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The map label for this gene is lrgB

Identifier: 82749968

GI number: 82749968

Start: 251912

End: 252613

Strand: Direct

Name: lrgB

Synonym: SAB0202

Alternate gene names: 82749968

Gene position: 251912-252613 (Clockwise)

Preceding gene: 82749967

Following gene: 82749970

Centisome position: 9.19

GC content: 36.47

Gene sequence:

>702_bases
ATGATTAACCACTTAGCACTAAACACACCTTACTTCGGAATACTGTTATCCGTTATACCATTTTTCTTAGCGACCATATT
ATTTGAAAAAACAAATCGTTTCTTCTTATTCGCACCGCTATTTGTCAGTATGGTATTTGGTGTGGCCTTCCTCTATTTAA
CAGGCATTCCGTATAAGACTTACAAAATAGGTGGAGACATTATTTACTTCTTCTTAGAACCAGCAACAATCTGTTTTGCG
ATTCCGTTATATAAAAAGCGTGAAGTGCTTGTTAAACATTGGCATCGTATCATCGGAGGTATTGGTATCGGTACAGTTGT
AGCGTTATTAATTATTTTAACTTTTGCGAAGTTAGCACAATTTGCCAATGATGTTATTTTATCAATGTTACCTCAAGCAG
CAACTACAGCGATTGCGTTACCAGTATCAGCTGGTATTGGTGGTATAAAAGAATTAACATCATTAGCAGTTATTTTAAAT
GGTGTCATTATTTATGCCCTAGGTAATAAATTCTTGAAGCTTTTCCGAATTACTAACCCTATTGCCCGAGGATTAGCACT
TGGAACAAGTGGTCACACATTAGGTGTAGCACCAGCCAAAGAATTAGGACCTGTAGAAGAATCAATGGCAAGTATAGCTT
TAGTGTTAGTTGGTGTAGTTGTTGTAGCAGTTGTGCCTGTCTTTGTAGCAATATTCTTCTAA

Upstream 100 bases:

>100_bases
ATTTGTACTGGCTATGTCACACAAATTATTATGAAAGTTACTTCGAGATCTAAAGGTGACAAAGTCACAAAAAAGATCAA
AATAGAGGAGGCACAAGCTC

Downstream 100 bases:

>100_bases
AACGAAAAACCTAAGCAAGATAATAGCAATTTGAGCCATTGTTATTATCGTAAAAAAACGTCTATATTCCGGTTTAAAAC
TGGGATATAGACGTTTTTAT

Product: antiholin-like protein LrgB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFA
IPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILN
GVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF

Sequences:

>Translated_233_residues
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFA
IPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILN
GVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
>Mature_233_residues
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKTYKIGGDIIYFFLEPATICFA
IPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQFANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILN
GVIIYALGNKFLKLFRITNPIARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF

Specific function: Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in p

COG id: COG1346

COG function: function code M; Putative effector of murein hydrolase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidB/LrgB family. LrgB subfamily

Homologues:

Organism=Escherichia coli, GI1788464, Length=216, Percent_Identity=36.5740740740741, Blast_Score=129, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LRGB_STAA1 (A7WXS7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001440852.1
- STRING:   A7WXS7
- EnsemblBacteria:   EBSTAT00000004240
- GeneID:   5561577
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_0262
- eggNOG:   COG1346
- GeneTree:   EBGT00050000024994
- HOGENOM:   HBG363009
- OMA:   IINFFLE
- ProtClustDB:   PRK04288
- BioCyc:   SAUR418127:SAHV_0262-MONOMER
- GO:   GO:0019835
- HAMAP:   MF_01142
- InterPro:   IPR007300

Pfam domain/function: PF04172 LrgB

EC number: NA

Molecular weight: Translated: 25098; Mature: 25098

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x970d840)-; HASH(0x95520f4)-; HASH(0x15c3fe30)-; HASH(0x1604c35c)-; HASH(0x15f840b4)-; HASH(0x15e7db2c)-; HASH(0x15993448)-;

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKT
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCEE
YKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQ
EEECCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
HHHHHEECCCCCEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
>Mature Secondary Structure
MINHLALNTPYFGILLSVIPFFLATILFEKTNRFFLFAPLFVSMVFGVAFLYLTGIPYKT
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCEE
YKIGGDIIYFFLEPATICFAIPLYKKREVLVKHWHRIIGGIGIGTVVALLIILTFAKLAQ
EEECCEEEEEEECHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FANDVILSMLPQAATTAIALPVSAGIGGIKELTSLAVILNGVIIYALGNKFLKLFRITNP
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARGLALGTSGHTLGVAPAKELGPVEESMASIALVLVGVVVVAVVPVFVAIFF
HHHHHEECCCCCEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA