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The map label for this gene is accC [H]

Identifier: 82703865

GI number: 82703865

Start: 3154617

End: 3155975

Strand: Reverse

Name: accC [H]

Synonym: Nmul_A2752

Alternate gene names: 82703865

Gene position: 3155975-3154617 (Counterclockwise)

Preceding gene: 82703866

Following gene: 162139860

Centisome position: 99.11

GC content: 55.85

Gene sequence:

>1359_bases
ATGTTTGAAAAAATACTGATAGCAAACCGTGGCGAGATTGCCTTGCGGATACAGCGTGCATGCCGTGAGATGGGTATCAA
GACTGTAGCGGTGCACTCCCAGGCCGATGCCGAGGCAAAATATGTAAAACTCGCTGATGAGTCCGTATGCATCGGACCTG
CTCCTTCGGCACAAAGCTACCTCAATATTCCCGCCATCATCAGCGCCGCAGAGGTCACCGATGCGGAAGCCATTCATCCG
GGTTACGGGTTTCTGTCGGAAAATGCCGATTTTGCCGAACGTGTGGAAAAAAGCGGCTTCGTCTTTATCGGCCCGCGGCC
CGAGACGATTCGGCTGATGGGCGACAAGGTCAGTGCCAAGAACGCCATGAAAAAGGCGGGCGTGCCTTGTGTCCCGGGCT
CGGACGGCGGTCTCCCCGAATCGGTGGACGAAATCAAAGCCATCGCTCGTGCCATCGGCTACCCTATCATTATCAAGGCC
GCGGCAGGTGGGGGCGGCCGTGGCATGCGCGTGGTGCACACTGAAGCAGCGTTATCGAACGCGGTGATCATTACGCGCAA
CGAAGCTCAGGCCGCCTTCGGCAACCCGACGGTCTACGCCGAAAAATATCTGGAGAACCCGCGCCACATCGAGTTTCAGG
TATTGGCGGATGAGCATCGCAACGCCATCTATCTGGGGGAACGGGATTGCTCCACGCAGCGCCGCCATCAGAAAATTATC
GAGGAAGCACCTGCCCTGGGCATTCCCCCCAGATTGCGCGACAGAATGGGAACCCGTTGCGTCGACGCATGCAAGCGCAT
CGGCTATCGCGGTGTGGGTACATTCGAGTTTCTGTTCGAAAAAAACGAGTTCTATTTCATTGAGATGAATACGCGCCTGC
AGGTCGAGCATACCATTACCGAGGCCATCACCGGGATCGATCTGGTGCAAGCGCAGATCCGCGTGGCAGCCGGCGAAAAG
CTCACTCTGCGGCAGCGCGACATCGTGTTGAAGGGTCATGCCATCGAATGCCGTATCGCGGCCGAAGACCCGTACAAGTT
CACCCCGTCGGCAGGGCGTATCACCCAGTATCATGCTCCCGGTGGCCCTGGCATTCGTGTGGATTCCCATATATATCATA
ACTACTTCGTGCCGCCCTATTACGATTCCATGATAGGCAAAATAATCGCGTATGGAGACAACCGCGAGCAGGCGATAGCA
CGAATGCGCATTGCGCTGTCGGAAATGGTGATCGGCGGCATCAAAACCAATACGCCGCTCCACCTTGACCTGTTGTCCGA
CGCCGCTTTTCTGAATGGCTGCACGAGCATTCATTATCTGGAGCAAAAGCTTGCCAATTATAATAACAATTCCGGCTGA

Upstream 100 bases:

>100_bases
ATTCGGCTTTTAGCCGCGCTACACGCTACCCCGAGGGACACCCGCATCAATAGAAGAGGAGAAATCACCTCCATCATGAA
ACCAGATACGAGCGGCAGAC

Downstream 100 bases:

>100_bases
GGCTCTATCGGCCTCGTTACTGGAACTCGGGTAACGGACGGGGGTGAGGTAGGAGCCTCTCGGGAAACGGGCCTGGAATG
TTCTGCCCGCCGTCTGCTTA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVHSQADAEAKYVKLADESVCIGPAPSAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFVFIGPRPETIRLMGDKVSAKNAMKKAGVPCVPGSDGGLPESVDEIKAIARAIGYPIIIKA
AAGGGGRGMRVVHTEAALSNAVIITRNEAQAAFGNPTVYAEKYLENPRHIEFQVLADEHRNAIYLGERDCSTQRRHQKII
EEAPALGIPPRLRDRMGTRCVDACKRIGYRGVGTFEFLFEKNEFYFIEMNTRLQVEHTITEAITGIDLVQAQIRVAAGEK
LTLRQRDIVLKGHAIECRIAAEDPYKFTPSAGRITQYHAPGGPGIRVDSHIYHNYFVPPYYDSMIGKIIAYGDNREQAIA
RMRIALSEMVIGGIKTNTPLHLDLLSDAAFLNGCTSIHYLEQKLANYNNNSG

Sequences:

>Translated_452_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVHSQADAEAKYVKLADESVCIGPAPSAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFVFIGPRPETIRLMGDKVSAKNAMKKAGVPCVPGSDGGLPESVDEIKAIARAIGYPIIIKA
AAGGGGRGMRVVHTEAALSNAVIITRNEAQAAFGNPTVYAEKYLENPRHIEFQVLADEHRNAIYLGERDCSTQRRHQKII
EEAPALGIPPRLRDRMGTRCVDACKRIGYRGVGTFEFLFEKNEFYFIEMNTRLQVEHTITEAITGIDLVQAQIRVAAGEK
LTLRQRDIVLKGHAIECRIAAEDPYKFTPSAGRITQYHAPGGPGIRVDSHIYHNYFVPPYYDSMIGKIIAYGDNREQAIA
RMRIALSEMVIGGIKTNTPLHLDLLSDAAFLNGCTSIHYLEQKLANYNNNSG
>Mature_452_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVHSQADAEAKYVKLADESVCIGPAPSAQSYLNIPAIISAAEVTDAEAIHP
GYGFLSENADFAERVEKSGFVFIGPRPETIRLMGDKVSAKNAMKKAGVPCVPGSDGGLPESVDEIKAIARAIGYPIIIKA
AAGGGGRGMRVVHTEAALSNAVIITRNEAQAAFGNPTVYAEKYLENPRHIEFQVLADEHRNAIYLGERDCSTQRRHQKII
EEAPALGIPPRLRDRMGTRCVDACKRIGYRGVGTFEFLFEKNEFYFIEMNTRLQVEHTITEAITGIDLVQAQIRVAAGEK
LTLRQRDIVLKGHAIECRIAAEDPYKFTPSAGRITQYHAPGGPGIRVDSHIYHNYFVPPYYDSMIGKIIAYGDNREQAIA
RMRIALSEMVIGGIKTNTPLHLDLLSDAAFLNGCTSIHYLEQKLANYNNNSG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=49.4356659142212, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=49.4356659142212, Blast_Score=427, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=49.4356659142212, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=47.2850678733032, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=46.6517857142857, Blast_Score=387, Evalue=1e-107,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=31.7120622568093, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=31.7120622568093, Blast_Score=245, Evalue=7e-65,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=31.7120622568093, Blast_Score=245, Evalue=8e-65,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=31.7120622568093, Blast_Score=244, Evalue=8e-65,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=31.7120622568093, Blast_Score=244, Evalue=1e-64,
Organism=Homo sapiens, GI134142062, Length=514, Percent_Identity=31.7120622568093, Blast_Score=240, Evalue=3e-63,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=68.2432432432432, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=49.4356659142212, Blast_Score=421, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=47.3922902494331, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=44.8660714285714, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=29.1836734693878, Blast_Score=215, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71997163, Length=508, Percent_Identity=28.740157480315, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71997168, Length=508, Percent_Identity=28.740157480315, Blast_Score=199, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=46.3087248322148, Blast_Score=353, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=47.6510067114094, Blast_Score=349, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=40.8577878103837, Blast_Score=339, Evalue=6e-94,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=30.9803921568627, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=466, Percent_Identity=31.9742489270386, Blast_Score=226, Evalue=8e-60,
Organism=Drosophila melanogaster, GI281363050, Length=445, Percent_Identity=47.1910112359551, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652224, Length=445, Percent_Identity=47.1910112359551, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652222, Length=445, Percent_Identity=47.1910112359551, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652220, Length=445, Percent_Identity=47.1910112359551, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652218, Length=445, Percent_Identity=47.1910112359551, Blast_Score=382, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652212, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652210, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652214, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI19921944, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24652216, Length=445, Percent_Identity=47.1910112359551, Blast_Score=381, Evalue=1e-106,
Organism=Drosophila melanogaster, GI24651757, Length=445, Percent_Identity=45.1685393258427, Blast_Score=379, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=44.3627450980392, Blast_Score=340, Evalue=2e-93,
Organism=Drosophila melanogaster, GI161076407, Length=499, Percent_Identity=31.6633266533066, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24586460, Length=499, Percent_Identity=31.6633266533066, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI161076409, Length=502, Percent_Identity=31.4741035856574, Blast_Score=232, Evalue=4e-61,
Organism=Drosophila melanogaster, GI24586458, Length=502, Percent_Identity=31.4741035856574, Blast_Score=232, Evalue=5e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49655; Mature: 49655

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVAVHSQADAEAKYVKLADESVCIGPAPSAQSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFVFIGPRPETIRLMGDKVSAK
CCCHHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCHHHH
NAMKKAGVPCVPGSDGGLPESVDEIKAIARAIGYPIIIKAAAGGGGRGMRVVHTEAALSN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECHHHCC
AVIITRNEAQAAFGNPTVYAEKYLENPRHIEFQVLADEHRNAIYLGERDCSTQRRHQKII
CEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPALGIPPRLRDRMGTRCVDACKRIGYRGVGTFEFLFEKNEFYFIEMNTRLQVEHTIT
HHCCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EAITGIDLVQAQIRVAAGEKLTLRQRDIVLKGHAIECRIAAEDPYKFTPSAGRITQYHAP
HHHHHHHHHHHHHEEECCCEEEEEECCEEEECCEEEEEEECCCCCEECCCCCCEEEEECC
GGPGIRVDSHIYHNYFVPPYYDSMIGKIIAYGDNREQAIARMRIALSEMVIGGIKTNTPL
CCCCCEECCEEEECCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCE
HLDLLSDAAFLNGCTSIHYLEQKLANYNNNSG
EEEEHHCHHHHHCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVAVHSQADAEAKYVKLADESVCIGPAPSAQSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEEECCCCCCHHH
LNIPAIISAAEVTDAEAIHPGYGFLSENADFAERVEKSGFVFIGPRPETIRLMGDKVSAK
CCCHHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCCHHHH
NAMKKAGVPCVPGSDGGLPESVDEIKAIARAIGYPIIIKAAAGGGGRGMRVVHTEAALSN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECHHHCC
AVIITRNEAQAAFGNPTVYAEKYLENPRHIEFQVLADEHRNAIYLGERDCSTQRRHQKII
CEEEEECCCCCCCCCCCCHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHHH
EEAPALGIPPRLRDRMGTRCVDACKRIGYRGVGTFEFLFEKNEFYFIEMNTRLQVEHTIT
HHCCCCCCCHHHHHHHCHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEEHHHHH
EAITGIDLVQAQIRVAAGEKLTLRQRDIVLKGHAIECRIAAEDPYKFTPSAGRITQYHAP
HHHHHHHHHHHHHEEECCCEEEEEECCEEEECCEEEEEEECCCCCEECCCCCCEEEEECC
GGPGIRVDSHIYHNYFVPPYYDSMIGKIIAYGDNREQAIARMRIALSEMVIGGIKTNTPL
CCCCCEECCEEEECCCCCCHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCE
HLDLLSDAAFLNGCTSIHYLEQKLANYNNNSG
EEEEHHCHHHHHCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]