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The map label for this gene is mutS [H]

Identifier: 82751650

GI number: 82751650

Start: 2058748

End: 2060358

Strand: Direct

Name: mutS [H]

Synonym: SAB1932

Alternate gene names: 82751650

Gene position: 2058748-2060358 (Clockwise)

Preceding gene: 82751649

Following gene: 82751651

Centisome position: 75.07

GC content: 30.23

Gene sequence:

>1611_bases
ATGAGCACAAATCAAACATTTTTAATATTTGTTATAGCAATTATTATACTTACATCGGTAATAGGAATTGTTGGACGATA
CATGAGTCGTCAACGTCTTTTAAAATCTATGGAAATATTATGGCAAACACTTTCTCCATTAGAGGCTTTTATCAGACCGA
ACTCACATTTCGACTATGAGTATAAGCTCTACAAGGATAAATTTGAATCACATTCATTAGTTGATGATAAAACTTGGTCC
GATTTAAATATGAATGCAATCTTTCATAAGATGAATTATAATTTAACATCTATTGGCGAAATGAAACTATATGCCTGTTT
ACGTGGAATGCTTTCAATTACGAACAAATCATTACTTAGTTTATTTAATGATAATGCTGAATTTAGAAAAAACGTAACAT
ATCATTTAGCTTTGATTGGTAAAACTGTTTATCCAACATTTCCAGACCAAATCACACCGGTAAAACGTCAAAATATATTG
TTTCTATGCCCGTTTTTACCAGTTATCTCATTTGCAGTTATATTTATTAATTCACAAGTTGGTATTTTATTATTTCTTAT
GAGTTGCCTATTTAATATCATTTTATCTGCAACTTTAAAGCGTACATATGAGGATGACTTAAAGTCTATCTTTTATGCAT
CCAATGTTTTAAAACAAGGCTATACTATCTCAAAAATTAAACATGCTCCACAACCTGAAGTCAATTTTAAGCAATTTAGA
ACAGCACGTCATTTAACAAGTGTTTTAGCTGAAGTTAATGATGAAGATATCGGAGCTATGGTAATTAAACTAGTTAAACT
TATTTTCATGCTTGATTATGTTTTATTCCATTCAATTCAAAAAAGCTATACAACACATATGAATGAGCTAAAAAATTGTT
TCGATTACATAGCTGAATTAGATAATCATTATGCATTAGCAATGTATCGTAGAACGCTAGAATGCTATACTGAACCACAA
ATTGATGATTCAAATGATGGCATAGTATTCTCTGAGTTAACACATCCACTCATAACAGATGCAGTAGCCAATGATTTCTC
ACTATCACAAAATATACTGTTAACTGGATCTAATGCTTCAGGTAAATCAACATTTATGAAATCCATAGCAATAAACATTA
TTCTTGCATCGGCTATACAAACAGTTACCGCAAACAAATTTGTATATCAACCTGGAATTGTGTTCACGTCAATGGCAAAT
GCCGATGATGTGTTATCAGGCGATAGTTATTTTATGGCTGAATTAAAATCTATTAAGCGTATTGTTGAAATTCCTGATAA
TCAAAAAATATACTGCTTTATCGATGAAATTTTTAAAGGTACCAACACAACTGAACGAATTGCCGCTTCAGAATCAGTAC
TATCATTTTTACATGAAAAATCTAACTTTAGAGTTATTGCAGCAACACATGATATTGAGTTAGCTGAACTCTTAAAACAA
CGTTATGAAAATTATCATTTCAATGAGGTAATAGAAAATAATAACATACATTTTGATTACAAAATTAAGCCTGGCAAAGC
AAATACACGTAATGCCATCGAATTATTAAAAATCACTTCATTTCCAGCAAAAATATATGAACGAGCAAAAGATAATGTTT
CCAATGGTTAG

Upstream 100 bases:

>100_bases
TATCAAAATCCATTGTTAATACATTTTCTTTATGAAATAATAATCACAATAATATCGAAGTATATTTTTATTATTATTAA
AAATAAATAAGGAGATAGTT

Downstream 100 bases:

>100_bases
AATGAATCTTGAACATCAATCAATGTTCTATGCTCTACGAAGTTATATTGGCAGTCTTTGACTAAATGAAAATGCGCTTG
TAATAAGTTTTTTCAATACT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSTNQTFLIFVIAIIILTSVIGIVGRYMSRQRLLKSMEILWQTLSPLEAFIRPNSHFDYEYKLYKDKFESHSLVDDKTWS
DLNMNAIFHKMNYNLTSIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNIL
FLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQ
IDDSNDGIVFSELTHPLITDAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTANKFVYQPGIVFTSMAN
ADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG

Sequences:

>Translated_536_residues
MSTNQTFLIFVIAIIILTSVIGIVGRYMSRQRLLKSMEILWQTLSPLEAFIRPNSHFDYEYKLYKDKFESHSLVDDKTWS
DLNMNAIFHKMNYNLTSIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNIL
FLCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQ
IDDSNDGIVFSELTHPLITDAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTANKFVYQPGIVFTSMAN
ADDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
>Mature_535_residues
STNQTFLIFVIAIIILTSVIGIVGRYMSRQRLLKSMEILWQTLSPLEAFIRPNSHFDYEYKLYKDKFESHSLVDDKTWSD
LNMNAIFHKMNYNLTSIGEMKLYACLRGMLSITNKSLLSLFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILF
LCPFLPVISFAVIFINSQVGILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFRT
ARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAELDNHYALAMYRRTLECYTEPQI
DDSNDGIVFSELTHPLITDAVANDFSLSQNILLTGSNASGKSTFMKSIAINIILASAIQTVTANKFVYQPGIVFTSMANA
DDVLSGDSYFMAELKSIKRIVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQR
YENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG

Specific function: This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity [H]

COG id: COG0249

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutS family [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=285, Percent_Identity=27.3684210526316, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI284813531, Length=280, Percent_Identity=25, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789089, Length=261, Percent_Identity=28.3524904214559, Blast_Score=89, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=246, Percent_Identity=27.2357723577236, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321912, Length=277, Percent_Identity=26.7148014440433, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=232, Percent_Identity=26.2931034482759, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320302, Length=142, Percent_Identity=30.2816901408451, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24664545, Length=296, Percent_Identity=26.0135135135135, Blast_Score=72, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24584320, Length=249, Percent_Identity=20.8835341365462, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005748
- InterPro:   IPR007695
- InterPro:   IPR000432
- InterPro:   IPR007861
- InterPro:   IPR007860
- InterPro:   IPR007696
- InterPro:   IPR016151 [H]

Pfam domain/function: PF01624 MutS_I; PF05188 MutS_II; PF05192 MutS_III; PF05190 MutS_IV; PF00488 MutS_V [H]

EC number: NA

Molecular weight: Translated: 61314; Mature: 61182

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNQTFLIFVIAIIILTSVIGIVGRYMSRQRLLKSMEILWQTLSPLEAFIRPNSHFDYE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YKLYKDKFESHSLVDDKTWSDLNMNAIFHKMNYNLTSIGEMKLYACLRGMLSITNKSLLS
EHHHHHHHCCCCCCCCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQV
HHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCH
GILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHH
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNHYALAMYRRTLECYTEPQIDDSNDGIVFSELTHPLITDAVANDFSLSQNILLTGSNAS
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKSTFMKSIAINIILASAIQTVTANKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKR
CHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
IVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
HHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
HHHCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
STNQTFLIFVIAIIILTSVIGIVGRYMSRQRLLKSMEILWQTLSPLEAFIRPNSHFDYE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
YKLYKDKFESHSLVDDKTWSDLNMNAIFHKMNYNLTSIGEMKLYACLRGMLSITNKSLLS
EHHHHHHHCCCCCCCCCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LFNDNAEFRKNVTYHLALIGKTVYPTFPDQITPVKRQNILFLCPFLPVISFAVIFINSQV
HHCCCHHHHHCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCH
GILLFLMSCLFNIILSATLKRTYEDDLKSIFYASNVLKQGYTISKIKHAPQPEVNFKQFR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCHHHHH
TARHLTSVLAEVNDEDIGAMVIKLVKLIFMLDYVLFHSIQKSYTTHMNELKNCFDYIAEL
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DNHYALAMYRRTLECYTEPQIDDSNDGIVFSELTHPLITDAVANDFSLSQNILLTGSNAS
CCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
GKSTFMKSIAINIILASAIQTVTANKFVYQPGIVFTSMANADDVLSGDSYFMAELKSIKR
CHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCCCCCHHHHHHHHHHHH
IVEIPDNQKIYCFIDEIFKGTNTTERIAASESVLSFLHEKSNFRVIAATHDIELAELLKQ
HHCCCCCCEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
RYENYHFNEVIENNNIHFDYKIKPGKANTRNAIELLKITSFPAKIYERAKDNVSNG
HHHCCCHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]