDLPEAEAELVAGYNVEYSAMTFA
HHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
LFFLGEYANMLMMGAMTSILFLGGWMAPFGLGWLPIPGLIWFVLKICLVMFVFLWVRATF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PRYRYDQLMRLGWKVFLPFSLFWLVLTASVLTAFGWLPNQG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
>Mature Secondary Structure
MVDLLTGLLPPFVWRLLIIVLQIVAIVLPLLIAVAYLTYAERKVIGAMQLRKGPNVVGPF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
GLLQPMADGLKLFVKETVLPTSANRVVFVGAPMLTFFLALVAWAVIPFDKGWVLADINVG
HHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCHH
VLYLFAISSLGVYGIIMAGWASNSKYAFLGGLRSAAQMVSYEVSIGFILISVLLTVGSLN
HHHHHHHHHCCHHHHHHCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSDVVTAQSKMWFIVPHFPLFILFIISGLAETNRAPFDLPEAEAELVAGYNVEYSAMTFA
HHHHHHHCCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCHHHHHHH
LFFLGEYANMLMMGAMTSILFLGGWMAPFGLGWLPIPGLIWFVLKICLVMFVFLWVRATF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
PRYRYDQLMRLGWKVFLPFSLFWLVLTASVLTAFGWLPNQG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA