Click here to switch to the map view.

The map label for this gene is cls1 [H]

Identifier: 82750917

GI number: 82750917

Start: 1285196

End: 1286677

Strand: Direct

Name: cls1 [H]

Synonym: SAB1180

Alternate gene names: 82750917

Gene position: 1285196-1286677 (Clockwise)

Preceding gene: 82750916

Following gene: 82750919

Centisome position: 46.86

GC content: 31.38

Gene sequence:

>1482_bases
ATGAAATTTTCATTTTCAAATGATTTAGGAACACTTTTTACCATTATTTTAGCAATTGCCTTTATCATTAATTTGGTTCT
AGCGTTTATTATTATTTTTTTAGAAAGAAATAGACGTACAGCCAGTTCAACATGGGCGTGGTTATTTGTACTTTTTGTAT
TACCATTAATTGGTTTTATCCTTTATCTATTTTTTGGAAGAACGGTTTCTGCGCGTAAACTAAATAAAAATAATGGGAAC
GTGTTAACAGATTTTGATGCGCTTTTAAAGCAGCAAATTGAAAGCTTTGATAAAGGTAATTATGGTACAGATAATAAACA
AGTTCAAAAGCACCATGATTTGGTACGTATGTTGTTAATGGATCAAGATGGCTTTTTAACTGAAAATAATAAAATTGATC
ATTTTATAGATGGAAATGATTTATATGATCAAGTTTTACAAGATATTAAAAATGCTAAAGAATACATCCATTTAGAGTAT
TATACATTCGCTCTAGATGGCTTAGGCCAAAAAATTTTAAAAGCGTTAGAAGAGAAATTGAAACAAGGTCTAGAAGTGAA
AGTTTTATATGATGACGTTGGTTCAAAGAAAGTTAAGATGGCTAATTTTGATCATTTTAAATCGTTAGGTGGAGAAGTTG
AAGCATTTTTTGCTTCTAAATTACCGTTATTGAATTTCAGAATGAATAATAGAAATCATAGAAAAATCATCGTAATCGAT
GGTCAACTAGGTTATGTCGGAGGATTTAACATTGGTGATGAATATCTAGGTTTAGGAAAATTAGGGTATTGGAGAGATAC
GCATTTACGTATACAAGGGGATGCAGTTGATGCACTGCAGTTGCGATTTATTTTAGACTGGAATTCGCAAGCACATCGAC
CTCAATTTGAATATGATGAAAAATATTTTCCTAAAAAGAATAAATCATTCGGTAATGCGCCAATCCAGATTGCTGCAAGT
GGTCCCGCCAGTGACTGGCATCAAATTGAATATGGTTATACAAAAATGATTATGACCGCTAAGAAGTCGGTATATTTGCA
ATCGCCTTATTTCATTCCGGACAACTCATATATAAATGCCATTAAAATTGCAGCTAAATCAGGGGTGGATGTTCATCTAA
TGATTCCATGTGAGCCAGACCATCCTTTAGTTTATTGGGCGACATTTTCAAATGCTTCTGACTTATTATCAAGTGGTGTT
AAAATTTATACGTATGAAAATGGATTTATACATTCTAAAATGTGCTTAATTGATGATGAAATCGTATCAGTGGGCACAGC
AAATATGGACTTTAGAAGTTTTGAATTAAATTTTGAAGTAAATGCCTTTGTATATGATGAAAATCTTGCTAAAGATTTAA
GAGCGGCTTATGAACATGATATTACAAAATCAAAACAACTTACTGAAGAATCTTATGCTAATAGACCATTGTCTGTTAAG
TTTAAAGAATCGTTAGCTAAATTAGTTTCGCCAATTTTATAA

Upstream 100 bases:

>100_bases
AAGAAGAGTTTAATGCAATATTAACTCTATCTGTAAATAAATAATCTGGAACGAAAGGTACAAAAGTTTTTTGTGCCTTT
CTTTATAGGAGAAATAAACT

Downstream 100 bases:

>100_bases
TTTATTTGTAAGGAGTCTCGATTATAGAGGCTCTTTTTATTTTATCCAAAATTAAATAACGATAAATGTGTTATGTAAAC
CTAATAATGACATTTGGCAT

Product: cardiolipin synthase

Products: NA

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MKFSFSNDLGTLFTIILAIAFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRTVSARKLNKNNGN
VLTDFDALLKQQIESFDKGNYGTDNKQVQKHHDLVRMLLMDQDGFLTENNKIDHFIDGNDLYDQVLQDIKNAKEYIHLEY
YTFALDGLGQKILKALEEKLKQGLEVKVLYDDVGSKKVKMANFDHFKSLGGEVEAFFASKLPLLNFRMNNRNHRKIIVID
GQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDEKYFPKKNKSFGNAPIQIAAS
GPASDWHQIEYGYTKMIMTAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCEPDHPLVYWATFSNASDLLSSGV
KIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRAAYEHDITKSKQLTEESYANRPLSVK
FKESLAKLVSPIL

Sequences:

>Translated_493_residues
MKFSFSNDLGTLFTIILAIAFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRTVSARKLNKNNGN
VLTDFDALLKQQIESFDKGNYGTDNKQVQKHHDLVRMLLMDQDGFLTENNKIDHFIDGNDLYDQVLQDIKNAKEYIHLEY
YTFALDGLGQKILKALEEKLKQGLEVKVLYDDVGSKKVKMANFDHFKSLGGEVEAFFASKLPLLNFRMNNRNHRKIIVID
GQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDEKYFPKKNKSFGNAPIQIAAS
GPASDWHQIEYGYTKMIMTAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCEPDHPLVYWATFSNASDLLSSGV
KIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRAAYEHDITKSKQLTEESYANRPLSVK
FKESLAKLVSPIL
>Mature_493_residues
MKFSFSNDLGTLFTIILAIAFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFILYLFFGRTVSARKLNKNNGN
VLTDFDALLKQQIESFDKGNYGTDNKQVQKHHDLVRMLLMDQDGFLTENNKIDHFIDGNDLYDQVLQDIKNAKEYIHLEY
YTFALDGLGQKILKALEEKLKQGLEVKVLYDDVGSKKVKMANFDHFKSLGGEVEAFFASKLPLLNFRMNNRNHRKIIVID
GQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDEKYFPKKNKSFGNAPIQIAAS
GPASDWHQIEYGYTKMIMTAKKSVYLQSPYFIPDNSYINAIKIAAKSGVDVHLMIPCEPDHPLVYWATFSNASDLLSSGV
KIYTYENGFIHSKMCLIDDEIVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRAAYEHDITKSKQLTEESYANRPLSVK
FKESLAKLVSPIL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=500, Percent_Identity=27.4, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1787007, Length=348, Percent_Identity=29.0229885057471, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 56426; Mature: 56426

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFSFSNDLGTLFTIILAIAFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LYLFFGRTVSARKLNKNNGNVLTDFDALLKQQIESFDKGNYGTDNKQVQKHHDLVRMLLM
HHHHHCCCCCHHEECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DQDGFLTENNKIDHFIDGNDLYDQVLQDIKNAKEYIHLEYYTFALDGLGQKILKALEEKL
CCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHHHHH
KQGLEVKVLYDDVGSKKVKMANFDHFKSLGGEVEAFFASKLPLLNFRMNNRNHRKIIVID
HCCCEEEEEEECCCCCEEEECCCHHHHHCCCCEEHHHHCCCCEEEEEECCCCCCEEEEEE
GQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDE
CCCCEECCCCCCHHHCCCCCCCCEECCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCC
KYFPKKNKSFGNAPIQIAASGPASDWHQIEYGYTKMIMTAKKSVYLQSPYFIPDNSYINA
CCCCCCCCCCCCCCEEEEECCCCCCCCEECCCHHHHHEEHHCEEEEECCEECCCCCCEEE
IKIAAKSGVDVHLMIPCEPDHPLVYWATFSNASDLLSSGVKIYTYENGFIHSKMCLIDDE
EEEEECCCCEEEEEEECCCCCCEEEEEECCCHHHHHHCCEEEEEECCCEEEEEEEEECCH
IVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRAAYEHDITKSKQLTEESYANRPLSVK
HHCCCCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEH
FKESLAKLVSPIL
HHHHHHHHHHCCC
>Mature Secondary Structure
MKFSFSNDLGTLFTIILAIAFIINLVLAFIIIFLERNRRTASSTWAWLFVLFVLPLIGFI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
LYLFFGRTVSARKLNKNNGNVLTDFDALLKQQIESFDKGNYGTDNKQVQKHHDLVRMLLM
HHHHHCCCCCHHEECCCCCCEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
DQDGFLTENNKIDHFIDGNDLYDQVLQDIKNAKEYIHLEYYTFALDGLGQKILKALEEKL
CCCCCEECCCCCCEEECCCHHHHHHHHHHHHHHHEEEEEEEEEEHHHHHHHHHHHHHHHH
KQGLEVKVLYDDVGSKKVKMANFDHFKSLGGEVEAFFASKLPLLNFRMNNRNHRKIIVID
HCCCEEEEEEECCCCCEEEECCCHHHHHCCCCEEHHHHCCCCEEEEEECCCCCCEEEEEE
GQLGYVGGFNIGDEYLGLGKLGYWRDTHLRIQGDAVDALQLRFILDWNSQAHRPQFEYDE
CCCCEECCCCCCHHHCCCCCCCCEECCEEEEECCCCCEEEEEEEEECCCCCCCCCCCCCC
KYFPKKNKSFGNAPIQIAASGPASDWHQIEYGYTKMIMTAKKSVYLQSPYFIPDNSYINA
CCCCCCCCCCCCCCEEEEECCCCCCCCEECCCHHHHHEEHHCEEEEECCEECCCCCCEEE
IKIAAKSGVDVHLMIPCEPDHPLVYWATFSNASDLLSSGVKIYTYENGFIHSKMCLIDDE
EEEEECCCCEEEEEEECCCCCCEEEEEECCCHHHHHHCCEEEEEECCCEEEEEEEEECCH
IVSVGTANMDFRSFELNFEVNAFVYDENLAKDLRAAYEHDITKSKQLTEESYANRPLSVK
HHCCCCCCCCEEEEEEEEEEEEEEECCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEH
FKESLAKLVSPIL
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA