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The map label for this gene is pleC [H]

Identifier: 83309666

GI number: 83309666

Start: 613978

End: 616245

Strand: Reverse

Name: pleC [H]

Synonym: amb0567

Alternate gene names: 83309666

Gene position: 616245-613978 (Counterclockwise)

Preceding gene: 83309667

Following gene: 83309665

Centisome position: 12.41

GC content: 69.09

Gene sequence:

>2268_bases
TTGGATTGCCGCCACCCTGTGATAGGGTATGGGCCGCTTTGGGGAGGGAAACAGGACCGAATGGCGGAGGGGGGCAACCG
GACCCTGACCTGGCTGGGCGGAGCACGGGGCCACCTGTTCCAGGTGGTGGTGCTGGGCCTTGTTCCCGCAGTTTTCCTCG
GCACCCTGGCCATCATCATCCAGCTGGCGGAATCCCTGTCCCTGCAGGCGGCGGGCTCCCAGGTGGAAACCCTGGCCCGC
ATGGCGGCCGCCATTCATGACCGCGGATTGGAAAGCTCGCGCGAGGCCCTGGCCGCCCTGGCCACCGATCCCGAAGACGA
CGAATGCGGCAGCCATTACCGCCACTTCCTGCTGGCCGTGGAGGGGCATTACGGCTTCTTGCGCACGGACCCGTCCGGGC
GGGCGGGATGCAGCATCGCCCAGGGCACCGATATCTCCTGGCTGACCAAGGGACCGCAGATCGGCCGCGCCATGGAAACC
GGAGCCTTCGCCACCGGCCCCTATGTCCAGCTCGAGGATGGGCGGGTCGCCCTGCCCATGGCCTATCCCATTCTCGACTG
GCTGGGCACGCCGCGCGGCGTGGTGGCGACCGCCCGGTCGCTGGACCATCTGGCCAAGGCGGTGGCCCCGCCCATCCTGC
CCGACGGGGCGCGCCTGCTGGTGCTGAAATCCGACGGCACCGTCCTGGCCCGCGTGCCCGCCCTTTCCGGTGACGCCCCG
GCCATCACCCCGGTCCCCGAATTGAGGGAGGCGGCGGCAAGGGGCCGCGGCGGATCTTTCACCGCCATCGCCATCACCGG
CGAGACCTCGGTCTTCGGCGTCGCCCCCCTGGGCCGCATGGCGCCCGAGACCATGGTGGCGGTGACCATGCCCGTGGAGA
TGCTGGGAGGGTCGGAACGCCAGTTCCTGCGCATGGCGGTCACCGCCTTCGGCATCGCCGGCTCGGGCGCCGTCCTGCTG
CTGTGGTATTCCAGCCGCCGCCTGCTGTTCCAGCCCCTGGGACGGCTGGCCGGCGCCATGCGCCGGGTGCGGGCCGGCGA
CATGGCCGCCCGCGCCGGCGGCGGCATCGGCGAAGTGGGCGAGATGGGCGACACCTTCGACACCATGGTCGGCGCCCTGA
ACGAACGCGAGGCTCGGCTGACCGAGAGCGAGGACCGCTTCCGCGCCACCTTCGAGCAGGCGGCGGTGGGCATGTGCCAC
ACGACCCTGGACCGCCGTTTCATCCGCATCAACAGCCGGTTCGCCGAGATGCTGGGCTGCGCGCCCCAGGAACTGATCGG
CCGCTCCGCCAGCGACTTCACCCATCCCGACGACCGCAAGCTGGGATTGGACGGCATCGACCACATCATCCAGGGCACCC
GGGAAAGCAACAGCATCGAGAAGCGCTATCTCCGCAAGGACGGCACGATCGTCTGGGCCAACCTGACCGTGTCGGCTCTG
CGCCGCGACGGTCAGGTCGAGTACATCATCGGGGTGGCCGAGGATATCAGCTGGCGCAAGCGGGCCGAGGACGAACTGCG
CGCCGCCAAGGAGCAGGCGGAAAGCGCCAGCCGCGCCAAGAGCGACTTCCTGGCCGGCATGAGCCACGAATTGCGGACTC
CGCTCAATGCCATCATCGGGTTCGCCGAGACCATGTATTCCCAGGTCCTCGGCCCCATGCCCGAGCGCTACCGCGAATAT
GCCGGCGATATCTCCGCCTCGGGCCGCCATCTGCTGGGGATCATCACCGACATCCTGGATCTGGCCAAGATCGAGGCGGG
CCGGATGGAGCTGGACGACCGCCCCATGGAAATCGCCCCGGTGGTCGACGTCGCCCTGCGTCTGCTGCGTGACCGCGGCG
CCGCCGCCGGCTTGAATTTGATCTCCGACCTTCCCCCGGGCCTCCCCCAGGTGATGGCCGATGAACGCCGGATCCGGCAG
GTGGTGATCAATCTGCTGGCCAATGCCGTCAAGTTCACGCCGTTTGGCGGCAGGGTCACCGTTTCCGCCAGCCTCACTCC
CGACGGCGGGTTGGAGCTGCATGTCAGCGACACCGGCATCGGCATGACCGAGGAAGAGGCGGCCCAGGTCATCGAGCCCT
TCGTCCAGGTGGACGCCCGCATCGCCCGACGGCACGAGGGCACTGGTCTGGGGCTGCCCATGGTGGCGGCCATCATGGAA
ATGCACGGCGGCGCCATCGCCATCGCCAGCCAGCCCGATGCCGGTACCCGGGTAACGGTGACCTTCCCACCGCGCCGCAT
CTTTGCCGTGACCGCGACCGGGCGCTGA

Upstream 100 bases:

>100_bases
CCCCATGACCCTGGAAGGCCTCGACGGGGCCATGCGCGACCTGAATCGGAACGGCCCCCGCACCAAATGACTGTCACACG
CTAGTGACGGATAGCCGATA

Downstream 100 bases:

>100_bases
CCCCAAGCCCCTGGCTCCGCCGGCCCGGTCGTGGCACAGTGCCGTGTCATCCATTAGCAGGGGCGCCCCAGGACTCATGG
TCAGCGAATTGCTACGTCCC

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MDCRHPVIGYGPLWGGKQDRMAEGGNRTLTWLGGARGHLFQVVVLGLVPAVFLGTLAIIIQLAESLSLQAAGSQVETLAR
MAAAIHDRGLESSREALAALATDPEDDECGSHYRHFLLAVEGHYGFLRTDPSGRAGCSIAQGTDISWLTKGPQIGRAMET
GAFATGPYVQLEDGRVALPMAYPILDWLGTPRGVVATARSLDHLAKAVAPPILPDGARLLVLKSDGTVLARVPALSGDAP
AITPVPELREAAARGRGGSFTAIAITGETSVFGVAPLGRMAPETMVAVTMPVEMLGGSERQFLRMAVTAFGIAGSGAVLL
LWYSSRRLLFQPLGRLAGAMRRVRAGDMAARAGGGIGEVGEMGDTFDTMVGALNEREARLTESEDRFRATFEQAAVGMCH
TTLDRRFIRINSRFAEMLGCAPQELIGRSASDFTHPDDRKLGLDGIDHIIQGTRESNSIEKRYLRKDGTIVWANLTVSAL
RRDGQVEYIIGVAEDISWRKRAEDELRAAKEQAESASRAKSDFLAGMSHELRTPLNAIIGFAETMYSQVLGPMPERYREY
AGDISASGRHLLGIITDILDLAKIEAGRMELDDRPMEIAPVVDVALRLLRDRGAAAGLNLISDLPPGLPQVMADERRIRQ
VVINLLANAVKFTPFGGRVTVSASLTPDGGLELHVSDTGIGMTEEEAAQVIEPFVQVDARIARRHEGTGLGLPMVAAIME
MHGGAIAIASQPDAGTRVTVTFPPRRIFAVTATGR

Sequences:

>Translated_755_residues
MDCRHPVIGYGPLWGGKQDRMAEGGNRTLTWLGGARGHLFQVVVLGLVPAVFLGTLAIIIQLAESLSLQAAGSQVETLAR
MAAAIHDRGLESSREALAALATDPEDDECGSHYRHFLLAVEGHYGFLRTDPSGRAGCSIAQGTDISWLTKGPQIGRAMET
GAFATGPYVQLEDGRVALPMAYPILDWLGTPRGVVATARSLDHLAKAVAPPILPDGARLLVLKSDGTVLARVPALSGDAP
AITPVPELREAAARGRGGSFTAIAITGETSVFGVAPLGRMAPETMVAVTMPVEMLGGSERQFLRMAVTAFGIAGSGAVLL
LWYSSRRLLFQPLGRLAGAMRRVRAGDMAARAGGGIGEVGEMGDTFDTMVGALNEREARLTESEDRFRATFEQAAVGMCH
TTLDRRFIRINSRFAEMLGCAPQELIGRSASDFTHPDDRKLGLDGIDHIIQGTRESNSIEKRYLRKDGTIVWANLTVSAL
RRDGQVEYIIGVAEDISWRKRAEDELRAAKEQAESASRAKSDFLAGMSHELRTPLNAIIGFAETMYSQVLGPMPERYREY
AGDISASGRHLLGIITDILDLAKIEAGRMELDDRPMEIAPVVDVALRLLRDRGAAAGLNLISDLPPGLPQVMADERRIRQ
VVINLLANAVKFTPFGGRVTVSASLTPDGGLELHVSDTGIGMTEEEAAQVIEPFVQVDARIARRHEGTGLGLPMVAAIME
MHGGAIAIASQPDAGTRVTVTFPPRRIFAVTATGR
>Mature_755_residues
MDCRHPVIGYGPLWGGKQDRMAEGGNRTLTWLGGARGHLFQVVVLGLVPAVFLGTLAIIIQLAESLSLQAAGSQVETLAR
MAAAIHDRGLESSREALAALATDPEDDECGSHYRHFLLAVEGHYGFLRTDPSGRAGCSIAQGTDISWLTKGPQIGRAMET
GAFATGPYVQLEDGRVALPMAYPILDWLGTPRGVVATARSLDHLAKAVAPPILPDGARLLVLKSDGTVLARVPALSGDAP
AITPVPELREAAARGRGGSFTAIAITGETSVFGVAPLGRMAPETMVAVTMPVEMLGGSERQFLRMAVTAFGIAGSGAVLL
LWYSSRRLLFQPLGRLAGAMRRVRAGDMAARAGGGIGEVGEMGDTFDTMVGALNEREARLTESEDRFRATFEQAAVGMCH
TTLDRRFIRINSRFAEMLGCAPQELIGRSASDFTHPDDRKLGLDGIDHIIQGTRESNSIEKRYLRKDGTIVWANLTVSAL
RRDGQVEYIIGVAEDISWRKRAEDELRAAKEQAESASRAKSDFLAGMSHELRTPLNAIIGFAETMYSQVLGPMPERYREY
AGDISASGRHLLGIITDILDLAKIEAGRMELDDRPMEIAPVVDVALRLLRDRGAAAGLNLISDLPPGLPQVMADERRIRQ
VVINLLANAVKFTPFGGRVTVSASLTPDGGLELHVSDTGIGMTEEEAAQVIEPFVQVDARIARRHEGTGLGLPMVAAIME
MHGGAIAIASQPDAGTRVTVTFPPRRIFAVTATGR

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=39.7489539748954, Blast_Score=165, Evalue=1e-41,
Organism=Escherichia coli, GI145693157, Length=371, Percent_Identity=32.0754716981132, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI87081816, Length=245, Percent_Identity=37.5510204081633, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI48994928, Length=482, Percent_Identity=26.7634854771784, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI1788713, Length=291, Percent_Identity=33.6769759450172, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788393, Length=233, Percent_Identity=30.0429184549356, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1786600, Length=237, Percent_Identity=30.8016877637131, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788549, Length=390, Percent_Identity=24.6153846153846, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=30.7053941908714, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790436, Length=219, Percent_Identity=28.7671232876712, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=29.3388429752066, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788381, Length=154, Percent_Identity=33.1168831168831, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082128, Length=270, Percent_Identity=25.5555555555556, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=230, Percent_Identity=26.9565217391304, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790861, Length=283, Percent_Identity=25.7950530035336, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=27.4336283185841, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790346, Length=225, Percent_Identity=23.5555555555556, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=232, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 80880; Mature: 80880

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDCRHPVIGYGPLWGGKQDRMAEGGNRTLTWLGGARGHLFQVVVLGLVPAVFLGTLAIII
CCCCCCCEECCCCCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLAESLSLQAAGSQVETLARMAAAIHDRGLESSREALAALATDPEDDECGSHYRHFLLAV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHEEEEEEE
EGHYGFLRTDPSGRAGCSIAQGTDISWLTKGPQIGRAMETGAFATGPYVQLEDGRVALPM
ECCCEEEEECCCCCCCCEECCCCCCEEECCCCCCCCHHHCCCCCCCCEEEECCCCEEEHH
AYPILDWLGTPRGVVATARSLDHLAKAVAPPILPDGARLLVLKSDGTVLARVPALSGDAP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCC
AITPVPELREAAARGRGGSFTAIAITGETSVFGVAPLGRMAPETMVAVTMPVEMLGGSER
CCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCCCEEEEEECHHHHCCCHH
QFLRMAVTAFGIAGSGAVLLLWYSSRRLLFQPLGRLAGAMRRVRAGDMAARAGGGIGEVG
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHH
EMGDTFDTMVGALNEREARLTESEDRFRATFEQAAVGMCHTTLDRRFIRINSRFAEMLGC
CCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCC
APQELIGRSASDFTHPDDRKLGLDGIDHIIQGTRESNSIEKRYLRKDGTIVWANLTVSAL
CCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHH
RRDGQVEYIIGVAEDISWRKRAEDELRAAKEQAESASRAKSDFLAGMSHELRTPLNAIIG
HCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHH
FAETMYSQVLGPMPERYREYAGDISASGRHLLGIITDILDLAKIEAGRMELDDRPMEIAP
HHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
VVDVALRLLRDRGAAAGLNLISDLPPGLPQVMADERRIRQVVINLLANAVKFTPFGGRVT
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
VSASLTPDGGLELHVSDTGIGMTEEEAAQVIEPFVQVDARIARRHEGTGLGLPMVAAIME
EEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MHGGAIAIASQPDAGTRVTVTFPPRRIFAVTATGR
HCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCC
>Mature Secondary Structure
MDCRHPVIGYGPLWGGKQDRMAEGGNRTLTWLGGARGHLFQVVVLGLVPAVFLGTLAIII
CCCCCCCEECCCCCCCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLAESLSLQAAGSQVETLARMAAAIHDRGLESSREALAALATDPEDDECGSHYRHFLLAV
HHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHEEEEEEE
EGHYGFLRTDPSGRAGCSIAQGTDISWLTKGPQIGRAMETGAFATGPYVQLEDGRVALPM
ECCCEEEEECCCCCCCCEECCCCCCEEECCCCCCCCHHHCCCCCCCCEEEECCCCEEEHH
AYPILDWLGTPRGVVATARSLDHLAKAVAPPILPDGARLLVLKSDGTVLARVPALSGDAP
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCC
AITPVPELREAAARGRGGSFTAIAITGETSVFGVAPLGRMAPETMVAVTMPVEMLGGSER
CCCCCHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCCCEEEEEECHHHHCCCHH
QFLRMAVTAFGIAGSGAVLLLWYSSRRLLFQPLGRLAGAMRRVRAGDMAARAGGGIGEVG
HHHHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHH
EMGDTFDTMVGALNEREARLTESEDRFRATFEQAAVGMCHTTLDRRFIRINSRFAEMLGC
CCCCHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHCC
APQELIGRSASDFTHPDDRKLGLDGIDHIIQGTRESNSIEKRYLRKDGTIVWANLTVSAL
CCHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCHHHH
RRDGQVEYIIGVAEDISWRKRAEDELRAAKEQAESASRAKSDFLAGMSHELRTPLNAIIG
HCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCHHHHHHH
FAETMYSQVLGPMPERYREYAGDISASGRHLLGIITDILDLAKIEAGRMELDDRPMEIAP
HHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHH
VVDVALRLLRDRGAAAGLNLISDLPPGLPQVMADERRIRQVVINLLANAVKFTPFGGRVT
HHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEE
VSASLTPDGGLELHVSDTGIGMTEEEAAQVIEPFVQVDARIARRHEGTGLGLPMVAAIME
EEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
MHGGAIAIASQPDAGTRVTVTFPPRRIFAVTATGR
HCCCEEEEECCCCCCCEEEEEECCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]