Click here to switch to the map view.

The map label for this gene is kdpD

Identifier: 82751681

GI number: 82751681

Start: 2096397

End: 2099054

Strand: Direct

Name: kdpD

Synonym: SAB1963

Alternate gene names: 82751681

Gene position: 2096397-2099054 (Clockwise)

Preceding gene: 82751664

Following gene: 82751682

Centisome position: 76.44

GC content: 31.64

Gene sequence:

>2658_bases
ATGTCAAACACTGAATCGCTAAACATAGGAAAAAAGCGTGGATCTTTAACAATTTACATCGGTTACAGTCCAGGTGTTGG
TAAAACATTTGAGATGCTTTCAAATGCCATTGAACTATTTCAAAGTAACGTTGATATTAAAATAGGATATATTGAACCCC
ATCAACGTGATGAAACAAATGCATTAGCTGAACAATTACCTAAAATCGCAACCAATTTTACTAAACATGGTAGTCATCAT
TTTCAATATTTAGATGTCGACCGCATAATCGAAGAATCGCCGACAATAGTACTTATCGATGAGTTAGCACATACGAATAT
TTCTAGAGATCGTCATGAAAAACGCTATATGGATATTGAAGAAATTTTAAATCATGGTATCGATGTTCATACTACTTTGA
ACATTCAACATATTGAAAGTTTAAGTAGTCAAATTGAACTGATGACCGGTGTACATGTTAAAGAACGTGTACCCGACTAT
TTCATAATGAGCGCCGATGTATTAGAAGTCGTAGATATCTCACCTGAACAATTAATTAAACGCTTAAAAGCTGGCAAGGT
ATATAAAAGGGATAGGCTAGATGTAGCATTTAATAATTTCTTTACGTATGCCCACCTAAGCGAACTGCGTACATTGACGT
TAAGAACAGTTGCCGACTTGATGAGTGATAAAGAAAAAGTCCGACACAACAATAAAACGTCACTCAAACCTCATATTGCT
GTGGCAATTAGTGGGAGTATTTATAATGAAGCAGTAATTAAAGAGGCATTCCACATTGCTCAAAAAGAACATGCAAAATT
CACTGCTATTTATATAGATGTATTCGAAAAAAACAGGCAATATAAAGATAGTCAAAAGCAAGTGCATCAACATCTCATGC
TTGCAAAATCATTAGGAGCAAAAGTAAAAGTAGTTTATAGCCAAACCGTTGCATTAGGATTAGACGAATGGTGTAAAAAT
CAAGATGTAACCAAATTAATTATCGGACAACATATTAGAAATAAGTGGCGAGACTTTTTCAATAAACCTTTAATTGACCA
TTTAATGTCCTTTGAACATAGCTATAAAATCGAAATCGTTCCAATCAAACAAATACCTGTTGAATTGAAAATGAACAAGT
CACCCTATCGTCCTAAAGGCAAACGTTTCGCCATAGATATGTTAAAAATGATTTTGATTCAAATAATTTGTGTAATGATG
GGACTATGGATTTATCAACTTGATAAGCATGAGTCTAGTACGATTATTTTAATGATTTTTCTCATCGGCATCATTTTATT
ATCCATTTGGACGCGGTCCTACATCATCGGCTTTTTAGCAGCAATTATTAACGTATTTGTTTTTAATTATTTTTTTACGG
AACCTAGATATACATTTGAAGTATACCGCTTTGACTATCCTATTACATTTATCGTTAGCATTTTAACAAGTATTTTAACG
AGTGCTTTATTAAAACAAATTAAATTCCAATACTCCATTACTAAAAAGCAACTTTATCGTACAGATTTATTATTTCAATT
TAATGATTCGATTAAACAAACTTATACAGTTGAAAACTTACTAATAAATGCTGGATACCAAATTAATCAATTATTGCAAC
AATCAATTACTATATACGTTATCAATCAATCCAAAGTAATTAAAACAATACCATTGCAAAACCATATCGATAATACGACT
CAACAGCATGAACAAGCATTAAGCTGGGTAATTAAAAATGAAAGACAAGCTGGTGCAACAACAGATACATTTCCAGGCAT
TAATAAATGGTTGATACCAATTGGCACATCTCCGATTAAAGGCATTCTAGCCATTGATTACCAAAGTTCTCAAGTGATTA
ATCCATATGATGCATCAATATTAGAATCAATGTTAAATGAACTTTCTCTCGCCGTTGAAAATGTGACGTTACTTAAACAA
ACGAGAGAATCCATGTTACAGGCTGAACGTCAACTGACACATTCAAATTTTTTAAGATCAATTTCGCATGACATACGTAC
ACCGTTAACAACAATTATGGGAAATTTAGATATTTTAGTATCACATAGTAAAGATATGTCTATCATAGAAAAGGAACAAT
TACTTGTGCATAGTTTTCAAGAAAGTCAGTATTTATATCTTTTAGTGACAAATATTTTATCATTAACAAAATTACAATCA
TCAAATGTTCAGATAAAATTGCAACCTTATCTCGTTAGTGAATTAGTAGAAGAAATCGATATGATTTTAGAACGTCGCCA
TTTAAAAAAGCGTATAACTATATCATCCTCAGTAGATTTACAGTTTATACACATTGACAGTAAGTTGATTTTACAAGCTT
TATTCAATTTGATTGAAAATGCAGTTAAACACACTTCTACTGACACCAAAATCAATTTATCTATTCGTTATGCTAGCGAT
GAACAAATCGAATTTGCCGTTATAGACGAAGGACCTGGAATTAGTTTAGAAGAACAACAAAAGATATTCGAGCCTTTTTA
CACAAGATCAAATAAATATTTTAAAGATAACCAAAAAGAAAGCATGGGACTAGGCTTATATTTAGTACAGACTATCCTAC
ACAAACATCAATCAAATTTACAATATAAACCAAACCAACCACACGGCAGTATATTCTATTTCAATATAGATACAGACTTT
AATGAAGGAGACATATAA

Upstream 100 bases:

>100_bases
AACTTAGTTATTAAGAAATCATTAAGATGTGTATGCAGAAATAAATTTTATAGCATTTAATTGTGAAGAATATTATGATA
TTGCTATCGAGGTGAAGGTT

Downstream 100 bases:

>100_bases
TGCAATCTAAAATATTGATAATTGAAGATGATCACGCAATCACACATTTACTTGATGTTGCATTAACTTTAGATTATTAC
AATGTAACTACAGCCGAAAA

Product: two component sensor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 885; Mature: 884

Protein sequence:

>885_residues
MSNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETNALAEQLPKIATNFTKHGSHH
FQYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIEEILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDY
FIMSADVLEVVDISPEQLIKRLKAGKVYKRDRLDVAFNNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNNKTSLKPHIA
VAISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGAKVKVVYSQTVALGLDEWCKN
QDVTKLIIGQHIRNKWRDFFNKPLIDHLMSFEHSYKIEIVPIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMM
GLWIYQLDKHESSTIILMIFLIGIILLSIWTRSYIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILT
SALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYVINQSKVIKTIPLQNHIDNTT
QQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIKGILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQ
TRESMLQAERQLTHSNFLRSISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQS
SNVQIKLQPYLVSELVEEIDMILERRHLKKRITISSSVDLQFIHIDSKLILQALFNLIENAVKHTSTDTKINLSIRYASD
EQIEFAVIDEGPGISLEEQQKIFEPFYTRSNKYFKDNQKESMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDF
NEGDI

Sequences:

>Translated_885_residues
MSNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETNALAEQLPKIATNFTKHGSHH
FQYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIEEILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDY
FIMSADVLEVVDISPEQLIKRLKAGKVYKRDRLDVAFNNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNNKTSLKPHIA
VAISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGAKVKVVYSQTVALGLDEWCKN
QDVTKLIIGQHIRNKWRDFFNKPLIDHLMSFEHSYKIEIVPIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMM
GLWIYQLDKHESSTIILMIFLIGIILLSIWTRSYIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILT
SALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYVINQSKVIKTIPLQNHIDNTT
QQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIKGILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQ
TRESMLQAERQLTHSNFLRSISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQS
SNVQIKLQPYLVSELVEEIDMILERRHLKKRITISSSVDLQFIHIDSKLILQALFNLIENAVKHTSTDTKINLSIRYASD
EQIEFAVIDEGPGISLEEQQKIFEPFYTRSNKYFKDNQKESMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDF
NEGDI
>Mature_884_residues
SNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETNALAEQLPKIATNFTKHGSHHF
QYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIEEILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDYF
IMSADVLEVVDISPEQLIKRLKAGKVYKRDRLDVAFNNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNNKTSLKPHIAV
AISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGAKVKVVYSQTVALGLDEWCKNQ
DVTKLIIGQHIRNKWRDFFNKPLIDHLMSFEHSYKIEIVPIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMMG
LWIYQLDKHESSTIILMIFLIGIILLSIWTRSYIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILTS
ALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYVINQSKVIKTIPLQNHIDNTTQ
QHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIKGILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQT
RESMLQAERQLTHSNFLRSISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQSS
NVQIKLQPYLVSELVEEIDMILERRHLKKRITISSSVDLQFIHIDSKLILQALFNLIENAVKHTSTDTKINLSIRYASDE
QIEFAVIDEGPGISLEEQQKIFEPFYTRSNKYFKDNQKESMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDFN
EGDI

Specific function: Member of the two-component regulatory system kdpD/kdpE involved in the regulation of the kdp operon. KdpD may function as a membrane-associated protein kinase that phosphorylates kdpE in response to environmental signals [H]

COG id: COG2205

COG function: function code T; Osmosensitive K+ channel histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=885, Percent_Identity=26.2146892655367, Blast_Score=354, Evalue=1e-98,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=30.2904564315353, Blast_Score=101, Evalue=2e-22,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=28.2051282051282, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1786600, Length=232, Percent_Identity=29.3103448275862, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=24.7787610619469, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=26.1224489795918, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1788279, Length=261, Percent_Identity=25.6704980842912, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789149, Length=240, Percent_Identity=24.1666666666667, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1790436, Length=243, Percent_Identity=23.0452674897119, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI1788393, Length=279, Percent_Identity=22.2222222222222, Blast_Score=65, Evalue=3e-11,
Organism=Escherichia coli, GI1786783, Length=212, Percent_Identity=25, Blast_Score=63, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR014729
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR003852
- InterPro:   IPR006016 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF02702 KdpD; PF00582 Usp [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 102298; Mature: 102166

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETN
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
ALAEQLPKIATNFTKHGSHHFQYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIE
HHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCCEEEEECHHCCCCCHHHHHHHCCCHH
EILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDYFIMSADVLEVVDISPEQLIK
HHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHHCCCHHHHHH
RLKAGKVYKRDRLDVAFNNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNNKTSLKPHIA
HHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VAISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGA
EEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCC
KVKVVYSQTVALGLDEWCKNQDVTKLIIGQHIRNKWRDFFNKPLIDHLMSFEHSYKIEIV
EEEEEEHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEE
PIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMMGLWIYQLDKHESSTIILMIF
EECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LIGIILLSIWTRSYIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHH
SALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYV
HHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHEECCHHHHHHHHCCCEEEE
INQSKVIKTIPLQNHIDNTTQQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIK
EECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
GILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQTRESMLQAERQLTHSNFLRS
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQS
HHHHHHCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SNVQIKLQPYLVSELVEEIDMILERRHLKKRITISSSVDLQFIHIDSKLILQALFNLIEN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECHHHHHHHHHHHHHH
AVKHTSTDTKINLSIRYASDEQIEFAVIDEGPGISLEEQQKIFEPFYTRSNKYFKDNQKE
HHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCH
SMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDFNEGDI
HCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCC
>Mature Secondary Structure 
SNTESLNIGKKRGSLTIYIGYSPGVGKTFEMLSNAIELFQSNVDIKIGYIEPHQRDETN
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
ALAEQLPKIATNFTKHGSHHFQYLDVDRIIEESPTIVLIDELAHTNISRDRHEKRYMDIE
HHHHHHHHHHHHHHHCCCCCEEEECHHHHHCCCCCEEEEECHHCCCCCHHHHHHHCCCHH
EILNHGIDVHTTLNIQHIESLSSQIELMTGVHVKERVPDYFIMSADVLEVVDISPEQLIK
HHHHCCCCEEEEECHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHHCCCHHHHHH
RLKAGKVYKRDRLDVAFNNFFTYAHLSELRTLTLRTVADLMSDKEKVRHNNKTSLKPHIA
HHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEE
VAISGSIYNEAVIKEAFHIAQKEHAKFTAIYIDVFEKNRQYKDSQKQVHQHLMLAKSLGA
EEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEEEHHCCCCCCHHHHHHHHHHHHHHHCCC
KVKVVYSQTVALGLDEWCKNQDVTKLIIGQHIRNKWRDFFNKPLIDHLMSFEHSYKIEIV
EEEEEEHHHHHHCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEEEEE
PIKQIPVELKMNKSPYRPKGKRFAIDMLKMILIQIICVMMGLWIYQLDKHESSTIILMIF
EECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
LIGIILLSIWTRSYIIGFLAAIINVFVFNYFFTEPRYTFEVYRFDYPITFIVSILTSILT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHH
SALLKQIKFQYSITKKQLYRTDLLFQFNDSIKQTYTVENLLINAGYQINQLLQQSITIYV
HHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHHEECCHHHHHHHHCCCEEEE
INQSKVIKTIPLQNHIDNTTQQHEQALSWVIKNERQAGATTDTFPGINKWLIPIGTSPIK
EECCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCCCC
GILAIDYQSSQVINPYDASILESMLNELSLAVENVTLLKQTRESMLQAERQLTHSNFLRS
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ISHDIRTPLTTIMGNLDILVSHSKDMSIIEKEQLLVHSFQESQYLYLLVTNILSLTKLQS
HHHHHHCHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SNVQIKLQPYLVSELVEEIDMILERRHLKKRITISSSVDLQFIHIDSKLILQALFNLIEN
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECHHHHHHHHHHHHHH
AVKHTSTDTKINLSIRYASDEQIEFAVIDEGPGISLEEQQKIFEPFYTRSNKYFKDNQKE
HHHCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCH
SMGLGLYLVQTILHKHQSNLQYKPNQPHGSIFYFNIDTDFNEGDI
HCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9226259; 11466286 [H]