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The map label for this gene is plp [H]

Identifier: 83309610

GI number: 83309610

Start: 547734

End: 548696

Strand: Reverse

Name: plp [H]

Synonym: amb0511

Alternate gene names: 83309610

Gene position: 548696-547734 (Counterclockwise)

Preceding gene: 83309619

Following gene: 83309609

Centisome position: 11.05

GC content: 65.01

Gene sequence:

>963_bases
ATGACTTTGCCGCATTCCAGGGTGATACCAATCGACCACTTGTGCCGACCCTCCGGTTGTGGTTCAACCGCAGGCACTGT
TGTCTCGGCCGTGGGCGCCGCTCCTGGCGCCCGGGCCATCGACGAGAAGGAACGTTCGCTCATGAAGATGCTGTTCGCGC
GCCGCCCGATGCTCGCCCTCTCCCTGGCGGCAGGGCTGGCCGCCAGCCCGGCCATCGCCGCCGATTCCGTTGTCGCCAAC
GTCAACGGCTCCGACATCAAGATGTCGCAGCTGGCCGAATACGGCCGCCAGATGGGCCCCCAGGCCCCCTACGAGGCGGT
GCTCGAAGTGGCCATCAACAACCAGCTGGTCTACGAGCAGGCCAAGCGCGACAAGCTGGACGCCGATCCCGACGTCAAGG
CCGCGCTGAAGCGGGTCGAGATCCAGCTCATGGCCCAGGCCCTGATGCAGAAGAAGGTGCGCGGCGCCGTCACCGACGAG
GCCGTCAAGGTCCGCTATGACCAGGCCGTCAAGAACTTCCAGCCGCAGGAAGAAGTGCACGCCCGCCACATCCTGGCGGA
AACCGAGGAAGGCGCCCGTTCGATCATCGCCGATCTGAACCGCGGCATGGACTTCGCCGAACTGGCCAAGACCCGTTCCA
AGGACACCGGTTCGGGCGCCATGGGCGGCGATCTGGGCTATTTCGTCCAGGGCGCCATGGTGCCGGAATTCGCGGCCGCC
GCCTTTGCCATGCGCCCGGGCGAGCTGTCCAAGACCCCGGTGAAGACCCAGTTCGGCTATCACGTGATCAAGGTCGAGGA
CAAGCGGATGGCCTCCATTCCTCCCTATGACCAGGCCAAGCCGGTGATCGCCCGCCAGATCGCCGAGGAACTGCAGGAAA
AGATGGTCGTCGAACTGCGCGAGAAGGCCAAGATCAAGCGGTTCAAGCCCGACGGCACGCCGCTCGAAGCGGCCAAGAAG
TAA

Upstream 100 bases:

>100_bases
GCGCGCGCGTATGGCGGCGCGCCCTGGCCTGCGAAGTCGGGGAACCATATTGCACAGAGTCGGTTCCGAATCCAGTGCTG
GGTGGGCGCGGAATTCCGCC

Downstream 100 bases:

>100_bases
AAGCCTGAATGGCCCGGCCGTCGAAAACGGCCGGGCCTTTTACCCTGCGACAACGGATTTCCCGCCATGACCACCGCCAT
CTCCCCCCTCGCCCCCGAGC

Product: parvulin-like peptidyl-prolyl isomerase

Products: NA

Alternate protein names: Peptidyl-prolyl cis-trans isomerase plp; Rotamase plp [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTLPHSRVIPIDHLCRPSGCGSTAGTVVSAVGAAPGARAIDEKERSLMKMLFARRPMLALSLAAGLAASPAIAADSVVAN
VNGSDIKMSQLAEYGRQMGPQAPYEAVLEVAINNQLVYEQAKRDKLDADPDVKAALKRVEIQLMAQALMQKKVRGAVTDE
AVKVRYDQAVKNFQPQEEVHARHILAETEEGARSIIADLNRGMDFAELAKTRSKDTGSGAMGGDLGYFVQGAMVPEFAAA
AFAMRPGELSKTPVKTQFGYHVIKVEDKRMASIPPYDQAKPVIARQIAEELQEKMVVELREKAKIKRFKPDGTPLEAAKK

Sequences:

>Translated_320_residues
MTLPHSRVIPIDHLCRPSGCGSTAGTVVSAVGAAPGARAIDEKERSLMKMLFARRPMLALSLAAGLAASPAIAADSVVAN
VNGSDIKMSQLAEYGRQMGPQAPYEAVLEVAINNQLVYEQAKRDKLDADPDVKAALKRVEIQLMAQALMQKKVRGAVTDE
AVKVRYDQAVKNFQPQEEVHARHILAETEEGARSIIADLNRGMDFAELAKTRSKDTGSGAMGGDLGYFVQGAMVPEFAAA
AFAMRPGELSKTPVKTQFGYHVIKVEDKRMASIPPYDQAKPVIARQIAEELQEKMVVELREKAKIKRFKPDGTPLEAAKK
>Mature_319_residues
TLPHSRVIPIDHLCRPSGCGSTAGTVVSAVGAAPGARAIDEKERSLMKMLFARRPMLALSLAAGLAASPAIAADSVVANV
NGSDIKMSQLAEYGRQMGPQAPYEAVLEVAINNQLVYEQAKRDKLDADPDVKAALKRVEIQLMAQALMQKKVRGAVTDEA
VKVRYDQAVKNFQPQEEVHARHILAETEEGARSIIADLNRGMDFAELAKTRSKDTGSGAMGGDLGYFVQGAMVPEFAAAA
FAMRPGELSKTPVKTQFGYHVIKVEDKRMASIPPYDQAKPVIARQIAEELQEKMVVELREKAKIKRFKPDGTPLEAAKK

Specific function: Ppiases Accelerate The Folding Of Proteins. Seems To Be Involved In The Folding Of Outer Membrane Proteins. Its Preference At The P1 Position Of The Peptide Substrate Is Glu > Leu > Ala > His > Val > Phe > Ile > Gly > Lys > Thr. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI38679892, Length=96, Percent_Identity=40.625, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786645, Length=135, Percent_Identity=31.8518518518519, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790211, Length=85, Percent_Identity=45.8823529411765, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786238, Length=102, Percent_Identity=41.1764705882353, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17537235, Length=96, Percent_Identity=44.7916666666667, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356303, Length=96, Percent_Identity=39.5833333333333, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 34680; Mature: 34548

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLPHSRVIPIDHLCRPSGCGSTAGTVVSAVGAAPGARAIDEKERSLMKMLFARRPMLAL
CCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
SLAAGLAASPAIAADSVVANVNGSDIKMSQLAEYGRQMGPQAPYEAVLEVAINNQLVYEQ
HHHHHHCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHH
AKRDKLDADPDVKAALKRVEIQLMAQALMQKKVRGAVTDEAVKVRYDQAVKNFQPQEEVH
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHH
ARHILAETEEGARSIIADLNRGMDFAELAKTRSKDTGSGAMGGDLGYFVQGAMVPEFAAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHH
AFAMRPGELSKTPVKTQFGYHVIKVEDKRMASIPPYDQAKPVIARQIAEELQEKMVVELR
HHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKAKIKRFKPDGTPLEAAKK
HHHHHHHCCCCCCCHHCCCC
>Mature Secondary Structure 
TLPHSRVIPIDHLCRPSGCGSTAGTVVSAVGAAPGARAIDEKERSLMKMLFARRPMLAL
CCCCCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHH
SLAAGLAASPAIAADSVVANVNGSDIKMSQLAEYGRQMGPQAPYEAVLEVAINNQLVYEQ
HHHHHHCCCCCHHHHHEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHH
AKRDKLDADPDVKAALKRVEIQLMAQALMQKKVRGAVTDEAVKVRYDQAVKNFQPQEEVH
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHH
ARHILAETEEGARSIIADLNRGMDFAELAKTRSKDTGSGAMGGDLGYFVQGAMVPEFAAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHCCCHHHHHHH
AFAMRPGELSKTPVKTQFGYHVIKVEDKRMASIPPYDQAKPVIARQIAEELQEKMVVELR
HHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
EKAKIKRFKPDGTPLEAAKK
HHHHHHHCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]