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The map label for this gene is rnc

Identifier: 82750837

GI number: 82750837

Start: 1183625

End: 1184356

Strand: Direct

Name: rnc

Synonym: SAB1097

Alternate gene names: 82750837

Gene position: 1183625-1184356 (Clockwise)

Preceding gene: 82750836

Following gene: 82750838

Centisome position: 43.16

GC content: 34.02

Gene sequence:

>732_bases
ATGTCTAAACAAAAGAAAAGTGAGATAATTAATCGTTTTAGAAAGCGCTTTGATACTAAAATGACAGAGTTAGGCTTTAC
TTATCAAAATATTGATTTATACCAACAAGCATTTTCGCATTCGAGTTTTATTAATGATTTTAATATGAATCGTTTAGACC
ATAATGAGCGTTTAGAGTTTTTGGGTGATGCGGTATTAGAATTGACGGTTTCACGATATTTATTTGATAAACATCCCAAC
TTGCCAGAAGGGAATTTAACAAAAATGCGTGCCACTATTGTATGTGAGCCCTCACTTGTAATATTTGCGAATAAAATTGG
ATTGAACGAAATGATTTTACTTGGTAAAGGTGAAGAGAAAACAGGGGGACGTACAAGACCATCATTAATATCAGATGTAT
TCGAAGCATTTATTGGGGCATTGTATTTGGATCAAGGACTAGATATAGTTTGGAAATTTGCTGAGAAAGTCATTTTCCCA
CATGTAGAACAAAATGAGTTATTAGGCGTGGTAGATTTTAAAACACAATTCCAAGAATATGTGCACCAGCAAAATAAAGG
TGATGTAACCTATAATTTAATAAAAGAAGAGGGACCGGCACATCATCGTCTATTCACTTCAGAAGTTATTCTGCAAGGGG
AAGCAATAGCTGAAGGTAAAGGGAAAACGAAAAAAGAATCAGAACAACGTGCTGCTGAAAGTGCCTATAAGCAATTAAAG
CAAATTAAATAG

Upstream 100 bases:

>100_bases
GGTCGTCAGTATTGTCGACTCAGTTTTTTTCTTTAATTATCAATAGTTTTAACGTAAAATTAAAGATGATTCAAGAGCAA
CACATAAAGGAGATAAAATA

Downstream 100 bases:

>100_bases
AAATTTATATGATACGACATATAGGTGTTCGATTTAGGATTTATGGAAGAATTTTTAATATTTTATGGAACAACCTCGAA
ATTTAATATACAAATACTAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPN
LPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFP
HVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLK
QIK

Sequences:

>Translated_243_residues
MSKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPN
LPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFP
HVEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLK
QIK
>Mature_242_residues
SKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEFLGDAVLELTVSRYLFDKHPNL
PEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEKTGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFPH
VEQNELLGVVDFKTQFQEYVHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLKQ
IK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=227, Percent_Identity=31.2775330396476, Blast_Score=103, Evalue=1e-22,
Organism=Homo sapiens, GI155030234, Length=227, Percent_Identity=31.2775330396476, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1788920, Length=241, Percent_Identity=34.0248962655602, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=29.7413793103448, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=29.7413793103448, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137682, Length=223, Percent_Identity=28.2511210762332, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27964; Mature: 27833

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEF
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEK
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEEECCCEEEEEECCCCCEEEEEECCCCC
TGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
VHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLK
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
QIK
HCC
>Mature Secondary Structure 
SKQKKSEIINRFRKRFDTKMTELGFTYQNIDLYQQAFSHSSFINDFNMNRLDHNERLEF
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
LGDAVLELTVSRYLFDKHPNLPEGNLTKMRATIVCEPSLVIFANKIGLNEMILLGKGEEK
HHHHHHHHHHHHHHHHCCCCCCCCCHHEEEEEEEECCCEEEEEECCCCCEEEEEECCCCC
TGGRTRPSLISDVFEAFIGALYLDQGLDIVWKFAEKVIFPHVEQNELLGVVDFKTQFQEY
CCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHH
VHQQNKGDVTYNLIKEEGPAHHRLFTSEVILQGEAIAEGKGKTKKESEQRAAESAYKQLK
HHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHHHHHHHHHHH
QIK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA