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The map label for this gene is tcaB

Identifier: 82751950

GI number: 82751950

Start: 2362884

End: 2364092

Strand: Reverse

Name: tcaB

Synonym: SAB2234c

Alternate gene names: 82751950

Gene position: 2364092-2362884 (Counterclockwise)

Preceding gene: 82751951

Following gene: 82751948

Centisome position: 86.2

GC content: 33.66

Gene sequence:

>1209_bases
ATGAATGATTTAACGCATTTTAACAAGCGTTCACCGATATTTATTATTATTTTAGGATCTTTGACGGCCATTGGAGCATT
ATCAATAGATATGTTTTTGCCTGGATTACCAGATATTAGACATGATTTTCAAACAACGACGTCTAACGCACAATTAACAT
TATCGATGTTTATGATTGGTTTAGCGTTTGGTAATTTGTTTGCTGGTCCAATTTCAGATTCAACTGGGCGCAGAAAGCTG
CTTATTATAGCTATGATTATTTTTACATTAGCAAGTTTAGGTATTGTTTTTGTACATAATATTTGGCTGATGGTTGCATT
AAGATTTCTTCAAGGAGTCACAGGTGGAGCAGCAGCAGTTATTTCAAGAGCTATAGCAAGTGATATGTATAGTGGTAATG
AACTAACTAAGTTTATGGCATTATTGATGCTTGTTAATGGTATTGCACCAGTTGTTGCGCCCACAATAGGGGGCATAATT
TTAAATTATTCTGTCTGGCGTATGGTCTTTGTCATTCTGACTATCTTTGGCTTCGTCATGGTCATAGGTTCTTTATTAAA
AGTACCTGAATCATTAACAGTGACAAATCGTGAGTCAAGTCGTGGATTAAAGACAATGTTTAAAAACTTCAAAATATTAT
TGAAGACGCCACGGTTTGTATTACCAATGCTCATTCAAGGTATGACATTTGTAATATTATTTACTTATATTTCTGCGTCT
CCGTTTATTATTCAAAAAATTTATGGCATGACTGCAATACAATTTAGTTGGATGTTTGCAGGAATTGGTATTACGCTCAT
CATATCAAGTCAACTTACTGGGTACCTTGTTGATTTTATAGACTCACAAAAATTGATGAGAGGCATGACGATGATTCAGA
TTATCGGTGTAATTTTAGTGACGATTGTATTGCTTAATCATTGGAACTTTTGGATTTTAGCGATAGGATTTATCATTTTA
ATAGCACCAGTGACAGGTGTTGCGACACTTGGTTTTACAATAGCTATGGATGAAAGTAGTAGTGGTAGAGGGAGTTCATC
AAGTTTATTAGGTTTAGTGCAGTTTTTATTTGGTGGTATTGCATCGCCATTAGTGGGGGTAAAAGGTGAAGATAATCCTA
TACCTTACATAATTATTATTATAGCTACAGCAGTTATATTAATTATTTTACAGATTTATAATATGAAGGTATTTAAAACA
AATCGATGA

Upstream 100 bases:

>100_bases
TGAAACTTGTGAGTAATGCTAATATATAAAAGAGCATATTTAAAATTAGTTTCTGTTCGTGATAGTTATAAACTAATCAT
TATATAAAGGAGATAGTCAT

Downstream 100 bases:

>100_bases
TAAACATAGTTTCTTCTATTATATTGAATTGAAAATTAAAAAACAAAACATGAGCTATTCATAGACCTATGAATTTAGCA
TCAAAAATAAAAATGCCGAG

Product: bicyclomycin and teicoplanin resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKL
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSRGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGIASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR

Sequences:

>Translated_402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKL
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSRGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGIASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR
>Mature_402_residues
MNDLTHFNKRSPIFIIILGSLTAIGALSIDMFLPGLPDIRHDFQTTTSNAQLTLSMFMIGLAFGNLFAGPISDSTGRRKL
LIIAMIIFTLASLGIVFVHNIWLMVALRFLQGVTGGAAAVISRAIASDMYSGNELTKFMALLMLVNGIAPVVAPTIGGII
LNYSVWRMVFVILTIFGFVMVIGSLLKVPESLTVTNRESSRGLKTMFKNFKILLKTPRFVLPMLIQGMTFVILFTYISAS
PFIIQKIYGMTAIQFSWMFAGIGITLIISSQLTGYLVDFIDSQKLMRGMTMIQIIGVILVTIVLLNHWNFWILAIGFIIL
IAPVTGVATLGFTIAMDESSSGRGSSSSLLGLVQFLFGGIASPLVGVKGEDNPIPYIIIIIATAVILIILQIYNMKVFKT
NR

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=378, Percent_Identity=29.8941798941799, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI48994889, Length=234, Percent_Identity=32.4786324786325, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1790794, Length=289, Percent_Identity=23.5294117647059, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790146, Length=243, Percent_Identity=27.5720164609054, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787065, Length=215, Percent_Identity=27.4418604651163, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87082312, Length=187, Percent_Identity=26.2032085561497, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787880, Length=347, Percent_Identity=25.3602305475504, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319480, Length=294, Percent_Identity=20.4081632653061, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43923; Mature: 43923

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCC
>Mature Secondary Structure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HCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]