Click here to switch to the map view.

The map label for this gene is hemA [H]

Identifier: 82751601

GI number: 82751601

Start: 2016985

End: 2018055

Strand: Reverse

Name: hemA [H]

Synonym: SAB1880c

Alternate gene names: 82751601

Gene position: 2018055-2016985 (Counterclockwise)

Preceding gene: 82751602

Following gene: 82751600

Centisome position: 73.58

GC content: 29.88

Gene sequence:

>1071_bases
GTGTTTTGTAGTAACGATTATTTAGGTATGTCTCAAAATCAAGAAGTAATAAATGTAATGGGTGATGCTTTAAAAGAATA
TGGTGCAGGGGCAGGTGGTTCAAGGAATATTGGTGGAAGCCATAAATATTTTAAACTATTAGAAAATGAGATAGCAAAAT
GGCATAAAAAGGACTCAGCTTTAGTTTTTCCAACAGGATACTCTTCAAATGATGCGTCTTTGCAAGGTTTATTAAGAATA
TTCCCAGAAATGATTGTATTTTCTGATTCTAAAAATCATGCGTCTATAATAAATGCTTTGCGAAGTGTTAAAAATAAGAT
TGAAATTTTTGAACATAATAATGTTAAACATTTAAATGAATTACTGAATCAATATGATATTAATACACCAAAGTTAATAG
TATTTGAGTCTGTATATTCAATGGATGGAGACATTGCACCAATAGTAGAGATAGTCGAATTAGCAAAAGAATATAATTCT
TTAACTTTTTTAGATGAAGTACATGCAATTGGCATGTATGGTGAAGAAGGAAGAGGATACTCTGATGTTGTTGGTGTTCA
GGAAGATATAGACATCATACAATCTACAATGGCAAAAGGAATCGGAATAATAGGAGGATATATAACCGGAGATCAATTAC
TCATAGATGTAATCAGATCATATTCTTCAGGTTTTATATTTACTACTGCATTACCTCCGGTTATTGCTGCGGGTTGTTTA
ACTAGTATAAAAATAGTCAGAAGTAATGATAAATTAAGAGAAGAATTGCAAGATAAAACGAAATACTTAAAAGAAAAATT
CAAAGAAAATGGTATTGAAGTTTTGAAACAAAGTAAGACACATATACTCCCAGTTATAATTGGAGATTCAAAAAAATGTG
AGGAAGCAGCAAAGTTACTTCTAGGTAAATTTAATATTTATGATCAAGCAATTAATTCACCTACTGTAGAAATTGGTACT
GAAAGATTTAGAATTAATGTAACGCCAAATCACACAAAAGAACAAATGGATTTATTGGTTTCTTCAATTGTTTATGTTTT
TGATTTTTTGAACATTAGGAGAAGTGTGTAA

Upstream 100 bases:

>100_bases
TGAATTAAAAGAAAAAGGAAGCTATAGAATATTTACTGAGATTAACAGGATTGCAAACAAATATCCATTAGCCAAAGGGG
AAGATGGTAAAGAGGTTGTT

Downstream 100 bases:

>100_bases
TTATGAATTATTTAATGTACATGTTTTGCATGTTTATATGGGGATTAAACTTTATAGCGGTAAAGATACAAGGAGATAGT
TTGCCTTTAGAAGTTGCTTT

Product: 5-aminolevulinate synthase

Products: NA

Alternate protein names: 5-aminolevulinic acid synthase; Delta-ALA synthase; Delta-aminolevulinate synthase [H]

Number of amino acids: Translated: 356; Mature: 356

Protein sequence:

>356_residues
MFCSNDYLGMSQNQEVINVMGDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDASLQGLLRI
FPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINTPKLIVFESVYSMDGDIAPIVEIVELAKEYNS
LTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCL
TSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLGKFNIYDQAINSPTVEIGT
ERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV

Sequences:

>Translated_356_residues
MFCSNDYLGMSQNQEVINVMGDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDASLQGLLRI
FPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINTPKLIVFESVYSMDGDIAPIVEIVELAKEYNS
LTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCL
TSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLGKFNIYDQAINSPTVEIGT
ERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
>Mature_356_residues
MFCSNDYLGMSQNQEVINVMGDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSALVFPTGYSSNDASLQGLLRI
FPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNELLNQYDINTPKLIVFESVYSMDGDIAPIVEIVELAKEYNS
LTFLDEVHAIGMYGEEGRGYSDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCL
TSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLLLGKFNIYDQAINSPTVEIGT
ERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV

Specific function: Unknown

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502025, Length=349, Percent_Identity=43.2664756446991, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI40316939, Length=349, Percent_Identity=43.2664756446991, Blast_Score=312, Evalue=4e-85,
Organism=Homo sapiens, GI83977442, Length=349, Percent_Identity=39.8280802292264, Blast_Score=304, Evalue=9e-83,
Organism=Homo sapiens, GI83977440, Length=349, Percent_Identity=39.8280802292264, Blast_Score=303, Evalue=1e-82,
Organism=Homo sapiens, GI83977444, Length=349, Percent_Identity=39.8280802292264, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=33.5260115606936, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI7657118, Length=346, Percent_Identity=33.5260115606936, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI4758668, Length=369, Percent_Identity=29.810298102981, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI119220554, Length=369, Percent_Identity=28.1842818428184, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI5454084, Length=367, Percent_Identity=26.9754768392371, Blast_Score=132, Evalue=5e-31,
Organism=Escherichia coli, GI1790046, Length=354, Percent_Identity=28.8135593220339, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1786993, Length=345, Percent_Identity=30.4347826086957, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71994529, Length=358, Percent_Identity=34.0782122905028, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI32566772, Length=357, Percent_Identity=29.1316526610644, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17560914, Length=313, Percent_Identity=28.7539936102236, Blast_Score=146, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17560912, Length=313, Percent_Identity=28.7539936102236, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71982617, Length=232, Percent_Identity=26.2931034482759, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982625, Length=232, Percent_Identity=26.2931034482759, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320438, Length=376, Percent_Identity=42.0212765957447, Blast_Score=304, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6320267, Length=368, Percent_Identity=27.9891304347826, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323954, Length=278, Percent_Identity=25.8992805755396, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17137420, Length=358, Percent_Identity=42.1787709497207, Blast_Score=311, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24662918, Length=352, Percent_Identity=33.8068181818182, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI17136286, Length=370, Percent_Identity=28.9189189189189, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24653280, Length=275, Percent_Identity=27.6363636363636, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653276, Length=275, Percent_Identity=27.6363636363636, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24653278, Length=275, Percent_Identity=27.6363636363636, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010961
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.37 [H]

Molecular weight: Translated: 39744; Mature: 39744

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCSNDYLGMSQNQEVINVMGDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LVFPTGYSSNDASLQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNE
EEEECCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLNQYDINTPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGY
HHHHHCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCH
SDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCL
HHHCCCHHHHHHHHHHHHCCCHHHCCEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH
TSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLL
HHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
LGKFNIYDQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
HHHHHHHHHHCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFCSNDYLGMSQNQEVINVMGDALKEYGAGAGGSRNIGGSHKYFKLLENEIAKWHKKDSA
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCE
LVFPTGYSSNDASLQGLLRIFPEMIVFSDSKNHASIINALRSVKNKIEIFEHNNVKHLNE
EEEECCCCCCHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHH
LLNQYDINTPKLIVFESVYSMDGDIAPIVEIVELAKEYNSLTFLDEVHAIGMYGEEGRGY
HHHHHCCCCCCEEEEEHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCH
SDVVGVQEDIDIIQSTMAKGIGIIGGYITGDQLLIDVIRSYSSGFIFTTALPPVIAAGCL
HHHCCCHHHHHHHHHHHHCCCHHHCCEECHHHHHHHHHHHHCCCEEEECHHHHHHHHHHH
TSIKIVRSNDKLREELQDKTKYLKEKFKENGIEVLKQSKTHILPVIIGDSKKCEEAAKLL
HHHHEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHH
LGKFNIYDQAINSPTVEIGTERFRINVTPNHTKEQMDLLVSSIVYVFDFLNIRRSV
HHHHHHHHHHCCCCCEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA