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The map label for this gene is purM [H]

Identifier: 82703730

GI number: 82703730

Start: 3002383

End: 3003522

Strand: Direct

Name: purM [H]

Synonym: Nmul_A2617

Alternate gene names: 82703730

Gene position: 3002383-3003522 (Clockwise)

Preceding gene: 82703716

Following gene: 82703731

Centisome position: 94.29

GC content: 55.88

Gene sequence:

>1140_bases
GTGTTAGGGTTCCTTGGCGCCATTTGCGGTAAAATTGCGGCTTCAAACGCCACTCTATCTGTAACAGGACGAGAATTCAA
CTTGACCACATCCAAACCCCACGAAGAAAACCTCTCTCCTCTCTCTTACCGCGCCGCCGGCGTCGATATAGACGCCGGCG
AACGTCTGGTGGAAAACATAAGGCCCTACGCAAAACGCACTCTGCGGCCCGAAGTGCTGGCCGGTATCGGCGGCTTTGGC
GCACTTTTCGAAATTTCCCGGAAATTCAACAATCCGGTACTGGTAGCAGGTACGGATGGGGTAGGTACCAAACTGAAGCT
CGCGTTCGAATCCGGCAGGCACGACACGGTCGGCATCGACCTGGTTGCAATGAGTGTGAACGATATTCTGGTGCAGGGGG
CAGAGCCGCTGTTTTTTCTGGACTATTTCGCGTGTGGGAAGCTGGACGTGGACACTGCCACCCTGGTAGTGAAGGGCATT
GCAGCCGGATGCGAGCAAGCCGGATGCGCCTTGATAGGCGGAGAAACCGCTGAGATGCCGGGGATGTATCCGGAAGGCGA
GTATGATCTTGCCGGTTTCGCTGTCGGCGCGGTCGAGAAGGATCGCATCATCACGGGCACAACCATCAAGGCAGGCGACG
CAGTACTGGGACTTGCTTCCAGCGGCGCCCATTCAAATGGCTATTCCCTGATCCGCAAGATCATCGAGAAAAATAATGTG
GATTTGTCCGCCGATTTTCATGGCAGGGCGTTAATAGATGTAATCATGGCGCCTACCCGGATTTACGTGAAGCCTCTGCT
CGAGCTCATGAGGCAGGTACCGGTTAAAGGCATGGCGCATATCACGGGCGGTGGCCTGCTGGAAAATATTCCGCGCATCC
TGCCTGAAGGCGTTACGGCAGTATTGAAGAAAGAAACCTGGGAGATGCCTCCGCTTTTTGCCTGGCTGCAGCGGGAAGGC
AATGTGGCCGATAATGAAATGCACCGCGTTTTCAATTGTGGCATTGGCATGGCCGTCGTCGTGGCGCCGGAGTATATCGA
TGCCGCCGCGCAATTGCTTCAATCAAAGGGAGAAATCGCATGGCGCATTGGCACCATTCGCGAGCAGCGCGCGGACGAAC
CCCGGACGATCCTCGAGTGA

Upstream 100 bases:

>100_bases
TTACTGGATATCAGGATAAGAAACAGGCGATACGGACGCAGACGTAGATCTGGAGTATTGTCCGAAAACGGCCATCAAAC
TCGAATGATGTCAGGGTTTC

Downstream 100 bases:

>100_bases
GCAGTGTGGAGCACTACACACATGCAACGTGAATCCCCTGCTGATCCATGAAGTCACTCGTGATCCTTATCTCCGGCCGC
GGCAGCAATATGCAAGCTCT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MLGFLGAICGKIAASNATLSVTGREFNLTTSKPHEENLSPLSYRAAGVDIDAGERLVENIRPYAKRTLRPEVLAGIGGFG
ALFEISRKFNNPVLVAGTDGVGTKLKLAFESGRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTATLVVKGI
AAGCEQAGCALIGGETAEMPGMYPEGEYDLAGFAVGAVEKDRIITGTTIKAGDAVLGLASSGAHSNGYSLIRKIIEKNNV
DLSADFHGRALIDVIMAPTRIYVKPLLELMRQVPVKGMAHITGGGLLENIPRILPEGVTAVLKKETWEMPPLFAWLQREG
NVADNEMHRVFNCGIGMAVVVAPEYIDAAAQLLQSKGEIAWRIGTIREQRADEPRTILE

Sequences:

>Translated_379_residues
MLGFLGAICGKIAASNATLSVTGREFNLTTSKPHEENLSPLSYRAAGVDIDAGERLVENIRPYAKRTLRPEVLAGIGGFG
ALFEISRKFNNPVLVAGTDGVGTKLKLAFESGRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTATLVVKGI
AAGCEQAGCALIGGETAEMPGMYPEGEYDLAGFAVGAVEKDRIITGTTIKAGDAVLGLASSGAHSNGYSLIRKIIEKNNV
DLSADFHGRALIDVIMAPTRIYVKPLLELMRQVPVKGMAHITGGGLLENIPRILPEGVTAVLKKETWEMPPLFAWLQREG
NVADNEMHRVFNCGIGMAVVVAPEYIDAAAQLLQSKGEIAWRIGTIREQRADEPRTILE
>Mature_379_residues
MLGFLGAICGKIAASNATLSVTGREFNLTTSKPHEENLSPLSYRAAGVDIDAGERLVENIRPYAKRTLRPEVLAGIGGFG
ALFEISRKFNNPVLVAGTDGVGTKLKLAFESGRHDTVGIDLVAMSVNDILVQGAEPLFFLDYFACGKLDVDTATLVVKGI
AAGCEQAGCALIGGETAEMPGMYPEGEYDLAGFAVGAVEKDRIITGTTIKAGDAVLGLASSGAHSNGYSLIRKIIEKNNV
DLSADFHGRALIDVIMAPTRIYVKPLLELMRQVPVKGMAHITGGGLLENIPRILPEGVTAVLKKETWEMPPLFAWLQREG
NVADNEMHRVFNCGIGMAVVVAPEYIDAAAQLLQSKGEIAWRIGTIREQRADEPRTILE

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=341, Percent_Identity=53.3724340175953, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI209869995, Length=341, Percent_Identity=53.3724340175953, Blast_Score=361, Evalue=1e-100,
Organism=Homo sapiens, GI209869993, Length=341, Percent_Identity=53.3724340175953, Blast_Score=361, Evalue=1e-100,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=56.4327485380117, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI17567511, Length=365, Percent_Identity=40.2739726027397, Blast_Score=260, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=353, Percent_Identity=48.7252124645892, Blast_Score=337, Evalue=2e-93,
Organism=Drosophila melanogaster, GI24582400, Length=271, Percent_Identity=43.9114391143911, Blast_Score=233, Evalue=1e-61,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 40547; Mature: 40547

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGFLGAICGKIAASNATLSVTGREFNLTTSKPHEENLSPLSYRAAGVDIDAGERLVENI
CCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHH
RPYAKRTLRPEVLAGIGGFGALFEISRKFNNPVLVAGTDGVGTKLKLAFESGRHDTVGID
HHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEE
LVAMSVNDILVQGAEPLFFLDYFACGKLDVDTATLVVKGIAAGCEQAGCALIGGETAEMP
EEEEEHHHHHHCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCHHHCCEEEECCCCCCCC
GMYPEGEYDLAGFAVGAVEKDRIITGTTIKAGDAVLGLASSGAHSNGYSLIRKIIEKNNV
CCCCCCCCCCCEEEECCCCCCCEEECCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DLSADFHGRALIDVIMAPTRIYVKPLLELMRQVPVKGMAHITGGGLLENIPRILPEGVTA
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
VLKKETWEMPPLFAWLQREGNVADNEMHRVFNCGIGMAVVVAPEYIDAAAQLLQSKGEIA
HHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEE
WRIGTIREQRADEPRTILE
EEECCHHHHCCCCCHHHCC
>Mature Secondary Structure
MLGFLGAICGKIAASNATLSVTGREFNLTTSKPHEENLSPLSYRAAGVDIDAGERLVENI
CCHHHHHHHHHHHCCCCEEEEECCEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHHHH
RPYAKRTLRPEVLAGIGGFGALFEISRKFNNPVLVAGTDGVGTKLKLAFESGRHDTVGID
HHHHHHCCCHHHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEEEEECCCCCEEEEE
LVAMSVNDILVQGAEPLFFLDYFACGKLDVDTATLVVKGIAAGCEQAGCALIGGETAEMP
EEEEEHHHHHHCCCCCEEEEEHHHCCCCCCCHHHHHHHHHHHCHHHCCEEEECCCCCCCC
GMYPEGEYDLAGFAVGAVEKDRIITGTTIKAGDAVLGLASSGAHSNGYSLIRKIIEKNNV
CCCCCCCCCCCEEEECCCCCCCEEECCEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DLSADFHGRALIDVIMAPTRIYVKPLLELMRQVPVKGMAHITGGGLLENIPRILPEGVTA
EEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHH
VLKKETWEMPPLFAWLQREGNVADNEMHRVFNCGIGMAVVVAPEYIDAAAQLLQSKGEIA
HHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCCEE
WRIGTIREQRADEPRTILE
EEECCHHHHCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA