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The map label for this gene is czrB

Identifier: 82751747

GI number: 82751747

Start: 2161215

End: 2162195

Strand: Direct

Name: czrB

Synonym: SAB2030

Alternate gene names: 82751747

Gene position: 2161215-2162195 (Clockwise)

Preceding gene: 82751746

Following gene: 82751748

Centisome position: 78.8

GC content: 33.33

Gene sequence:

>981_bases
ATGTCTCATTCACATCATCATCATGACCATATGCATAGTCATGTAACTACAAATAATAAGAAAGTATTGTTTATATCGTT
TTTAATAATCGGTCTATATATGTTTATCGAAATCATCGGCGGTCTCCTTGCTAATAGTTTGGCATTATTATCTGACGGTA
TCCATATGTTTAGCGACACATTCTCATTAGGTGTTGCTTTAATCGCATTTATATATGCTGAAAAGAACGCCATAGCTACG
AAAACATTTGGTTATAAACGTTTCGAAGTACTCGCAGCGTTATTTAATGGTGTAACGCTTTTTGTAATAAGTATTTTGAT
TGTTTTTGAAGCGATTAAACGCTTCTTTGTTCCTTCTGAAGTTCAATCAAAAGAAATGTTAATCATTAGCATTATTGGTT
TAATTGTCAATATCGTTGTTGCATTCTTTATGTTTAAAGGCGGCGACACGTCACACAATTTAAATATGCGTGGTGCTTTT
CTACATGTTATCGGAGACTTATTAGGTTCAGTTGGCGCCATTACTGCAGCTATTTTAATTTGGGCATTTGGATGGACAAT
CGCCGATCCTATCGCAAGTATTTTAGTTTCCGTTATTATTTTAAAAAGTGCTTGGGGTATCACAAAATCTTCAATTAACA
TTTTAATGGAAGGCACACCAAGTGATGTTGATATAGATGAAGTTATAACTACTATTAAAAAGGATTCACGAATACAAAGT
GTGCATGATTGCCATGTTTGGACAATTTCAAATGATATGAATGCATTAAGTTGTCATGTTGTTGTAGACCATACATTGAC
AATGAAAGAATGTGAATTATTATTAGAAAACATCGAGCATGATTTATTACATTTAAATATCCACCATATGACTATTCAAT
TAGAAACGCCTAATCACAAACATGATGAATCGATGATATGTTCAGGAACACATAGTCATTCGCATAACCATCATGCTCAT
CATCACGCGCATGTACATTAA

Upstream 100 bases:

>100_bases
GGCCAATCAATGATTTATTCATTAGATGACATCCACGTAGCAACTATGTTAAAGCAAGCCATACATCACGCGAATCATCC
TAAAGAAAGTGGGTTATAAT

Downstream 100 bases:

>100_bases
TAATTTTAACCTACTGCCATTACATCGATTAAACTTTTCAATGGCAGTAGGTTTTTATGTCTTTATGGCGACTTGTTTAG
TCTTTGATGATGCAATGTTT

Product: cation-efflux system membrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNAIAT
KTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAF
LHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESMICSGTHSHSHNHHAH
HHAHVH

Sequences:

>Translated_326_residues
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNAIAT
KTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAF
LHVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESMICSGTHSHSHNHHAH
HHAHVH
>Mature_325_residues
SHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDTFSLGVALIAFIYAEKNAIATK
TFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSEVQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFL
HVIGDLLGSVGAITAAILIWAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQSV
HDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHKHDESMICSGTHSHSHNHHAHH
HAHVH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=327, Percent_Identity=28.1345565749235, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=27.8996865203762, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI21361112, Length=336, Percent_Identity=27.0833333333333, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI21359890, Length=321, Percent_Identity=27.1028037383178, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI289803013, Length=285, Percent_Identity=28.4210526315789, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803009, Length=285, Percent_Identity=28.4210526315789, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803007, Length=285, Percent_Identity=28.4210526315789, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI289803003, Length=285, Percent_Identity=28.4210526315789, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI64762489, Length=288, Percent_Identity=28.4722222222222, Blast_Score=124, Evalue=8e-29,
Organism=Homo sapiens, GI14210520, Length=237, Percent_Identity=27.4261603375527, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI52351208, Length=192, Percent_Identity=31.25, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI222080086, Length=109, Percent_Identity=33.0275229357798, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI40255009, Length=109, Percent_Identity=33.0275229357798, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI52352803, Length=124, Percent_Identity=35.4838709677419, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=42.7083333333333, Blast_Score=189, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI193210990, Length=328, Percent_Identity=28.9634146341463, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555794, Length=325, Percent_Identity=30.7692307692308, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI17555796, Length=327, Percent_Identity=30.5810397553517, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32564488, Length=324, Percent_Identity=29.9382716049383, Blast_Score=139, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6320411, Length=191, Percent_Identity=34.5549738219895, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324892, Length=134, Percent_Identity=39.5522388059701, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6323899, Length=139, Percent_Identity=38.1294964028777, Blast_Score=83, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24656728, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656724, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656720, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24656715, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21357035, Length=337, Percent_Identity=27.299703264095, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24583858, Length=333, Percent_Identity=25.5255255255255, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24645863, Length=141, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24584409, Length=162, Percent_Identity=30.8641975308642, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI28574430, Length=162, Percent_Identity=30.8641975308642, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585900, Length=144, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585898, Length=144, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24585896, Length=144, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19921672, Length=144, Percent_Identity=31.25, Blast_Score=82, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36281; Mature: 36150

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDT
CCCCCCCHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSLGVALIAFIYAEKNAIATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSE
HHHHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
VQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHH
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHK
HHCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCCC
HDESMICSGTHSHSHNHHAHHHAHVH
CCCCEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHSHHHHDHMHSHVTTNNKKVLFISFLIIGLYMFIEIIGGLLANSLALLSDGIHMFSDT
CCCCCCHHHHHHHEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
FSLGVALIAFIYAEKNAIATKTFGYKRFEVLAALFNGVTLFVISILIVFEAIKRFFVPSE
HHHHHHHHHHHHHCCCCCEEHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
VQSKEMLIISIIGLIVNIVVAFFMFKGGDTSHNLNMRGAFLHVIGDLLGSVGAITAAILI
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
WAFGWTIADPIASILVSVIILKSAWGITKSSINILMEGTPSDVDIDEVITTIKKDSRIQS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHH
VHDCHVWTISNDMNALSCHVVVDHTLTMKECELLLENIEHDLLHLNIHHMTIQLETPNHK
HHCEEEEEEECCCCEEEEEEEEECCCCHHHHHHHHHHCCHHHEEEEEEEEEEEEECCCCC
HDESMICSGTHSHSHNHHAHHHAHVH
CCCCEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]