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The map label for this gene is hda [H]

Identifier: 82703729

GI number: 82703729

Start: 3001594

End: 3002268

Strand: Reverse

Name: hda [H]

Synonym: Nmul_A2616

Alternate gene names: 82703729

Gene position: 3002268-3001594 (Counterclockwise)

Preceding gene: 82703737

Following gene: 82703728

Centisome position: 94.29

GC content: 54.81

Gene sequence:

>675_bases
ATGAAGCAATTGCCGCTGGACATAATCCCTCCGCCACCGACCTTATCCAATTTCGTGACGGGCCGCAACGCGGAGTTGTT
GCAAACCCTGGATAACCTTCTAATGATGCGGAAGCACGAGCGTTTTGTTTATATATGGGGGGGAACGGGTTGCGGAAAAA
GTCATCTGCTGCAAGGCGTTGCCAGTGCGTGCAAGCGCAATGACATGAACACGCTTTATTTCGCGTGTGGCGAGAGAACG
TCTTTCGCGAATGGCAGCGAGGCCGATTGCGTGATGGTGGACGACGTGGATCGCCTTGGTGCCGATGCCCAGATCGGACT
GTTTCATCTCTATAATCGTATCCGTGATGAAGGGCAAGCGTTCCTGCTGGTAAGCGGTTCCGTCGCTCCCACGCAGCTGA
AGCTGCGCGCAGATCTGCTTACCCGCCTTGCATGGGGGCTGGTGTACGAGGTTCATGAATTGACTGATGAGGAAAAAATG
GAAGCCATGAAAAGCCACGCCAGCAGCCGCGGCCTTGCTTTGCCACAGGAGGTATGTGACTACCTGCTGCGACATGAGCG
GCGCGATTTGACTTCCCTGATGGCGAAGCTTAACGCGCTGGATAAATATTCGCTGGCGAGTCACCGGAAAATAACTGTTC
CGCTGGTACGCGAGCTATTGCAGGCCGCCTCATGA

Upstream 100 bases:

>100_bases
ATTCGAGTTTGATGGCCGTTTTCGGACAATACTCCAGATCTACGTCTGCGTCCGTATCGCCTGTTTCTTATCCTGATATC
CAGTAACAGCTCCCTCGTTG

Downstream 100 bases:

>100_bases
ATCTTGCTTTATTTGACCTCGATAATACCCTGCTTGCGGGCGATAGCGACTTCCAGTGGGGACAGCACCTCATCGAGCAG
GGGGTGCTCGACCGCGAACT

Product: DnaA regulatory inactivator Hda

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKQLPLDIIPPPPTLSNFVTGRNAELLQTLDNLLMMRKHERFVYIWGGTGCGKSHLLQGVASACKRNDMNTLYFACGERT
SFANGSEADCVMVDDVDRLGADAQIGLFHLYNRIRDEGQAFLLVSGSVAPTQLKLRADLLTRLAWGLVYEVHELTDEEKM
EAMKSHASSRGLALPQEVCDYLLRHERRDLTSLMAKLNALDKYSLASHRKITVPLVRELLQAAS

Sequences:

>Translated_224_residues
MKQLPLDIIPPPPTLSNFVTGRNAELLQTLDNLLMMRKHERFVYIWGGTGCGKSHLLQGVASACKRNDMNTLYFACGERT
SFANGSEADCVMVDDVDRLGADAQIGLFHLYNRIRDEGQAFLLVSGSVAPTQLKLRADLLTRLAWGLVYEVHELTDEEKM
EAMKSHASSRGLALPQEVCDYLLRHERRDLTSLMAKLNALDKYSLASHRKITVPLVRELLQAAS
>Mature_224_residues
MKQLPLDIIPPPPTLSNFVTGRNAELLQTLDNLLMMRKHERFVYIWGGTGCGKSHLLQGVASACKRNDMNTLYFACGERT
SFANGSEADCVMVDDVDRLGADAQIGLFHLYNRIRDEGQAFLLVSGSVAPTQLKLRADLLTRLAWGLVYEVHELTDEEKM
EAMKSHASSRGLALPQEVCDYLLRHERRDLTSLMAKLNALDKYSLASHRKITVPLVRELLQAAS

Specific function: Mediates the interactions of dnaA with the beta subunit sliding clamp, promoting hydrolysis of dnaA-bound ATP. It is essential for the control of initiation of DNA replication by inhibiting reinitiation of replication [H]

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family. HdA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510964, Length=226, Percent_Identity=34.5132743362832, Blast_Score=138, Evalue=3e-34,
Organism=Escherichia coli, GI2367267, Length=229, Percent_Identity=23.1441048034935, Blast_Score=64, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020591
- InterPro:   IPR017788
- InterPro:   IPR013317
- InterPro:   IPR022864 [H]

Pfam domain/function: PF00308 Bac_DnaA [H]

EC number: NA

Molecular weight: Translated: 25043; Mature: 25043

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQLPLDIIPPPPTLSNFVTGRNAELLQTLDNLLMMRKHERFVYIWGGTGCGKSHLLQGV
CCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
ASACKRNDMNTLYFACGERTSFANGSEADCVMVDDVDRLGADAQIGLFHLYNRIRDEGQA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCE
FLLVSGSVAPTQLKLRADLLTRLAWGLVYEVHELTDEEKMEAMKSHASSRGLALPQEVCD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHH
YLLRHERRDLTSLMAKLNALDKYSLASHRKITVPLVRELLQAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure
MKQLPLDIIPPPPTLSNFVTGRNAELLQTLDNLLMMRKHERFVYIWGGTGCGKSHLLQGV
CCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHH
ASACKRNDMNTLYFACGERTSFANGSEADCVMVDDVDRLGADAQIGLFHLYNRIRDEGQA
HHHHHCCCCCEEEEEECCCCCCCCCCCCCEEEECCHHHHCCCCHHHHHHHHHHHHCCCCE
FLLVSGSVAPTQLKLRADLLTRLAWGLVYEVHELTDEEKMEAMKSHASSRGLALPQEVCD
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHH
YLLRHERRDLTSLMAKLNALDKYSLASHRKITVPLVRELLQAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA