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The map label for this gene is citC

Identifier: 82751282

GI number: 82751282

Start: 1677382

End: 1678650

Strand: Reverse

Name: citC

Synonym: SAB1553c

Alternate gene names: 82751282

Gene position: 1678650-1677382 (Counterclockwise)

Preceding gene: 82751283

Following gene: 82751281

Centisome position: 61.21

GC content: 34.99

Gene sequence:

>1269_bases
ATGACTGCAGAAAAAATTACTCAAGGAACTGAAGGATTAAACGTACCTAATGAACCAATTATCCCATTTATTATCGGTGA
TGGAATTGGACCGGATATTTGGAAGGCAGCAAGCCGAGTTATAGATGCTGCTGTTGAGAAAGCCTATAATGGCGAAAAAC
GCATTGAATGGAAAGAAGTGCTAGCTGGCCAAAAAGCATTTGATACAACTGGCGAATGGTTACCTCAAGAAACACTTGAT
ACAATTAAAGAATATTTAATTGCTGTTAAGGGACCTTTAACAACACCAATTGGTGGTGGTATTAGATCATTAAATGTAGC
TTTACGCCAAGAATTAGATTTATTTACTTGTTTAAGACCGGTACGTTGGTTTAAAGGAGTACCATCACCTGTTAAACGTC
CACAAGATGTTGATATGGTTATTTTCCGTGAAAATACTGAAGACATTTATGCTGGTATTGAATTTAAAGAAGGTACAACA
GAAGTTAAAAAGGTAATTGACTTCTTACAAAACGAAATGGGTGCGACAAACATTCGATTCCCAGAAACTTCAGGTATTGG
TATTAAACCAGTTTCTAAAGAAGGTACTGAGCGATTAGCTAGAGCAGCTATTCAATATGCTATCGATAATAATCGTAAAT
CAGTTACTTTAGTTCATAAAGGTAATATTATGAAATTTACAGAAGGCTCATTTAAGCAGTGGGGTTACGATTTAGCATTA
ACTGAATTTGGTGATCAAGTATTCACTTGGCAACAATATGACGAAATTGTTGAAAATGAAGGCAGAGATGCTGCTAATGC
TGCACAAGAAAAAGCTGAAAAAGAAGGCAAGATTATCATTAAAGATTCTATTGCTGACATTTTCTTACAACAAATTTTAA
CTCGTCCAGCTGAGCATGATGTTGTAGCAACTATGAACTTGAATGGTGACTATATTTCAGATGCTTTAGCTGCACAAGTT
GGTGGTATTGGTATTGCGCCAGGTGCAAACATTAATTATGAAACAGGTCATGCTATTTTTGAAGCAACACATGGTACAGC
TCCAAAATATGCAGGTTTAAACAAAGTGAATCCATCTTCAGTAATTTTAAGTTCTGTATTAATGTTAGAACATTTAGGAT
GGCAAGAAGCGGCAGATAAGATTACAGATTCAATTGAAGATACAATTGCTTCAAAAGTTGTTACTTATGACTTTGCCCGT
TTAATGGATGGTGCTGAAGAAGTTTCTACATCATCATTTGCAGATGAATTGATTAAAAATTTAAAATAA

Upstream 100 bases:

>100_bases
ATATATTGGCGAAACGAATCGTAAGTATATCCCGCTTGAAGAAAGAAAATAATCAATACAAATTAAAAATGAAGATGTAA
AATTTGGAGGTAAAATAACT

Downstream 100 bases:

>100_bases
GCAAAATAAACTTAGGTGAGTCTAGCAACTTTAATTGCTAGGTTCGCCTTTTTAAATGAATTGAAGTTGGCAACAGGACA
GAAATAATTAAGAGTCACTA

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD
TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTT
EVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLARAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
TEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFAR
LMDGAEEVSTSSFADELIKNLK

Sequences:

>Translated_422_residues
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD
TIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTT
EVKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLARAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
TEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQV
GGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFAR
LMDGAEEVSTSSFADELIKNLK
>Mature_421_residues
TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLDT
IKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTE
VKKVIDFLQNEMGATNIRFPETSGIGIKPVSKEGTERLARAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALT
EFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATMNLNGDYISDALAAQVG
GIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARL
MDGAEEVSTSSFADELIKNLK

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=423, Percent_Identity=30.9692671394799, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI28178816, Length=368, Percent_Identity=27.9891304347826, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI28178821, Length=368, Percent_Identity=27.9891304347826, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI4758582, Length=368, Percent_Identity=27.9891304347826, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI28178838, Length=368, Percent_Identity=27.9891304347826, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI28178819, Length=199, Percent_Identity=30.6532663316583, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1787381, Length=422, Percent_Identity=62.5592417061611, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1788101, Length=413, Percent_Identity=30.5084745762712, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081683, Length=411, Percent_Identity=27.4939172749392, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71986051, Length=371, Percent_Identity=31.266846361186, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI25144293, Length=378, Percent_Identity=30.4232804232804, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17505779, Length=362, Percent_Identity=29.0055248618785, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324709, Length=404, Percent_Identity=31.6831683168317, Blast_Score=177, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6322097, Length=376, Percent_Identity=31.1170212765957, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6324291, Length=403, Percent_Identity=29.2803970223325, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24643268, Length=402, Percent_Identity=32.5870646766169, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24643270, Length=409, Percent_Identity=32.7628361858191, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI24661184, Length=403, Percent_Identity=32.0099255583127, Blast_Score=185, Evalue=4e-47,
Organism=Drosophila melanogaster, GI161078635, Length=320, Percent_Identity=30.625, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI161078637, Length=320, Percent_Identity=30.625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078633, Length=320, Percent_Identity=30.625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24650122, Length=320, Percent_Identity=30.625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI161078639, Length=320, Percent_Identity=30.625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI281362242, Length=413, Percent_Identity=25.90799031477, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648872, Length=413, Percent_Identity=25.90799031477, Blast_Score=99, Evalue=8e-21,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46425; Mature: 46294

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEV
CCHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF
HHHHCCCCCHHCCCCCCCEEEEECCCCHHEECCEECCCHHHHHHHHHHHHHHCCCCCCCC
PETSGIGIKPVSKEGTERLARAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHCCCEEHH
TEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD
HHHCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCC
VVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSS
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSSFADELIKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LK
CC
>Mature Secondary Structure 
TAEKITQGTEGLNVPNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEV
CHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
LAGQKAFDTTGEWLPQETLDTIKEYLIAVKGPLTTPIGGGIRSLNVALRQELDLFTCLRP
HCCCHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VRWFKGVPSPVKRPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRF
HHHHCCCCCHHCCCCCCCEEEEECCCCHHEECCEECCCHHHHHHHHHHHHHHCCCCCCCC
PETSGIGIKPVSKEGTERLARAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLAL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCHHHCCCEEHH
TEFGDQVFTWQQYDEIVENEGRDAANAAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHD
HHHCCHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCCCC
VVATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSS
EEEEEECCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCHHH
VILSSVLMLEHLGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSSFADELIKN
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA