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The map label for this gene is hemA

Identifier: 82703755

GI number: 82703755

Start: 3027395

End: 3028657

Strand: Reverse

Name: hemA

Synonym: Nmul_A2642

Alternate gene names: 82703755

Gene position: 3028657-3027395 (Counterclockwise)

Preceding gene: 82703759

Following gene: 82703754

Centisome position: 95.11

GC content: 59.07

Gene sequence:

>1263_bases
GTGTCCTCGACGCAGTTATTTGCCTTTGGCATCAACCATCAGACCGCGCCGCTCGATGTGCGCGAGCAGGTGTCGTTCCC
CGCGGATGCGATGGAGCATGCGCTGCATGATCTGGTAAGCCATCGTCCGGTGAGAGAGGCGGCGATTGTTTCCACCTGCA
ATCGCACCGAGATTTATTGCAGTACCGATAAGCCGGACGAAGCCACCCATTGGCTGGCGGATTTTCACCGTTTGCCGACC
CGCGAGCTTGAGCCGTATCTCTACAGGCTGCCGAGGGAAAAGGCCGTGAAGCACGCTTTCCGCGTTGCCAGCGGACTGGA
TTCCATGGTACTGGGCGAACCGCAGATACTTGGCCAGTTGAAGGATGCGGTGAAATCGGCTGAGCATGCGGGCACGCTCG
GCATGCTGTTGCACAAGCTGTTCCAGCGCACCTTTTTTGTTGCGAAGGAGGTTCGCAGCTCCACCGAAATCGGGACAAAT
TCCGTTTCCATGGCAGCGGCCTCCACCCGGCTGGCGGAGCGCATTTTTGGAGACATCGGCGAGCAGCGCGTGTTATTCAT
CGGTGCGGGCGAGATGATCGAGCTCTGCGCGAGCCATTTCGCTGCCCGTCATCCGAAGCGCATTACCGTCGCCAATCGGA
CTGTCGAGCGGGCACAGGCCCTGGCGCACCGGTTGAACGGGCAAGTCATCACCCTGAATGAATTGCCCGACCAGTTGGCG
CTTCATGATATTGTCGTCACCTGTACCGCGAGCACGCTCCCCATTCTCGGCAAGGGCATGCTGGAGCGGGCGATCAAGGC
ACGCAAGCACCGACCGATTTTCATGGTGGATCTTGCGGTGCCACGGGACGTGGAGCCCGAGGTGGCGGAACTGGATGACG
TGTTCCTCTATTCTGTGGATGATCTTGCCGATATCGTCAAGGAAGGCCTGGATTCCCGGCAGGGGGCGGTGGCGCAGGCA
GAGGCGATTATCGACTCGAATGTGGTCAATTTCATGCACTGGCTGGAATCGCGCCAGGTTGTGCCCACCATACGCGCCTT
GCGCGACCAGGCGGAGCGTTACCGACGGCATGAACTGGAACGGGCAAAAAAACTGCTGGCCAAAGGGGAGGATCCGCGGA
AAATCATCGAATCCCTGAGCAACGGGCTTACCAACAAGTTCCTCCATTTACCCTCCTATGCGCTCAACCACGCCGCTGAG
GACGAGCGTGACGATCTGGTCGACCTGATCAGCCGCCTGTATCACCTTCATCCCTCAGAATGA

Upstream 100 bases:

>100_bases
ATATTTTTTTCTGGACCCGAAACTCTTCCAATTGTTGGTATTCAAATGCTTGTAATACTATAATCACGAAATTTTAAAAT
TCAGCCGGTACTGAGCCAAC

Downstream 100 bases:

>100_bases
ACAAAAGTATGACTGCCAAGCTCACGCAACTCAGCGTGCGCCTGGAGGAGTTGAATCGTCTGCTGAGCAGCGAAAGCATC
ACGGTCAATCTCGATCAATA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MSSTQLFAFGINHQTAPLDVREQVSFPADAMEHALHDLVSHRPVREAAIVSTCNRTEIYCSTDKPDEATHWLADFHRLPT
RELEPYLYRLPREKAVKHAFRVASGLDSMVLGEPQILGQLKDAVKSAEHAGTLGMLLHKLFQRTFFVAKEVRSSTEIGTN
SVSMAAASTRLAERIFGDIGEQRVLFIGAGEMIELCASHFAARHPKRITVANRTVERAQALAHRLNGQVITLNELPDQLA
LHDIVVTCTASTLPILGKGMLERAIKARKHRPIFMVDLAVPRDVEPEVAELDDVFLYSVDDLADIVKEGLDSRQGAVAQA
EAIIDSNVVNFMHWLESRQVVPTIRALRDQAERYRRHELERAKKLLAKGEDPRKIIESLSNGLTNKFLHLPSYALNHAAE
DERDDLVDLISRLYHLHPSE

Sequences:

>Translated_420_residues
MSSTQLFAFGINHQTAPLDVREQVSFPADAMEHALHDLVSHRPVREAAIVSTCNRTEIYCSTDKPDEATHWLADFHRLPT
RELEPYLYRLPREKAVKHAFRVASGLDSMVLGEPQILGQLKDAVKSAEHAGTLGMLLHKLFQRTFFVAKEVRSSTEIGTN
SVSMAAASTRLAERIFGDIGEQRVLFIGAGEMIELCASHFAARHPKRITVANRTVERAQALAHRLNGQVITLNELPDQLA
LHDIVVTCTASTLPILGKGMLERAIKARKHRPIFMVDLAVPRDVEPEVAELDDVFLYSVDDLADIVKEGLDSRQGAVAQA
EAIIDSNVVNFMHWLESRQVVPTIRALRDQAERYRRHELERAKKLLAKGEDPRKIIESLSNGLTNKFLHLPSYALNHAAE
DERDDLVDLISRLYHLHPSE
>Mature_419_residues
SSTQLFAFGINHQTAPLDVREQVSFPADAMEHALHDLVSHRPVREAAIVSTCNRTEIYCSTDKPDEATHWLADFHRLPTR
ELEPYLYRLPREKAVKHAFRVASGLDSMVLGEPQILGQLKDAVKSAEHAGTLGMLLHKLFQRTFFVAKEVRSSTEIGTNS
VSMAAASTRLAERIFGDIGEQRVLFIGAGEMIELCASHFAARHPKRITVANRTVERAQALAHRLNGQVITLNELPDQLAL
HDIVVTCTASTLPILGKGMLERAIKARKHRPIFMVDLAVPRDVEPEVAELDDVFLYSVDDLADIVKEGLDSRQGAVAQAE
AIIDSNVVNFMHWLESRQVVPTIRALRDQAERYRRHELERAKKLLAKGEDPRKIIESLSNGLTNKFLHLPSYALNHAAED
ERDDLVDLISRLYHLHPSE

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=409, Percent_Identity=43.2762836185819, Blast_Score=340, Evalue=7e-95,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_NITMU (Q2Y5P2)

Other databases:

- EMBL:   CP000103
- RefSeq:   YP_413321.1
- ProteinModelPortal:   Q2Y5P2
- SMR:   Q2Y5P2
- STRING:   Q2Y5P2
- GeneID:   3785253
- GenomeReviews:   CP000103_GR
- KEGG:   nmu:Nmul_A2642
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q2Y5P2
- ProtClustDB:   PRK00045
- BioCyc:   NMUL323848:NMUL_A2642-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 47106; Mature: 46975

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 53-53 BINDING 108-108 BINDING 119-119

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTQLFAFGINHQTAPLDVREQVSFPADAMEHALHDLVSHRPVREAAIVSTCNRTEIYC
CCCCEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEE
STDKPDEATHWLADFHRLPTRELEPYLYRLPREKAVKHAFRVASGLDSMVLGEPQILGQL
CCCCCCHHHHHHHHHHHCCCHHCCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHH
KDAVKSAEHAGTLGMLLHKLFQRTFFVAKEVRSSTEIGTNSVSMAAASTRLAERIFGDIG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EQRVLFIGAGEMIELCASHFAARHPKRITVANRTVERAQALAHRLNGQVITLNELPDQLA
CCEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCEEECCCCCHHHH
LHDIVVTCTASTLPILGKGMLERAIKARKHRPIFMVDLAVPRDVEPEVAELDDVFLYSVD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHH
DLADIVKEGLDSRQGAVAQAEAIIDSNVVNFMHWLESRQVVPTIRALRDQAERYRRHELE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RAKKLLAKGEDPRKIIESLSNGLTNKFLHLPSYALNHAAEDERDDLVDLISRLYHLHPSE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSTQLFAFGINHQTAPLDVREQVSFPADAMEHALHDLVSHRPVREAAIVSTCNRTEIYC
CCCEEEEEECCCCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEE
STDKPDEATHWLADFHRLPTRELEPYLYRLPREKAVKHAFRVASGLDSMVLGEPQILGQL
CCCCCCHHHHHHHHHHHCCCHHCCHHHHHCCHHHHHHHHHHHHHCCCHHHCCCHHHHHHH
KDAVKSAEHAGTLGMLLHKLFQRTFFVAKEVRSSTEIGTNSVSMAAASTRLAERIFGDIG
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
EQRVLFIGAGEMIELCASHFAARHPKRITVANRTVERAQALAHRLNGQVITLNELPDQLA
CCEEEEEECCHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHCCCEEECCCCCHHHH
LHDIVVTCTASTLPILGKGMLERAIKARKHRPIFMVDLAVPRDVEPEVAELDDVFLYSVD
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHCCHH
DLADIVKEGLDSRQGAVAQAEAIIDSNVVNFMHWLESRQVVPTIRALRDQAERYRRHELE
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
RAKKLLAKGEDPRKIIESLSNGLTNKFLHLPSYALNHAAEDERDDLVDLISRLYHLHPSE
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA