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The map label for this gene is rkpK [H]

Identifier: 83309675

GI number: 83309675

Start: 624049

End: 625356

Strand: Reverse

Name: rkpK [H]

Synonym: amb0576

Alternate gene names: 83309675

Gene position: 625356-624049 (Counterclockwise)

Preceding gene: 83309676

Following gene: 83309673

Centisome position: 12.59

GC content: 64.3

Gene sequence:

>1308_bases
ATGCGCATCGCCATGATCGGCACCGGCTATGTGGGTCTGGTGTCGGGAACCTGCTTCTCGGAATTCGGCATCGACGTGGT
CTGCGTCGACAAGGACGCGGCCAAGATCGAGAAGCTGCACCAGAATATCATGCCCATCTACGAGCCGGGCCTGGACGACA
TGGTCGCCGCCAATGTGGAGGCGGGGCGCCTGTCCTTCACCACCGACCTCAAGGAAGCGGTCAAGGATGCCGACGCGGTG
TTCATCGCGGTGGGCACGCCGAGCCGCCGCGGCGATGGCCATGCCGACCTCAGCTACGTCTATGCCGCGGCCGAGGAAAT
CGCCGATTCCATGACCGGCTACACCGTGGTGGTGACCAAGTCCACCGTGCCGGTAGGCACCGGCGACGAGGTGGAGCGCA
TCATCCGGGCACGGCGTCCCGATGCCCAGTTCGACGTGGTCTCCAATCCGGAATTCCTGCGCGAAGGCTCGGCCATCAAC
GACTTCATGCGGCCCGACCGCGTGGTCATCGGCACCGAGTCCGAGAAGGCCCGCAAGGTGATGAAGCAGCTCTATCGGGT
GCTGTACCTGATCGAGACGCCCATCGCCTTCACGTCGCGGCGCACCTCGGAACTGATCAAATACGCCGGCAACACCTTCC
TGGCCACCAAGATCACCTTCATCAACGAGATCGCCGATCTGTGCGAGAAGGTGGGCGCCGACGTTCACGACGTGGCCAAG
GGCATCGGCCTCGACGGCCGCATCGGCAAGAAGTTCCTGCATCCCGGCCCCGGCTATGGCGGCTCGTGCTTCCCCAAGGA
CACCCTGGCCCTGGTCAAGACCGCCCGCGACTACAACGCCCCCTTGCGCATCGTCGAGACGGTGGTCGCCGTCAACGAGG
CCCGCAAGAAGCAGATGGCCGAGCGGGTCATCGCCGCCTGCGGCGGCTCGGTGAAGGGCAAGACCATCTCGGTGCTGGGC
CTGACCTTCAAGCCCAACACAGACGACATGCGCGACTCCCCCTCCATCGACATCGTCTCGGCGCTGATCGAGGCGGGAGC
CACAGTCAAGGCCTTCGACCCGGAGGGCATGGAAGAAGCCAAAAAGCTGCTTCCCGCCGCTGTCGAGTATTGCAAGGACG
CCTACGCCACCATGCCCGGCGCCCATTGCGCCGTGATCATCACCGAGTGGAACGAGTTCCGGGCGCTGGACCTCAAGAAG
GTCAAGTCGCTGCTGGCCCAGCCCAGCATCGTCGACCTGCGCAACGTCTATGTCCCCGAGGAAATGGCCGAACTGGGCTT
CGCCTATTCCAGCATCGGCCGTCCGTAA

Upstream 100 bases:

>100_bases
GGGCTGGCTGGAAGCCAACCTCGCCTTTGCCCTGGCCCGTGACGACACCGCCGAGGCCGCCCGCGACCTGATCACCCGCT
TCCATAAGGACTGACGCCCC

Downstream 100 bases:

>100_bases
TCCATCAAGCCTCCGCCATCGGCCGCCTGTTCCGGCCGATGGCGGGATTGACCGACGCCCGCCGGCACAATTCCGGATAG
GCCGGCTCCTCCAGGCCGAT

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MRIAMIGTGYVGLVSGTCFSEFGIDVVCVDKDAAKIEKLHQNIMPIYEPGLDDMVAANVEAGRLSFTTDLKEAVKDADAV
FIAVGTPSRRGDGHADLSYVYAAAEEIADSMTGYTVVVTKSTVPVGTGDEVERIIRARRPDAQFDVVSNPEFLREGSAIN
DFMRPDRVVIGTESEKARKVMKQLYRVLYLIETPIAFTSRRTSELIKYAGNTFLATKITFINEIADLCEKVGADVHDVAK
GIGLDGRIGKKFLHPGPGYGGSCFPKDTLALVKTARDYNAPLRIVETVVAVNEARKKQMAERVIAACGGSVKGKTISVLG
LTFKPNTDDMRDSPSIDIVSALIEAGATVKAFDPEGMEEAKKLLPAAVEYCKDAYATMPGAHCAVIITEWNEFRALDLKK
VKSLLAQPSIVDLRNVYVPEEMAELGFAYSSIGRP

Sequences:

>Translated_435_residues
MRIAMIGTGYVGLVSGTCFSEFGIDVVCVDKDAAKIEKLHQNIMPIYEPGLDDMVAANVEAGRLSFTTDLKEAVKDADAV
FIAVGTPSRRGDGHADLSYVYAAAEEIADSMTGYTVVVTKSTVPVGTGDEVERIIRARRPDAQFDVVSNPEFLREGSAIN
DFMRPDRVVIGTESEKARKVMKQLYRVLYLIETPIAFTSRRTSELIKYAGNTFLATKITFINEIADLCEKVGADVHDVAK
GIGLDGRIGKKFLHPGPGYGGSCFPKDTLALVKTARDYNAPLRIVETVVAVNEARKKQMAERVIAACGGSVKGKTISVLG
LTFKPNTDDMRDSPSIDIVSALIEAGATVKAFDPEGMEEAKKLLPAAVEYCKDAYATMPGAHCAVIITEWNEFRALDLKK
VKSLLAQPSIVDLRNVYVPEEMAELGFAYSSIGRP
>Mature_435_residues
MRIAMIGTGYVGLVSGTCFSEFGIDVVCVDKDAAKIEKLHQNIMPIYEPGLDDMVAANVEAGRLSFTTDLKEAVKDADAV
FIAVGTPSRRGDGHADLSYVYAAAEEIADSMTGYTVVVTKSTVPVGTGDEVERIIRARRPDAQFDVVSNPEFLREGSAIN
DFMRPDRVVIGTESEKARKVMKQLYRVLYLIETPIAFTSRRTSELIKYAGNTFLATKITFINEIADLCEKVGADVHDVAK
GIGLDGRIGKKFLHPGPGYGGSCFPKDTLALVKTARDYNAPLRIVETVVAVNEARKKQMAERVIAACGGSVKGKTISVLG
LTFKPNTDDMRDSPSIDIVSALIEAGATVKAFDPEGMEEAKKLLPAAVEYCKDAYATMPGAHCAVIITEWNEFRALDLKK
VKSLLAQPSIVDLRNVYVPEEMAELGFAYSSIGRP

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=461, Percent_Identity=37.7440347071584, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI296040438, Length=362, Percent_Identity=38.3977900552486, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI296040443, Length=310, Percent_Identity=38.3870967741935, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1788340, Length=362, Percent_Identity=30.3867403314917, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI48994968, Length=441, Percent_Identity=28.7981859410431, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17560350, Length=460, Percent_Identity=35.6521739130435, Blast_Score=272, Evalue=2e-73,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=37.012987012987, Blast_Score=299, Evalue=2e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47192; Mature: 47192

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIAMIGTGYVGLVSGTCFSEFGIDVVCVDKDAAKIEKLHQNIMPIYEPGLDDMVAANVE
CEEEEEECCHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHCCCC
AGRLSFTTDLKEAVKDADAVFIAVGTPSRRGDGHADLSYVYAAAEEIADSMTGYTVVVTK
CCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
STVPVGTGDEVERIIRARRPDAQFDVVSNPEFLREGSAINDFMRPDRVVIGTESEKARKV
CCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHCCCCEEEEECCCHHHHHH
MKQLYRVLYLIETPIAFTSRRTSELIKYAGNTFLATKITFINEIADLCEKVGADVHDVAK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDGRIGKKFLHPGPGYGGSCFPKDTLALVKTARDYNAPLRIVETVVAVNEARKKQMA
CCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ERVIAACGGSVKGKTISVLGLTFKPNTDDMRDSPSIDIVSALIEAGATVKAFDPEGMEEA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHH
KKLLPAAVEYCKDAYATMPGAHCAVIITEWNEFRALDLKKVKSLLAQPSIVDLRNVYVPE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCH
EMAELGFAYSSIGRP
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MRIAMIGTGYVGLVSGTCFSEFGIDVVCVDKDAAKIEKLHQNIMPIYEPGLDDMVAANVE
CEEEEEECCHHHHHCCCHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHCCCC
AGRLSFTTDLKEAVKDADAVFIAVGTPSRRGDGHADLSYVYAAAEEIADSMTGYTVVVTK
CCCEEEHHHHHHHHCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
STVPVGTGDEVERIIRARRPDAQFDVVSNPEFLREGSAINDFMRPDRVVIGTESEKARKV
CCCCCCCCHHHHHHHHHCCCCCCEEECCCHHHHHCCCHHHHHCCCCEEEEECCCHHHHHH
MKQLYRVLYLIETPIAFTSRRTSELIKYAGNTFLATKITFINEIADLCEKVGADVHDVAK
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCHHHHHH
GIGLDGRIGKKFLHPGPGYGGSCFPKDTLALVKTARDYNAPLRIVETVVAVNEARKKQMA
CCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ERVIAACGGSVKGKTISVLGLTFKPNTDDMRDSPSIDIVSALIEAGATVKAFDPEGMEEA
HHHHHHCCCCCCCCEEEEEEEEECCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHH
KKLLPAAVEYCKDAYATMPGAHCAVIITEWNEFRALDLKKVKSLLAQPSIVDLRNVYVPE
HHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHCCCCH
EMAELGFAYSSIGRP
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]