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The map label for this gene is lukE

Identifier: 82751409

GI number: 82751409

Start: 1831611

End: 1832546

Strand: Reverse

Name: lukE

Synonym: SAB1687c

Alternate gene names: 82751409

Gene position: 1832546-1831611 (Counterclockwise)

Preceding gene: 82751411

Following gene: 82751408

Centisome position: 66.82

GC content: 32.48

Gene sequence:

>936_bases
ATGTTTAAGAAAAAAATGTTAGCTGCAACTTTGTCAGTTGGATTGATAGCACCTTTAGCATCTCCGATTCAAGAATCTAG
AGCAAATACTAATATTGAAAATATTGGTGATGGTGCTGAAGTAATCAAACGAACGGAGGGTGTAAGTAGTAAGAAATGGG
GCGTTACTCAAAATGTTCAATTTGACTTTGTAAAAGATAAAAAATATAACAAAGACGCTTTAATTGTTAAAATGCAAGGT
TTTATCAATTCCAGAACTTCATTTTCAGATGTGAAGGGTAGTGGATATGAATTAACTAAACGAATGATTTGGCCATTTCA
ATATAATATAGGACTGACGACTAAAGATCCAAATGTTAGCTTAATCAATTACCTTCCTAAAAACAAAATAGAAACTACAG
ATGTTGGTCAAACATTAGGATATAACATTGGAGGTAATTTCCAGTCAGCACCATCTATAGGTGGCAATGGCTCATTTAAT
TATTCTAAAACAATTAGTTATACCCAAAAGAGTTATGTCAGTGAAGTAGACAAGCAAAACTCAAAATCTGTTAAATGGGG
TGTTAAAGCAAACGAATTTGTTACGCCTGATGGTAAAAAATCTGCGCATGATAGATATTTATTCGTACAAAGTCCAAATG
GTCCGTCAGGTTCAGCAAGAGAATATTTTGCTCCTGATAATCAATTGCCACCATTAGTTCAAAGTGGCTTTAATCCATCA
TTTATCACTACACTATCACATGAAAAAGGTTCAAGTGATACGAGTGAATTTGAAATTTCATATGGTAGAAACTTAGATAT
TACATATGCGACTTTATTCCCTAGAACTGGTATTTACGCAGAAAGAAAGCATAATGCATTTGTAAATAGAAACTTTGTAG
TTAGATATGAAGTTAACTGGAAAACACATGAAATTAAAGTGAAAGGACATAATTAA

Upstream 100 bases:

>100_bases
TAGCATTTTATTTTTTAATGAACAGTTAATTTTATAAATAATTGAAATAATCTATAATAAATTTGTATTAAAAATTTATT
ATAGAAAGAAAGTGAAACTT

Downstream 100 bases:

>100_bases
TATGAAAATGAAAAAATTAGTCAAATCATCAGTTGCTTCATCAATTGCACTGCTTTTGCTATCGAATACAGTTGATGCAG
CTCAACATATCACACCTGTA

Product: leukotoxin E subunit

Products: NA

Alternate protein names: H-gamma-2; H-gamma-II [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEGVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Sequences:

>Translated_311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEGVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN
>Mature_311_residues
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEGVSSKKWGVTQNVQFDFVKDKKYNKDALIVKMQG
FINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVSLINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFN
YSKTISYTQKSYVSEVDKQNSKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREYFAPDNQLPPLVQSGFNPS
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNWKTHEIKVKGHN

Specific function: Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerolysin family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003963
- InterPro:   IPR001340
- InterPro:   IPR016183 [H]

Pfam domain/function: PF07968 Leukocidin [H]

EC number: NA

Molecular weight: Translated: 34747; Mature: 34747

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEGVSSKKWGVTQNVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCE
FDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVS
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEE
LINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQN
EEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
SKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREYFAPDNQLPPLVQSGFNPS
CCCEEECCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNW
EEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECC
KTHEIKVKGHN
EEEEEEEECCC
>Mature Secondary Structure
MFKKKMLAATLSVGLIAPLASPIQESRANTNIENIGDGAEVIKRTEGVSSKKWGVTQNVQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCE
FDFVKDKKYNKDALIVKMQGFINSRTSFSDVKGSGYELTKRMIWPFQYNIGLTTKDPNVS
EEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEHHEEECEEEEEEEEECCCCCEE
LINYLPKNKIETTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSKTISYTQKSYVSEVDKQN
EEECCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCC
SKSVKWGVKANEFVTPDGKKSAHDRYLFVQSPNGPSGSAREYFAPDNQLPPLVQSGFNPS
CCCEEECCCCCCEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCC
FITTLSHEKGSSDTSEFEISYGRNLDITYATLFPRTGIYAERKHNAFVNRNFVVRYEVNW
EEEEECCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCEECCCCCEEECCCEEEEEEECC
KTHEIKVKGHN
EEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA