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The map label for this gene is cobA [H]

Identifier: 82751994

GI number: 82751994

Start: 2409334

End: 2410311

Strand: Reverse

Name: cobA [H]

Synonym: SAB2278c

Alternate gene names: 82751994

Gene position: 2410311-2409334 (Counterclockwise)

Preceding gene: 82751995

Following gene: 82751993

Centisome position: 87.89

GC content: 36.81

Gene sequence:

>978_bases
ATGTCTGTAGATGAATATGGCAAGGTTTACTTGATAGGTGCGGGACCAGGTAATCCGAATTATTTGACTAAAAAGGCTGA
GCGTTTAATACGTGAAGCGGATGTCATTCTATATGATCGATTAGTGAATCCGTTGATTTTACAATATGCGAATTTGACTA
CTGAAATTATCGATGTTGGTAAAAAGCCGTATGCAAAACATATTCAGCAAGAAAAAATAAATGACTGTATCGTGGAAGCA
GCGCGTCGTTATAACAAGGTTGTTAGACTTAAAGGTGGCGATCCAGCGATATTTGGTCGTGTGCAAGAAGAAGTCGACAC
ACTAAATGAACATCATATTGCGTTTGAAATTGTACCAGGGGTGACATCAGCGAGCGCAGCAGTTGCTAGTATGCAGACAG
GTTTGACAATGCGTACAGTTGCTAAAAGTGTGACATTTTCTACAGGTCACTTTAAAGATTCAGAAGAAAATGAAGTGGAT
GTCAATTCCTTAGTGAATGGTGGCACGTTAGCAATTTATATGGGAGTAAAACGTTTAGGGAAAATTATCACACAGATACA
ACAGTACACAGATATTGATTACCCGATAGCGATTGTCTTTCAAGCATCGTGTTTTAACGAGTTTGTTGTTAAGGGGCGTT
TAAGTAATATTATTTCAAAATTGCAACACTATTCAATTGAGGCGAAACCAGGTATATGTATTATTGGGGAAGTTGTTGGT
TATACTGAAAACACTCCTAAATCATATGATTCTACGAAGCAATTTTATGTAGTAAGTGGTTCTAAACATGACGCCCTTAT
GCTCTGTGAATATTTATATGACAAAGGTTATGGCTGTTTGCTAAACCCAAATGATACATCGAATGGCACATATCATTCGT
CGCAATATGATTACTATGATGCATTTATTAAGCATCAAGAAAATGTAACATATATTTCAACCGATTGTGCAGATGCTAAT
ACAGTGTTATGTCACTAA

Upstream 100 bases:

>100_bases
ACGATCAAAAAATTGATTTAAATACAGGTATTGTTCAAGAACCTGATGAAGGTTGTGTAGATGTTTATGAGGTAGAAGTT
ACAGACGGGAACGTATATAT

Downstream 100 bases:

>100_bases
TTTATAAAAAATAAATGAATAAGTAAGGTTTCAACCGAGAGAATATATTTGTGTTGAAGCCTTATTTGTCGTTGTGCCAA
TTTGAACGATTTAGATTGGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSVDEYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINDCIVEA
ARRYNKVVRLKGGDPAIFGRVQEEVDTLNEHHIAFEIVPGVTSASAAVASMQTGLTMRTVAKSVTFSTGHFKDSEENEVD
VNSLVNGGTLAIYMGVKRLGKIITQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIISKLQHYSIEAKPGICIIGEVVG
YTENTPKSYDSTKQFYVVSGSKHDALMLCEYLYDKGYGCLLNPNDTSNGTYHSSQYDYYDAFIKHQENVTYISTDCADAN
TVLCH

Sequences:

>Translated_325_residues
MSVDEYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINDCIVEA
ARRYNKVVRLKGGDPAIFGRVQEEVDTLNEHHIAFEIVPGVTSASAAVASMQTGLTMRTVAKSVTFSTGHFKDSEENEVD
VNSLVNGGTLAIYMGVKRLGKIITQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIISKLQHYSIEAKPGICIIGEVVG
YTENTPKSYDSTKQFYVVSGSKHDALMLCEYLYDKGYGCLLNPNDTSNGTYHSSQYDYYDAFIKHQENVTYISTDCADAN
TVLCH
>Mature_324_residues
SVDEYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVGKKPYAKHIQQEKINDCIVEAA
RRYNKVVRLKGGDPAIFGRVQEEVDTLNEHHIAFEIVPGVTSASAAVASMQTGLTMRTVAKSVTFSTGHFKDSEENEVDV
NSLVNGGTLAIYMGVKRLGKIITQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIISKLQHYSIEAKPGICIIGEVVGY
TENTPKSYDSTKQFYVVSGSKHDALMLCEYLYDKGYGCLLNPNDTSNGTYHSSQYDYYDAFIKHQENVTYISTDCADANT
VLCH

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=242, Percent_Identity=37.1900826446281, Blast_Score=145, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6322922, Length=262, Percent_Identity=30.5343511450382, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 36190; Mature: 36059

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00840 SUMT_2 ; PS00473 GNRH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVDEYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVG
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKPYAKHIQQEKINDCIVEAARRYNKVVRLKGGDPAIFGRVQEEVDTLNEHHIAFEIVPG
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECC
VTSASAAVASMQTGLTMRTVAKSVTFSTGHFKDSEENEVDVNSLVNGGTLAIYMGVKRLG
CCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHCCCCEEEEHHHHHHHH
KIITQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIISKLQHYSIEAKPGICIIGEVVG
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
YTENTPKSYDSTKQFYVVSGSKHDALMLCEYLYDKGYGCLLNPNDTSNGTYHSSQYDYYD
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEECCCCHHHH
AFIKHQENVTYISTDCADANTVLCH
HHHHCCCCEEEEEECCCCCCEEEEC
>Mature Secondary Structure 
SVDEYGKVYLIGAGPGNPNYLTKKAERLIREADVILYDRLVNPLILQYANLTTEIIDVG
CCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KKPYAKHIQQEKINDCIVEAARRYNKVVRLKGGDPAIFGRVQEEVDTLNEHHIAFEIVPG
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEEEECC
VTSASAAVASMQTGLTMRTVAKSVTFSTGHFKDSEENEVDVNSLVNGGTLAIYMGVKRLG
CCCHHHHHHHHHCCCHHHHHHHHHEECCCCCCCCCCCCCCHHHHCCCCEEEEHHHHHHHH
KIITQIQQYTDIDYPIAIVFQASCFNEFVVKGRLSNIISKLQHYSIEAKPGICIIGEVVG
HHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECC
YTENTPKSYDSTKQFYVVSGSKHDALMLCEYLYDKGYGCLLNPNDTSNGTYHSSQYDYYD
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCEECCCCHHHH
AFIKHQENVTYISTDCADANTVLCH
HHHHCCCCEEEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1906874 [H]