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The map label for this gene is lysP

Identifier: 82751270

GI number: 82751270

Start: 1659727

End: 1661220

Strand: Reverse

Name: lysP

Synonym: SAB1541c

Alternate gene names: 82751270

Gene position: 1661220-1659727 (Counterclockwise)

Preceding gene: 82751271

Following gene: 82751269

Centisome position: 60.57

GC content: 35.07

Gene sequence:

>1494_bases
ATGTCAAAAGTTCAAAATGAAAGTAACAATGTTGTCAAAAGGGGACTTAAAGATCGTCATATTTCTATGATTGCGATTGG
GGGTTGTATTGGTACAGGTTTATTTGTAACTTCTGGTGGAGCAATTCATGATGCAGGTGCTTTGGGAGCATTAATAGGAT
ACGCAATTATCGGAATAATGGTATTTTTCTTAATGACGTCACTTGGCGAAATGGCTACTTATTTGCCAGTATCAGGTTCA
TTTAGTACATATGCCACAAGATTTGTTGATCCATCTTTAGGGTTTGCGCTTGGTTGGAACTATTGGTTTAACTGGGTAGT
AACTGTAGCAGCAGATATTACGATTGCAGCACAAGTCATTCAATATTGGACACCATTGCAAGGCATACCCGCTTGGGCGT
GGAGTGCGTTGTTCTTAGTTATAATTTTTAGTCTGAATTCGTTATCGGTTCGTGTCTATGGTGAAAGTGAATATTGGCTT
GCATTAATAAAGGTTGTTACAGTTATCGTTTTTATTGCTATTGGTTTATTAACGATTGTAGGAATTATGGGTGGACATTT
TGTAGGATTTGAAATATTTAATAAAGGTGAAGGACCTATTTTAGGTGGCAACCTAGGAGGAAGTTTGTTATCAATTCTAG
GTGTATTCTTAATCGCTGGTTTCTCATTCCAAGGTACTGAATTAATTGGTATTACGGCTGGTGAATCAGAAAATCCTGAA
CGTGCTGTGCCGAAAGCGATTAAACAAGTATTCTGGAGAATTTTATTATTTTATATTTTAGCCATTTTTGTTATCGGTAT
GTTAATTCCTTATGATAGTAGTGCATTAATGGGAGGCGGTAATGACGTTGCAACCTCTCCGTTCACGCTAGTTTTTAAAA
ATGCAGGATTTGCTTTTGCAGCCTCATTTATGAATGCAGTTATCTTAACATCAGTTTTATCAGCAGGTAACTCAGGTATG
TATGCTTCAACTCGAATGCTATATTCAATGAGTAAAGATAAATTGGCGTTTGAAACATTTGGGAAAACAAATAAAAATGG
TGTGCCATATATGTCTTTATTAGTAACTGCAATTATTGTAGTCATCATATTTGTGGTACAAAGTGTTACAGAAGGTGCTT
ATCAATATATCGTTGCTGCCAGTGGGTTGACTGGCTTTATTGCCTGGGTAGGTATCGCAGTGAGTCATTACCGATTTAGA
AGGGCATTTGATAAACAAAATTATGATAAATCTAAATTGAAATATACAGCTAAATTGTTTCCGTTCGGACCTATTTTTGC
AGCTATCTTATGTATTGTTGTAATCATCGGTCAAGATGTGGATTTTATTAAAACAGGAGATTTTAATTTTAGCCGCTTCT
TAATTACGTATATGGGAATTCCAGTATTTTTAGCATTCTTTATTTATCATAAGCTTCGATATAAAACGAAAAAAATTCCA
TTAGAACAAGTAGATTTACGTCAAGATGTGTCAATGGATGAAATAAAAGGTTAA

Upstream 100 bases:

>100_bases
TTTTTTACTTTTAATATCACTATATTCTGTAAAAAAAGGGTATGAAAGTAAATAAAGGTTATTTATTACTTGGCCTCTAA
AACATGGAAAGGGAGCTTAT

Downstream 100 bases:

>100_bases
AATAAAAATAATTACAGTTATAGTGTTGACTTAAATGTGAATTGTTGATATGATTAACAACGTTGAATACGAAACGAACC
AAGTAGAAGCACCCGCTTCT

Product: lysine specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGS
FSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWL
ALIKVVTVIVFIAIGLLTIVGIMGGHFVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGGNDVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGM
YASTRMLYSMSKDKLAFETFGKTNKNGVPYMSLLVTAIIVVIIFVVQSVTEGAYQYIVAASGLTGFIAWVGIAVSHYRFR
RAFDKQNYDKSKLKYTAKLFPFGPIFAAILCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
LEQVDLRQDVSMDEIKG

Sequences:

>Translated_497_residues
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGS
FSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWL
ALIKVVTVIVFIAIGLLTIVGIMGGHFVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGGNDVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGM
YASTRMLYSMSKDKLAFETFGKTNKNGVPYMSLLVTAIIVVIIFVVQSVTEGAYQYIVAASGLTGFIAWVGIAVSHYRFR
RAFDKQNYDKSKLKYTAKLFPFGPIFAAILCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
LEQVDLRQDVSMDEIKG
>Mature_496_residues
SKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIMVFFLMTSLGEMATYLPVSGSF
STYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVIQYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLA
LIKVVTVIVFIAIGLLTIVGIMGGHFVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPER
AVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGGNDVATSPFTLVFKNAGFAFAASFMNAVILTSVLSAGNSGMY
ASTRMLYSMSKDKLAFETFGKTNKNGVPYMSLLVTAIIVVIIFVVQSVTEGAYQYIVAASGLTGFIAWVGIAVSHYRFRR
AFDKQNYDKSKLKYTAKLFPFGPIFAAILCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIPL
EQVDLRQDVSMDEIKG

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=490, Percent_Identity=50.8163265306122, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI87081708, Length=442, Percent_Identity=38.0090497737557, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1786789, Length=472, Percent_Identity=36.228813559322, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1786302, Length=483, Percent_Identity=35.4037267080745, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI48994972, Length=442, Percent_Identity=36.8778280542986, Blast_Score=251, Evalue=5e-68,
Organism=Escherichia coli, GI1789017, Length=449, Percent_Identity=32.9621380846325, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1790653, Length=422, Percent_Identity=34.8341232227488, Blast_Score=227, Evalue=2e-60,
Organism=Escherichia coli, GI87081915, Length=403, Percent_Identity=34.4913151364764, Blast_Score=226, Evalue=3e-60,
Organism=Escherichia coli, GI1786602, Length=409, Percent_Identity=35.2078239608802, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI87081869, Length=414, Percent_Identity=23.4299516908213, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=434, Percent_Identity=21.6589861751152, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=484, Percent_Identity=38.8429752066116, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6320772, Length=493, Percent_Identity=38.7423935091278, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324990, Length=492, Percent_Identity=35.9756097560976, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6324059, Length=496, Percent_Identity=37.7016129032258, Blast_Score=310, Evalue=4e-85,
Organism=Saccharomyces cerevisiae, GI6322892, Length=496, Percent_Identity=36.2903225806452, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324553, Length=502, Percent_Identity=34.2629482071713, Blast_Score=273, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=33, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319824, Length=502, Percent_Identity=30.8764940239044, Blast_Score=253, Evalue=7e-68,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=30.6, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6320717, Length=494, Percent_Identity=29.7570850202429, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319543, Length=496, Percent_Identity=30.4435483870968, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6321053, Length=490, Percent_Identity=31.8367346938775, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6322967, Length=507, Percent_Identity=30.3747534516765, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319542, Length=489, Percent_Identity=29.4478527607362, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320251, Length=490, Percent_Identity=28.3673469387755, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6324981, Length=494, Percent_Identity=31.1740890688259, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6319608, Length=504, Percent_Identity=28.1746031746032, Blast_Score=200, Evalue=5e-52,
Organism=Saccharomyces cerevisiae, GI6320364, Length=551, Percent_Identity=27.4047186932849, Blast_Score=184, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54219; Mature: 54088

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIM
CCCCCCCCHHHHHCCCCCCCEEEEEECCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHH
VFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVVTVIVFIAIGLLTIV
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GIMGGHFVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
HHHCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCH
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGGNDVATSPFTLVFKNAGFAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEEEECCCHHHH
ASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFETFGKTNKNGVPYMSLLVTAIIV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
VIIFVVQSVTEGAYQYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
PFGPIFAAILCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
CCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LEQVDLRQDVSMDEIKG
HHHHHHHHCCCHHHCCC
>Mature Secondary Structure 
SKVQNESNNVVKRGLKDRHISMIAIGGCIGTGLFVTSGGAIHDAGALGALIGYAIIGIM
CCCCCCCHHHHHCCCCCCCEEEEEECCHHHCCCEEECCCCCCCHHHHHHHHHHHHHHHH
VFFLMTSLGEMATYLPVSGSFSTYATRFVDPSLGFALGWNYWFNWVVTVAADITIAAQVI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QYWTPLQGIPAWAWSALFLVIIFSLNSLSVRVYGESEYWLALIKVVTVIVFIAIGLLTIV
HHHCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
GIMGGHFVGFEIFNKGEGPILGGNLGGSLLSILGVFLIAGFSFQGTELIGITAGESENPE
HHHCCCEEEEEEEECCCCCEECCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCH
RAVPKAIKQVFWRILLFYILAIFVIGMLIPYDSSALMGGGNDVATSPFTLVFKNAGFAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCEEEEEECCCHHHH
ASFMNAVILTSVLSAGNSGMYASTRMLYSMSKDKLAFETFGKTNKNGVPYMSLLVTAIIV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHHH
VIIFVVQSVTEGAYQYIVAASGLTGFIAWVGIAVSHYRFRRAFDKQNYDKSKLKYTAKLF
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHC
PFGPIFAAILCIVVIIGQDVDFIKTGDFNFSRFLITYMGIPVFLAFFIYHKLRYKTKKIP
CCHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LEQVDLRQDVSMDEIKG
HHHHHHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]