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The map label for this gene is ddh

Identifier: 82752107

GI number: 82752107

Start: 2533956

End: 2534765

Strand: Direct

Name: ddh

Synonym: SAB2398

Alternate gene names: 82752107

Gene position: 2533956-2534765 (Clockwise)

Preceding gene: 82752105

Following gene: 82752109

Centisome position: 92.39

GC content: 32.96

Gene sequence:

>810_bases
ATGTACATAATCTTTAATTTCACTCATTTACTTTTCAATCTTTTAAAAGCGAGGTTTTTAATAATGACAAAAATTATGTT
CTTTGGTACGCGTGATTATGAGAAAGAGATGGCATTAAATTGGGGGAAAAAGAATAATGTCGAAGTAACTACTTCTAAAG
AGCTATTATCAAGTGCTACAGTCGATCAATTAAAAGATTACGATGGCGTAACTACAATGCAATTTGGTAAGTTAGAAAAT
GACGTTTATCCTAAATTAGAATCTTACGGTATTAAACAAATTGCACAACGTACTGCTGGATTTGATATGTATGATTTAGA
TTTAGCTAAAAAACACAACATTGTGATATCTAACGTTCCTAGTTATTCACCTGAAACAATTGCAGAGTATTCTGTTTCTA
TCGCCCTACAATTAGTGCGTCGCTTCCCAGATATTGAACGCCGTGTACAAGCACATGATTTTACTTGGCAAGCAGAAATC
ATGTCTAAACCAGTTAAAAATATGACTGTTGCAATTATCGGTACGGGTCGTATCGGTGCTGCTACAGCTAAAATATATGC
AGGATTTGGTGCTACAATTACAGCTTATGACGCTTATCCTAATAAAGATTTAGACTTTTTAACTTATAAAGATAGTGTTA
AAGAAGCTATTAAAGATGCCGATATTATTTCTTTACATGTTCCAGCGAACAAAGAAAGCTATCATTTATTCGATAAAGCA
ATGTTTGATCATGTGAAAAAAGGTGCAATCTTAGTTAACGCAGCATTATCTGTCATTAACACTGGTACATGTGAAACACG
TTTAAATTAA

Upstream 100 bases:

>100_bases
TATAAGTTTTCTGCAATAAAACACACTTTTGAATTTTGGAAAATTTAGTGTTATAATATATTTGTGATATTTTTCACAAT
TAAATTGTGGCGTGATTTTA

Downstream 100 bases:

>100_bases
TATATATTTAAAAGCAAAGGCGCGCTATGTGCCTTTGCTTTTTATTTTGTGTATCTGTATCAAAATCGATTTGATTAAAA
TCCGCTTTATTTTATCATCT

Product: D-lactate dehydrogenase

Products: NA

Alternate protein names: D-LDH; D-specific D-2-hydroxyacid dehydrogenase [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAALSVINTGTCETRLN

Sequences:

>Translated_269_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAALSVINTGTCETRLN
>Mature_269_residues
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSATVDQLKDYDGVTTMQFGKLEN
DVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVPSYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEI
MSKPVKNMTVAIIGTGRIGAATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
MFDHVKKGAILVNAALSVINTGTCETRLN

Specific function: Fermentative Lactate Dehydrogenase. [C]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=235, Percent_Identity=23.4042553191489, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI145580575, Length=180, Percent_Identity=26.1111111111111, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI4557497, Length=174, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI61743967, Length=174, Percent_Identity=27.0114942528736, Blast_Score=69, Evalue=6e-12,
Organism=Homo sapiens, GI145580578, Length=174, Percent_Identity=26.4367816091954, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI4557499, Length=174, Percent_Identity=26.4367816091954, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787645, Length=233, Percent_Identity=29.6137339055794, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI87082289, Length=165, Percent_Identity=27.8787878787879, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=231, Percent_Identity=25.5411255411255, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=157, Percent_Identity=27.3885350318471, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=173, Percent_Identity=26.5895953757225, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322116, Length=161, Percent_Identity=26.0869565217391, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24646446, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646448, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646452, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24646450, Length=180, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI62472511, Length=174, Percent_Identity=27.5862068965517, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.28 [H]

Molecular weight: Translated: 30381; Mature: 30381

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSAT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHH
VDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVP
HHHHHCCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCC
SYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEHHHHHHCCCCCEEEEEEECCCCCH
ATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
HHHHEEECCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
MFDHVKKGAILVNAALSVINTGTCETRLN
HHHHHHCCEEEEEHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MYIIFNFTHLLFNLLKARFLIMTKIMFFGTRDYEKEMALNWGKKNNVEVTTSKELLSSAT
CEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEEEEHHHHHHHHH
VDQLKDYDGVTTMQFGKLENDVYPKLESYGIKQIAQRTAGFDMYDLDLAKKHNIVISNVP
HHHHHCCCCCCEEECCCCCCCCCCCHHHCCHHHHHHHHCCCCEEECCHHCCCCEEEECCC
SYSPETIAEYSVSIALQLVRRFPDIERRVQAHDFTWQAEIMSKPVKNMTVAIIGTGRIGA
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEHHHHHHCCCCCEEEEEEECCCCCH
ATAKIYAGFGATITAYDAYPNKDLDFLTYKDSVKEAIKDADIISLHVPANKESYHLFDKA
HHHHEEECCCCEEEEEECCCCCCCCEEEEHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
MFDHVKKGAILVNAALSVINTGTCETRLN
HHHHHHCCEEEEEHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA