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The map label for this gene is yyxA [H]

Identifier: 82751315

GI number: 82751315

Start: 1717507

End: 1718781

Strand: Direct

Name: yyxA [H]

Synonym: SAB1586

Alternate gene names: 82751315

Gene position: 1717507-1718781 (Clockwise)

Preceding gene: 82751311

Following gene: 82751317

Centisome position: 62.62

GC content: 34.51

Gene sequence:

>1275_bases
ATGTCAGATTTTAATCATACAGATCATTCTACAACAAACCATAGCCAAACACCTAGATACAGAAGACCTAAATTTCCATG
GTTTAAAACAGTCATCGTTGCATTGATTGCTGGAATCATTGGTGCACTTCTAGTACTTGGTATAGGCAAAGTATTAAATA
GTACAATTTTAAATAAAGATGGTTCAACTGTCCAGACAACAAATAATAAAGGTGGCAATCAATTAGACGGTCAAAGCAAG
AAATTCGGTACCGTTCATGAAATGATAAAATCTGTCTCCCCTACAATTGTTGGAGTTATTAACATGCAAAAAGCATCAAG
TGTAGACGACTTATTAAAAGGCAAATCATCTAAACCATCTGAAGCCGGAGTAGGTTCAGGTGTCATCTATCAAATAAACA
ACAATTCAGCTTATATCGTTACAAACAATCATGTTATTGATGGCGCAAATGAAATTAGAGTCCAATTACATAATAAAAAA
CAAGTTAAAGCGAAATTAGTTGGTAAAGATGCAGTAACTGATATTGCTGTACTTAAAATTGAAAATACAAAAGGTATTAA
AGCGATTCAATTCGCCAACTCTTCAAAAGTACAAACTGGTGATAGCGTATTCGCAATGGGTAACCCATTAGGATTACAAT
TTGCTAACTCTGTAACATCTGGTATCATTTCAGCAAGTGAACGTACTATTGACACTGAGACAACTGGTGGCAATACAAAA
GTCAGCGTTCTTCAAACAGATGCTGCTATTAACCCAGGTAACTCAGGTGGCGCATTAGTAGATATTAATGGTAATTTAGT
TGGTATTAACTCAATGAAAATTGCTGCGACACAAGTTGAAGGTATCGGGTTTGCCATTCCAAGTAATGAAGTTAAAGTAA
CAATTGAACAACTTGTAAAACATGGTAAAATTGACCGCCCTTCGATTGGTATTGGTTTAATTAATTTGAAAGATATTCCT
GAAGAAGAACGCGAGCAACTTCATACTGATAGCGAAGACGGTATTTATGTCGCAAAAGCTGATAGTGATATTGATCTTAA
AAAAGGTGATATTATTACAGAAATTGATGGCAAGAAAATTAAAGATGATGTTGATTTAAGAAGCTATTTATATGAAAATA
AAAAACCTGGTGAATCAGTCACTGTTACCGTTATCCGTGATGGTAAAACAAAAGAAGTTAAAGTGAAATTAAAACAACAA
AAAGAACAACCAAAACGTCAAAGCCGATCAGAGCGTCAATCACCTGGCCAAGGCGATAGAGATTTCTTTAGATAA

Upstream 100 bases:

>100_bases
GTCTGAAAATACATCTAAAGTTGTATAGTGTATTACTAGCAATAATTATAAAAAAAAGACATAATTAAAGCATATATAAA
TCATATAATGGAGGTTAAGT

Downstream 100 bases:

>100_bases
TTTACAGACAGAAAAGTACATTAAGAGCCTACTCATATTCATTCCTAAGAATGTAATGAGTAGGCTCTAATTTATTTAGC
TATGCAATTATATTTATTGA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSDFNHTDHSTTNHSQTPRYRRPKFPWFKTVIVALIAGIIGALLVLGIGKVLNSTILNKDGSTVQTTNNKGGNQLDGQSK
KFGTVHEMIKSVSPTIVGVINMQKASSVDDLLKGKSSKPSEAGVGSGVIYQINNNSAYIVTNNHVIDGANEIRVQLHNKK
QVKAKLVGKDAVTDIAVLKIENTKGIKAIQFANSSKVQTGDSVFAMGNPLGLQFANSVTSGIISASERTIDTETTGGNTK
VSVLQTDAAINPGNSGGALVDINGNLVGINSMKIAATQVEGIGFAIPSNEVKVTIEQLVKHGKIDRPSIGIGLINLKDIP
EEEREQLHTDSEDGIYVAKADSDIDLKKGDIITEIDGKKIKDDVDLRSYLYENKKPGESVTVTVIRDGKTKEVKVKLKQQ
KEQPKRQSRSERQSPGQGDRDFFR

Sequences:

>Translated_424_residues
MSDFNHTDHSTTNHSQTPRYRRPKFPWFKTVIVALIAGIIGALLVLGIGKVLNSTILNKDGSTVQTTNNKGGNQLDGQSK
KFGTVHEMIKSVSPTIVGVINMQKASSVDDLLKGKSSKPSEAGVGSGVIYQINNNSAYIVTNNHVIDGANEIRVQLHNKK
QVKAKLVGKDAVTDIAVLKIENTKGIKAIQFANSSKVQTGDSVFAMGNPLGLQFANSVTSGIISASERTIDTETTGGNTK
VSVLQTDAAINPGNSGGALVDINGNLVGINSMKIAATQVEGIGFAIPSNEVKVTIEQLVKHGKIDRPSIGIGLINLKDIP
EEEREQLHTDSEDGIYVAKADSDIDLKKGDIITEIDGKKIKDDVDLRSYLYENKKPGESVTVTVIRDGKTKEVKVKLKQQ
KEQPKRQSRSERQSPGQGDRDFFR
>Mature_423_residues
SDFNHTDHSTTNHSQTPRYRRPKFPWFKTVIVALIAGIIGALLVLGIGKVLNSTILNKDGSTVQTTNNKGGNQLDGQSKK
FGTVHEMIKSVSPTIVGVINMQKASSVDDLLKGKSSKPSEAGVGSGVIYQINNNSAYIVTNNHVIDGANEIRVQLHNKKQ
VKAKLVGKDAVTDIAVLKIENTKGIKAIQFANSSKVQTGDSVFAMGNPLGLQFANSVTSGIISASERTIDTETTGGNTKV
SVLQTDAAINPGNSGGALVDINGNLVGINSMKIAATQVEGIGFAIPSNEVKVTIEQLVKHGKIDRPSIGIGLINLKDIPE
EEREQLHTDSEDGIYVAKADSDIDLKKGDIITEIDGKKIKDDVDLRSYLYENKKPGESVTVTVIRDGKTKEVKVKLKQQK
EQPKRQSRSERQSPGQGDRDFFR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI24308541, Length=301, Percent_Identity=29.9003322259136, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI4506141, Length=293, Percent_Identity=30.0341296928328, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI22129776, Length=314, Percent_Identity=29.2993630573248, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=30.7958477508651, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786356, Length=286, Percent_Identity=40.2097902097902, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789629, Length=334, Percent_Identity=36.5269461077844, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789630, Length=387, Percent_Identity=30.749354005168, Blast_Score=142, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646839, Length=378, Percent_Identity=28.5714285714286, Blast_Score=126, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 45764; Mature: 45633

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFNHTDHSTTNHSQTPRYRRPKFPWFKTVIVALIAGIIGALLVLGIGKVLNSTILNKD
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSTVQTTNNKGGNQLDGQSKKFGTVHEMIKSVSPTIVGVINMQKASSVDDLLKGKSSKPS
CCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHCCHHHHHCCCCCCCC
EAGVGSGVIYQINNNSAYIVTNNHVIDGANEIRVQLHNKKQVKAKLVGKDAVTDIAVLKI
CCCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEE
ENTKGIKAIQFANSSKVQTGDSVFAMGNPLGLQFANSVTSGIISASERTIDTETTGGNTK
ECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEE
VSVLQTDAAINPGNSGGALVDINGNLVGINSMKIAATQVEGIGFAIPSNEVKVTIEQLVK
EEEEEECCCCCCCCCCCEEEEECCCEEEECCEEEEEEEECCEEEECCCCCEEEEHHHHHH
HGKIDRPSIGIGLINLKDIPEEEREQLHTDSEDGIYVAKADSDIDLKKGDIITEIDGKKI
CCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCC
KDDVDLRSYLYENKKPGESVTVTVIRDGKTKEVKVKLKQQKEQPKRQSRSERQSPGQGDR
CCHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEHHHHCCHHHHHHHHHCCCCCCCH
DFFR
HHCC
>Mature Secondary Structure 
SDFNHTDHSTTNHSQTPRYRRPKFPWFKTVIVALIAGIIGALLVLGIGKVLNSTILNKD
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSTVQTTNNKGGNQLDGQSKKFGTVHEMIKSVSPTIVGVINMQKASSVDDLLKGKSSKPS
CCEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEECCHHCCHHHHHCCCCCCCC
EAGVGSGVIYQINNNSAYIVTNNHVIDGANEIRVQLHNKKQVKAKLVGKDAVTDIAVLKI
CCCCCCCEEEEECCCEEEEEECCEEECCCCEEEEEECCCCEEEEEECCCCCCCEEEEEEE
ENTKGIKAIQFANSSKVQTGDSVFAMGNPLGLQFANSVTSGIISASERTIDTETTGGNTK
ECCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEE
VSVLQTDAAINPGNSGGALVDINGNLVGINSMKIAATQVEGIGFAIPSNEVKVTIEQLVK
EEEEEECCCCCCCCCCCEEEEECCCEEEECCEEEEEEEECCEEEECCCCCEEEEHHHHHH
HGKIDRPSIGIGLINLKDIPEEEREQLHTDSEDGIYVAKADSDIDLKKGDIITEIDGKKI
CCCCCCCCCCEEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEEECCCCCC
KDDVDLRSYLYENKKPGESVTVTVIRDGKTKEVKVKLKQQKEQPKRQSRSERQSPGQGDR
CCHHHHHHHHHCCCCCCCEEEEEEEECCCCCEEEEEEHHHHCCHHHHHHHHHCCCCCCCH
DFFR
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]