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The map label for this gene is metC [H]

Identifier: 83310393

GI number: 83310393

Start: 1413659

End: 1414831

Strand: Reverse

Name: metC [H]

Synonym: amb1294

Alternate gene names: 83310393

Gene position: 1414831-1413659 (Counterclockwise)

Preceding gene: 83310394

Following gene: 83310392

Centisome position: 28.48

GC content: 68.2

Gene sequence:

>1173_bases
ATGAAGAAATCCACTCGCATCCTCCACGCCGGCCGCAAGCCGGAGGCCTTCCACGGTGCGGTCAATCCGCCGGTCTACCA
TGCCTCGACCATCCTCCACCCCTCGGTGGCGGCCATGGAGAAGAGCGGCAAGACCCCGTTCGAAGGCGTGCGCTATGGCC
GCTTCGGCACGCCCACCACCTTCGCCCTGGAGGAGGCGGTGGCCGAGCTGGAAGGCGGGCACCGTACCGTCGCCACTTCG
TCGGGTCTGGCCGCCATCACCGGCGCGCTGCTGGCCTTCCTCAAGGCGGGCGACCACCTGCTGATGGTCGACACGACCTA
TTTCCCCACGCGGAAGTTCTGCGATTCGGTGCTGGGCGGCCTCGGCATCGAGACCACCTATTACGACCCGCTGGTCGGCG
CCGGAATCACGGCCCTGATGCGGCCCAATACCCGGGTGGTGTTCACCGAGAGCCCCGGCTCGCTGACCTTCGAGGTGCAG
GACATTCCCGCCATCGCCGAGGCGGCCCATGCCGGCGGGGCCGTGGTCATGATGGACAACACCTGGGGCGTGCTGCACTT
CCAGCCCTTCACCAAGGGCATCGATATCTCCATCCAGGCGGCGACCAAGTATATCGTCGGCCATGCCGACGCCATGCTGG
GCACCATCACCGCCGCCACGCCCGAGCTGTGGCTGCAGGTCAAGACCTCGCTGGCGGCCTTCGGCGCCTCGCCGGGGACC
GAGGAGATGTATCTCGGCCTGCGGGGCCTGCGCACCCTACCCGTGCGGCTGCGCCAGCACGCCGAGAGCGCCCTGCGCCT
GACCCGATGGCTGGAGGCCCGGCCCGAGGTGGACCGCGTGCTGTATCCGCCCCTGGCCTCGGATCCGGGGCATGAGCTGT
GGAAGCGGGACTTCACCGGCGGCTGCGGCCTGTTCGGCGTGATCCTCAAGCCCGCCTCCAAGGCGGCGGTGGATGCCATG
CTGGACGGCTATTCCCATTTCAAGCTGGGCTTCTCGTGGGGCGGCTTCGAAAGCCTGGTGATTCCCACCTCGGGCCATTC
CATCATCCGCACCGCCACGCCCTGGACGCCCGTCGGGCCAAGCTTGCGCTTCCACGCCGGACTGGAAGACGCCGACGACC
TGGAGGAAGACCTGGAACGCGGCTTCGAGCGGCTGGCATGCGCCGTTTCCTGA

Upstream 100 bases:

>100_bases
GCCATCGCCGCGTTCCTGGCAGGCTGAGTCGCGAAAGTCCTTGGCTTGAACGGCTTCGGCGGGGCACCATGCCCGCCCTG
AAAGCCATTGCCGGGGCACC

Downstream 100 bases:

>100_bases
CCCGAACGGCGTGTCATCCCGAGCGCCTGCGAGGGATCTCCGCCCGGCACGGCGGTGCCAGGGCGGAAATGCCCGGGCGG
AACGAGATCCCTCCTCCCGC

Product: cystathionine beta-lyase/cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKKSTRILHAGRKPEAFHGAVNPPVYHASTILHPSVAAMEKSGKTPFEGVRYGRFGTPTTFALEEAVAELEGGHRTVATS
SGLAAITGALLAFLKAGDHLLMVDTTYFPTRKFCDSVLGGLGIETTYYDPLVGAGITALMRPNTRVVFTESPGSLTFEVQ
DIPAIAEAAHAGGAVVMMDNTWGVLHFQPFTKGIDISIQAATKYIVGHADAMLGTITAATPELWLQVKTSLAAFGASPGT
EEMYLGLRGLRTLPVRLRQHAESALRLTRWLEARPEVDRVLYPPLASDPGHELWKRDFTGGCGLFGVILKPASKAAVDAM
LDGYSHFKLGFSWGGFESLVIPTSGHSIIRTATPWTPVGPSLRFHAGLEDADDLEEDLERGFERLACAVS

Sequences:

>Translated_390_residues
MKKSTRILHAGRKPEAFHGAVNPPVYHASTILHPSVAAMEKSGKTPFEGVRYGRFGTPTTFALEEAVAELEGGHRTVATS
SGLAAITGALLAFLKAGDHLLMVDTTYFPTRKFCDSVLGGLGIETTYYDPLVGAGITALMRPNTRVVFTESPGSLTFEVQ
DIPAIAEAAHAGGAVVMMDNTWGVLHFQPFTKGIDISIQAATKYIVGHADAMLGTITAATPELWLQVKTSLAAFGASPGT
EEMYLGLRGLRTLPVRLRQHAESALRLTRWLEARPEVDRVLYPPLASDPGHELWKRDFTGGCGLFGVILKPASKAAVDAM
LDGYSHFKLGFSWGGFESLVIPTSGHSIIRTATPWTPVGPSLRFHAGLEDADDLEEDLERGFERLACAVS
>Mature_390_residues
MKKSTRILHAGRKPEAFHGAVNPPVYHASTILHPSVAAMEKSGKTPFEGVRYGRFGTPTTFALEEAVAELEGGHRTVATS
SGLAAITGALLAFLKAGDHLLMVDTTYFPTRKFCDSVLGGLGIETTYYDPLVGAGITALMRPNTRVVFTESPGSLTFEVQ
DIPAIAEAAHAGGAVVMMDNTWGVLHFQPFTKGIDISIQAATKYIVGHADAMLGTITAATPELWLQVKTSLAAFGASPGT
EEMYLGLRGLRTLPVRLRQHAESALRLTRWLEARPEVDRVLYPPLASDPGHELWKRDFTGGCGLFGVILKPASKAAVDAM
LDGYSHFKLGFSWGGFESLVIPTSGHSIIRTATPWTPVGPSLRFHAGLEDADDLEEDLERGFERLACAVS

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=339, Percent_Identity=34.2182890855457, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI299473759, Length=339, Percent_Identity=30.0884955752212, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI25453487, Length=337, Percent_Identity=29.9703264094956, Blast_Score=145, Evalue=6e-35,
Organism=Escherichia coli, GI1789383, Length=392, Percent_Identity=44.3877551020408, Blast_Score=331, Evalue=5e-92,
Organism=Escherichia coli, GI1790375, Length=393, Percent_Identity=30.0254452926209, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71980708, Length=391, Percent_Identity=30.9462915601023, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=340, Percent_Identity=33.2352941176471, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17560056, Length=342, Percent_Identity=32.7485380116959, Blast_Score=161, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6321170, Length=334, Percent_Identity=44.9101796407186, Blast_Score=292, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6319307, Length=397, Percent_Identity=32.2418136020151, Blast_Score=156, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321904, Length=347, Percent_Identity=27.9538904899135, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323333, Length=434, Percent_Identity=26.9585253456221, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321254, Length=322, Percent_Identity=27.0186335403727, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922554, Length=388, Percent_Identity=33.7628865979381, Blast_Score=194, Evalue=9e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 41915; Mature: 41915

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSTRILHAGRKPEAFHGAVNPPVYHASTILHPSVAAMEKSGKTPFEGVRYGRFGTPTT
CCCCCCEEECCCCCCHHCCCCCCCCEEHHHHCCCHHHHHHHCCCCCHHCCCCCCCCCCHH
FALEEAVAELEGGHRTVATSSGLAAITGALLAFLKAGDHLLMVDTTYFPTRKFCDSVLGG
HHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCC
LGIETTYYDPLVGAGITALMRPNTRVVFTESPGSLTFEVQDIPAIAEAAHAGGAVVMMDN
CCCCCEECCCHHHCCHHEEECCCEEEEEEECCCCEEEEECCCCHHHHHHCCCCEEEEEEC
TWGVLHFQPFTKGIDISIQAATKYIVGHADAMLGTITAATPELWLQVKTSLAAFGASPGT
CCEEEEEECCCCCCCEEEEEHHEEHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
EEMYLGLRGLRTLPVRLRQHAESALRLTRWLEARPEVDRVLYPPLASDPGHELWKRDFTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCCC
GCGLFGVILKPASKAAVDAMLDGYSHFKLGFSWGGFESLVIPTSGHSIIRTATPWTPVGP
CCCHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCC
SLRFHAGLEDADDLEEDLERGFERLACAVS
CEEEECCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKSTRILHAGRKPEAFHGAVNPPVYHASTILHPSVAAMEKSGKTPFEGVRYGRFGTPTT
CCCCCCEEECCCCCCHHCCCCCCCCEEHHHHCCCHHHHHHHCCCCCHHCCCCCCCCCCHH
FALEEAVAELEGGHRTVATSSGLAAITGALLAFLKAGDHLLMVDTTYFPTRKFCDSVLGG
HHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCC
LGIETTYYDPLVGAGITALMRPNTRVVFTESPGSLTFEVQDIPAIAEAAHAGGAVVMMDN
CCCCCEECCCHHHCCHHEEECCCEEEEEEECCCCEEEEECCCCHHHHHHCCCCEEEEEEC
TWGVLHFQPFTKGIDISIQAATKYIVGHADAMLGTITAATPELWLQVKTSLAAFGASPGT
CCEEEEEECCCCCCCEEEEEHHEEHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
EEMYLGLRGLRTLPVRLRQHAESALRLTRWLEARPEVDRVLYPPLASDPGHELWKRDFTG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHCCCC
GCGLFGVILKPASKAAVDAMLDGYSHFKLGFSWGGFESLVIPTSGHSIIRTATPWTPVGP
CCCHHHHHHCCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCEEEECCCCCCCCC
SLRFHAGLEDADDLEEDLERGFERLACAVS
CEEEECCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]