Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 82751098

GI number: 82751098

Start: 1493261

End: 1494745

Strand: Direct

Name: zwf [H]

Synonym: SAB1366

Alternate gene names: 82751098

Gene position: 1493261-1494745 (Clockwise)

Preceding gene: 82751096

Following gene: 82751099

Centisome position: 54.45

GC content: 33.27

Gene sequence:

>1485_bases
TTGAGTACTAAAAACAAACACATCCCTTGTTTAATCACAATCTTTGGTGCAACTGGTGACTTAAGCCATCGTAAGTTGTT
TCCATCAATATTCCATCTCTACCAACAAGACAATTTAGATGAACATATTGCCATCATCGGTATTGGACGTCGTGACATTA
CTAATGATGATTTCCGTAATCAAGTAAAATCATCAATTCAAAAGCACGTAAAAGATACAAACAAAATTGACGCGTTTATG
GAACATGTCTTCTATCATAGACATGATGTTAGTAATGAAGAAAGCTATCAAGAATTATTAGATTTTAGTAATGAATTAGA
TAGCCAATTTGAATTAAAAGGTAATCGACTATTCTATTTAGCAATGGCACCACAATTCTTTGGCGTTATTTCTGATTATC
TAAAATCTTCTGGTCTTACTGATACAAAAGGATTTAAACGCCTTGTTATCGAAAAACCATTCGGTAGTGATTTAAAATCA
GCCGAAGCATTAAACAATCAAATTCGTAAATCATTTAAAGAAGAAGAAATTTATCGTATTGACCACTATTTAGGAAAAGA
CATGGTTCAAAATATCGAGGTATTACGTTTTGCGAATGCGATGTTTGAACCATTATGGAATAACAAATATATTTCAAACA
TCCAAGTTACATCTTCTGAAATACTAGGTGTTGAAGATCGTGGTGGTTATTATGAATCAAGTGGTGCGCTAAAAGATATG
GTGCAAAACCACATGTTACAAATGGTTGCATTATTAGCTATGGAAGCACCTATTAGTTTAAATAGTGAAGATATCCGTGC
TGAGAAAGTAAAAGTACTTAAATCACTGCGTCATTTCCAATCTGAAGATGTTAAAAAGAACTTTGTTCGTGGTCAATATG
CCGAAGGCTATATCGATGGTAAACAAGTTAAAGCATACCGTGATGAAGATCGCGTTGCAGATGACTCTAACACTCCTACC
TTTGTTTCAGGTAAATTAACAATTGATAACTTTAGATGGGCTGGCGTACCATTCTATATCCGTACTGGTAAACGTATGAA
ATCTAAAACAATTCAAGTTGTCGTTGAATTTAAAGAAGTACCAATGAACTTATACTATGAAACTGATAAACTGTTAGATT
CAAACCTATTAGTAATCAATATTCAACCTAATGAAGGTGTATCTTTACATCTAAATGCTAAGAAAAATACACAAGGTATC
GAAACTGAACCTGTTCAATTGTCTTATTCAATGAGCGCTCAAGATAAAATGAATACTGTAGATGCATATGAAAATCTATT
ATTCGATTGTCTTAAAGGTGATGCCACTAACTTTACGCACTGGGAAGAATTAAAATCAACATGGAAATTTGTTGATGCAA
TTCAAGATGAATGGAATATGGTTGATCCAGAATTCCCTAACTATGAATCAGGTACTAATGGTCCATTAGAAAGTGATTTA
TTACTTGCTCGTGATGGTAACCATTGGTGGGACGATATTCAATAA

Upstream 100 bases:

>100_bases
TTTAAGACACTGCATACTGTCGAGCATATTGAATGACCTGCTGAATGGATTATCTTATAATAATAAATCATATATCTAAT
TAAGAATTGAGGTTTTAATC

Downstream 100 bases:

>100_bases
TTGATTTAAAACGCACATGTTAAACAAAAATAAATGAGCGAATGACAAGGATTGATTACGAATCATGTAAATCAATTGTT
CTATCATTCGCTTTTTTTCT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD; Vegetative protein 11; VEG11 [H]

Number of amino acids: Translated: 494; Mature: 493

Protein sequence:

>494_residues
MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDTNKIDAFM
EHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKS
AEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM
VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYAEGYIDGKQVKAYRDEDRVADDSNTPT
FVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGI
ETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDL
LLARDGNHWWDDIQ

Sequences:

>Translated_494_residues
MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDTNKIDAFM
EHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKS
AEALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM
VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYAEGYIDGKQVKAYRDEDRVADDSNTPT
FVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGI
ETEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDL
LLARDGNHWWDDIQ
>Mature_493_residues
STKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRNQVKSSIQKHVKDTNKIDAFME
HVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYLAMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSA
EALNNQIRKSFKEEEIYRIDHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDMV
QNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYAEGYIDGKQVKAYRDEDRVADDSNTPTF
VSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEVPMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGIE
TEPVQLSYSMSAQDKMNTVDAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDLL
LARDGNHWWDDIQ

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=479, Percent_Identity=36.9519832985386, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI109389365, Length=479, Percent_Identity=36.9519832985386, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI52145310, Length=368, Percent_Identity=30.9782608695652, Blast_Score=153, Evalue=3e-37,
Organism=Escherichia coli, GI1788158, Length=495, Percent_Identity=38.3838383838384, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17538218, Length=485, Percent_Identity=36.701030927835, Blast_Score=327, Evalue=1e-89,
Organism=Saccharomyces cerevisiae, GI6324088, Length=480, Percent_Identity=36.0416666666667, Blast_Score=290, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24643350, Length=479, Percent_Identity=35.0730688935282, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24643352, Length=479, Percent_Identity=35.0730688935282, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI221513548, Length=473, Percent_Identity=28.1183932346723, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56980; Mature: 56849

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRN
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
QVKSSIQKHVKDTNKIDAFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEE
AMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNNQIRKSFKEEEIYRI
EECHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEHHHEEEECCCCCEECCCCHHHHH
VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYAEGYIDG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KQVKAYRDEDRVADDSNTPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEV
HHHEEECCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCHHHHHHEEEEEEHHHC
PMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQLSYSMSAQDKMNTV
CCEEEEEHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHH
DAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
LLARDGNHWWDDIQ
EEEECCCCCCCCCC
>Mature Secondary Structure 
STKNKHIPCLITIFGATGDLSHRKLFPSIFHLYQQDNLDEHIAIIGIGRRDITNDDFRN
CCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHH
QVKSSIQKHVKDTNKIDAFMEHVFYHRHDVSNEESYQELLDFSNELDSQFELKGNRLFYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEE
AMAPQFFGVISDYLKSSGLTDTKGFKRLVIEKPFGSDLKSAEALNNQIRKSFKEEEIYRI
EECHHHHHHHHHHHHHCCCCCCCCHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
DHYLGKDMVQNIEVLRFANAMFEPLWNNKYISNIQVTSSEILGVEDRGGYYESSGALKDM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECEEEEEHHHEEEECCCCCEECCCCHHHHH
VQNHMLQMVALLAMEAPISLNSEDIRAEKVKVLKSLRHFQSEDVKKNFVRGQYAEGYIDG
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
KQVKAYRDEDRVADDSNTPTFVSGKLTIDNFRWAGVPFYIRTGKRMKSKTIQVVVEFKEV
HHHEEECCCCCCCCCCCCCEEEEEEEEECCEEECCCCEEEECCCHHHHHHEEEEEEHHHC
PMNLYYETDKLLDSNLLVINIQPNEGVSLHLNAKKNTQGIETEPVQLSYSMSAQDKMNTV
CCEEEEEHHHHCCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHHHHH
DAYENLLFDCLKGDATNFTHWEELKSTWKFVDAIQDEWNMVDPEFPNYESGTNGPLESDL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCE
LLARDGNHWWDDIQ
EEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9298659 [H]