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The map label for this gene is hslU

Identifier: 82750855

GI number: 82750855

Start: 1207674

End: 1209077

Strand: Direct

Name: hslU

Synonym: SAB1116

Alternate gene names: 82750855

Gene position: 1207674-1209077 (Clockwise)

Preceding gene: 82750854

Following gene: 82750856

Centisome position: 44.04

GC content: 34.83

Gene sequence:

>1404_bases
ATGGATACAGCTGGAATAAGATTAACTCCAAAAGAAATCGTATCTAAATTAAATGAATACATCGTTGGACAAAATGATGC
TAAACGTAAAGTGGCAATTGCCCTGCGTAATCGATACAGAAGAAGTTTATTAGATGAGGAATCAAAGCAAGAAATTTCAC
CTAAAAATATTTTGATGATTGGACCAACCGGCGTTGGTAAAACTGAAATTGCAAGAAGAATGGCCAAAGTTGTCGGCGCG
CCATTTATAAAAGTAGAAGCTACTAAATTTACTGAAGTAGGTTATGTAGGACGAGATGTTGAAAGTATGGTTAGAGATCT
TGTTGATGTTTCAGTAAGATTAGTCAAGGCGCAGAAAAAATCATTGGTACAAGATGAAGCAACGGCTAAGGCCAATGAAA
AACTTGTTAAGTTATTAGTTCCAAGTATGAAAAAGAAAGCATCTCAAACGAATAATCCTTTAGAGTCTCTTTTCGGAGGT
GCAATTCCAAATTTCGGACAAAATAACGAAGATGAAGAAGAACCACCTACTGAGGAAATTAAAACAAAACGTTCTGAAAT
TAAGAGGCAATTAGAAGAAGGCAAACTTGAAAAAGAAAAGGTAAGAATTAAAGTTGAACAAGATCCTGGTGCTTTAGGTA
TGCTAGGTACAAATCAAAATCAGCAAATGCAAGAGATGATGAATCAATTAATGCCTAAAAAGAAAGTTGAGCGAGAAGTT
GCTGTTGAGACGGCAAGGAAAATCTTAGCTGATAGTTATGCGGATGAACTAATTGATCAAGAAAGCGCTAACCAAGAAGC
GCTTGAATTAGCAGAACAAATGGGTATCATCTTTATAGATGAAATCGACAAAGTTGCGACGAATAATCATAATAGTGGTC
AAGATGTCTCAAGACAAGGTGTTCAAAGAGATATTTTACCTATACTTGAAGGTAGCGTTATTCAAACCAAATATGGTACT
GTGAATACTGAACATATGCTGTTTATAGGTGCTGGAGCTTTCCATGTATCTAAGCCGAGTGACTTGATACCAGAATTGCA
AGGTCGTTTTCCGCTTAGAGTTGAACTTGATAGTTTATCGGTAGAAGATTTTGTAAGAATTTTGACAGAACCAAAATTGT
CATTAATTAAACAATATGAAGCATTGCTTCAAACAGAAGAAGTTACTGTAAACTTTACCGATGAAGCAATTACTCGCTTA
GCTGAGATTGCTTATCAAGTAAATCAAGATACAGACAACATTGGTGCACGTCGACTTCATACAATTTTAGAAAAGATGTT
AGAAGATTTATCATTCGAAGCACCAAGTATGCCGAATGCAGTTGTAGATATTACCCCACAATATGTTGATGATAAATTAA
AATCAATTTCAACAAATAAAGATTTAAGTGCATTTATTCTATAA

Upstream 100 bases:

>100_bases
TTACCAACGATAATATTGTTGTCGAAACACTATAATAATCAGAGCACGATAAATAATTACGAGCAATTAATTTTAGTTAA
AAGACGGAGGAATGAAATTA

Downstream 100 bases:

>100_bases
AAATATACAAAAGGAGAAAAATTCATGAGCTTATTATCTAAAACGAGAGAGTTAAACACGTTACTTCAAAAACACAAAGG
TATTGCGGTTGATTTTAAAG

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPLRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL

Sequences:

>Translated_467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPLRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
>Mature_467_residues
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMIGPTGVGKTEIARRMAKVVGA
PFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKKSLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGG
AIPNFGQNNEDEEEPPTEEIKTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQGVQRDILPILEGSVIQTKYGT
VNTEHMLFIGAGAFHVSKPSDLIPELQGRFPLRVELDSLSVEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRL
AEIAYQVNQDTDNIGARRLHTILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Homo sapiens, GI7242140, Length=111, Percent_Identity=36.036036036036, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI1790366, Length=464, Percent_Identity=46.7672413793103, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786642, Length=219, Percent_Identity=33.3333333333333, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71988663, Length=258, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319704, Length=169, Percent_Identity=28.9940828402367, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648291, Length=243, Percent_Identity=30.0411522633745, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24648289, Length=243, Percent_Identity=30.0411522633745, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 52316; Mature: 52316

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMI
CCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEE
GPTGVGKTEIARRMAKVVGAPFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKK
CCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHH
VQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPLRVELDSLS
HHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCC
VEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHH
TILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCHHHCC
>Mature Secondary Structure
MDTAGIRLTPKEIVSKLNEYIVGQNDAKRKVAIALRNRYRRSLLDEESKQEISPKNILMI
CCCCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHCCCCCCEEEE
GPTGVGKTEIARRMAKVVGAPFIKVEATKFTEVGYVGRDVESMVRDLVDVSVRLVKAQKK
CCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SLVQDEATAKANEKLVKLLVPSMKKKASQTNNPLESLFGGAIPNFGQNNEDEEEPPTEEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHH
KTKRSEIKRQLEEGKLEKEKVRIKVEQDPGALGMLGTNQNQQMQEMMNQLMPKKKVEREV
HHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHCCHHHHHHHH
AVETARKILADSYADELIDQESANQEALELAEQMGIIFIDEIDKVATNNHNSGQDVSRQG
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCEEEEECHHHHHCCCCCCCCHHHHHH
VQRDILPILEGSVIQTKYGTVNTEHMLFIGAGAFHVSKPSDLIPELQGRFPLRVELDSLS
HHHHHHHHHCCCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCC
VEDFVRILTEPKLSLIKQYEALLQTEEVTVNFTDEAITRLAEIAYQVNQDTDNIGARRLH
HHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHHHHHHCCCCCHHHHHHHH
TILEKMLEDLSFEAPSMPNAVVDITPQYVDDKLKSISTNKDLSAFIL
HHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA