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The map label for this gene is th1

Identifier: 82750065

GI number: 82750065

Start: 353336

End: 354517

Strand: Direct

Name: th1

Synonym: SAB0304

Alternate gene names: 82750065

Gene position: 353336-354517 (Clockwise)

Preceding gene: 82750063

Following gene: 82750071

Centisome position: 12.88

GC content: 38.32

Gene sequence:

>1182_bases
ATGACGAGAGTCGTATTAGCAGCAGCATACAGGACACCTATTGGCGTTTTTGGAGGTGCGTTTAAAGACGTGCCAGCCTA
TGATTTAGGTGCGACTTTAATAGAACATATTATTAAAGAGACGGGTTTGAATCCAAGTGAGATTAATGAAGTCATCATCG
GTAACGTACTACAAGCAGGACAAGGACAAAATCCAGCACGAATTGCTGCTATGAAAGGTGGCTTGCCAGAAACAGTACCT
GTATTTACAGTGAATAAAGTATGTGGTTCTGGGTTAAAGTCGATTCAATTAGCATATCAATCTATTGTGACTGGTGAAAA
TGACATCGTGCTAGCTGGCGGTATGGAGAATATGTCTCAATCACCAATGCTTGTCAACAACAGTCGCTTTGGTTTTAAAA
TGGGACATCAATCAATGGTTGATAGCATGGTATATGATGGTTTAACAGATGTATTTAATCAATATCATATGGGTATTACT
GCTGAAAATTTAGTAGAGCAATATGGTATTTCAAGAGAAGAACAAGATACATTTGCTGTTAATTCTCAGAAAAAGGCGGC
AAATGCACAACAAAATGGTGGATTTGATAGTGAAATAGTTCCAGTATCGATTCCTCAACGTAAAGGTGAACCAATCGTTG
TCACTAAGGATGAAGGTGTACGTGAAAATGTATCAGTTGAAAAATTAAGTCGCTTAAGACCAGCTTTCAAAAAAGACGGT
ACAGTTACAGCAGGTAATGCATCAGGAATCAATGATGGTGCTGCGATGATGTTAGTCATGTCAGAAGACAAAGCTAAAGA
ATTAAATATCGAACCATTGGCAGTGCTTGATGGCTTTGGAAGTCATGGTGTAGATCCTTCTATTATGGGTATTGCACCAG
TTGGCGCTGTTGAAAAGGCTTTGAAACGTAGTAAAAAAGAATTAAGCGATATTGATGTATTTGAATTAAATGAAGCATTT
GCAGCACAATCATTAGCTGTAGATCGCGAATTAAAATTACCTCCTGAAAAGGTGAATGTTAAAGGTGGCGCTATTGCATT
AGGACACCCTATTGGTGCATCTGGTGCTAGAGTTTTAGTGACATTATTGCATCAACTGAATGATGAAGTCGAAACTGGTT
TAACATCATTGTGTATTGGTGGCGGTCAAGCTATCGCTGCAGTTGTATCAAAGTATAAATAA

Upstream 100 bases:

>100_bases
TACGTAGCAATTGGTTTCATAAATTGGATGTTAGTGGCGTATTGGTTCATTAGACGTATTAGTAATAAAATTGTATATAT
CATAAGGAGATGAATATGAC

Downstream 100 bases:

>100_bases
TAAGAAAACAGGTTATCACAACAGTATTAATTACATGTTGGCATAACCTGTTTTTATTTGTTTATGGATTTATTGGGTAA
TATTAGTCATTTGATGGTTT

Product: acetyl-CoA acetyltransferase protein

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MTRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEINEVIIGNVLQAGQGQNPARIAAMKGGLPETVP
VFTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQSPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGIT
AENLVEQYGISREEQDTFAVNSQKKAANAQQNGGFDSEIVPVSIPQRKGEPIVVTKDEGVRENVSVEKLSRLRPAFKKDG
TVTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKALKRSKKELSDIDVFELNEAF
AAQSLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLVTLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK

Sequences:

>Translated_393_residues
MTRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEINEVIIGNVLQAGQGQNPARIAAMKGGLPETVP
VFTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQSPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGIT
AENLVEQYGISREEQDTFAVNSQKKAANAQQNGGFDSEIVPVSIPQRKGEPIVVTKDEGVRENVSVEKLSRLRPAFKKDG
TVTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKALKRSKKELSDIDVFELNEAF
AAQSLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLVTLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK
>Mature_392_residues
TRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEINEVIIGNVLQAGQGQNPARIAAMKGGLPETVPV
FTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQSPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGITA
ENLVEQYGISREEQDTFAVNSQKKAANAQQNGGFDSEIVPVSIPQRKGEPIVVTKDEGVRENVSVEKLSRLRPAFKKDGT
VTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKALKRSKKELSDIDVFELNEAFA
AQSLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLVTLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=50.383631713555, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=44.0721649484536, Blast_Score=323, Evalue=2e-88,
Organism=Homo sapiens, GI4557237, Length=392, Percent_Identity=43.8775510204082, Blast_Score=319, Evalue=3e-87,
Organism=Homo sapiens, GI4501853, Length=392, Percent_Identity=44.1326530612245, Blast_Score=299, Evalue=2e-81,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=33.0210772833724, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI194353979, Length=393, Percent_Identity=34.6055979643766, Blast_Score=191, Evalue=1e-48,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=52.0408163265306, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=53.1806615776081, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=40.3990024937656, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI48994986, Length=401, Percent_Identity=42.14463840399, Blast_Score=268, Evalue=3e-73,
Organism=Escherichia coli, GI1788683, Length=400, Percent_Identity=30.5, Blast_Score=184, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI133906874, Length=390, Percent_Identity=45.1282051282051, Blast_Score=328, Evalue=4e-90,
Organism=Caenorhabditis elegans, GI25147385, Length=386, Percent_Identity=41.9689119170984, Blast_Score=295, Evalue=4e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=391, Percent_Identity=41.9437340153453, Blast_Score=281, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17551802, Length=429, Percent_Identity=32.8671328671329, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=31.6326530612245, Blast_Score=179, Evalue=3e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=394, Percent_Identity=44.6700507614213, Blast_Score=301, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6322031, Length=394, Percent_Identity=39.5939086294416, Blast_Score=245, Evalue=8e-66,
Organism=Drosophila melanogaster, GI24655093, Length=392, Percent_Identity=51.7857142857143, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI17648125, Length=389, Percent_Identity=43.9588688946015, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24640423, Length=392, Percent_Identity=43.3673469387755, Blast_Score=308, Evalue=6e-84,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.1176470588235, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41589; Mature: 41458

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEINEVIIGNVLQAG
CCEEEEEEHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
QGQNPARIAAMKGGLPETVPVFTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQ
CCCCCCEEEEECCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
SPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGITAENLVEQYGISREEQDTFAV
CCEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEE
NSQKKAANAQQNGGFDSEIVPVSIPQRKGEPIVVTKDEGVRENVSVEKLSRLRPAFKKDG
CCHHHHCCCHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCC
TVTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKA
CEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEECCHHHHHHH
LKRSKKELSDIDVFELNEAFAAQSLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLV
HHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK
HHHHHHCHHHHHCHHHHHHCCCHHHHHHHHHCC
>Mature Secondary Structure 
TRVVLAAAYRTPIGVFGGAFKDVPAYDLGATLIEHIIKETGLNPSEINEVIIGNVLQAG
CEEEEEEHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
QGQNPARIAAMKGGLPETVPVFTVNKVCGSGLKSIQLAYQSIVTGENDIVLAGGMENMSQ
CCCCCCEEEEECCCCCCCCCEEEEHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCC
SPMLVNNSRFGFKMGHQSMVDSMVYDGLTDVFNQYHMGITAENLVEQYGISREEQDTFAV
CCEEEECCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEE
NSQKKAANAQQNGGFDSEIVPVSIPQRKGEPIVVTKDEGVRENVSVEKLSRLRPAFKKDG
CCHHHHCCCHHCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHCHHHHCCC
TVTAGNASGINDGAAMMLVMSEDKAKELNIEPLAVLDGFGSHGVDPSIMGIAPVGAVEKA
CEEECCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCCEEECCHHHHHHH
LKRSKKELSDIDVFELNEAFAAQSLAVDRELKLPPEKVNVKGGAIALGHPIGASGARVLV
HHHHHHHHHCCCCEECHHHHHHHHHHCCCCCCCCHHHCCCCCCEEEECCCCCCCHHHHHH
TLLHQLNDEVETGLTSLCIGGGQAIAAVVSKYK
HHHHHHCHHHHHCHHHHHHCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA