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The map label for this gene is shc [H]

Identifier: 82703671

GI number: 82703671

Start: 2924736

End: 2926697

Strand: Reverse

Name: shc [H]

Synonym: Nmul_A2556

Alternate gene names: 82703671

Gene position: 2926697-2924736 (Counterclockwise)

Preceding gene: 82703672

Following gene: 82703670

Centisome position: 91.91

GC content: 57.95

Gene sequence:

>1962_bases
ATGAAAAAATTCGGAGGTATGGCGAGAACTTCATTGCAAGCTCAATCCCCGGGCTCAAACAATACTCCCTCAATGGACGA
AAAAATGCTGAAAGCGGGACTGGAAGCGGCACGCGGTGCGCTGCTGGCTCAGCAGAGGGAGGATGGCCACTGGTGCTTTC
CATTGGAGGCCGATTGCACGATTCCCGCCGAGTATATACTGATGATGCACTTCATGGATGAAGTGGACCTGGATCTGGAG
GTCAGGATTGCCCGTTTTATTCGTGAAAAACAGGATGTAGCGCACGGAGGCTGGCCGCTCTACTACGGCGGTGAATTCGA
TCTGAGTTGTTCGGTCAAGGCCTATTATGCTCTGAAAATTGTGGGGGACTCCCCGGACGCGCCCCACATGGTGCGTGCGC
GTGCAGCAATTCTGAAACATGGCGGCGCAGCGAGAGCAAATGTATTTACACGCCTGCTGCTTGCCATGTATGACCAGCTT
CCCTGGCGAGGCGTGCCATTTGTGCCGGTGGAAATCATACTGTTCCCCAAGTGGTTTCCATTCCATACCAGCAAGGTCGC
ATACTGGTCGCGGACCGTAATGGTTCCGCTATCTATCCTGTGCAGCCTGAAGGCGCGCGCGGCGAATCCGCGCAAAGTCG
CCATTCGTGAATTGTTTACGGTACCTCCGGGGGAGGAGCGGAATTATTTTCCGGTACGTACTGCGCTCAATCGCGTGTTT
CTGCTGATCGAGCGCACTCTCTCCCTGCTCGAACCCTTCATACCCCAAGGGGTGCGCAGATTGGCGCTGCGGCGGGCGGA
AAGCTGGATCGTGGAAAGGCTGAACGGCGACTCAGGCCTGGGGGCGATCTTTCCTGCCATGGTGAATGCCGGCGAAGCTC
TGGCATTGCTTGGATACCCATATGATCATCCCGCGCGGGAGCAATGCCGCAAGGCGCTGCGCCTGCTGCTGGTGGAGGAA
GGCGAGCGTACCTGGTGCCAGCCCTGTGTTTCCCCAGTATGGGATACCGTCCTGACCTGTCTCGCCTTTCAGGAGGATAC
GGAGGTCGATCAGAAGCCCATCCGGAAAGCGCTCGACTGGCTGGTTCCCTGTCAGGTGCTCGATGCGCCGGCGGACTGGC
AAGAAGATCATCCCGGATTACCGGGCGGGGGCTGGGCTTTTCAGTATGCAAATCCCCACTATCCCGATCTCGACGACACG
GCTGCGGTGGCGTGGGCACTGTACCAGGCCGACCCTAAGGCTTATCAGGAAAGCATCAGCCGGGCCGCCGACTGGCTGGC
GGGGATGCAGTCCAGCAATGGGGGGTTTGCGGCTTTCGACAGCGACAATACGTATTACTATCTCAACGAGATCCCGTTTG
CCGATCATGGGGCGCTCCTTGATCCTCCCACCAGTGATGTTTCCGCCCGCTGTGCAGGTTTTCTCGCCTTGTACGGCCAG
TCCAGGCATAAACAGGCGCTGGAACGGAGTCTGGCATACCTCTTCAATGAACAGGAGGCCAGTGGCGCCTGGTTCGGCCG
CTGGGGCAGCAATTACATCTATGGAACGTGGTCTGTGCTGGAGGCCTTCCGTCTGGCCGGGATAGATGCCGGTCATCCTG
CCATCCGACGCGCGGTGCACTGGCTCAAATCCGTGCAGCGGGAGGATGGCGGATGGGGAGAAAGTAACGACAGCTATCTT
TCCCCCCAGCAGGCAGGCCAGTTTCATACCAGTACTTCTTTTCATACCGCATGGGCACTGCTTGCACTGATGGGAGCCGG
CGAATGGCGAAGTCATGAGGTTCACCGGGGAATTGCCTACCTCTTGCGGGAACAGGACAGCGACGGGCTCTGGCATGAGC
CCTGGTTTACCGCTCCCGGCTTCCCGCGGGTTTTCTACCTCAAGTACTACGGGTATACGAAATATTTCCCGGTATGGGCA
TTGACCCGATTTCATGCATTGAACCGGAAGTTCCCCGGGTGA

Upstream 100 bases:

>100_bases
AATCGAGTAAAATCATGCTTTTAATAGTTTTTATGGCTGCACTCACACCCCTGCGATATGGTCTTCCCTGAAACTTTAAA
GAGGCGCTAGGTAAAAATAC

Downstream 100 bases:

>100_bases
CGGCGGTCGGCATCATTGTCGCCATGCGGATGGAGGCGGGTTGCATAACGCCATTGCGCCTCTCCTTCAATCAAAGGACA
GATCTCGGGAATGGCGCTGC

Product: squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 653; Mature: 653

Protein sequence:

>653_residues
MKKFGGMARTSLQAQSPGSNNTPSMDEKMLKAGLEAARGALLAQQREDGHWCFPLEADCTIPAEYILMMHFMDEVDLDLE
VRIARFIREKQDVAHGGWPLYYGGEFDLSCSVKAYYALKIVGDSPDAPHMVRARAAILKHGGAARANVFTRLLLAMYDQL
PWRGVPFVPVEIILFPKWFPFHTSKVAYWSRTVMVPLSILCSLKARAANPRKVAIRELFTVPPGEERNYFPVRTALNRVF
LLIERTLSLLEPFIPQGVRRLALRRAESWIVERLNGDSGLGAIFPAMVNAGEALALLGYPYDHPAREQCRKALRLLLVEE
GERTWCQPCVSPVWDTVLTCLAFQEDTEVDQKPIRKALDWLVPCQVLDAPADWQEDHPGLPGGGWAFQYANPHYPDLDDT
AAVAWALYQADPKAYQESISRAADWLAGMQSSNGGFAAFDSDNTYYYLNEIPFADHGALLDPPTSDVSARCAGFLALYGQ
SRHKQALERSLAYLFNEQEASGAWFGRWGSNYIYGTWSVLEAFRLAGIDAGHPAIRRAVHWLKSVQREDGGWGESNDSYL
SPQQAGQFHTSTSFHTAWALLALMGAGEWRSHEVHRGIAYLLREQDSDGLWHEPWFTAPGFPRVFYLKYYGYTKYFPVWA
LTRFHALNRKFPG

Sequences:

>Translated_653_residues
MKKFGGMARTSLQAQSPGSNNTPSMDEKMLKAGLEAARGALLAQQREDGHWCFPLEADCTIPAEYILMMHFMDEVDLDLE
VRIARFIREKQDVAHGGWPLYYGGEFDLSCSVKAYYALKIVGDSPDAPHMVRARAAILKHGGAARANVFTRLLLAMYDQL
PWRGVPFVPVEIILFPKWFPFHTSKVAYWSRTVMVPLSILCSLKARAANPRKVAIRELFTVPPGEERNYFPVRTALNRVF
LLIERTLSLLEPFIPQGVRRLALRRAESWIVERLNGDSGLGAIFPAMVNAGEALALLGYPYDHPAREQCRKALRLLLVEE
GERTWCQPCVSPVWDTVLTCLAFQEDTEVDQKPIRKALDWLVPCQVLDAPADWQEDHPGLPGGGWAFQYANPHYPDLDDT
AAVAWALYQADPKAYQESISRAADWLAGMQSSNGGFAAFDSDNTYYYLNEIPFADHGALLDPPTSDVSARCAGFLALYGQ
SRHKQALERSLAYLFNEQEASGAWFGRWGSNYIYGTWSVLEAFRLAGIDAGHPAIRRAVHWLKSVQREDGGWGESNDSYL
SPQQAGQFHTSTSFHTAWALLALMGAGEWRSHEVHRGIAYLLREQDSDGLWHEPWFTAPGFPRVFYLKYYGYTKYFPVWA
LTRFHALNRKFPG
>Mature_653_residues
MKKFGGMARTSLQAQSPGSNNTPSMDEKMLKAGLEAARGALLAQQREDGHWCFPLEADCTIPAEYILMMHFMDEVDLDLE
VRIARFIREKQDVAHGGWPLYYGGEFDLSCSVKAYYALKIVGDSPDAPHMVRARAAILKHGGAARANVFTRLLLAMYDQL
PWRGVPFVPVEIILFPKWFPFHTSKVAYWSRTVMVPLSILCSLKARAANPRKVAIRELFTVPPGEERNYFPVRTALNRVF
LLIERTLSLLEPFIPQGVRRLALRRAESWIVERLNGDSGLGAIFPAMVNAGEALALLGYPYDHPAREQCRKALRLLLVEE
GERTWCQPCVSPVWDTVLTCLAFQEDTEVDQKPIRKALDWLVPCQVLDAPADWQEDHPGLPGGGWAFQYANPHYPDLDDT
AAVAWALYQADPKAYQESISRAADWLAGMQSSNGGFAAFDSDNTYYYLNEIPFADHGALLDPPTSDVSARCAGFLALYGQ
SRHKQALERSLAYLFNEQEASGAWFGRWGSNYIYGTWSVLEAFRLAGIDAGHPAIRRAVHWLKSVQREDGGWGESNDSYL
SPQQAGQFHTSTSFHTAWALLALMGAGEWRSHEVHRGIAYLLREQDSDGLWHEPWFTAPGFPRVFYLKYYGYTKYFPVWA
LTRFHALNRKFPG

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=698, Percent_Identity=26.7908309455587, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI47933397, Length=698, Percent_Identity=26.7908309455587, Blast_Score=153, Evalue=5e-37,
Organism=Homo sapiens, GI224177558, Length=653, Percent_Identity=26.9525267993874, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI224177556, Length=698, Percent_Identity=26.3610315186246, Blast_Score=144, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321863, Length=613, Percent_Identity=21.8597063621533, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 73624; Mature: 73624

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFGGMARTSLQAQSPGSNNTPSMDEKMLKAGLEAARGALLAQQREDGHWCFPLEADCT
CCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IPAEYILMMHFMDEVDLDLEVRIARFIREKQDVAHGGWPLYYGGEFDLSCSVKAYYALKI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEECEEECEEEEEEEEE
VGDSPDAPHMVRARAAILKHGGAARANVFTRLLLAMYDQLPWRGVPFVPVEIILFPKWFP
ECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
FHTSKVAYWSRTVMVPLSILCSLKARAANPRKVAIRELFTVPPGEERNYFPVRTALNRVF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHH
LLIERTLSLLEPFIPQGVRRLALRRAESWIVERLNGDSGLGAIFPAMVNAGEALALLGYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCC
YDHPAREQCRKALRLLLVEEGERTWCQPCVSPVWDTVLTCLAFQEDTEVDQKPIRKALDW
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LVPCQVLDAPADWQEDHPGLPGGGWAFQYANPHYPDLDDTAAVAWALYQADPKAYQESIS
HCCHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
RAADWLAGMQSSNGGFAAFDSDNTYYYLNEIPFADHGALLDPPTSDVSARCAGFLALYGQ
HHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SRHKQALERSLAYLFNEQEASGAWFGRWGSNYIYGTWSVLEAFRLAGIDAGHPAIRRAVH
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHH
WLKSVQREDGGWGESNDSYLSPQQAGQFHTSTSFHTAWALLALMGAGEWRSHEVHRGIAY
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLREQDSDGLWHEPWFTAPGFPRVFYLKYYGYTKYFPVWALTRFHALNRKFPG
HHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKKFGGMARTSLQAQSPGSNNTPSMDEKMLKAGLEAARGALLAQQREDGHWCFPLEADCT
CCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCC
IPAEYILMMHFMDEVDLDLEVRIARFIREKQDVAHGGWPLYYGGEFDLSCSVKAYYALKI
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEECEEECEEEEEEEEE
VGDSPDAPHMVRARAAILKHGGAARANVFTRLLLAMYDQLPWRGVPFVPVEIILFPKWFP
ECCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
FHTSKVAYWSRTVMVPLSILCSLKARAANPRKVAIRELFTVPPGEERNYFPVRTALNRVF
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEHHHHHHHHHH
LLIERTLSLLEPFIPQGVRRLALRRAESWIVERLNGDSGLGAIFPAMVNAGEALALLGYP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCC
YDHPAREQCRKALRLLLVEEGERTWCQPCVSPVWDTVLTCLAFQEDTEVDQKPIRKALDW
CCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LVPCQVLDAPADWQEDHPGLPGGGWAFQYANPHYPDLDDTAAVAWALYQADPKAYQESIS
HCCHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
RAADWLAGMQSSNGGFAAFDSDNTYYYLNEIPFADHGALLDPPTSDVSARCAGFLALYGQ
HHHHHHHHCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
SRHKQALERSLAYLFNEQEASGAWFGRWGSNYIYGTWSVLEAFRLAGIDAGHPAIRRAVH
HHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEHHHHHHHHHHHCCCCCCHHHHHHHH
WLKSVQREDGGWGESNDSYLSPQQAGQFHTSTSFHTAWALLALMGAGEWRSHEVHRGIAY
HHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LLREQDSDGLWHEPWFTAPGFPRVFYLKYYGYTKYFPVWALTRFHALNRKFPG
HHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]