Click here to switch to the map view.

The map label for this gene is serS

Identifier: 83311620

GI number: 83311620

Start: 2702881

End: 2704149

Strand: Reverse

Name: serS

Synonym: amb2521

Alternate gene names: 83311620

Gene position: 2704149-2702881 (Counterclockwise)

Preceding gene: 83311621

Following gene: 83311619

Centisome position: 54.44

GC content: 66.43

Gene sequence:

>1269_bases
ATGCATGACCTCAAGTCCATTCGCGACAACCCGGACGGATTCGATGCGGGACTGAAGCGCCGGGGCCTCGAGCCCAAGGC
CGCCGCCATCCTCGACCTGGACACGCGGCGCCGCGCCGCCCAGACCGCCTTCCAGGAAATGCAGGCCCGGCGCAACGACG
CCTCCAAGCAGATCGGCGCCCTCAAGAAGAGCGGCGGCGACGCTTCCGCCCTGATGGACGAGGTGGCGAGCCTGAAGGAG
CGCATGCCGGCGGCCGAGGAAGAGGACAAGGCGCTGGGCGCCGAGATCGAGTCCATCCTGGCCTCCATTCCCAATCTGCC
GGCGTCCGATGTGCCGGACGGTCCCGACGAGGACCATAACGTCGAATTGCGCAAGTGGGGCACGCCCAAGAGCTTCGCCT
TCACCGCGCTGGACCACGACGCCATCGGCGCCAAGCTGGGCCTGATGGATTTCGACGGCGCCGCCAAGCTGTCGGGGGCC
CGCTTCGTCGTATTGAAGGGCCAGTTGGCCCGGCTGCAACGCGCCATCGGCCAGTTCATGCTGGATTTGCAGACGGTCGA
GCACGGCTACACCGAGATGGACCCGCCGCTGATGGTCAAGGACGGTGCCGCCTTCGGCACCGGCCAATTGCCCAAGTTCG
GCGAGGATCTGTTCAAGACCAATACCGGCCACTGGTTGATTCCCACCGCTGAGGTGCCGCTGACCAATCTGGTCAGCGAC
GAGATCCTGGACGAGAAGGCGCTGCCGCTGCGCATGACCGCTCTCACGCCGTGTTTCCGCTCGGAAGCCGGGGCGGCGGG
CAAGGACACCCGCGGCATGATCCGCCAGCACCAGTTCCACAAGGTGGAGATGGTCTCCATCGCCCATCCCGATGCCTCCG
GCGCCGAGCACGAGCGCATGACCCAATGCGCCGAGACGGTGCTGCAGCGCCTGGGGCTGGCCTATCGCGTCATCGTGCTG
TGCACCGGCGACATGGGCTTTTCGGCGCAGAAGACTTATGACATCGAAGTCTGGCTGCCGGGCCAGCAGCGCTACCGGGA
AATCTCGTCCTGCTCTAATTGCGGCGACTTCCAGGCCCGGCGCATGAAGGCCCGCTTCCGCCCCGAGGGCGAGAAGGGGA
CGCGCTTCGTCCATACCCTGAACGGCTCGGGCCTCGCCGTGGGTCGCACCCTGATCGCCGTGATGGAAAACTATCAGCGC
GAGGACGGCACCATCGAGGTGCCCGAGGCGCTGCGCCCCTATATGGGCGGTCTGGAGGTCATCGGCTGA

Upstream 100 bases:

>100_bases
GCTGGGCCGAAAAGAAGCGGGAGCAGGCGCTGAATGACGATGGCGAGGATGACGCCACCCACGACGACACCGATTTCAAC
GCGTAGCCGGAATTTTTGCC

Downstream 100 bases:

>100_bases
GATGACCTTTCCGCCCGTCGCCGACCCTTCGTCGCTCCGCATCCTGATTTCCAACGATGACGGCATCAACGCGCCGGGCA
TCAAGGTTCTGGAACGCATC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MHDLKSIRDNPDGFDAGLKRRGLEPKAAAILDLDTRRRAAQTAFQEMQARRNDASKQIGALKKSGGDASALMDEVASLKE
RMPAAEEEDKALGAEIESILASIPNLPASDVPDGPDEDHNVELRKWGTPKSFAFTALDHDAIGAKLGLMDFDGAAKLSGA
RFVVLKGQLARLQRAIGQFMLDLQTVEHGYTEMDPPLMVKDGAAFGTGQLPKFGEDLFKTNTGHWLIPTAEVPLTNLVSD
EILDEKALPLRMTALTPCFRSEAGAAGKDTRGMIRQHQFHKVEMVSIAHPDASGAEHERMTQCAETVLQRLGLAYRVIVL
CTGDMGFSAQKTYDIEVWLPGQQRYREISSCSNCGDFQARRMKARFRPEGEKGTRFVHTLNGSGLAVGRTLIAVMENYQR
EDGTIEVPEALRPYMGGLEVIG

Sequences:

>Translated_422_residues
MHDLKSIRDNPDGFDAGLKRRGLEPKAAAILDLDTRRRAAQTAFQEMQARRNDASKQIGALKKSGGDASALMDEVASLKE
RMPAAEEEDKALGAEIESILASIPNLPASDVPDGPDEDHNVELRKWGTPKSFAFTALDHDAIGAKLGLMDFDGAAKLSGA
RFVVLKGQLARLQRAIGQFMLDLQTVEHGYTEMDPPLMVKDGAAFGTGQLPKFGEDLFKTNTGHWLIPTAEVPLTNLVSD
EILDEKALPLRMTALTPCFRSEAGAAGKDTRGMIRQHQFHKVEMVSIAHPDASGAEHERMTQCAETVLQRLGLAYRVIVL
CTGDMGFSAQKTYDIEVWLPGQQRYREISSCSNCGDFQARRMKARFRPEGEKGTRFVHTLNGSGLAVGRTLIAVMENYQR
EDGTIEVPEALRPYMGGLEVIG
>Mature_422_residues
MHDLKSIRDNPDGFDAGLKRRGLEPKAAAILDLDTRRRAAQTAFQEMQARRNDASKQIGALKKSGGDASALMDEVASLKE
RMPAAEEEDKALGAEIESILASIPNLPASDVPDGPDEDHNVELRKWGTPKSFAFTALDHDAIGAKLGLMDFDGAAKLSGA
RFVVLKGQLARLQRAIGQFMLDLQTVEHGYTEMDPPLMVKDGAAFGTGQLPKFGEDLFKTNTGHWLIPTAEVPLTNLVSD
EILDEKALPLRMTALTPCFRSEAGAAGKDTRGMIRQHQFHKVEMVSIAHPDASGAEHERMTQCAETVLQRLGLAYRVIVL
CTGDMGFSAQKTYDIEVWLPGQQRYREISSCSNCGDFQARRMKARFRPEGEKGTRFVHTLNGSGLAVGRTLIAVMENYQR
EDGTIEVPEALRPYMGGLEVIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=348, Percent_Identity=35.0574712643678, Blast_Score=188, Evalue=1e-47,
Organism=Homo sapiens, GI8923421, Length=321, Percent_Identity=33.6448598130841, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI225579074, Length=321, Percent_Identity=33.6448598130841, Blast_Score=175, Evalue=8e-44,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=57.2093023255814, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17539260, Length=458, Percent_Identity=30.7860262008734, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=336, Percent_Identity=30.0595238095238, Blast_Score=147, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6320226, Length=402, Percent_Identity=31.3432835820896, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321799, Length=386, Percent_Identity=31.6062176165803, Blast_Score=197, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17737985, Length=278, Percent_Identity=38.4892086330935, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24581334, Length=333, Percent_Identity=33.9339339339339, Blast_Score=175, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_MAGSA (Q2W4A0)

Other databases:

- EMBL:   AP007255
- RefSeq:   YP_421884.1
- HSSP:   Q9N0F3
- ProteinModelPortal:   Q2W4A0
- SMR:   Q2W4A0
- STRING:   Q2W4A0
- GeneID:   3805626
- GenomeReviews:   AP007255_GR
- KEGG:   mag:amb2521
- NMPDR:   fig|342108.5.peg.2221
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q2W4A0
- ProtClustDB:   PRK05431
- BioCyc:   MMAG342108:AMB2521-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 46237; Mature: 46237

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 283-283 BINDING 383-383

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDLKSIRDNPDGFDAGLKRRGLEPKAAAILDLDTRRRAAQTAFQEMQARRNDASKQIGA
CCCHHHHCCCCCCHHHHHHHCCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKSGGDASALMDEVASLKERMPAAEEEDKALGAEIESILASIPNLPASDVPDGPDEDHN
HHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VELRKWGTPKSFAFTALDHDAIGAKLGLMDFDGAAKLSGARFVVLKGQLARLQRAIGQFM
EEEEECCCCCCEEEEECCCHHCCCEECCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHH
LDLQTVEHGYTEMDPPLMVKDGAAFGTGQLPKFGEDLFKTNTGHWLIPTAEVPLTNLVSD
HHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHH
EILDEKALPLRMTALTPCFRSEAGAAGKDTRGMIRQHQFHKVEMVSIAHPDASGAEHERM
HHHCCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCHHHHH
TQCAETVLQRLGLAYRVIVLCTGDMGFSAQKTYDIEVWLPGQQRYREISSCSNCGDFQAR
HHHHHHHHHHHCHHEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCHHHHH
RMKARFRPEGEKGTRFVHTLNGSGLAVGRTLIAVMENYQREDGTIEVPEALRPYMGGLEV
HHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCEEE
IG
CC
>Mature Secondary Structure
MHDLKSIRDNPDGFDAGLKRRGLEPKAAAILDLDTRRRAAQTAFQEMQARRNDASKQIGA
CCCHHHHCCCCCCHHHHHHHCCCCCHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKKSGGDASALMDEVASLKERMPAAEEEDKALGAEIESILASIPNLPASDVPDGPDEDHN
HHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VELRKWGTPKSFAFTALDHDAIGAKLGLMDFDGAAKLSGARFVVLKGQLARLQRAIGQFM
EEEEECCCCCCEEEEECCCHHCCCEECCEECCCCCCCCCCEEEEECCHHHHHHHHHHHHH
LDLQTVEHGYTEMDPPLMVKDGAAFGTGQLPKFGEDLFKTNTGHWLIPTAEVPLTNLVSD
HHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEECCCCCHHHHHHH
EILDEKALPLRMTALTPCFRSEAGAAGKDTRGMIRQHQFHKVEMVSIAHPDASGAEHERM
HHHCCCCCCEEHHHHCHHHHHCCCCCCCCHHHHHHHHHCCEEEEEEEECCCCCCCHHHHH
TQCAETVLQRLGLAYRVIVLCTGDMGFSAQKTYDIEVWLPGQQRYREISSCSNCGDFQAR
HHHHHHHHHHHCHHEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHHHCCCCHHHHH
RMKARFRPEGEKGTRFVHTLNGSGLAVGRTLIAVMENYQREDGTIEVPEALRPYMGGLEV
HHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCCEEE
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA