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The map label for this gene is hemE

Identifier: 82751486

GI number: 82751486

Start: 1891854

End: 1892891

Strand: Reverse

Name: hemE

Synonym: SAB1765c

Alternate gene names: 82751486

Gene position: 1892891-1891854 (Counterclockwise)

Preceding gene: 82751488

Following gene: 82751485

Centisome position: 69.02

GC content: 34.87

Gene sequence:

>1038_bases
ATGGTGCATAATAAAAACAATACAATTTTGAAAATGATTAAAGGTGAAGAAACGACACATACACCTGTTTGGTTTATGCG
ACAAGCTGGCCGTTCGCAACCAGAATATCGAAAATTGAAAGAAAAATATTCACTATTCGATATTACACATCAGCCGGAGT
TGTGCGCTTATGTTACACATTTACCAGTTGATAATTATCATACAGATGCAGCAATTTTATACAAAGATATTATGACACCA
TTAAAGCCAATTGGTGTCGATGTAGAAATTAAATCGGGTATTGGTCCAGTGATTCATAATCCTATCAAAACAATTCAAGA
TGTTGAGAAACTTTCTCAAATAGACCCCGAACGAGATGTACCATATGTATTAGATACAATTAAACTTTTAACAGAAGAAA
AGTTAAATGTACCGCTAATAGGATTTACTGGGGCACCATTTACATTAGCGTCATATATGATTGAAGGCGGACCATCGAAA
AATTACAATTTTACAAAAGCGATGATGTTTAGAGATGAAGCAACATGGTTTGCTTTAATGAATCATTTAGTTGATGTATC
TGTTAAATATGTAACAGCTCAAGTCGAAGCAGGTGCTGAACTGATTCAAATTTTCGATTCATGGGTAGGTGCATTAAATG
TCGAGGATTACAGACGTTACATTAAACCACATATGATTCGATTAATCAGTGAGGTTAAAGAAAAACATGATGTGCCGGTA
ATTTTATTCGGTGTAGGTGCCAGTCATTTAATCAATGAATGGAATGATTTGCCGATTGATGTATTAGGCCTAGATTGGAG
AACGTCTATTAATCAGGCTCAACAATTAGGCGTTACTAAAACATTACAAGGGAATTTAGATCCATCAATTTTATTAGCAC
CATGGAATGTCATTGAAGAGAGATTGAAACCAATATTAGATCAAGGCATGGAGAACGGTAAACACATCTTTAATTTAGGA
CATGGTGTTTTCCCAGAAGTGCACCCAGAGACGTTACGTAAAGTAAGCGAATTTGTACACACATATACACAAAGATAA

Upstream 100 bases:

>100_bases
GTAATTTAATGTCAGTTTTATGACATTTATTTATTGAAAATACGAACGAATGAGCGATATGATAATATAGATAAGAATGA
TTTTAATTTAGGAGGCCTTT

Downstream 100 bases:

>100_bases
TCATAGTATTACATTGAAGCACATGAAAGATAATTCATTTAAAGGAAGGTATTATCAATGACTAAAAAAATGGGATTATT
AGTTATGGCTTATGGCACAC

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMFRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVHPETLRKVSEFVHTYTQR

Sequences:

>Translated_345_residues
MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMFRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVHPETLRKVSEFVHTYTQR
>Mature_345_residues
MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTHLPVDNYHTDAAILYKDIMTP
LKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDVPYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSK
NYNFTKAMMFRDEATWFALMNHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEERLKPILDQGMENGKHIFNLG
HGVFPEVHPETLRKVSEFVHTYTQR

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=35.7954545454545, Blast_Score=217, Evalue=1e-56,
Organism=Escherichia coli, GI2367337, Length=351, Percent_Identity=37.8917378917379, Blast_Score=239, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=31.3390313390313, Blast_Score=192, Evalue=6e-50,
Organism=Drosophila melanogaster, GI221330099, Length=344, Percent_Identity=34.8837209302326, Blast_Score=211, Evalue=4e-55,
Organism=Drosophila melanogaster, GI19921920, Length=344, Percent_Identity=34.8837209302326, Blast_Score=211, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 39360; Mature: 39360

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMFRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVHPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVHNKNNTILKMIKGEETTHTPVWFMRQAGRSQPEYRKLKEKYSLFDITHQPELCAYVTH
CCCCCCCCEEEEECCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHH
LPVDNYHTDAAILYKDIMTPLKPIGVDVEIKSGIGPVIHNPIKTIQDVEKLSQIDPERDV
CCCCCCCCHHHHHHHHHHCCHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
PYVLDTIKLLTEEKLNVPLIGFTGAPFTLASYMIEGGPSKNYNFTKAMMFRDEATWFALM
CHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCHHHHHHH
NHLVDVSVKYVTAQVEAGAELIQIFDSWVGALNVEDYRRYIKPHMIRLISEVKEKHDVPV
HHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
ILFGVGASHLINEWNDLPIDVLGLDWRTSINQAQQLGVTKTLQGNLDPSILLAPWNVIEE
EEEECCHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCHHHHCCCCCCCEEECCHHHHHH
RLKPILDQGMENGKHIFNLGHGVFPEVHPETLRKVSEFVHTYTQR
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA