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The map label for this gene is hssR [H]

Identifier: 82751956

GI number: 82751956

Start: 2369688

End: 2370362

Strand: Direct

Name: hssR [H]

Synonym: SAB2240

Alternate gene names: 82751956

Gene position: 2369688-2370362 (Clockwise)

Preceding gene: 82751953

Following gene: 82751957

Centisome position: 86.41

GC content: 35.26

Gene sequence:

>675_bases
ATGGTGCAATGTCTTGTTGTCGATGACGATTCTCGAATCCTAAATTATATAGCTAGCCATTTACAAACAGAGCACATTGA
TGCATACACACAACCAAGTGGTGAAGCTGCATTAAAACTTTTAGAAAAACAGCGTGTCGATATTGCAGTGATAGATATTA
TGATGGATGGTATGGACGGCTTTCAATTATGTAATACATTAAAAAATGATTATGATATACCAGTTATTATGTTAACAGCG
CGGGATGCACTTAGTGACAAAGAGCGTGCGTTTATAAGCGGTACTGACGATTATGTAACCAAACCCTTTGAGGTTAAGGA
ACTTATTTTTAGAATTCGTGCGGTATTACGTCGATATAATATCAATTCAAATTCAGAAATGACCATTGGCAACTTAACGC
TAAACCAATCTTATTTGGAACTCCAAGTATCTAATAAAACGATGACGTTACCGAACAAGGAATTTCAATTACTATTTATG
CTTGCAACACGTCCTAAGCAAATCTTTACTCGTGAACAGATAATAGAAAAAATTTGGGGCTATGATTATGAAGGAGATGA
ACGAACAGTTGACGTTCATATTAAGCGACTACGCCAAAGATTAAAAAAATTAAATGCCACACTTACAATTGAAACAGTAA
GAGGTCAAGGCTATAAGGTGGAGAATCATGTTTAA

Upstream 100 bases:

>100_bases
AGTATAAGGTTGAAATATGAACTCAATATGAACAATTGTTTTTTTACGCAAAAATATTTTACATGTATAATAAATGAAAA
AGATAAGGGAGTTTATAGCT

Downstream 100 bases:

>100_bases
AACACTCTATGCTAGAATTGCGATTTATTCCATTACGGTTATTTTATTTAGTGCATTAATAAGTTTTGTATTAACAAACG
TTTACTATCATTATAATTTA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MVQCLVVDDDSRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVIDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LATRPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV

Sequences:

>Translated_224_residues
MVQCLVVDDDSRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVIDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LATRPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
>Mature_224_residues
MVQCLVVDDDSRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVIDIMMDGMDGFQLCNTLKNDYDIPVIMLTA
RDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYNINSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFM
LATRPKQIFTREQIIEKIWGYDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated hssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=37.2727272727273, Blast_Score=147, Evalue=8e-37,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=33.9366515837104, Blast_Score=140, Evalue=7e-35,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=35.3211009174312, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.8888888888889, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=32.1266968325792, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=28.9592760180996, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=32.15859030837, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1789402, Length=220, Percent_Identity=31.3636363636364, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=27.7533039647577, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=27.8481012658228, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=26.5765765765766, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=26.2443438914027, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=28.3783783783784, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1786911, Length=205, Percent_Identity=24.8780487804878, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=31.8965517241379, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25980; Mature: 25980

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00230 MAP1B_NEURAXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQCLVVDDDSRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVIDIMMDGMDG
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCH
FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCC
INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLATRPKQIFTREQIIEKIWG
CCCCCCEEEEEEEECCEEEEEEECCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCC
YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
CCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCC
>Mature Secondary Structure
MVQCLVVDDDSRILNYIASHLQTEHIDAYTQPSGEAALKLLEKQRVDIAVIDIMMDGMDG
CEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCH
FQLCNTLKNDYDIPVIMLTARDALSDKERAFISGTDDYVTKPFEVKELIFRIRAVLRRYN
HHHHHHHCCCCCCCEEEEECCCCCCCCCCEEECCCHHHCCCCHHHHHHHHHHHHHHHHCC
INSNSEMTIGNLTLNQSYLELQVSNKTMTLPNKEFQLLFMLATRPKQIFTREQIIEKIWG
CCCCCCEEEEEEEECCEEEEEEECCCEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCC
YDYEGDERTVDVHIKRLRQRLKKLNATLTIETVRGQGYKVENHV
CCCCCCCEEHHHHHHHHHHHHHHCCCEEEEEEECCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA