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The map label for this gene is yfhQ [H]

Identifier: 82751522

GI number: 82751522

Start: 1936518

End: 1937555

Strand: Reverse

Name: yfhQ [H]

Synonym: SAB1801c

Alternate gene names: 82751522

Gene position: 1937555-1936518 (Counterclockwise)

Preceding gene: 82751524

Following gene: 82751521

Centisome position: 70.65

GC content: 34.01

Gene sequence:

>1038_bases
ATGTATCAGCAGTCTAGTTTTAAAGAAAATTTGATACACTGGTTTGATGAAAATCAAAGAGAAATGCCATGGCGACAAAC
GACCAATCCGTACTATATTTGGTTAAGTGAAGTCATGTTACAACAGACACAAGTTAAAACAGTTATTGACTATTATCATC
GTTTTGTTGAACGATTTCCAACTGTGGAAGTTTTGAGTCAAGCTTCGGAAGATGAAGTGTTAAAGTACTGGGAAGGCTTA
GGATATTATAGTAGAGCTCGAAATTTTCATACGGCTATTAAAGAAGTTCGTGATAAATATGAAGGCTTAGTTCCCAAAGA
TCCTGATCAATTTATAGCGTTAAAAGGTGTTGGCCCATACACACAAGCTGCAGTAATGAGCATTGCATATAATGTACCAC
TAGCAACTGTAGACGGAAATGTTTTTCGAGTATGGTCTAGATTGAATGATGACTATCGAGATATTAAATTACAATCGACG
AGGAAATCGTACGAACAAGAATTATTACCGTATGTTACTACAGAATCTGGAACGTTTAATCAAGCTATGATGGAATTAGG
GGCATTAATTTGTACACCGAAAAATCCATTATGCTTATTTTGTCCAGTTCAAGAAAACTGTGTGGCATTTGATAAAGGTA
CATTTGAAAAGTTACCTGTTAAATCTAAAAATGTAAGTAAAAAAGTAATTGAGCAATCCGTCTTTTTAATTAGAAATAAT
CAAGGTCAATATCTGTTGCAAAAGCGTAGCGAAAAATTATTGCATGGTATGTGGCAATTTCCTATGTTTGAAAGTGAGCA
TGCTAGACGTGAAATGACTGAAAAAATCGGTCATGACATTCAACCAGTAGAAACACCTATTTTTGAGTTGAAGCATCAAT
TTACTCATTTAACATGGAAGATAAAGGTATACGCCGTTTCAGGAACAATTAACATTGAAACATTACCAGATGACATGATT
TGGTTTGATTTAAGTGATCGAGATCAATATACATTCCCTGTACCTATGTCAAAGATTTATCAATTTATAAATGGGTAA

Upstream 100 bases:

>100_bases
CAAATAACTAAATTAACTTACATACTAACCATGATTTTAATGTACAATAAAAACATTATGAGTAAAGACAATTAATTTTG
GTGAGGAAAGGGTTTTATAA

Downstream 100 bases:

>100_bases
CATTCGATGATTGATAAGATTATCGAAAAATATAGTGACATTAATTTTAAAAATGTATAAATGATATCTTTAAATCTCAT
AGAATAACAATGTCAAAAAG

Product: A/G-specific adenine glycosylase DNA repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGL
GYYSRARNFHTAIKEVRDKYEGLVPKDPDQFIALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQST
RKSYEQELLPYVTTESGTFNQAMMELGALICTPKNPLCLFCPVQENCVAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNN
QGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAVSGTINIETLPDDMI
WFDLSDRDQYTFPVPMSKIYQFING

Sequences:

>Translated_345_residues
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGL
GYYSRARNFHTAIKEVRDKYEGLVPKDPDQFIALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQST
RKSYEQELLPYVTTESGTFNQAMMELGALICTPKNPLCLFCPVQENCVAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNN
QGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAVSGTINIETLPDDMI
WFDLSDRDQYTFPVPMSKIYQFING
>Mature_345_residues
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFPTVEVLSQASEDEVLKYWEGL
GYYSRARNFHTAIKEVRDKYEGLVPKDPDQFIALKGVGPYTQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQST
RKSYEQELLPYVTTESGTFNQAMMELGALICTPKNPLCLFCPVQENCVAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNN
QGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWKIKVYAVSGTINIETLPDDMI
WFDLSDRDQYTFPVPMSKIYQFING

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine, 8- oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal effici

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HhH domain [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI190358497, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI6912520, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI115298654, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI115298652, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=8e-46,
Organism=Homo sapiens, GI115298650, Length=413, Percent_Identity=28.8135593220339, Blast_Score=181, Evalue=8e-46,
Organism=Escherichia coli, GI1789331, Length=352, Percent_Identity=34.0909090909091, Blast_Score=197, Evalue=9e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 40645; Mature: 40645

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00764 ENDONUCLEASE_III_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFP
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEVLSQASEDEVLKYWEGLGYYSRARNFHTAIKEVRDKYEGLVPKDPDQFIALKGVGPY
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCH
TQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQSTRKSYEQELLPYVTTESGTFN
HHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHEEEHHHHHHHHHHHCCEEECCCCCHH
QAMMELGALICTPKNPLCLFCPVQENCVAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNN
HHHHHHHHEEECCCCCEEEEECCCCCEEEECCCCCHHCCCCCCCHHHHHHHHHEEEEECC
QGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWK
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEE
IKVYAVSGTINIETLPDDMIWFDLSDRDQYTFPVPMSKIYQFING
EEEEEEEEEEEEEECCCCEEEEEECCCCCEECCCCHHHHHHHHCC
>Mature Secondary Structure
MYQQSSFKENLIHWFDENQREMPWRQTTNPYYIWLSEVMLQQTQVKTVIDYYHRFVERFP
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCC
TVEVLSQASEDEVLKYWEGLGYYSRARNFHTAIKEVRDKYEGLVPKDPDQFIALKGVGPY
HHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCH
TQAAVMSIAYNVPLATVDGNVFRVWSRLNDDYRDIKLQSTRKSYEQELLPYVTTESGTFN
HHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHEEEHHHHHHHHHHHCCEEECCCCCHH
QAMMELGALICTPKNPLCLFCPVQENCVAFDKGTFEKLPVKSKNVSKKVIEQSVFLIRNN
HHHHHHHHEEECCCCCEEEEECCCCCEEEECCCCCHHCCCCCCCHHHHHHHHHEEEEECC
QGQYLLQKRSEKLLHGMWQFPMFESEHARREMTEKIGHDIQPVETPIFELKHQFTHLTWK
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEEEEEE
IKVYAVSGTINIETLPDDMIWFDLSDRDQYTFPVPMSKIYQFING
EEEEEEEEEEEEEECCCCEEEEEECCCCCEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]