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The map label for this gene is phoP

Identifier: 82751281

GI number: 82751281

Start: 1676289

End: 1676993

Strand: Reverse

Name: phoP

Synonym: SAB1552c

Alternate gene names: 82751281

Gene position: 1676993-1676289 (Counterclockwise)

Preceding gene: 82751282

Following gene: 82751280

Centisome position: 61.15

GC content: 33.9

Gene sequence:

>705_bases
ATGTCACAAAAAGTGTTGGTAGTAGATGACGAACATTCAATCGTAACATTACTTAAATATAACTTAGAAACAGCTGGTTA
TGAAGTTGTTGTCGCATTTGATGGTGATGAGGCTTTAGAAAAGGTAGAAAATGAACAGCCAGATTTAATTATTTTAGATG
TTATGCTACCTAAAAAAGATGGCATTGACGTATGTAAGACTGTAAGAACAAATAAAAATTTAGTCCCTATATTAATGTTA
ACGGCGAAAAATGATGAATTTGATCGGGTATTAGGTTTAGAATTAGGTGCCGATGACTATATGACTAAGCCTTTTTCACC
TAGAGAAGTTGTTGCCCGTGTGAAAGCCATTTTAAGACGTTCTCAATTTGTAAAAGAAGTAGAAGAGATTGACGATGATA
TTACCATCGGATCGATACGTATTAGACCCGATTATTTTGAAGTATATAAGCATAATGAGCTATTGGAGCTAACACCGAAA
GAATTTGAACTGTTGCTTTATTTGATAGAAAGACAAGGCAGAGTCATTACGAGAGAGCATATGTTAAATACGGTATGGAA
TTATGAATTCGCAGGAGACTCAAGAATTGTTGATGTACATATCAGTCATTTAAGAGATAAATTAGAAGATAATCCTAAGA
AGCCACAACTTATTAAAACTGTGCGTGGCTTAGGCTATAAATTGGAAAGACCTAAAGAACAATGA

Upstream 100 bases:

>100_bases
AAAGTAATGTAAAAAATGTGTAAAGATAATGTGTAGGATGTTATTTTTATAAATAGTTCGGTTATAATGTAAATATAATT
ATAAGTTAGGGAGGCATACC

Downstream 100 bases:

>100_bases
TGAAGTTTCACCACCGCTTAATGTTATTGATAAGCAGTATATTAATTATCAGTTTTATTACATTAGGCATTATTATTCAC
GCTTCCATCACATATGTTTT

Product: alkaline phosphatase synthesis transcriptional regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVENEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILML
TAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPK
EFELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ

Sequences:

>Translated_234_residues
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVENEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILML
TAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPK
EFELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
>Mature_233_residues
SQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVENEQPDLIILDVMLPKKDGIDVCKTVRTNKNLVPILMLT
AKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRRSQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKE
FELLLYLIERQGRVITREHMLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=41.9213973799127, Blast_Score=171, Evalue=5e-44,
Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=41.7391304347826, Blast_Score=169, Evalue=1e-43,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=43.8053097345133, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=36.4444444444444, Blast_Score=164, Evalue=4e-42,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=40.7894736842105, Blast_Score=153, Evalue=9e-39,
Organism=Escherichia coli, GI1786784, Length=231, Percent_Identity=38.5281385281385, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=37.3333333333333, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.8017621145374, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1790552, Length=225, Percent_Identity=34.2222222222222, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1790863, Length=236, Percent_Identity=33.4745762711864, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=33.7777777777778, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=34.4978165938865, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=33.7719298245614, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=32.4786324786325, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1788550, Length=132, Percent_Identity=28.7878787878788, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790299, Length=118, Percent_Identity=33.0508474576271, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790437, Length=101, Percent_Identity=37.6237623762376, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787487, Length=133, Percent_Identity=31.5789473684211, Blast_Score=68, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27150; Mature: 27018

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVENEQPDLIILDVMLPKKD
CCCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEEEECCCC
GIDVCKTVRTNKNLVPILMLTAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRR
CHHHHHHHHCCCCEEEEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKEFELLLYLIERQGRVITREH
HHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEHHH
MLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
HHHHHHCEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC
>Mature Secondary Structure 
SQKVLVVDDEHSIVTLLKYNLETAGYEVVVAFDGDEALEKVENEQPDLIILDVMLPKKD
CCCEEEEECCCCEEEEEEECCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEEEECCCC
GIDVCKTVRTNKNLVPILMLTAKNDEFDRVLGLELGADDYMTKPFSPREVVARVKAILRR
CHHHHHHHHCCCCEEEEEEEEECCCCCHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHH
SQFVKEVEEIDDDITIGSIRIRPDYFEVYKHNELLELTPKEFELLLYLIERQGRVITREH
HHHHHHHHHCCCCEEEEEEEECCHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCEEEHHH
MLNTVWNYEFAGDSRIVDVHISHLRDKLEDNPKKPQLIKTVRGLGYKLERPKEQ
HHHHHHCEEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHHCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]