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The map label for this gene is ggt [H]

Identifier: 82749917

GI number: 82749917

Start: 184260

End: 186266

Strand: Direct

Name: ggt [H]

Synonym: SAB0148

Alternate gene names: 82749917

Gene position: 184260-186266 (Clockwise)

Preceding gene: 82749916

Following gene: 82749919

Centisome position: 6.72

GC content: 38.32

Gene sequence:

>2007_bases
ATGGTCATTAACTTAAATGACAAACAGACAAAAACATCTAAAGAAGGGTTAATTTCCGTATCACATCCTCTTGCGGCTAA
AATTGGTAAGGATGTATTAGATCAAGGTGGCAACGCCATGGATGCAGTGATTGCAATTCAACTGGCATTGAATGTGGTAG
AACCATTTGCATCAGGTATTGGTGGTGGCGGGTACTTGCTATATTATGAGCAAAGTACTGGCAGTATAACTGCGTTTGAT
GCGCGTGAGACAGCCCCTGCACATGTAGACAAACAATTTTATCTAGATGATTCAGGCGAATATAAATCATTTTTTGATAT
GACTACACATGGTAAAACTGTCGCTGTGCCAGCAATTCCAAAGCTGTTTGATTATATTCACAAGCGTTATGCTAAATTGT
CATTGGAAGATTTAATTAATCCTGCAATTGAACTAGCCATTGAAGGTCATTCAGCCAATTGGGCTACTGAAAAATATTCG
CGCCAGCAACACGCACGATTGACAAAGTATCACGAAACAGCTCAAGTATTTACGCATGAAAATCAATATTGGCGTGAAGG
TGATTGGATTGTACAACCCGAATTAGGCAAGACGTTTCAAATATTAAGAGAACAAGGGTTTAATGCATTTTATAAAGGTG
ACATTGCGAAACAATTAGTCAATGTTGTCAAAGCATGTGGTGGGACAATCGCTTTAGAGGATTTAGCCAATTATGACATT
CAGATTAAAGCGCCAATCAGTGCGACATTTAAAGACTATGACATTTATTCAATGGGTCCATCTAGTTCCGGTGGTATCAC
GGTAATTCAAATATTGAAGTTATTAGAACACATCGATTTACCATCTATGGGTTCAAGATCTGTCGATTACTTGCATCATT
TGATACAGGCAATGCATTTAGCATATAGTGATCGCGCGCAATACTTGGCAGATGATAATTTTCATGAGGTGCCTGTACAG
TCATTAATTGAAGACGATTATTTAAAAGCACGCAGTAAGCTCATTGATAGCAATAAAGCAAATATTGATATAGAGCATGG
TGTTGTGTCTAATTGCATTAGTCATACAGATGTTGAAGAAAATCATACCGAAACAACTCATTTTTGTGTGATTGATAAGG
AAGGTAATATTGCTTCATTTACGACATCAATCGGTATGATTTACGGGTCGGGTATTACGATTCCAGGCTACGGCGTGTTA
TTGAATACCACAATGGATGGTTTTGATGTTGTGGCGGGTGGAATCAATGAAATTGCACCTTATAAACGACCACTAAGTAA
CATGGCTCCAACGATTGTGATGCATCACGGGAAGCCAATATTAACAGTAGGTGCACCTGGTGCTATAAGTATCATTGCTA
GTGTTGCGCAAACATTAATCAATGTATTAGTGTTTGGCATGGATATTCAGCAGGCTATAAATGAATCTAGAATTTATAGT
AGCCATCCTAATCGCATTGAATGGGAGCCTCAATTTTCACAATCTACAATATTAGCATTGATTGCACGTGGACATGCAAT
GGAACATAAACCAGATGCCTATATTGGAGATGTACATGGACTACAAGTTGACTCAATAACGTATGAAGCTTCGGGTGGCA
GTGATGATACTAGAGAAGGCACCGTAATGGGTGGCGAGGTGTTAGTGATTAGAAAACAGCCATTACCATATCGGCATATG
TATGATAATGACGGCTTTCGTGTATATCTTAATGGCATACAGTTGCCATTATATGCTGAACAAGTGCGATGGATGCATGG
CACTTGTTGGATTGAGGAGAGTGTTGTTAGAATCATCTTCTCTGAAGTTAGGGCACATATTGAAGACTTAAGAAGTTATG
AAATCGCTGGAGAAAATTATATAGATATTGTCTGGTTGGCACGGAAAAATGCTTATCAAGTGGCATTGAAAGATGACGGT
TTATATTTAAATGATGAAGCATATCATTCAGTGAAACGGAACACAAATGCATACTATAGATATGATCGAGATAGTATCAC
AAGATAG

Upstream 100 bases:

>100_bases
GTCGATACTGGTAACAAGCAACGTCAAGATTTAGAAAAAGTAGAAAAAGCCATTAATCAATAATGTTTTAAATATTTAAC
AGAAAGTAGGAGGATATAGT

Downstream 100 bases:

>100_bases
TTTATACGCTTGATATGAAGTTTGTAGTGGATAAGGGCTTTTATTGAATGAAAGGATTCGATTTCGAACTTTAGCGTGAC
GCTTGAGTGTATTAATGTTG

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPAHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHSANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIALEDLANYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHIDLPSMGSRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIEDDYLKARSKLIDSNKANIDIEHGVVSNCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVAGGINEIAPYKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAINESRIYS
SHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDSITYEASGGSDDTREGTVMGGEVLVIRKQPLPYRHM
YDNDGFRVYLNGIQLPLYAEQVRWMHGTCWIEESVVRIIFSEVRAHIEDLRSYEIAGENYIDIVWLARKNAYQVALKDDG
LYLNDEAYHSVKRNTNAYYRYDRDSITR

Sequences:

>Translated_668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPAHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHSANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIALEDLANYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHIDLPSMGSRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIEDDYLKARSKLIDSNKANIDIEHGVVSNCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVAGGINEIAPYKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAINESRIYS
SHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDSITYEASGGSDDTREGTVMGGEVLVIRKQPLPYRHM
YDNDGFRVYLNGIQLPLYAEQVRWMHGTCWIEESVVRIIFSEVRAHIEDLRSYEIAGENYIDIVWLARKNAYQVALKDDG
LYLNDEAYHSVKRNTNAYYRYDRDSITR
>Mature_668_residues
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGIGGGGYLLYYEQSTGSITAFD
ARETAPAHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIPKLFDYIHKRYAKLSLEDLINPAIELAIEGHSANWATEKYS
RQQHARLTKYHETAQVFTHENQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIALEDLANYDI
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHIDLPSMGSRSVDYLHHLIQAMHLAYSDRAQYLADDNFHEVPVQ
SLIEDDYLKARSKLIDSNKANIDIEHGVVSNCISHTDVEENHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVL
LNTTMDGFDVVAGGINEIAPYKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAINESRIYS
SHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDSITYEASGGSDDTREGTVMGGEVLVIRKQPLPYRHM
YDNDGFRVYLNGIQLPLYAEQVRWMHGTCWIEESVVRIIFSEVRAHIEDLRSYEIAGENYIDIVWLARKNAYQVALKDDG
LYLNDEAYHSVKRNTNAYYRYDRDSITR

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=543, Percent_Identity=28.3609576427256, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915090, Length=543, Percent_Identity=28.3609576427256, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915096, Length=543, Percent_Identity=28.3609576427256, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI73915094, Length=543, Percent_Identity=28.3609576427256, Blast_Score=190, Evalue=4e-48,
Organism=Homo sapiens, GI113429324, Length=541, Percent_Identity=27.5415896487985, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI113429326, Length=547, Percent_Identity=27.6051188299817, Blast_Score=167, Evalue=4e-41,
Organism=Homo sapiens, GI153266885, Length=517, Percent_Identity=25.9187620889749, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI153266901, Length=518, Percent_Identity=25.8687258687259, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI153266907, Length=517, Percent_Identity=24.1779497098646, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI109148539, Length=518, Percent_Identity=25.0965250965251, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI30581157, Length=152, Percent_Identity=34.2105263157895, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI30581155, Length=152, Percent_Identity=34.2105263157895, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1789856, Length=512, Percent_Identity=34.9609375, Blast_Score=311, Evalue=9e-86,
Organism=Caenorhabditis elegans, GI212646519, Length=506, Percent_Identity=30.2371541501976, Blast_Score=186, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI72000294, Length=506, Percent_Identity=30.2371541501976, Blast_Score=185, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI193208245, Length=508, Percent_Identity=30.7086614173228, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI193208247, Length=508, Percent_Identity=30.7086614173228, Blast_Score=184, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17542894, Length=540, Percent_Identity=27.962962962963, Blast_Score=171, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17506189, Length=517, Percent_Identity=26.6924564796905, Blast_Score=170, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI72001497, Length=264, Percent_Identity=25, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72001495, Length=264, Percent_Identity=25, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323330, Length=516, Percent_Identity=28.1007751937984, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI161077496, Length=526, Percent_Identity=27.3764258555133, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI18859893, Length=514, Percent_Identity=28.4046692607004, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI161077878, Length=518, Percent_Identity=27.027027027027, Blast_Score=159, Evalue=7e-39,
Organism=Drosophila melanogaster, GI24642670, Length=518, Percent_Identity=27.2200772200772, Blast_Score=159, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24642666, Length=518, Percent_Identity=27.2200772200772, Blast_Score=159, Evalue=8e-39,
Organism=Drosophila melanogaster, GI161077880, Length=518, Percent_Identity=27.2200772200772, Blast_Score=159, Evalue=8e-39,
Organism=Drosophila melanogaster, GI45551474, Length=522, Percent_Identity=27.2030651340996, Blast_Score=158, Evalue=1e-38,
Organism=Drosophila melanogaster, GI18859741, Length=521, Percent_Identity=26.679462571977, Blast_Score=153, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 74524; Mature: 74524

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGI
CEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
GGGGYLLYYEQSTGSITAFDARETAPAHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIP
CCCEEEEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHEEEECCCCEEECCCHH
KLFDYIHKRYAKLSLEDLINPAIELAIEGHSANWATEKYSRQQHARLTKYHETAQVFTHE
HHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECC
NQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIALEDLANYDI
CCCEECCCEEECCCCCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCEEEEHHHCCCCE
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHIDLPSMGSRSVDYLHHLIQAMHL
EEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AYSDRAQYLADDNFHEVPVQSLIEDDYLKARSKLIDSNKANIDIEHGVVSNCISHTDVEE
HHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHCCCCCC
NHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVAGGINEIAP
CCCCCEEEEEEECCCCEEEEHHHEEEEEECCCCCCCCCEEEECCCCCHHHHHCCHHHHCC
YKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAINESRIYS
CCCCHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHCCC
SHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDSITYEASGGSDDTREG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEEEEECCCCCCCCCCC
TVMGGEVLVIRKQPLPYRHMYDNDGFRVYLNGIQLPLYAEQVRWMHGTCWIEESVVRIIF
EEECCEEEEEECCCCCCHHCCCCCCEEEEEECEECCEEHHHHHHHHCEEEHHHHHHHHHH
SEVRAHIEDLRSYEIAGENYIDIVWLARKNAYQVALKDDGLYLNDEAYHSVKRNTNAYYR
HHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEECCCEEECCHHHHHHHCCCCCEEE
YDRDSITR
ECCCCCCC
>Mature Secondary Structure
MVINLNDKQTKTSKEGLISVSHPLAAKIGKDVLDQGGNAMDAVIAIQLALNVVEPFASGI
CEECCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
GGGGYLLYYEQSTGSITAFDARETAPAHVDKQFYLDDSGEYKSFFDMTTHGKTVAVPAIP
CCCEEEEEEECCCCCEEEECCCCCCCCCCCCEEEECCCCCCCHHEEEECCCCEEECCCHH
KLFDYIHKRYAKLSLEDLINPAIELAIEGHSANWATEKYSRQQHARLTKYHETAQVFTHE
HHHHHHHHHHHHCCHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHEECC
NQYWREGDWIVQPELGKTFQILREQGFNAFYKGDIAKQLVNVVKACGGTIALEDLANYDI
CCCEECCCEEECCCCCHHHHHHHHCCCCCEECCHHHHHHHHHHHHCCCEEEEHHHCCCCE
QIKAPISATFKDYDIYSMGPSSSGGITVIQILKLLEHIDLPSMGSRSVDYLHHLIQAMHL
EEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
AYSDRAQYLADDNFHEVPVQSLIEDDYLKARSKLIDSNKANIDIEHGVVSNCISHTDVEE
HHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHCCCCCC
NHTETTHFCVIDKEGNIASFTTSIGMIYGSGITIPGYGVLLNTTMDGFDVVAGGINEIAP
CCCCCEEEEEEECCCCEEEEHHHEEEEEECCCCCCCCCEEEECCCCCHHHHHCCHHHHCC
YKRPLSNMAPTIVMHHGKPILTVGAPGAISIIASVAQTLINVLVFGMDIQQAINESRIYS
CCCCHHHCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHCCC
SHPNRIEWEPQFSQSTILALIARGHAMEHKPDAYIGDVHGLQVDSITYEASGGSDDTREG
CCCCCEECCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCEEEEEEEEECCCCCCCCCCC
TVMGGEVLVIRKQPLPYRHMYDNDGFRVYLNGIQLPLYAEQVRWMHGTCWIEESVVRIIF
EEECCEEEEEECCCCCCHHCCCCCCEEEEEECEECCEEHHHHHHHHCEEEHHHHHHHHHH
SEVRAHIEDLRSYEIAGENYIDIVWLARKNAYQVALKDDGLYLNDEAYHSVKRNTNAYYR
HHHHHHHHHHHHEEECCCCEEEEEEEECCCEEEEEEECCCEEECCHHHHHHHCCCCCEEE
YDRDSITR
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA