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The map label for this gene is lysA [H]

Identifier: 82703782

GI number: 82703782

Start: 3064174

End: 3065406

Strand: Reverse

Name: lysA [H]

Synonym: Nmul_A2669

Alternate gene names: 82703782

Gene position: 3065406-3064174 (Counterclockwise)

Preceding gene: 82703783

Following gene: 82703781

Centisome position: 96.27

GC content: 58.31

Gene sequence:

>1233_bases
ATGACGGATTCCCGGCCAAGACACGCGCCCATTCAGTTTTCCGTAAACGATGATTGCCTCGAGATCGGAGGGCTGCCTCT
CACACGCCTGGCGCAGCGCGCGGGAAAGACACCTTTCTACGCGTATGACCGGCAAAGGCTGACGGATCGCGTGGCGTTCC
TGCGTCAGCATCTGCCTGCGGAAATTCACTTGCACTATGCGATGAAAGCCAATCCCATGCCGGCCGTCGTGCAGCATATG
GCTCGATTGGTGGATGGATTGGACGTTGCTTCAGCGGGAGAAATGAAGGTTGCGCTCGATACTCCTATGCCACCCGGTGA
AATCAGCTTCGCCGGTCCGGGCAAGAGCGACAGCGAACTTTCCTGCGCCATTGCCGCCGGCATCGTTCTCAATATGGAAT
CCGAGCAGGAGATGGAGCGAATCGCCATCCTGGGGGAATATCTGGGGGTTCGCCCAAAAGTGGCTGTTCGCGTCAATCCG
GATTTTGAACTTAAATCATCCAGCATGAAAATGGGCGGGGGCCCCAAGCAATTTGGAGTGGATGCCGAACGCGTTCCTGC
CATGCTGGCCCGACTGGGAAGACTGGCGCTCGATTTCGAAGGATTTCATATTTTCAGCGGCTCTCAGAACCTGAGAGTGG
CTGCCCTGCAGGAAGCACACGAAAAGACCTTCCAGCTGGGCATTGCGCTCGCGAAGCATGCTCCCGCTCCCGTCCGCATG
CTGAACATAGGCGGTGGTTTCGGTACGCCTTATTTTCCCGGGGATGAAGCGCTGGATCTGGCGGCGGTTGGCGAGAATCT
GCGGCGCCTCATACCCGGAGTGAGACAGGCGCTACCGGAGGCGCGCATCGTCATCGAGCTTGGCCGGTACCTCGTGGCGG
AGGCGGGCATCTACGTTTGCCGGGTGCTCGAACGCAAGGAATCCAGAGGACAGATATTCCTGATCACGGATGGAGGATTG
CATCATCATCTGGCGGCTTCCGGCAACTTCGGTCAGGTGATACGCAAGAATTACCCGGTCATGGTGGGAAATCGGGTACA
GGGAACCGACAGGGAAGTTGTTTCGGTGGTGGGACCGCTTTGCACGCCGCTGGATCTTCTGGCCGACCGCATGGAGATGA
GCAGGGCGGAAGCAGGCGATCTTATCGTCGTGTTCCAATCCGGCGCATACGGCTTGACCGCTAGTCCTACCGCGTTTCTC
AGTCATCCGCCGCCCATGGAAATGCTGGTCTAG

Upstream 100 bases:

>100_bases
TCGAGTACAGAGAGGGCAGTTTACCGCGCAACCCCAATGGCAAGATCGATCGCAAGCGTCTTGCTCAGGAGTTGCACGAT
ATTTTCATGGAAGCCGGCGC

Downstream 100 bases:

>100_bases
CAGATTAAGCGCTGTCATGCACGAGGATCGTTATGCCTTTTGACCAAGAGGGTGGCAAAAAGCAAATAATCCACAAAAAA
TCCATCAGATAACGAGAAGC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTDSRPRHAPIQFSVNDDCLEIGGLPLTRLAQRAGKTPFYAYDRQRLTDRVAFLRQHLPAEIHLHYAMKANPMPAVVQHM
ARLVDGLDVASAGEMKVALDTPMPPGEISFAGPGKSDSELSCAIAAGIVLNMESEQEMERIAILGEYLGVRPKVAVRVNP
DFELKSSSMKMGGGPKQFGVDAERVPAMLARLGRLALDFEGFHIFSGSQNLRVAALQEAHEKTFQLGIALAKHAPAPVRM
LNIGGGFGTPYFPGDEALDLAAVGENLRRLIPGVRQALPEARIVIELGRYLVAEAGIYVCRVLERKESRGQIFLITDGGL
HHHLAASGNFGQVIRKNYPVMVGNRVQGTDREVVSVVGPLCTPLDLLADRMEMSRAEAGDLIVVFQSGAYGLTASPTAFL
SHPPPMEMLV

Sequences:

>Translated_410_residues
MTDSRPRHAPIQFSVNDDCLEIGGLPLTRLAQRAGKTPFYAYDRQRLTDRVAFLRQHLPAEIHLHYAMKANPMPAVVQHM
ARLVDGLDVASAGEMKVALDTPMPPGEISFAGPGKSDSELSCAIAAGIVLNMESEQEMERIAILGEYLGVRPKVAVRVNP
DFELKSSSMKMGGGPKQFGVDAERVPAMLARLGRLALDFEGFHIFSGSQNLRVAALQEAHEKTFQLGIALAKHAPAPVRM
LNIGGGFGTPYFPGDEALDLAAVGENLRRLIPGVRQALPEARIVIELGRYLVAEAGIYVCRVLERKESRGQIFLITDGGL
HHHLAASGNFGQVIRKNYPVMVGNRVQGTDREVVSVVGPLCTPLDLLADRMEMSRAEAGDLIVVFQSGAYGLTASPTAFL
SHPPPMEMLV
>Mature_409_residues
TDSRPRHAPIQFSVNDDCLEIGGLPLTRLAQRAGKTPFYAYDRQRLTDRVAFLRQHLPAEIHLHYAMKANPMPAVVQHMA
RLVDGLDVASAGEMKVALDTPMPPGEISFAGPGKSDSELSCAIAAGIVLNMESEQEMERIAILGEYLGVRPKVAVRVNPD
FELKSSSMKMGGGPKQFGVDAERVPAMLARLGRLALDFEGFHIFSGSQNLRVAALQEAHEKTFQLGIALAKHAPAPVRML
NIGGGFGTPYFPGDEALDLAAVGENLRRLIPGVRQALPEARIVIELGRYLVAEAGIYVCRVLERKESRGQIFLITDGGLH
HHLAASGNFGQVIRKNYPVMVGNRVQGTDREVVSVVGPLCTPLDLLADRMEMSRAEAGDLIVVFQSGAYGLTASPTAFLS
HPPPMEMLV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=398, Percent_Identity=24.6231155778894, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI16506287, Length=378, Percent_Identity=24.8677248677249, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789203, Length=427, Percent_Identity=25.0585480093677, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24586474, Length=359, Percent_Identity=27.0194986072423, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44459; Mature: 44328

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSRPRHAPIQFSVNDDCLEIGGLPLTRLAQRAGKTPFYAYDRQRLTDRVAFLRQHLPA
CCCCCCCCCCEEEECCCCHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCC
EIHLHYAMKANPMPAVVQHMARLVDGLDVASAGEMKVALDTPMPPGEISFAGPGKSDSEL
EEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCE
SCAIAAGIVLNMESEQEMERIAILGEYLGVRPKVAVRVNPDFELKSSSMKMGGGPKQFGV
EEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCHHCCC
DAERVPAMLARLGRLALDFEGFHIFSGSQNLRVAALQEAHEKTFQLGIALAKHAPAPVRM
CHHHHHHHHHHHHHHEEEECCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEE
LNIGGGFGTPYFPGDEALDLAAVGENLRRLIPGVRQALPEARIVIELGRYLVAEAGIYVC
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RVLERKESRGQIFLITDGGLHHHLAASGNFGQVIRKNYPVMVGNRVQGTDREVVSVVGPL
HHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEECCCCCCCHHHHHHHHCCC
CTPLDLLADRMEMSRAEAGDLIVVFQSGAYGLTASPTAFLSHPPPMEMLV
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCHHHCC
>Mature Secondary Structure 
TDSRPRHAPIQFSVNDDCLEIGGLPLTRLAQRAGKTPFYAYDRQRLTDRVAFLRQHLPA
CCCCCCCCCEEEECCCCHHHHCCCCHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCCC
EIHLHYAMKANPMPAVVQHMARLVDGLDVASAGEMKVALDTPMPPGEISFAGPGKSDSEL
EEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCEEECCCCCCCCCE
SCAIAAGIVLNMESEQEMERIAILGEYLGVRPKVAVRVNPDFELKSSSMKMGGGPKQFGV
EEEEEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCCCCCCHHCCC
DAERVPAMLARLGRLALDFEGFHIFSGSQNLRVAALQEAHEKTFQLGIALAKHAPAPVRM
CHHHHHHHHHHHHHHEEEECCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCEEE
LNIGGGFGTPYFPGDEALDLAAVGENLRRLIPGVRQALPEARIVIELGRYLVAEAGIYVC
EEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RVLERKESRGQIFLITDGGLHHHLAASGNFGQVIRKNYPVMVGNRVQGTDREVVSVVGPL
HHHHHHCCCCEEEEEECCCCEEEEECCCCHHHHHHCCCCEEECCCCCCCHHHHHHHHCCC
CTPLDLLADRMEMSRAEAGDLIVVFQSGAYGLTASPTAFLSHPPPMEMLV
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEECCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]