Click here to switch to the map view.

The map label for this gene is metR [H]

Identifier: 82703748

GI number: 82703748

Start: 3020982

End: 3021917

Strand: Direct

Name: metR [H]

Synonym: Nmul_A2635

Alternate gene names: 82703748

Gene position: 3020982-3021917 (Clockwise)

Preceding gene: 82703746

Following gene: 82703751

Centisome position: 94.87

GC content: 58.01

Gene sequence:

>936_bases
ATGACTTCCCTGCTTGAACTTCGGCACCTCCGCACTCTCGCAGCCTTGGATGAAACAGGCAGCGTCTCGCGGGCGGCAAA
ACGCGTGCACCTGACCCAATCGGCATTGTCGCACCAAATCAAAGCGTTGCAGAACCATTACGGCTTGCCGATATTGCGCC
GCCAGGGGCAAAGCATCGAACTGACTGAAGCGGGACAGCATCTGGTCACGTTGGCGCGCAAGGTACTCGAGGAAATACAG
GCGACTGAACGAAATCTTGCCAAAATGTCGGAGCATGCCTCAGGTAGCTTGCGCATCGTACTGGAGTGCCACACCTGCTT
CGACTGGCTGATGCCGCTGATGGACGCATTCCGCCAGAACTGGCCGGAGGTCGAACTCGATCTGGTTTCGGGATTTCACA
GCGATCCCCTTCAGCTTCTGGAGGAAGGCGGGGCAGATGTAGTGATCGGATCGGAGCAGACTGAGCGACGCAGCATCGTT
CACCACCCGCTCTTCCGCTTCGAAATTCTTGCGGTGCTGGCGCCGGAACACCCGTTACGCGCGAAGAAAATCCTGCATGC
ACGCGACTTCGCCGGCGAGACGCTGATCACCTATCCCGTGCCGGAAGAGCGTATCGATCTTATTCGCAACGTGCTGAAAC
CGGCAGGCGTTCAACCCGAGCGGCGCACAGCCGAGCTTACCGTGGCGATCCTGCAACTGGTCGCCAGCCGACGGGGTATT
GCCGCGCTGCCCAGCTGGGGACTTAAAAACTATGTCGAGCACGATTATGTAATCGCGCGACGCATTGGTCCGCAAGGACT
GTGGAGTGACTTGTACGTATCAACGCTGGCGGAAACCGCCACCCGGCCCTATCTGCGCGATTTTCTGGTTACTGCAAGGA
ATACGTGCTTCGCAACGCTGGATGGAATCATTCCCCTGAAGTCGGCGGAGCAATAA

Upstream 100 bases:

>100_bases
CTCTGTGGAGTGACTGACGATTTTGTGGCAGACTTGGTTATGAATCAAATGAAATGTTGTAAAATATTAATGAATAAAAT
TCATAAATTTCTATGTGACG

Downstream 100 bases:

>100_bases
GCGCCCAACAGGTAGCAGACAGGAGAAACAGTGGAGAGAAGAAGTGAAGAAGAGGTATAAAGAGAAGGAGGCGGGATAGG
CAGGCAAGTACAAACTGCCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MTSLLELRHLRTLAALDETGSVSRAAKRVHLTQSALSHQIKALQNHYGLPILRRQGQSIELTEAGQHLVTLARKVLEEIQ
ATERNLAKMSEHASGSLRIVLECHTCFDWLMPLMDAFRQNWPEVELDLVSGFHSDPLQLLEEGGADVVIGSEQTERRSIV
HHPLFRFEILAVLAPEHPLRAKKILHARDFAGETLITYPVPEERIDLIRNVLKPAGVQPERRTAELTVAILQLVASRRGI
AALPSWGLKNYVEHDYVIARRIGPQGLWSDLYVSTLAETATRPYLRDFLVTARNTCFATLDGIIPLKSAEQ

Sequences:

>Translated_311_residues
MTSLLELRHLRTLAALDETGSVSRAAKRVHLTQSALSHQIKALQNHYGLPILRRQGQSIELTEAGQHLVTLARKVLEEIQ
ATERNLAKMSEHASGSLRIVLECHTCFDWLMPLMDAFRQNWPEVELDLVSGFHSDPLQLLEEGGADVVIGSEQTERRSIV
HHPLFRFEILAVLAPEHPLRAKKILHARDFAGETLITYPVPEERIDLIRNVLKPAGVQPERRTAELTVAILQLVASRRGI
AALPSWGLKNYVEHDYVIARRIGPQGLWSDLYVSTLAETATRPYLRDFLVTARNTCFATLDGIIPLKSAEQ
>Mature_310_residues
TSLLELRHLRTLAALDETGSVSRAAKRVHLTQSALSHQIKALQNHYGLPILRRQGQSIELTEAGQHLVTLARKVLEEIQA
TERNLAKMSEHASGSLRIVLECHTCFDWLMPLMDAFRQNWPEVELDLVSGFHSDPLQLLEEGGADVVIGSEQTERRSIVH
HPLFRFEILAVLAPEHPLRAKKILHARDFAGETLITYPVPEERIDLIRNVLKPAGVQPERRTAELTVAILQLVASRRGIA
ALPSWGLKNYVEHDYVIARRIGPQGLWSDLYVSTLAETATRPYLRDFLVTARNTCFATLDGIIPLKSAEQ

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=309, Percent_Identity=39.1585760517799, Blast_Score=227, Evalue=6e-61,
Organism=Escherichia coli, GI1790399, Length=256, Percent_Identity=28.125, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI157672245, Length=213, Percent_Identity=28.169014084507, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1787530, Length=315, Percent_Identity=24.1269841269841, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790208, Length=256, Percent_Identity=27.734375, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786401, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788887, Length=288, Percent_Identity=25.6944444444444, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788296, Length=181, Percent_Identity=30.3867403314917, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787879, Length=250, Percent_Identity=28.4, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082024, Length=181, Percent_Identity=28.7292817679558, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787589, Length=127, Percent_Identity=30.7086614173228, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788748, Length=277, Percent_Identity=29.2418772563177, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693105, Length=247, Percent_Identity=23.8866396761134, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789173, Length=120, Percent_Identity=32.5, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789506, Length=176, Percent_Identity=24.4318181818182, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI87081904, Length=226, Percent_Identity=26.1061946902655, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786713, Length=180, Percent_Identity=26.1111111111111, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1786508, Length=188, Percent_Identity=23.4042553191489, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788706, Length=175, Percent_Identity=25.7142857142857, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI145693193, Length=181, Percent_Identity=25.9668508287293, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34941; Mature: 34810

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLLELRHLRTLAALDETGSVSRAAKRVHLTQSALSHQIKALQNHYGLPILRRQGQSIE
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEE
LTEAGQHLVTLARKVLEEIQATERNLAKMSEHASGSLRIVLECHTCFDWLMPLMDAFRQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCC
WPEVELDLVSGFHSDPLQLLEEGGADVVIGSEQTERRSIVHHPLFRFEILAVLAPEHPLR
CCCEEHHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
AKKILHARDFAGETLITYPVPEERIDLIRNVLKPAGVQPERRTAELTVAILQLVASRRGI
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
AALPSWGLKNYVEHDYVIARRIGPQGLWSDLYVSTLAETATRPYLRDFLVTARNTCFATL
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGIIPLKSAEQ
CCCCCCCCCCC
>Mature Secondary Structure 
TSLLELRHLRTLAALDETGSVSRAAKRVHLTQSALSHQIKALQNHYGLPILRRQGQSIE
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEE
LTEAGQHLVTLARKVLEEIQATERNLAKMSEHASGSLRIVLECHTCFDWLMPLMDAFRQN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHCC
WPEVELDLVSGFHSDPLQLLEEGGADVVIGSEQTERRSIVHHPLFRFEILAVLAPEHPLR
CCCEEHHHHCCCCCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCHH
AKKILHARDFAGETLITYPVPEERIDLIRNVLKPAGVQPERRTAELTVAILQLVASRRGI
HHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCC
AALPSWGLKNYVEHDYVIARRIGPQGLWSDLYVSTLAETATRPYLRDFLVTARNTCFATL
CCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DGIIPLKSAEQ
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]