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The map label for this gene is epiD [H]

Identifier: 82751402

GI number: 82751402

Start: 1824537

End: 1825055

Strand: Reverse

Name: epiD [H]

Synonym: SAB1680c

Alternate gene names: 82751402

Gene position: 1825055-1824537 (Counterclockwise)

Preceding gene: 82751403

Following gene: 82751401

Centisome position: 66.55

GC content: 26.2

Gene sequence:

>519_bases
ATGGGAAAAAATGTATTGATTTGTTTGTGTGGCTCAGTAAATAGTATCAACATTAGCCATTATATTATTGAATTGAAATC
AAAATTTGATGAAGTAAATGTAATTGCATCAACGAATGGTAGAAAGTTTATTAACGGTGAAATATTAAAACAATTTTGTG
ATAACTATTATGACGAATTTGACAATCCTTTTTTAAATCATGTTGATATAGCAAATAAACATGACAAGATTATTATTTTA
CCTGCGACATCTAATACAATTAATAAAATAGCAAATGGTATATGTGACAATTTATTACTAACTATTTGTCATACAGCTTT
TGAAAAACTCTCAATATTTCCAAATATGAATTTACGCATGTGGGAAAATCCAGTTACTCAAAATAATATTCGATTATTAA
AAGATTATGGTGTATCAATATATCCAGTAAATATTTCAGAAAGTTATGAATTAGCGTCAAAAACATTTAAAAAGAATGTT
GTCGCACCAGAACCATATAAAGTTCTGGAATTCATTTGA

Upstream 100 bases:

>100_bases
AGGAGTCTATTTAACATTGATAACATTGCAAAATACAAATATTCTCAATGAAAAAAATTGGACAAATGCGTTTTTAATCA
GCTGAATGGAGGCGTATATT

Downstream 100 bases:

>100_bases
GATAAGAAGATGAAAACCATAAAGCGCGTGCTTAATAATTTAATAATATTGAGTCTTTTAATTTCTTTTACAATGAGTAC
TGCATCAGCGTCGGAAGAAC

Product: hypothetical protein

Products: N-(R)-4-Phosphopantothenoyl)-L-cysteine; CMP; H+; Diphosphate [C]

Alternate protein names: Epidermin-modifying enzyme epiD [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MGKNVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDNYYDEFDNPFLNHVDIANKHDKIIIL
PATSNTINKIANGICDNLLLTICHTAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPVNISESYELASKTFKKNV
VAPEPYKVLEFI

Sequences:

>Translated_172_residues
MGKNVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDNYYDEFDNPFLNHVDIANKHDKIIIL
PATSNTINKIANGICDNLLLTICHTAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPVNISESYELASKTFKKNV
VAPEPYKVLEFI
>Mature_171_residues
GKNVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDNYYDEFDNPFLNHVDIANKHDKIIILP
ATSNTINKIANGICDNLLLTICHTAFEKLSIFPNMNLRMWENPVTQNNIRLLKDYGVSIYPVNISESYELASKTFKKNVV
APEPYKVLEFI

Specific function: Catalyzes the removal of two reducing equivalents (oxidative decarboxylation) from the cysteine residue of the C- terminal meso-lanthionine of epidermin to form a --C==C-- double bond [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=145, Percent_Identity=23.448275862069, Blast_Score=73, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17560194, Length=145, Percent_Identity=31.0344827586207, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24657262, Length=155, Percent_Identity=30.3225806451613, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003382 [H]

Pfam domain/function: PF02441 Flavoprotein [H]

EC number: 4.1.1.36; 6.3.2.5 [C]

Molecular weight: Translated: 19606; Mature: 19475

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKNVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDNYYDEF
CCCCEEEEEECCCCEEEHHHHEEEEHHCCCEEEEEEECCCCEEECHHHHHHHHHHHHHHH
DNPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPNMNLRM
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
WENPVTQNNIRLLKDYGVSIYPVNISESYELASKTFKKNVVAPEPYKVLEFI
ECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCC
>Mature Secondary Structure 
GKNVLICLCGSVNSINISHYIIELKSKFDEVNVIASTNGRKFINGEILKQFCDNYYDEF
CCCEEEEEECCCCEEEHHHHEEEEHHCCCEEEEEEECCCCEEECHHHHHHHHHHHHHHH
DNPFLNHVDIANKHDKIIILPATSNTINKIANGICDNLLLTICHTAFEKLSIFPNMNLRM
CCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
WENPVTQNNIRLLKDYGVSIYPVNISESYELASKTFKKNVVAPEPYKVLEFI
ECCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-4'-Phosphopantothenate; CTP; L-Cysteine [C]

Specific reaction: D-4'-Phosphopantothenate + CTP + L-Cysteine --> N-((R)-4-Phosphopantothenoyl)-L-cysteine + CMP + H+ + Diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740156; 1644762; 11101502 [H]